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BE2010C018I2 - - Google Patents

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Publication number
BE2010C018I2
BE2010C018I2 BE2010C018C BE2010C018C BE2010C018I2 BE 2010C018 I2 BE2010C018 I2 BE 2010C018I2 BE 2010C018 C BE2010C018 C BE 2010C018C BE 2010C018 C BE2010C018 C BE 2010C018C BE 2010C018 I2 BE2010C018 I2 BE 2010C018I2
Authority
BE
Belgium
Application number
BE2010C018C
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26901947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2010C018(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BE2010C018I2 publication Critical patent/BE2010C018I2/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hard Magnetic Materials (AREA)
  • Information Transfer Systems (AREA)
  • Vehicle Body Suspensions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
BE2010C018C 2000-05-25 2010-04-13 BE2010C018I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20708400P 2000-05-25 2000-05-25
US22892900P 2000-08-30 2000-08-30
PCT/US2001/016863 WO2001089457A2 (fr) 2000-05-25 2001-05-24 Mimiques de thrombopoietine

Publications (1)

Publication Number Publication Date
BE2010C018I2 true BE2010C018I2 (fr) 2020-08-20

Family

ID=26901947

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2010C018C BE2010C018I2 (fr) 2000-05-25 2010-04-13

Country Status (30)

Country Link
US (9) US7160870B2 (fr)
EP (3) EP1294378B1 (fr)
JP (2) JP3813875B2 (fr)
KR (2) KR100847172B1 (fr)
CN (4) CN101343251B (fr)
AR (2) AR030696A1 (fr)
AT (2) ATE445606T1 (fr)
AU (2) AU7493801A (fr)
BE (1) BE2010C018I2 (fr)
BR (1) BRPI0111116B8 (fr)
CA (1) CA2411468C (fr)
CY (4) CY2010012I2 (fr)
CZ (1) CZ303176B6 (fr)
DE (4) DE60130760T2 (fr)
DK (3) DK1889838T3 (fr)
ES (3) ES2294000T3 (fr)
FR (1) FR10C0034I2 (fr)
HK (1) HK1056114A1 (fr)
HU (3) HU227476B1 (fr)
IL (5) IL152988A0 (fr)
LU (1) LU91681I2 (fr)
MX (1) MXPA02011621A (fr)
MY (1) MY136707A (fr)
NO (3) NO324246B1 (fr)
NZ (2) NZ533308A (fr)
PL (2) PL216528B1 (fr)
PT (3) PT1889838E (fr)
SI (3) SI1294378T1 (fr)
TW (1) TWI305207B (fr)
WO (1) WO2001089457A2 (fr)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2401706A1 (fr) 2000-03-08 2001-09-13 Metabasis Therapeutics, Inc. Nouveaux inhibiteurs de la fructose-1,6-biophosphatase, a base d'aryle
US20110212054A1 (en) * 2000-05-25 2011-09-01 Glaxosmithkline Llc. Thrombopoietin mimetics
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
WO2002085343A1 (fr) * 2001-03-01 2002-10-31 Smithkline Beecham Corporation Mimetiques de la thrombopoietine
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
AR040083A1 (es) * 2002-05-22 2005-03-16 Smithkline Beecham Corp Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac
EP1556059A4 (fr) * 2002-06-06 2010-06-30 Smithkline Beecham Mimetiques de la thrombopoietine
EP1552828A4 (fr) 2002-08-14 2007-01-24 Nissan Chemical Ind Ltd Activateur du recepteur de la thrombopoietine et procede de production
TWI324593B (en) 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
US20100004302A1 (en) * 2003-04-29 2010-01-07 Connie Erickson-Miller Methods for Treating Degenerative Diseases/Injuries
US20090143453A1 (en) * 2003-04-29 2009-06-04 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
EP1622609A4 (fr) * 2003-04-29 2008-09-03 Smithkline Beecham Corp Procedes de traitement de maladies/lesions degeneratives
US20090298179A1 (en) * 2003-04-29 2009-12-03 Connie Erickson-Miller Methods For Treating Degenerative Diseases/Injuries
US20090048318A1 (en) * 2003-04-29 2009-02-19 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
US7753958B2 (en) * 2003-08-05 2010-07-13 Gordon Charles R Expandable intervertebral implant
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
TW200526638A (en) * 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
WO2005118551A2 (fr) 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Composes modulant l'activite de la thrombopoietine et methodes associees
RU2007110731A (ru) * 2004-09-23 2008-10-27 Редди Юс Терапевтикс Новые соединения пиримидина, способ их получения и содержащие их композиции
NZ554662A (en) * 2004-10-25 2008-11-28 Ligand Pharm Inc Thrombopoietin activity modulating compounds and methods
MX2007006819A (es) 2004-12-08 2007-07-24 Nissan Chemical Ind Ltd Compuestos heterociclicos sustituidos con 3-etilidenohidrazino como activadores del receptor de trombopoyetina.
EP1845090A4 (fr) 2004-12-14 2009-11-11 Nissan Chemical Ind Ltd Compose d' amide et activateur du recepteur de la thrombopoietine
PE20070083A1 (es) 2005-06-08 2007-01-27 Smithkline Beecham Corp (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona
CA2609319C (fr) 2005-07-15 2014-02-04 Nissan Chemical Industries, Ltd. Composes thiophenes et activateurs du recepteur thrombopoietine
TWI330184B (en) 2005-07-20 2010-09-11 Nissan Chemical Ind Ltd Pyrazole compounds and thrombopoietin receptor activators
WO2007044982A2 (fr) * 2005-10-13 2007-04-19 Smithkline Beecham Corporation Méthodes pour conserver l'efficacité de plaquettes pendant le stockage
EP1947101A4 (fr) 2005-11-07 2009-09-16 Nissan Chemical Ind Ltd Composé de type hydrazide et activateur du récepteur de la thrombopoïétine
EP2025671A4 (fr) 2006-06-07 2011-04-06 Nissan Chemical Ind Ltd Composé hétérocyclique azoté et activateur de récepteur de thrombopoïétine
AU2007329464A1 (en) * 2006-12-01 2008-06-12 Stategics, Inc. Thrombopoietin mimetics
UY30915A1 (es) * 2007-02-16 2008-09-02 Smithkline Beecham Corp Método de tratamiento de canceres
US20110129550A1 (en) * 2007-02-16 2011-06-02 Connie Erickson-Miller Cancer treatment method
US20110160130A1 (en) * 2007-02-16 2011-06-30 Connie Erickson-Miller Cancer treatment method
EP2152811A4 (fr) * 2007-04-24 2011-03-16 Glaxosmithkline Llc Nouveaux procédés de fabrication de dérivés d'hydroxy-1-azo en tant que mimétiques de tpo
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
EP2211855A4 (fr) * 2007-10-09 2011-12-07 Univ Pennsylvania Agoniste du récepteur de la thrombopoïétine (tpora) détruisant les cellules de la leucémie aiguë myéloïde humaine
CN101481352A (zh) 2008-01-10 2009-07-15 上海恒瑞医药有限公司 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用
WO2009131957A2 (fr) 2008-04-21 2009-10-29 Institute For Oneworld Health Composés, compositions et traitements comprenant des dérivés d'oxydiazoles
WO2009131951A2 (fr) 2008-04-21 2009-10-29 Institute For Oneworld Health Composés, compositions et procédés comprenant des dérivés isoxazole
WO2009151862A1 (fr) * 2008-05-15 2009-12-17 Smithkline Beecham Corporation Procédé de traitement
EP2348858A4 (fr) * 2008-10-16 2013-06-12 Glaxosmithkline Llc Méthode de traitement de la thrombocytopénie
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
JP2012522792A (ja) * 2009-04-01 2012-09-27 プリバ フルバトゥスカ ドゥ．オ．オ． エルトロンボパグ及びエルトロンボパグ塩の多形体、並びにその調製方法
US8343976B2 (en) 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
WO2010129738A1 (fr) * 2009-05-07 2010-11-11 Glaxosmithkline Llc Procédé de traitement de la thrombocytopénie
US8476249B2 (en) 2009-05-07 2013-07-02 Glaxosmithkline Llc Method of treating thrombocytopenia
US8680150B2 (en) * 2009-05-28 2014-03-25 Ligand Pharmaceuticals, Inc. Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors
JP2012528184A (ja) * 2009-05-29 2012-11-12 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー トロンボポエチンアゴニスト化合物の投与の方法
CN101921232A (zh) * 2009-06-11 2010-12-22 上海恒瑞医药有限公司 双环取代吡唑酮偶氮类衍生物的盐,其制备方法及其在医药上的应用
WO2011067246A1 (fr) 2009-12-01 2011-06-09 Basf Se Système de résine de pultrusion à base de polyuréthane
CN101805291A (zh) * 2010-04-26 2010-08-18 西北大学 1-(4-异丙苯基)-3-甲基-5-吡唑啉酮及其制备方法和应用
CA2808908A1 (fr) 2010-09-01 2012-03-08 Novartis Ag Association d'inhibiteurs de hdac et de medicaments contre la thrombopenie
WO2012102937A2 (fr) 2011-01-25 2012-08-02 Irm Llc Composés qui développent des cellules souches hématopoïétiques
WO2012121958A2 (fr) * 2011-03-08 2012-09-13 Glaxosmithkline Llc Association
WO2012121957A1 (fr) * 2011-03-08 2012-09-13 Glaxosmithkline Llc Association
US20120309796A1 (en) 2011-06-06 2012-12-06 Fariborz Firooznia Benzocycloheptene acetic acids
EP2729560A4 (fr) * 2011-07-06 2014-12-03 Cellerant Therapeutics Inc Cellules progénitrices mégacaryocytaires pour la production de plaquettes
EP3243515B1 (fr) * 2011-08-30 2019-10-16 CHDI Foundation, Inc. Inhibiteurs de kynurenine-3-monooxygenase, compositions pharmaceutiques et leurs procédés d'utilisation
WO2013072921A2 (fr) 2011-09-13 2013-05-23 Glenmark Generics Limited Procédé de préparation de composés substitués de l'acide 3'-hydrazino-biphényl-3-carboxylique
WO2013049605A1 (fr) 2011-09-28 2013-04-04 Assia Chemical Industries Ltd. Procédés de préparation d'un intermédiaire dans la synthèse de l'eltrombopag
CA3173988A1 (fr) 2011-10-11 2013-04-18 Dana-Farber Cancer Institute, Inc. Pyrazol-3-ones qui activent le bax pro-apoptotique
CN104039761A (zh) 2011-11-14 2014-09-10 利亘制药公司 与粒细胞集落刺激因子受体相关的方法和组合物
HK1203081A1 (en) 2011-12-08 2015-10-16 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
RS59002B1 (sr) 2012-01-27 2019-08-30 Univ Montreal Pirimido[4,5-b]indol derivati i njihova primena u ekspanziji hematopoetskih matičnih ćelija
CN103360317B (zh) * 2012-04-11 2016-12-14 齐鲁制药有限公司 双环取代吡唑酮偶氮类衍生物、其制备方法及用途
JP2015154715A (ja) * 2012-05-22 2015-08-27 国立大学法人旭川医科大学 ヒト単核球由来の新規血管再生細胞群及びその分化誘導法
US20140047572A1 (en) * 2012-08-13 2014-02-13 University Of Rochester Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury
WO2014150252A1 (fr) 2013-03-15 2014-09-25 Ligand Pharmaceuticals Incorporated Méthodes de traitement associées au récepteur du facteur de stimulation des colonies de granulocytes
EP2799425A1 (fr) 2013-04-29 2014-11-05 Esteve Química, S.A. Procédé de préparation d'un agoniste du récepteur de la thrombopoïétine
WO2015029074A2 (fr) 2013-09-02 2015-03-05 Hetero Research Foundation Compositions d'eltrombopag
ITMI20131782A1 (it) * 2013-10-25 2015-04-26 Dipharma Francis Srl Procedimento per la preparazione di un agonista della trombopoietina
CN104628647A (zh) * 2013-11-12 2015-05-20 上海医药工业研究院 3-甲基-1-(3,4-二甲基苯基)-2-吡唑啉-5-酮的制备方法
CN104725318A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种爱曲伯帕的合成方法
WO2015111085A2 (fr) 2014-01-27 2015-07-30 Cadila Healthcare Limited Procédés de préparation d'eltrombopag et sels pharmaceutiquement acceptables, solvates et intermédiaires de celui-ci
CN103819406B (zh) * 2014-03-17 2015-04-08 苏州明锐医药科技有限公司 艾曲波帕的制备方法
ES2788977T3 (es) 2014-04-22 2020-10-23 Univ Montreal Compuestos y uso de los mismos en la expansión de células madre hematopoyéticas y/o células progenitoras hematopoyéticas
CN105085276A (zh) * 2014-05-12 2015-11-25 上海医药工业研究院 艾曲波帕中间体及其制备方法和应用
CN105085287A (zh) * 2014-05-12 2015-11-25 上海医药工业研究院 3`-氨基-2`-羟基-[1,1`-联苯]-3-羧酸的制备方法
EA034528B1 (ru) 2014-07-17 2020-02-17 Сиэйчдиай Фаундэйшн, Инк. Способ лечения нарушений, связанных с вич
EP3188737A4 (fr) 2014-09-05 2018-05-02 Hetero Research Foundation Forme cristalline d'acide libre eltrombopag
WO2016055935A1 (fr) 2014-10-06 2016-04-14 Glaxosmithkline Intellectual Property (No.2) Limited Combinaison d'inhibiteur de déméthylase 1 spécifique à la lysine et d'agoniste de thrombopoïétine
SG11201703407UA (en) 2014-10-31 2017-05-30 Nissan Chemical Ind Ltd Ligand-binding fiber and cell culture substrate using said fiber
CN104829593B (zh) * 2015-03-26 2017-08-25 苏州福来兹检测科技有限公司 一种用于检测溶液中金属离子含量的有机化合物及其应用
WO2017042839A1 (fr) 2015-09-08 2017-03-16 Actavis Group Ptc Ehf. Nouveau sel d'eltrombopag et préparation de celui-ci
MX2018012870A (es) 2016-04-21 2019-03-28 Basf Se Metodo para la produccion de productos pultruidos a base de poliuretano.
EP3474834B1 (fr) 2016-06-27 2025-04-09 The General Hospital Corporation Dba Massachusetts General Hospital Stimulation de la formation de plaquettes avec du bézafibrate, du resvératrol ou du srt1720 pour traiter la thrombocytopénie
WO2018162519A1 (fr) 2017-03-09 2018-09-13 Basf Se Formulations de polyuréthane pour la production d'éléments composites
CN107021928B (zh) * 2017-04-01 2022-11-18 常州制药厂有限公司 艾曲波帕新的中间体及其制备方法和应用
EP3395331B1 (fr) 2017-04-26 2019-08-21 Alfred E. Tiefenbacher (GmbH & Co. KG) Composition de comprimé pharmaceutique comprenant eltrombopag olamine
EP3692021A1 (fr) 2017-10-06 2020-08-12 Assia Chemical Industries Ltd Formes à l'état solide d'eltrombopag choline
EP3409272B1 (fr) * 2018-03-07 2020-06-24 Alfred E. Tiefenbacher (GmbH & Co. KG) Composition pharmaceutique comprenant de l'eltrombopag olamine, du sucre réducteur et un liant polymérique
CN110467531B (zh) * 2018-05-09 2022-04-19 新发药业有限公司 一种3’-硝基-2’-羟基联苯-3-甲酸的制备方法
US11161821B2 (en) * 2018-06-01 2021-11-02 Aurobindo Pharma Ltd. Process for the preparation of Eltrombopag olamine and its intermediates
ES2815924T3 (es) 2018-08-02 2021-03-31 Fis Fabbrica Italiana Sintetici Spa Forma D1 cristalina altamente estable de la sal de monoetanolamina de eltrombopag
EP3604284B1 (fr) 2018-08-02 2020-11-11 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Forme cristalline d du sel de monoéthanolamine d'eltrombopag
JP2022517211A (ja) * 2019-01-08 2022-03-07 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 二環式置換ピラゾロンアゾ誘導体の投与レジメン
WO2021001044A1 (fr) 2019-07-04 2021-01-07 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Procédé de préparation d'intermédiaires clés pour la synthèse d'eltrombopag ou d'un sel de celui-ci
JP7083793B2 (ja) * 2019-09-10 2022-06-13 Ｊｆｅケミカル株式会社 パラターフェニルテトラカルボン酸およびパラターフェニルテトラカルボン酸二無水物の製造方法
WO2021055820A1 (fr) 2019-09-20 2021-03-25 Novartis Ag Acide 3'-[(2z)-[1-(3,4-diméthylphényl)-1,5-dihydro-3-méthyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphényl]-3-carboxylique et sa formulation de sels
WO2021078077A1 (fr) * 2019-10-21 2021-04-29 广东东阳光药业有限公司 Nouvelle forme cristalline d'eltrombopag acétylé et son procédé de préparation
WO2021078076A1 (fr) * 2019-10-21 2021-04-29 广东东阳光药业有限公司 Nouvelle forme cristalline d'eltrombopag acétylé et son procédé de préparation
CA3160779A1 (fr) 2019-12-06 2021-06-10 Synthon B.V. Composition pharmaceutique comprenant de l'eltrombopag bis(monoethanolamine)
WO2021110942A1 (fr) 2019-12-06 2021-06-10 Synthon B.V. Composition pharmaceutique comprenant de l'eltrombopag bis(monoéthanolamine)
TR202014694A1 (tr) 2020-09-16 2022-03-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Eltrombopag olami̇n i̇çeren bi̇r kati oral farmasöri̇k formülasyon
WO2022201087A1 (fr) 2021-03-25 2022-09-29 Novartis Ag Formulation d'acide 3'-[(2z)-[1-(3,4-diméthylphényl)-1,5-dihydro-3-méthyl-5-oxo-4h-pyrazol-4-ylidène]hydrazino]-2'-hydroxy-[1,1'-biphényl]-3-carboxylique et de ses sels
CN113336704B (zh) * 2021-06-11 2022-10-11 上海大学 丹参素衍生物及其制备方法和医药用途
CN114507186A (zh) * 2021-12-02 2022-05-17 天津力生制药股份有限公司 一种艾曲波帕的制备方法
WO2023111187A1 (fr) 2021-12-15 2023-06-22 Galenicum Health, S.L.U Compositions pharmaceutiques comprenant de l'eltrombopag
CN116354885A (zh) * 2021-12-27 2023-06-30 苏州特瑞药业股份有限公司 一种艾曲波帕新晶型及其制备方法
WO2025140275A1 (fr) * 2023-12-25 2025-07-03 江苏恒瑞医药股份有限公司 Composé phosphate de dérivé azoïque de pyrazoline substitué ou sel pharmaceutiquement acceptable de celui-ci

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE193350C (fr)
US851444A (en) 1905-11-13 1907-04-23 Agfa Ag Amido-oxy-sulfonic acid of phenylnaphthimidazol and process of making same.
GB779880A (en) 1953-02-27 1957-07-24 Ciba Ltd Functional derivatives of azo-dyestuffs containing sulphonic acid groups and processfor making them
US2809963A (en) * 1954-10-26 1957-10-15 Ciba Ltd Azo-dyestuffs
DE1046220B (de) * 1956-04-21 1958-12-11 Bayer Ag Verfahren zur Herstellung von Monoazofarbstoffen und deren Metallkomplexverbindungen
GB826207A (en) 1956-07-23 1959-12-31 Bayer Ag ú´-ú´-dihydroxy-monoazo dyestuffs containing pyrrolidonyl residues and their metal complex compounds
US2950273A (en) 1956-11-20 1960-08-23 Agfa Ag Process for the production of symmetrical and unsymmetrical azo compounds
US3366619A (en) 1965-04-09 1968-01-30 Interchem Corp Disazo pyrazolone pigments
US4435417A (en) 1981-02-20 1984-03-06 Gruppo Lepetit S.P.A. Antiinflammatory 3H-naphtho[1,2-d]imidazoles
ES523609A0 (es) 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2559483B1 (fr) * 1984-02-10 1986-12-05 Sandoz Sa Composes heterocycliques contenant des groupes basiques et/ou cationiques, leur preparation et leur utilisation comme colorants
FI91869C (fi) 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
US4880788A (en) 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
US5326776A (en) 1992-03-02 1994-07-05 Abbott Laboratories Angiotensin II receptor antagonists
IL109570A0 (en) 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
EP0638617A1 (fr) 1993-08-13 1995-02-15 Ciba-Geigy Ag Sels de pigments
DE69423661T2 (de) 1993-12-28 2000-11-23 Dai Nippon Printing Co., Ltd. Thermische Übertragungsaufzeichnungsschicht, die einen bestimmten Farbstoff verwendet
GB2285446B (en) * 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
HUT75359A (en) 1994-02-14 1997-05-28 Univ Washington Hematopoietic protein and materials and methods for making it
US5482546A (en) 1994-03-30 1996-01-09 Canon Kabushiki Kaisha Dye, ink containing the same, and ink-jet recording method and instrument using the ink
US5760038A (en) 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5746821A (en) 1995-02-13 1998-05-05 Engelhard Corporation Pigment compositions
PL188795B1 (pl) 1995-06-07 2005-04-29 Glaxo Group Ltd Związek wiążący się z receptorem trombopoetyny, kompozycja farmaceutyczna i zastosowanie związku wiążącego się z receptorem trombopoetyny
US5622818A (en) * 1995-11-29 1997-04-22 Eastman Kodak Company Color photographic elements containing yellow colored magenta dye forming masking couplers
US5669967A (en) 1996-05-30 1997-09-23 Engelhard Corporation Pigment compositions
US5932546A (en) 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
SE9701398D0 (sv) 1997-04-15 1997-04-15 Astra Pharma Prod Novel compounds
GB9715830D0 (en) 1997-07-25 1997-10-01 Basf Ag Reactive dyes containing piperazine
WO1999011262A1 (fr) 1997-09-02 1999-03-11 Roche Diagnostics Gmbh Ligands du recepteur mpl, leur procede de preparation, medicaments les contenant et leur utilisation pour le traitement et la prevention de la thrombocytopenie et l'anemie
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
DE69837279T2 (de) 1997-10-31 2007-11-15 Smithkline Beecham Corp. Neue metall-komplexe
DE19851389A1 (de) 1998-11-07 2000-05-11 Dystar Textilfarben Gmbh & Co Gelbe Farbstoffmischungen von wasserlöslichen faserreaktiven Azofarbstoffen und ihre Verwendung
GC0000177A (en) * 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
KR20020069183A (ko) 1999-07-26 2002-08-29 시오노기세이야쿠가부시키가이샤 트롬보포이에틴 작동성을 나타내는 의약 조성물
ES2256038T3 (es) * 1999-09-10 2006-07-16 Smithkline Beecham Corporation Mimeticos de trombopoyetina.
AU771460B2 (en) * 1999-09-24 2004-03-25 Smithkline Beecham Corporation Thrombopoietin mimetics
WO2001034585A1 (fr) 1999-11-05 2001-05-17 Smithkline Beecham Corporation Derives de semicarbazone et leur utilisation en tant que mimetiques de la thrombopoietine
EP1104674A1 (fr) 1999-11-10 2001-06-06 Curacyte AG Colorants o-o'-dihydroxy azoiques dans des médicaments ayant une activité TPO-agoniste ou synergétique
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
AR030273A1 (es) 2000-03-10 2003-08-20 Smithkline Beecham Corp Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina
US6436915B1 (en) 2000-04-07 2002-08-20 Kinetek Pharmaceuticals, Inc. Pyrazole compounds
US6214813B1 (en) * 2000-04-07 2001-04-10 Kinetek Pharmaceuticals, Inc. Pyrazole compounds
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
US6642265B1 (en) * 2000-09-08 2003-11-04 Smithkline Beecham Corporation Thrombopoietin mimetics
WO2002049413A2 (fr) 2000-12-19 2002-06-27 Smithkline Beecham Corporation Mimetiques de thrombopoietine
EP1351979B1 (fr) 2000-12-21 2008-01-16 Smithkline Beecham Corporation Activation regulee des recepteurs de la membrane cellulaire au moyen d'agonistes chelateurs des metaux
BR0206670A (pt) 2001-01-26 2004-02-25 Shionogi & Co Compostos halogenados que exibem agonismo para receptor de trombopoietina
US7169931B2 (en) 2001-01-26 2007-01-30 Shionogi & Co., Ltd. Cyclic compounds exhibiting thrombopoietin receptor agonism
WO2002085343A1 (fr) 2001-03-01 2002-10-31 Smithkline Beecham Corporation Mimetiques de la thrombopoietine
JP3927001B2 (ja) 2001-06-15 2007-06-06 三菱化学株式会社 色素セット、インクセット並びに記録方法
US6560161B1 (en) * 2001-08-30 2003-05-06 Micron Technology, Inc. Synchronous flash memory command sequence
AU2002333114B2 (en) 2001-11-30 2008-09-04 Qlt Inc. Hydrazonopyrazole derivatives and their use as therapeutics
AU2003213673A1 (en) 2002-03-01 2003-09-16 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
AR040083A1 (es) 2002-05-22 2005-03-16 Smithkline Beecham Corp Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac
EP1556059A4 (fr) * 2002-06-06 2010-06-30 Smithkline Beecham Mimetiques de la thrombopoietine
TWI324593B (en) * 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
JP2006514951A (ja) 2002-12-13 2006-05-18 スミスクライン・ビーチャム・コーポレイション トロンボポエチン模倣物
US20090298179A1 (en) * 2003-04-29 2009-12-03 Connie Erickson-Miller Methods For Treating Degenerative Diseases/Injuries
EP1622609A4 (fr) * 2003-04-29 2008-09-03 Smithkline Beecham Corp Procedes de traitement de maladies/lesions degeneratives
TW200526638A (en) * 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
WO2005118551A2 (fr) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Composes modulant l'activite de la thrombopoietine et methodes associees
NZ554662A (en) * 2004-10-25 2008-11-28 Ligand Pharm Inc Thrombopoietin activity modulating compounds and methods
WO2007044982A2 (fr) * 2005-10-13 2007-04-19 Smithkline Beecham Corporation Méthodes pour conserver l'efficacité de plaquettes pendant le stockage
AU2007329464A1 (en) * 2006-12-01 2008-06-12 Stategics, Inc. Thrombopoietin mimetics

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