AU6296898A - Acarbose (acb) cluster from (actinoplanes) sp. se 50/110 - Google Patents

Acarbose (acb) cluster from (actinoplanes) sp. se 50/110

Info

Publication number: AU6296898A
Authority: AU; Australia
Prior art keywords: actinoplanes; acb; acarbose; cluster
Prior art date: 1997-02-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU62968/98A

Inventor

Heiner Apeler

Anneliese Crueger

Paz Marta Diaz-Guardamino Uribe

Jurgen Distler

Klaus Goeke

Martin Jarling

Hermann Pape

Wolfgang Piepersberg

Werner Schroder

Ansgar Stratmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-28

Filing date

1998-02-16

Publication date

1998-09-18

1998-02-16 Application filed by Bayer AG filed Critical Bayer AG

1998-09-18 Publication of AU6296898A publication Critical patent/AU6296898A/en

Status Abandoned legal-status Critical Current

Links

XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 title 1
241000187844 Actinoplanes Species 0.000 title 1
229960002632 acarbose Drugs 0.000 title 1
XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

AU62968/98A 1997-02-28 1998-02-16 Acarbose (acb) cluster from (actinoplanes) sp. se 50/110 Abandoned AU6296898A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19708127		1997-02-28
DE19708127A DE19708127A1 (en)	1997-02-28	1997-02-28	Acarbose acb clusters: isolation of other genes of acarbose biosynthesis and acarbose metabolism from Actinoplanes sp. SE 50/110 and its use
PCT/EP1998/000862 WO1998038313A1 (en)	1997-02-28	1998-02-16	Acarbose (acb) cluster from actinoplanes sp. se 50/110

Publications (1)

Publication Number	Publication Date
AU6296898A true AU6296898A (en)	1998-09-18

Family

ID=7821816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU62968/98A Abandoned AU6296898A (en)	1997-02-28	1998-02-16	Acarbose (acb) cluster from (actinoplanes) sp. se 50/110

Country Status (15)

Country	Link
EP (1)	EP0968294A1 (en)
KR (1)	KR20000075777A (en)
CN (1)	CN1249001A (en)
AU (1)	AU6296898A (en)
BG (1)	BG103672A (en)
BR (1)	BR9807640A (en)
CA (1)	CA2282735A1 (en)
CZ (1)	CZ9903054A3 (en)
DE (1)	DE19708127A1 (en)
HU (1)	HUP0000889A2 (en)
IL (1)	IL131433A0 (en)
NO (1)	NO994164D0 (en)
PL (1)	PL335369A1 (en)
WO (1)	WO1998038313A1 (en)
ZA (1)	ZA981659B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0796915A3 (en) *	1996-03-22	1999-04-14	Bayer Ag	Process for the preparation and use of acarviosyl-transferase in the conversion of ascarbose-homologous in acarbose and in the preparation of acarbose-homologous
TW201217533A (en) *	2010-08-04	2012-05-01	Bayer Pharma AG	Genomics of actinoplanes utahensis
CN106167814B (en) *	2016-08-31	2019-08-09	河北华荣制药有限公司	A method of improving acarbose fermentation unit
CN106566796B (en) *	2016-10-28	2020-11-10	上海交通大学	Genetic manipulation system of acarbose-producing strain Actinoplanes spp.
EP4045520A1 (en) *	2019-10-16	2022-08-24	Bayer Aktiengesellschaft	Methods for the improved formation of acarbose
CN112592878B (en) *	2020-12-25	2022-08-26	上海交通大学	Method for enhancing expression of positive regulatory protein gene to improve acarbose fermentation level
CN113444670A (en) *	2021-07-28	2021-09-28	山东鲁抗医药股份有限公司	Screening method and culture method of high-activity acarbose producing strain

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19507214A1 (en) *	1995-03-02	1996-10-31	Bayer Ag	Acarbose biosynthesis genes from Actinoplanes sp., Process for their isolation and their use
DE19622783A1 (en) *	1996-06-07	1997-12-11	Hoechst Ag	Isolation of the biosynthetic genes for pseudo-oligosaccharides from Streptomyces glaucescens GLA.O and their use

1997
- 1997-02-28 DE DE19708127A patent/DE19708127A1/en not_active Withdrawn
1998
- 1998-02-16 BR BR9807640A patent/BR9807640A/en not_active Application Discontinuation
- 1998-02-16 WO PCT/EP1998/000862 patent/WO1998038313A1/en not_active Ceased
- 1998-02-16 IL IL13143398A patent/IL131433A0/en unknown
- 1998-02-16 CA CA002282735A patent/CA2282735A1/en not_active Abandoned
- 1998-02-16 AU AU62968/98A patent/AU6296898A/en not_active Abandoned
- 1998-02-16 EP EP98906953A patent/EP0968294A1/en not_active Withdrawn
- 1998-02-16 HU HU0000889A patent/HUP0000889A2/en unknown
- 1998-02-16 KR KR1019997007849A patent/KR20000075777A/en not_active Withdrawn
- 1998-02-16 CN CN98802927A patent/CN1249001A/en active Pending
- 1998-02-16 CZ CZ993054A patent/CZ9903054A3/en unknown
- 1998-02-16 PL PL98335369A patent/PL335369A1/en unknown
- 1998-02-27 ZA ZA981659A patent/ZA981659B/en unknown
1999
- 1999-08-20 BG BG103672A patent/BG103672A/en unknown
- 1999-08-27 NO NO994164A patent/NO994164D0/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1249001A (en)	2000-03-29
NO994164L (en)	1999-08-27
DE19708127A1 (en)	1998-09-03
IL131433A0 (en)	2001-01-28
PL335369A1 (en)	2000-04-25
NO994164D0 (en)	1999-08-27
CZ9903054A3 (en)	1999-11-17
CA2282735A1 (en)	1998-09-03
KR20000075777A (en)	2000-12-26
ZA981659B (en)	1998-09-10
EP0968294A1 (en)	2000-01-05
HUP0000889A2 (en)	2000-07-28
BG103672A (en)	2000-05-31
BR9807640A (en)	2000-03-21
WO1998038313A1 (en)	1998-09-03

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Legal Events

Date	Code	Title	Description
2001-11-15	MK5	Application lapsed section 142(2)(e) - patent request and compl. specification not accepted