NO994164D0 - Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110 - Google Patents

Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110

Info

Publication number: NO994164D0
Authority: NO; Norway
Prior art keywords: actinoplanes; acb; acarbose; clusters; see
Prior art date: 1997-02-28

Application number

NO994164A

Other languages

Norwegian (no)

Other versions

NO994164L (en

Inventor

Anneliese Crueger

Heiner Apeler

Werner Schroeder

Hermann Pape

Klaus Goeke

Wolfgang Piepersberg

Juergen Distler

Paz Marta Diaz-Guardamin Uribe

Martin Jarling

Ansgar Stratmann

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-28

Filing date

1999-08-27

Publication date

1999-08-27

1999-08-27 Application filed by Bayer Ag filed Critical Bayer Ag

1999-08-27 Publication of NO994164D0 publication Critical patent/NO994164D0/en

1999-08-27 Publication of NO994164L publication Critical patent/NO994164L/en

Links

XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 title 2
241000187712 Actinoplanes sp. Species 0.000 title 1
229960002632 acarbose Drugs 0.000 title 1
XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Enzymes And Modification Thereof (AREA)

NO994164A 1997-02-28 1999-08-27 Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110 NO994164L (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19708127A DE19708127A1 (en)	1997-02-28	1997-02-28	Acarbose acb clusters: isolation of other genes of acarbose biosynthesis and acarbose metabolism from Actinoplanes sp. SE 50/110 and its use
PCT/EP1998/000862 WO1998038313A1 (en)	1997-02-28	1998-02-16	Acarbose (acb) cluster from actinoplanes sp. se 50/110

Publications (2)

Publication Number	Publication Date
NO994164D0 true NO994164D0 (en)	1999-08-27
NO994164L NO994164L (en)	1999-08-27

Family

ID=7821816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO994164A NO994164L (en)	1997-02-28	1999-08-27	Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110

Country Status (15)

Country	Link
EP (1)	EP0968294A1 (en)
KR (1)	KR20000075777A (en)
CN (1)	CN1249001A (en)
AU (1)	AU6296898A (en)
BG (1)	BG103672A (en)
BR (1)	BR9807640A (en)
CA (1)	CA2282735A1 (en)
CZ (1)	CZ9903054A3 (en)
DE (1)	DE19708127A1 (en)
HU (1)	HUP0000889A2 (en)
IL (1)	IL131433A0 (en)
NO (1)	NO994164L (en)
PL (1)	PL335369A1 (en)
WO (1)	WO1998038313A1 (en)
ZA (1)	ZA981659B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0796915A3 (en) *	1996-03-22	1999-04-14	Bayer Ag	Process for the preparation and use of acarviosyl-transferase in the conversion of ascarbose-homologous in acarbose and in the preparation of acarbose-homologous
TW201217533A (en) *	2010-08-04	2012-05-01	Bayer Pharma AG	Genomics of actinoplanes utahensis
CN106167814B (en) *	2016-08-31	2019-08-09	河北华荣制药有限公司	A method of improving acarbose fermentation unit
CN106566796B (en) *	2016-10-28	2020-11-10	上海交通大学	Genetic manipulation system of acarbose-producing strain Actinoplanes spp.
EP4045520A1 (en) *	2019-10-16	2022-08-24	Bayer Aktiengesellschaft	Methods for the improved formation of acarbose
CN112592878B (en) *	2020-12-25	2022-08-26	上海交通大学	Method for enhancing expression of positive regulatory protein gene to improve acarbose fermentation level
CN113444670A (en) *	2021-07-28	2021-09-28	山东鲁抗医药股份有限公司	Screening method and culture method of high-activity acarbose producing strain

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19507214A1 (en) *	1995-03-02	1996-10-31	Bayer Ag	Acarbose biosynthesis genes from Actinoplanes sp., Process for their isolation and their use
DE19622783A1 (en) *	1996-06-07	1997-12-11	Hoechst Ag	Isolation of the biosynthetic genes for pseudo-oligosaccharides from Streptomyces glaucescens GLA.O and their use

1997
- 1997-02-28 DE DE19708127A patent/DE19708127A1/en not_active Withdrawn
1998
- 1998-02-16 BR BR9807640A patent/BR9807640A/en not_active Application Discontinuation
- 1998-02-16 CN CN98802927A patent/CN1249001A/en active Pending
- 1998-02-16 KR KR1019997007849A patent/KR20000075777A/en not_active Withdrawn
- 1998-02-16 HU HU0000889A patent/HUP0000889A2/en unknown
- 1998-02-16 EP EP98906953A patent/EP0968294A1/en not_active Withdrawn
- 1998-02-16 CZ CZ993054A patent/CZ9903054A3/en unknown
- 1998-02-16 CA CA002282735A patent/CA2282735A1/en not_active Abandoned
- 1998-02-16 AU AU62968/98A patent/AU6296898A/en not_active Abandoned
- 1998-02-16 WO PCT/EP1998/000862 patent/WO1998038313A1/en not_active Ceased
- 1998-02-16 IL IL13143398A patent/IL131433A0/en unknown
- 1998-02-16 PL PL98335369A patent/PL335369A1/en unknown
- 1998-02-27 ZA ZA981659A patent/ZA981659B/en unknown
1999
- 1999-08-20 BG BG103672A patent/BG103672A/en unknown
- 1999-08-27 NO NO994164A patent/NO994164L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO994164L (en)	1999-08-27
CN1249001A (en)	2000-03-29
WO1998038313A1 (en)	1998-09-03
DE19708127A1 (en)	1998-09-03
BG103672A (en)	2000-05-31
IL131433A0 (en)	2001-01-28
CA2282735A1 (en)	1998-09-03
EP0968294A1 (en)	2000-01-05
BR9807640A (en)	2000-03-21
CZ9903054A3 (en)	1999-11-17
ZA981659B (en)	1998-09-10
HUP0000889A2 (en)	2000-07-28
KR20000075777A (en)	2000-12-26
PL335369A1 (en)	2000-04-25
AU6296898A (en)	1998-09-18

Publication	Publication Date	Title
EE03832B1 (en)	2002-08-15	Heptapeptide analogs
DE69814815D1 (en)	2003-06-26	REED VALVE
ID23498A (en)	2000-04-27	REPLACE INHALATION
DE69839082D1 (en)	2008-03-20	XDSL separator for main distributor
DE59807316D1 (en)	2003-04-03	ENDOSCOPIC SYSTEM
NO982097L (en)	1999-11-09	peptides
NO982098D0 (en)	1998-05-08	peptides
DE59807396D1 (en)	2003-04-10	FILTER FOR PURE AIR
ID19773A (en)	1998-07-30	DURUNAN-DURUN 1,3,8-TRIAZA-SPIRO (4,5) DEKAN-4-ONA SUBSTITUTED-8
DZ2196A1 (en)	2002-12-02	Nanoparticulate compositions of cyclosporine a.
DE69841276D1 (en)	2009-12-17	Respirator
DE69838271D1 (en)	2007-10-04	Improved respirator
DE69941708D1 (en)	2010-01-07	PACAP PEPTIDE ANALOGS
NO991451D0 (en)	1999-03-25	Subscriber-controlled unsubscribe from phonebook
NO985680D0 (en)	1998-12-04	peptide
EP0939518A4 (en)	2005-07-20	ATM REPEATER
DE69834941D1 (en)	2006-07-27	SPEAKING VALVE ARRANGEMENT
NO983849D0 (en)	1998-08-21	peptide
NO994164D0 (en)	1999-08-27	Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110
NO962808D0 (en)	1996-07-03	tobacco replacement
BR9606756A (en)	1998-01-06	Peptide
NO981052D0 (en)	1998-03-10	peptide
FI970744L (en)	1997-02-21	New immunosuppressive peptides
ATE235511T1 (en)	2003-04-15	DIVERSE BRANCHED PEPTIDE CONSTRUCTIONS
NO981051D0 (en)	1998-03-10	peptide

Legal Events

Date	Code	Title	Description
2001-11-05	FC2A	Withdrawal, rejection or dismissal of laid open patent application