BG63153B1 - Метод за получаване на протеинов хидролизат и използването му за предотвратяване или лечение на алергии - Google Patents

Метод за получаване на протеинов хидролизат и използването му за предотвратяване или лечение на алергии Download PDF

Info

Publication number: BG63153B1
Authority: BG; Bulgaria
Prior art keywords: lactobacillus; atcc; bacteria; protein hydrolyzate; bacterial preparation
Prior art date: 1995-06-14

Application number

BG102144A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG102144A (en

Inventor

Erika Isolauri

Leena Metsaeniitty

Hannu Korhonen

Seppo Salminen

Eeva-Liisa Syvaeoja

Original Assignee

Valio Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-14

Filing date

1997-12-23

Publication date

2001-05-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8543602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63153(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-12-23 Application filed by Valio Oy filed Critical Valio Oy

1998-12-30 Publication of BG102144A publication Critical patent/BG102144A/xx

2001-05-31 Publication of BG63153B1 publication Critical patent/BG63153B1/bg

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Mycology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nutrition Science (AREA)
Molecular Biology (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pulmonology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Dairy Products (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BG102144A 1995-06-14 1997-12-23 Метод за получаване на протеинов хидролизат и използването му за предотвратяване или лечение на алергии BG63153B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI952926A FI104465B (fi)	1995-06-14	1995-06-14	Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
PCT/FI1996/000350 WO1997000078A1 (en)	1995-06-14	1996-06-12	Methods of preventing or treating allergies

Publications (2)

Publication Number	Publication Date
BG102144A BG102144A (en)	1998-12-30
BG63153B1 true BG63153B1 (bg)	2001-05-31

Family

ID=8543602

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102144A BG63153B1 (bg)	1995-06-14	1997-12-23	Метод за получаване на протеинов хидролизат и използването му за предотвратяване или лечение на алергии

Country Status (26)

Country	Link
US (2)	US6506380B1 (et)
EP (1)	EP0833649B2 (et)
JP (1)	JP3983804B2 (et)
KR (1)	KR100494741B1 (et)
CN (1)	CN1154506C (et)
AR (1)	AR003960A1 (et)
AT (1)	ATE230606T1 (et)
BG (1)	BG63153B1 (et)
BR (1)	BR9607827A (et)
CA (1)	CA2224320C (et)
CZ (1)	CZ291904B6 (et)
DE (1)	DE69625690T3 (et)
DK (1)	DK0833649T4 (et)
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Families Citing this family (168)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI104465B (fi) *	1995-06-14	2000-02-15	Valio Oy	Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
EP0986314B1 (en) *	1997-06-03	2008-09-10	Ganeden Biotech, Inc.	Probiotic lactic acid bacterium to treat bacterial infections associated with sids
WO2000042561A2 (en)	1999-01-19	2000-07-20	Maxygen, Inc.	Oligonucleotide mediated nucleic acid recombination
ES2321797T3 (es)	1999-08-05	2009-06-12	Societe Des Produits Nestle S.A.	Bifidobacterias que previenen la diarrea causada por bacterias patogenicas.
CA2378426C (en)	1999-08-05	2010-03-23	Societe Des Produits Nestle S.A.	Bifidobacteria capable of preventing diarrhea
WO2001057534A2 (en) *	2000-02-04	2001-08-09	Bioseek	Compositions and methods for reducing autoimmunity
FI110668B (fi)	2000-06-20	2003-03-14	Aboatech Ab Oy	Probioottien käyttö atooppisten sairauksien primaariseen ehkäisyyn
US7498162B2 (en) *	2000-09-25	2009-03-03	Nestec S.A.	Lactic acid bacteria capable of reducing an individual's tendency to develop allergic reactions
JP4510376B2 (ja) *	2000-10-06	2010-07-21	ソシエテ・デ・プロデュイ・ネスレ・エス・アー	皮膚の免疫系のバランスを保つためのプロバイオティック乳酸菌の使用
FI109602B (fi) *	2001-01-25	2002-09-13	Valio Oy	Probioottiyhdistelmä
EP1228707A1 (en) *	2001-02-01	2002-08-07	Campina Melkunie B.V.	Use of alpha-lactalbumin as prebiotic agent
CN1638650A (zh) *	2001-03-09	2005-07-13	雀巢制品公司	改善与年龄有关的生理缺陷并延长寿命的组合物
JP2003137804A (ja) *	2001-10-31	2003-05-14	Morinaga Milk Ind Co Ltd	インターロイキン−１８誘導剤
EP1364586A1 (en) *	2002-05-24	2003-11-26	Nestec S.A.	Probiotics and oral tolerance
ES2540926T3 (es)	2002-06-04	2015-07-14	Dsm Ip Assets B.V.	Hidrolizado de proteínas rico en tripéptidos
ES2311729T5 (es)	2002-06-28	2013-02-14	Biosearch S.A.	Cepas probióticas, un procedimiento para la selección de ellas, composiciones de las mismas y su uso
EP1384483A1 (en) *	2002-07-23	2004-01-28	Nestec S.A.	Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function
US7105336B2 (en) *	2002-10-07	2006-09-12	Biogaia Ab	Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter
US20040208863A1 (en) *	2003-01-30	2004-10-21	James Versalovic	Anti-inflammatory activity from lactic acid bacteria
WO2004112509A2 (en) *	2003-06-23	2004-12-29	Nestec S.A.	Nutritional formula for optimal gut barrier function
KR101225918B1 (ko)	2004-02-25	2013-01-24	파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드	신규한 바실루스 투링기엔시스 결정 폴리펩티드,폴리뉴클레오티드, 및 이의 조성물
US20050265946A1 (en) *	2004-05-28	2005-12-01	Kao Corporation	Elastase inhibitor
US7862808B2 (en)	2004-07-01	2011-01-04	Mead Johnson Nutrition Company	Method for preventing or treating respiratory infections and acute otitis media in infants using Lactobacillus rhamnosus LGG and Bifidobacterium lactis Bb-12
CA2604338A1 (en)	2005-04-13	2006-10-19	Nestec S.A.	Infant formula with probiotics
US7303745B2 (en) *	2005-04-15	2007-12-04	Bristol-Myers Squibb Company	Method for preventing or treating the development of respiratory allergies
US20060233762A1 (en) *	2005-04-15	2006-10-19	Mcmahon Robert J	Method for treating or preventing systemic inflammation in formula-fed infants
WO2007054587A1 (en) *	2005-11-14	2007-05-18	Nestec S.A.	Oral tolerance promotion with glycated proteins
MY148872A (en)	2006-02-15	2013-06-14	Nestec Sa	Use of bifidobacterium longum for the prevention and treatment of inflammation
RU2448720C2 (ru)	2006-03-07	2012-04-27	Нестек С.А.	Синбиотическая смесь
CN101460067B (zh) *	2006-06-15	2012-09-26	雀巢产品技术援助有限公司	诱导对卵蛋白的耐受
ES2381232T3 (es) *	2007-02-28	2012-05-24	Mead Johnson Nutrition Company	Procedimiento para el tratamiento o la prevención de la inflamación sistémica
EP1974734A1 (en) †	2007-03-28	2008-10-01	Nestec S.A.	Probiotics for reduction of risk of obesity
EP1974735A1 (en)	2007-03-28	2008-10-01	Nestec S.A.	Reduction of risk of diarrhoea
EP1974743A1 (en)	2007-03-28	2008-10-01	Nestec S.A.	Probiotics to Improve Gut Microbiota
CN101273736B (zh)	2007-03-28	2012-08-08	北京弗蒙特生物技术有限公司	一种在常温下保持高活菌数的发酵乳的制备方法
WO2009029554A2 (en)	2007-08-24	2009-03-05	Codexis, Inc.	Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
EP2072052A1 (en)	2007-12-17	2009-06-24	Nestec S.A.	Prevention of opportunistic infections in immune-compromised subjects
UA101176C2 (ru)	2008-01-24	2013-03-11	Нестек С.А.	Капсула для применения в устройстве для приготовления напитков, которая содержит питательные ингредиенты и способ получения питательной жидкости из капсулы
ES2585407T3 (es)	2008-02-01	2016-10-05	Murdoch Childrens Research Institute	Un método para inducir tolerancia a un alérgeno
EP2265135B1 (en)	2008-03-14	2017-12-20	Nestec S.A.	Synbiotic mixture
EP2127661A1 (en)	2008-05-27	2009-12-02	Nestec S.A.	Probiotics to improve gut microbiotica
US20090312196A1 (en)	2008-06-13	2009-12-17	Codexis, Inc.	Method of synthesizing polynucleotide variants
CN102066561B (zh)	2008-06-13	2013-09-25	科德克希思公司	合成多核苷酸变体的方法
WO2010008828A2 (en)	2008-06-24	2010-01-21	Codexis, Inc.	Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
EP2147678A1 (en)	2008-07-21	2010-01-27	Nestec S.A.	Probiotics to increase IgA secretion in infants born by caesarean section
RU2392001C2 (ru) *	2008-08-04	2010-06-20	Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию"	Способ лечения желтушных форм вирусного гепатита а у детей с пищевой аллергией
EP2329013B1 (en)	2008-08-27	2015-10-28	Codexis, Inc.	Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
HUE052297T2 (hu)	2009-01-08	2021-04-28	Codexis Inc	Transzamináz polipeptidek
BRPI1013886A2 (pt)	2009-03-17	2016-10-11	Codexis Inc	variantes de endoglucanases, polinucleotídeos e usos a elas relacionados
CA2757040C (en)	2009-03-31	2016-02-09	Codexis, Inc.	Improved endoglucanases
US8357523B2 (en)	2009-06-16	2013-01-22	Codexis, Inc.	Beta-glucosidase variant enzymes and related polynucleotides
SG177331A1 (en)	2009-06-22	2012-02-28	Codexis Inc	Ketoreductase-mediated stereoselective route to alpha chloroalcohols
WO2011011630A2 (en)	2009-07-23	2011-01-27	Codexis, Inc.	Nitrilase biocatalysts
EP2467032B1 (en)	2009-08-18	2018-02-21	Nestec S.A.	A nutritional composition comprising bifidobacterium longum strains and reducing food allergy symptoms, especially in infants and children
PT2467031E (pt) *	2009-08-18	2014-10-30	Nestec Sa	Composição nutricional compreendendo estirpes lactococcus e redução de sintomas de alergia, especialmente em bebés e crianças
US9102959B2 (en)	2009-08-19	2015-08-11	Codexis, Inc.	Ketoreductase polypeptides for the preparation of phenylephrine
EP2473604B1 (en)	2009-09-04	2017-01-11	Codexis, Inc.	Variant cbh2 cellulases and related polynucleotides
EP2295535A1 (en) *	2009-09-11	2011-03-16	Mead Johnson Nutrition Company	Probiotic material
DK2478137T3 (da)	2009-09-18	2017-11-27	Codexis Inc	Reduceret kodonmutagenese
EP2504431A4 (en)	2009-11-25	2013-10-16	Codexis Inc	RECOMBINANT BETA-GLUCOSIDASE VARIANTS OF THERMOASCUS AURIENTIACUS FOR THE PRODUCTION OF FERMENTABLE SUGARS FROM CELLULOSIC BIOMASS
PL2504017T3 (pl)	2009-11-25	2014-06-30	Codexis Inc	Rekombinacyjne warianty beta-glukozydazy do wytwarzania rozpuszczalnych cukrów z biomasy celulozowej
AU2010329990B2 (en)	2009-12-08	2015-07-16	Nestec S.A.	Infant formula with probiotics and milk fat globule membrane components
WO2011071982A2 (en)	2009-12-08	2011-06-16	Codexis, Inc.	Synthesis of prazole compounds
CA2786001A1 (en)	2009-12-31	2011-07-07	Pioneer Hi-Bred International, Inc.	Engineering plant resistance to diseases caused by pathogens
HUE026367T2 (en)	2010-05-04	2016-06-28	Codexis Inc	Biocatalysts for ezetimibe synthesis
EP2569331A1 (en)	2010-05-10	2013-03-20	Perseid Therapeutics LLC	Polypeptide inhibitors of vla4
EP2576804B1 (en)	2010-05-28	2016-12-14	Codexis, Inc.	Pentose fermentation by a recombinant microorganism
WO2011159910A2 (en)	2010-06-17	2011-12-22	Codexis, Inc.	Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol
US8574878B2 (en)	2010-06-28	2013-11-05	Behnaz Behrouzian	Fatty alcohol forming acyl reductases (FARs) and methods of use thereof
AU2011272878B2 (en)	2010-06-30	2015-04-23	Codexis, Inc.	Highly stable beta-class carbonic anhydrases useful in carbon capture systems
CA2808098C (en)	2010-08-16	2020-03-10	Merck Sharp & Dohme Corp.	Process for preparing aminocyclohexyl ether compounds
US9493802B2 (en)	2010-08-20	2016-11-15	Codexis, Inc.	Use of glycohydrolase 61 protein variants with improved thermostability for processing cellulose
WO2012078800A2 (en)	2010-12-08	2012-06-14	Codexis, Inc.	Biocatalysts and methods for the synthesis of armodafinil
EE05750B1 (et)	2011-02-25	2015-06-15	OÜ Tervisliku Piima Biotehnoloogiate Arenduskeskus	Isoleeritud mikroorganismi tüvi Lactobacillus gasseri MCC2 DSM 23882 ning selle kasutamine
EP2691517A4 (en)	2011-03-30	2015-04-22	Codexis Inc	FERMENTATION OF PENTOSES BY A RECOMBINANT MICROORGANISM
EP2697662B1 (en)	2011-04-13	2018-06-06	Codexis, Inc.	Biocatalytic process for preparing eslicarbazepine and analogs thereof
UA111078C2 (uk) *	2011-05-03	2016-03-25	Нестек С.А.	Гідролізат білкового субстрату і спосіб його виготовлення
US8778652B2 (en)	2011-06-30	2014-07-15	Codexis, Inc.	Pentose fermentation by a recombinant microorganism
EP2748317B1 (en)	2011-08-22	2017-04-19	Codexis, Inc.	Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity
CN103998461B (zh)	2011-09-08	2018-02-02	科德克希思公司	用于合成取代的内酰胺的生物催化剂和方法
US20130084608A1 (en)	2011-09-30	2013-04-04	Codexis, Inc.	Fungal proteases
WO2013052101A1 (en) *	2011-10-03	2013-04-11	Kelly Foods Corporation	Probiotic composition for pets and method of providing the same
US20130089638A1 (en) *	2011-10-11	2013-04-11	Mead Johnson Nutrition Company	Compositions Comprising Maltotriose And Methods Of Using Same To Inhibit Damage Caused By Dehydration Processes
CN104053771B (zh)	2011-11-18	2016-11-09	科德克希思公司	用于制备羟基取代的氨基甲酸酯的生物催化剂
EP2794871A4 (en)	2011-12-20	2015-12-30	Codexis Inc	VARIANTS OF ENDOGLUCANASE-1B (EG1B)
US20130251829A1 (en) *	2012-03-23	2013-09-26	Mead Johnson Nutrition Company	Probiotic derived non-viable material for infection prevention and treatment
DK2828385T3 (en)	2012-03-23	2018-03-12	Codexis Inc	BIOCATALIZATORS AND METHODS FOR SYNTHETIZING DERIVATIVES AND TRYPTAMIN AND TRYPTAMINE ANALOGS
ES2712682T3 (es)	2012-05-08	2019-05-14	Codexis Inc	Biocatalizadores y métodos para la hidroxilación de compuestos químicos
US9193957B2 (en)	2012-05-11	2015-11-24	Codexis, Inc.	Engineered imine reductases and methods for the reductive animation of ketone and amine compounds
DK2859099T3 (da)	2012-06-11	2019-07-29	Codexis Inc	Svampe-beta-xylosidase-varianter
WO2014081605A1 (en)	2012-11-20	2014-05-30	Codexis, Inc.	Pentose fermentation by a recombinant microorganism
US9738915B2 (en)	2012-12-07	2017-08-22	Merck Sharp & Dohme Corp.	Biocatalytic transamination process
CN105008528A (zh)	2012-12-21	2015-10-28	科德克希思公司	用于合成手性胺的工程化的生物催化剂和方法
WO2014113521A1 (en)	2013-01-18	2014-07-24	Codexis, Inc.	Engineered biocatalysts useful for carbapenem synthesis
JP6436541B2 (ja)	2013-02-28	2018-12-12	コデクシス，インコーポレイテッド	工業的生体触媒作用のための操作されたトランスアミナーゼポリペプチド
CN103355405A (zh) *	2013-04-07	2013-10-23	苏州旭优食品科技有限公司	一种低过敏性含乳制品的加工工艺
KR102218930B1 (ko)	2013-04-18	2021-02-23	코덱시스, 인코포레이티드	조작된 페닐알라닌 암모니아 리아제 폴리펩티드
CA2929664C (en)	2013-11-13	2023-01-24	Codexis, Inc.	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
HUE056444T2 (hu)	2014-04-16	2022-02-28	Codexis Inc	Génmódosított tirozin-ammónia-liáz
US9708587B2 (en)	2014-07-09	2017-07-18	Codexis, Inc.	P450-BM3 variants with improved activity
US10370648B2 (en)	2014-11-25	2019-08-06	Codexis, Inc.	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
MA41020A (fr)	2014-11-25	2017-10-03	Evelo Biosciences Inc	Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome
KR102702200B1 (ko)	2014-12-22	2024-09-02	코덱시스, 인코포레이티드	인간 알파-갈락토시다제 변이체
WO2016130412A1 (en)	2015-02-10	2016-08-18	Codexis, Inc.	Ketoreductase polypeptides for the synthesis of chiral compounds
SG11201708356PA (en)	2015-05-07	2017-11-29	Codexis Inc	Penicillin-g acylases
WO2017007547A1 (en)	2015-07-07	2017-01-12	Codexis, Inc.	Novel p450-bm3 variants with improved activity
US10724025B2 (en)	2016-05-05	2020-07-28	Codexis, Inc.	Penicillin-G acylases
US10184117B2 (en)	2016-06-09	2019-01-22	Codexis, Inc.	Biocatalysts and methods for hydroxylation of chemical compounds
EP3471744A4 (en)	2016-06-15	2020-07-29	Codexis, Inc.	REVISED BETA-GLUCOSIDASES AND GLUCOSYLATION PROCESSES
EP4223766A3 (en)	2016-08-26	2023-10-18	Codexis, Inc.	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CA3048475A1 (en)	2017-01-05	2018-07-12	Codexis, Inc.	Penicillin-g acylases
CN110914445B (zh)	2017-02-03	2024-08-27	泰莱解决方案美国有限责任公司	工程化糖基转移酶和甜菊醇糖苷葡糖基化方法
EP3579867A4 (en)	2017-02-13	2021-03-10	Codexis, Inc.	MANIPULATED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
ES2926255T3 (es)	2017-04-24	2022-10-24	Tesaro Inc	Métodos de fabricación de niraparib
WO2018200214A2 (en)	2017-04-27	2018-11-01	Codexis, Inc.	Ketoreductase polypeptides and polynucleotides
MX2019013289A (es)	2017-05-08	2020-01-15	Codexis Inc	Variantes de ligasa modificadas geneticamente.
WO2018231462A1 (en)	2017-06-14	2018-12-20	Codexis, Inc.	Engineered transaminase polypeptides for industrial biocatalysis
WO2019005337A1 (en)	2017-06-27	2019-01-03	Codexis, Inc.	PENICILLIN G ACYLASES
WO2019005540A1 (en)	2017-06-30	2019-01-03	Codexis, Inc.	T7 POLYMERASE RNA VARIANTS
WO2019005539A1 (en)	2017-06-30	2019-01-03	Codexis, Inc.	T7 POLYMERASE RNA VARIANTS
CA3080512A1 (en)	2017-11-07	2019-05-16	Codexis, Inc.	Transglutaminase variants
CA3085261A1 (en)	2017-12-13	2019-06-20	Glaxosmithkline Intellectual Property Development Limited	Carboxyesterase biocatalysts
WO2019118557A1 (en)	2017-12-13	2019-06-20	Codexis, Inc.	Carboxyesterase polypeptides for amide coupling
US10900055B2 (en)	2018-06-12	2021-01-26	Codexis, Inc.	Engineered tyrosine ammonia lyase
MX2021000326A (es)	2018-07-09	2021-03-25	Codexis Inc	Desoxirribosa-fosfato aldolasas modificadas geneticamente.
AU2019300837B2 (en)	2018-07-09	2025-05-22	Codexis, Inc.	Engineered galactose oxidase variant enzymes
KR20210031929A (ko)	2018-07-09	2021-03-23	코덱시스, 인코포레이티드	조작된 판토테네이트 키나제 변이체 효소
SG11202012109UA (en)	2018-07-09	2021-01-28	Codexis Inc	Engineered phosphopentomutase variant enzymes
CA3103718A1 (en)	2018-07-09	2020-01-16	Codexis, Inc.	Engineered purine nucleoside phosphorylase variant enzymes
US11198861B2 (en)	2018-07-12	2021-12-14	Codexis, Inc.	Engineered phenylalanine ammonia lyase polypeptides
JP7584401B2 (ja)	2018-07-30	2024-11-15	テイトアンドライルソリューションズユー・エス・エーエル・エル・シー	操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
CN113316635A (zh)	2018-10-29	2021-08-27	科德克希思公司	工程化dna聚合酶变体
WO2020123286A1 (en)	2018-12-14	2020-06-18	Codexis, Inc.	Engineered tyrosine ammonia lyase
CA3123598A1 (en)	2018-12-20	2020-06-25	Codexis, Inc.	Human alpha-galactosidase variants
EP3911738A4 (en)	2019-01-15	2023-03-01	Codexis, Inc.	Engineered transaminase polypeptides
CA3137734A1 (en)	2019-05-01	2020-11-05	Codexis, Inc.	Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds
EP3963057A4 (en)	2019-05-01	2023-06-14	Codexis, Inc.	MANIPULATED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
SG11202113108UA (en)	2019-07-02	2021-12-30	Codexis Inc	Engineered acetate kinase variant enzymes
CN114072165A (zh)	2019-07-02	2022-02-18	科德克希思公司	工程化蔗糖磷酸化酶变体酶
WO2021013862A1 (en)	2019-07-23	2021-01-28	Frieslandcampina Nederland B.V.	Nutritional composition comprising milk fat and immunoglobulin
JP7699107B2 (ja)	2019-08-30	2025-06-26	ソシエテ・デ・プロデュイ・ネスレ・エス・アー	操作されたリパーゼ改変体
WO2021050348A1 (en)	2019-09-12	2021-03-18	Codexis, Inc.	Peroxidase activity towards 10-acetyl-3,7-dihydroxyphenoxazine
CN114746745B (zh)	2019-10-02	2025-06-17	美国雅培糖尿病护理公司	通过蛋白质开关检测分析物
US12344865B2 (en)	2019-11-26	2025-07-01	Codexis, Inc.	Biocatalysts and methods for hydroxylation of chemical compounds
BR112022011760A2 (pt)	2019-12-20	2022-08-30	Codexis Inc	Fragmento de alfa glicosidase ácida recombinante e/ou de alfa glicosidase ácida recombinante biologicamente ativa, alfa glicosidase ácida recombinante, composição, sequência polinucleotídica recombinante, vetor de expressão, vetor de expressão pdh, célula hospedeira, método para produzir uma variante de alfa glicosidase ácida recombinante, variante de alfa glicosidase ácida recombinante, composição farmacêutica para o tratamento da doença de pompe, composição farmacêutica, método para tratar e/ou prevenir os sintomas da doença de pompe em um indivíduo, e, uso das composições
CA3168922A1 (en)	2020-02-04	2021-08-12	Codexis, Inc.	Engineered leucine decarboxylases
EP4133064A4 (en)	2020-04-10	2024-07-24	Codexis, Inc.	Engineered transaminase polypeptides
CN116897205A (zh)	2020-08-28	2023-10-17	科德克希思公司	工程化淀粉酶变体
WO2022047262A1 (en)	2020-08-28	2022-03-03	Codexis, Inc.	Engineered protease variants
WO2022125960A1 (en)	2020-12-11	2022-06-16	Willow Biosciences, Inc.	Recombinant acyl activating enzyme (aae) genes for enhanced biosynthesis of cannabinoids and cannabinoid precursors
US11898174B2 (en)	2020-12-18	2024-02-13	Codexis, Inc.	Engineered uridine phosphorylase variant enzymes
IL305922A (en)	2021-04-02	2023-11-01	Codexis Inc	Transgenic enzymes of variant guanylate kinase
WO2022212824A1 (en)	2021-04-02	2022-10-06	Codexis, Inc.	Engineered adenylate kinase variant enzymes
WO2022212832A1 (en)	2021-04-02	2022-10-06	Codexis, Inc.	Engineered cyclic gmp-amp synthase (cgas) variant enzymes
CA3215105A1 (en)	2021-04-02	2022-10-06	Codexis, Inc.	Engineered acetate kinase variant enzymes
CA3220735A1 (en)	2021-05-21	2022-11-24	Codexis, Inc.	Engineered methionine gamma lyase variants
CA3227215A1 (en)	2021-07-30	2023-02-02	Trish Choudhary	Recombinant prenyltransferase polypeptides engineered for enhanced biosynthesis of cannabinoids
WO2023023621A1 (en)	2021-08-19	2023-02-23	Willow Biosciences, Inc.	Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids
CN118103501A (zh)	2021-10-15	2024-05-28	科德克希思公司	工程化dna聚合酶变体
WO2023069921A1 (en)	2021-10-19	2023-04-27	Epimeron Usa, Inc.	Recombinant thca synthase polypeptides engineered for enhanced biosynthesis of cannabinoids
CA3236731A1 (en)	2021-11-01	2023-05-04	Jonathan Benjamin ASFAHA	Engineered leucine decarboxylases
US20250207108A1 (en)	2022-03-31	2025-06-26	Qingdao Kingagroot Chemical Compound Co., Ltd.	Monoamine oxidase and application thereof
WO2024040020A1 (en)	2022-08-15	2024-02-22	Absci Corporation	Quantitative affinity activity specific cell enrichment
WO2024150146A1 (en)	2023-01-12	2024-07-18	Novartis Ag	Engineered ketoreductase polypeptides
WO2025061911A1 (en)	2023-09-22	2025-03-27	Glaxosmithkline Intellectual Property Development Limited	Methods of producing nucleotide triphosphates (ntps)
WO2025144700A1 (en)	2023-12-27	2025-07-03	Absci Corporation	Nanobody library screening using bacterial surface display
WO2025235589A1 (en)	2024-05-08	2025-11-13	Codexis, Inc.	Dna polymerase variants
WO2025242702A1 (en)	2024-05-23	2025-11-27	Glaxosmithkline Intellectual Property Development Limited	Enzymatic process for producing n-acetyl galactosamine clusters

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3886288A (en) *	1970-06-15	1975-05-27	Swift & Co	Cheese manufacture using highly active proteolytic enzymes
JPS5279086A (en)	1975-12-25	1977-07-02	Nippon Soda Co Ltd	Preparation of antibiotic tunicamycin
JPS5279083A (en) *	1975-12-26	1977-07-02	Morinaga Milk Industry Co Ltd	Production of protein decomposed substance not having bitterness and antigen property
JPS6041751B2 (ja)	1976-06-22	1985-09-18	ジエコ−株式会社	デジタル電子時計
JPS548785A (en)	1977-06-21	1979-01-23	Kikkoman Corp	Preparation of protein hydrolyzate
US4839281A (en) †	1985-04-17	1989-06-13	New England Medical Center Hospitals, Inc.	Lactobacillus strains and methods of selection
DK589785A (da) *	1985-12-18	1987-06-19	Samuelsson Ernst Gunnar	Peptidpraeparat, fremgangsmaade til fremstilling deraf samt anvendelse af peptidpraeparatet
EP0322589B1 (fr) †	1987-12-23	1993-01-20	Societe Des Produits Nestle S.A.	Procédé de préparation d'un hydrolysat de protéines de lactosérum et d'un aliment hypoallergéniques
DD281540A5 (de)	1988-08-08	1990-08-15	Berlin Chemie Veb	Verfahren zur herstellung von nutritiva
ES2063882T5 (es) †	1989-10-02	2001-12-01	Novartis Nutrition Ag	Hidrolizados de proteinas.
JP3071877B2 (ja) †	1991-06-27	2000-07-31	財団法人糧食研究会	経口寛容誘導能を有する低アレルゲン性酵素分解ペプチド組成物
US5952034A (en) *	1991-10-12	1999-09-14	The Regents Of The University Of California	Increasing the digestibility of food proteins by thioredoxin reduction
ES2111625T3 (es) *	1992-07-06	1998-03-16	Nestle Sa	Agente antigastritis.
FI94089C (fi)	1992-12-10	1995-07-25	Valio Oy	Menetelmä allergiaa aiheuttavien yhdisteiden poistamiseksi proteiinipitoisista koostumuksista
RU2031586C1 (ru)	1993-02-05	1995-03-27	Тамара Георгиевна Извекова	Биологически активный кисломолочный продукт "ацидолакт-наринэ" и способ его получения
GB9312369D0 (en) *	1993-06-16	1993-07-28	Sandoz Nutrition Ltd	Organic compounds
WO1995014485A1 (en)	1993-11-23	1995-06-01	Kabushiki Kaisha Wado Doctors Group	Intestinal flora improver composition, and apparatus and system for producing the same
FI104465B (fi) *	1995-06-14	2000-02-15	Valio Oy	Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö

1995
- 1995-06-14 FI FI952926A patent/FI104465B/fi not_active IP Right Cessation
1996
- 1996-06-11 MY MYPI96002357A patent/MY113912A/en unknown
- 1996-06-12 CZ CZ19973997A patent/CZ291904B6/cs not_active IP Right Cessation
- 1996-06-12 IL IL12257796A patent/IL122577A0/xx not_active IP Right Cessation
- 1996-06-12 KR KR1019970709383A patent/KR100494741B1/ko not_active Expired - Lifetime
- 1996-06-12 US US08/973,963 patent/US6506380B1/en not_active Expired - Lifetime
- 1996-06-12 DE DE69625690T patent/DE69625690T3/de not_active Expired - Lifetime
- 1996-06-12 DK DK96918707T patent/DK0833649T4/da active
- 1996-06-12 WO PCT/FI1996/000350 patent/WO1997000078A1/en not_active Ceased
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- 1996-06-12 EP EP96918707A patent/EP0833649B2/en not_active Expired - Lifetime
- 1996-06-12 CN CNB961947527A patent/CN1154506C/zh not_active Expired - Lifetime
- 1996-06-12 AT AT96918707T patent/ATE230606T1/de active
- 1996-06-12 RO RO97-02328A patent/RO120243B1/ro unknown
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- 1996-06-12 CA CA2224320A patent/CA2224320C/en not_active Expired - Lifetime
- 1996-06-12 BR BR9607827-8A patent/BR9607827A/pt not_active Application Discontinuation
- 1996-06-12 ES ES96918707T patent/ES2191103T5/es not_active Expired - Lifetime
- 1996-06-12 JP JP50267197A patent/JP3983804B2/ja not_active Expired - Lifetime
- 1996-06-12 EE EE9700339A patent/EE03424B1/et unknown
- 1996-06-12 SK SK1715-97A patent/SK284245B6/sk not_active IP Right Cessation
- 1996-06-13 AR ARP960103134A patent/AR003960A1/es unknown
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1997
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Also Published As

Publication number	Publication date
BG102144A (en)	1998-12-30
JP3983804B2 (ja)	2007-09-26
US7172756B2 (en)	2007-02-06
ATE230606T1 (de)	2003-01-15
SK284245B6 (sk)	2004-12-01
DK0833649T3 (da)	2003-04-07
CA2224320C (en)	2012-03-20
DE69625690D1 (de)	2003-02-13
ES2191103T5 (es)	2009-11-03
US20030113340A1 (en)	2003-06-19
NZ310478A (en)	2000-01-28
DE69625690T2 (de)	2003-11-06
EE03424B1 (et)	2001-06-15
EP0833649A1 (en)	1998-04-08
AR003960A1 (es)	1998-09-30
NO975832D0 (no)	1997-12-11
KR19990022914A (ko)	1999-03-25
DK0833649T4 (da)	2009-07-20
CN1154506C (zh)	2004-06-23
AU6127896A (en)	1997-01-15
AU710126B2 (en)	1999-09-16
FI952926A0 (fi)	1995-06-14
US6506380B1 (en)	2003-01-14
PL185123B1 (pl)	2003-02-28
JPH11510791A (ja)	1999-09-21
CZ291904B6 (cs)	2003-06-18
NO975832L (no)	1997-12-11
NO321504B1 (no)	2006-05-15
MX9710109A (es)	1998-10-31
EE9700339A (et)	1998-06-15
CN1187772A (zh)	1998-07-15
ZA965088B (en)	1997-01-22
DE69625690T3 (de)	2009-12-24
BR9607827A (pt)	1999-11-30
PL324010A1 (en)	1998-04-27
SK171597A3 (en)	1998-11-04
FI952926L (fi)	1996-12-15
FI104465B (fi)	2000-02-15
IL122577A0 (en)	1998-06-15
HK1010081A1 (en)	1999-06-11
WO1997000078A1 (en)	1997-01-03
MY113912A (en)	2002-06-29
EP0833649B2 (en)	2009-06-03
KR100494741B1 (ko)	2005-09-30
ES2191103T3 (es)	2003-09-01
CA2224320A1 (en)	1997-01-03
CZ399797A3 (cs)	1998-06-17
EP0833649B1 (en)	2003-01-08
RO120243B1 (ro)	2005-11-30

Publication	Publication Date	Title
BG63153B1 (bg)	2001-05-31	Метод за получаване на протеинов хидролизат и използването му за предотвратяване или лечение на алергии
Sütas et al.	1996	Suppression of lymphocyte proliferation in vitro by bovine caseins hydrolyzed with Lactobacillus casei GG–derived enzymes
Majamaa et al.	1997	Probiotics: a novel approach in the management of food allergy
Urisu et al.	1997	Allergenic activity of heated and ovomucoid-depleted egg white
Isolauri	2001	Probiotics in human disease
RU2522282C2 (ru)	2014-07-10	Применение штамма вifidobacterium для получения композиции, предназначенной для профилактики и/или лечения проявлений аллергического типа
RU2262943C2 (ru)	2005-10-27	Сомногенная активность непатогенных молочно-кислых бактерий
Prioult et al.	2005	Allergenicity of acidic peptides from bovine β-lactoglobulin is reduced by hydrolysis with Bifidobacterium lactis NCC362 enzymes
Pescuma et al.	2019	Hydrolysate of β-lactoglobulin by Lactobacillus delbrueckii subsp. bulgaricus CRL 656 suppresses the immunoreactivity of β-lactoglobulin as revealed by in vivo assays
US6506388B1 (en)	2003-01-14	Immunomodulator, immunomodulator food
JP2968374B2 (ja)	1999-10-25	ＩｇＡ産生促進剤
RU2174012C2 (ru)	2001-09-27	Способы профилактики или лечения аллергии
AU710126C (en)	2000-09-07	Methods of preventing or treating allergies
HK1010081B (en)	2003-08-29	Methods of preventing or treating allergies
Crane	2002	Pro and anti: the biotics of allergic disease