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NO994164L - Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110 - Google Patents

Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110

Info

Publication number
NO994164L
NO994164L NO994164A NO994164A NO994164L NO 994164 L NO994164 L NO 994164L NO 994164 A NO994164 A NO 994164A NO 994164 A NO994164 A NO 994164A NO 994164 L NO994164 L NO 994164L
Authority
NO
Norway
Prior art keywords
actinoplanes
see
acarbose
acb
clusters
Prior art date
Application number
NO994164A
Other languages
Norwegian (no)
Other versions
NO994164D0 (en
Inventor
Anneliese Crueger
Heiner Apeler
Werner Schroeder
Hermann Pape
Klaus Goeke
Wolfgang Piepersberg
Juergen Distler
Paz Marta Diaz-Guardamin Uribe
Martin Jarling
Ansgar Stratmann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO994164D0 publication Critical patent/NO994164D0/en
Publication of NO994164L publication Critical patent/NO994164L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Biosyntescgener fra acarbosqgenklusteren fra Actinoplanes sp. SE 50/110. Deres isolering fra Actinoplanes sp eller fra produsenter av pseudooligosakkarider beskrives, videre beskrives det en fremgangsmåte for isolering av biosyntesegenen», proteinene som kodes av genene, ekspresjonen av proteinene i heterologe vertsstammer samt anvendelsen av acarbose-biosyntesegener for optimalisering av prosessen.Biosynthesis Genes from the Acarbosgene Cluster of Actinoplanes sp. SEE 50/110. Their isolation from Actinoplanes sp or from producers of pseudooligosaccharides is further described, a method for isolating the biosynthetic gene », the proteins encoded by the genes, the expression of the proteins in heterologous host strains, and the use of acarbose biosynthetic genes to optimize the process.

NO994164A 1997-02-28 1999-08-27 Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110 NO994164L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19708127A DE19708127A1 (en) 1997-02-28 1997-02-28 Acarbose acb clusters: isolation of other genes of acarbose biosynthesis and acarbose metabolism from Actinoplanes sp. SE 50/110 and its use
PCT/EP1998/000862 WO1998038313A1 (en) 1997-02-28 1998-02-16 Acarbose (acb) cluster from actinoplanes sp. se 50/110

Publications (2)

Publication Number Publication Date
NO994164D0 NO994164D0 (en) 1999-08-27
NO994164L true NO994164L (en) 1999-08-27

Family

ID=7821816

Family Applications (1)

Application Number Title Priority Date Filing Date
NO994164A NO994164L (en) 1997-02-28 1999-08-27 Acarbose (ACB) clusters from Actinoplanes sp. SEE 50/110

Country Status (15)

Country Link
EP (1) EP0968294A1 (en)
KR (1) KR20000075777A (en)
CN (1) CN1249001A (en)
AU (1) AU6296898A (en)
BG (1) BG103672A (en)
BR (1) BR9807640A (en)
CA (1) CA2282735A1 (en)
CZ (1) CZ9903054A3 (en)
DE (1) DE19708127A1 (en)
HU (1) HUP0000889A2 (en)
IL (1) IL131433A0 (en)
NO (1) NO994164L (en)
PL (1) PL335369A1 (en)
WO (1) WO1998038313A1 (en)
ZA (1) ZA981659B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796915A3 (en) * 1996-03-22 1999-04-14 Bayer Ag Process for the preparation and use of acarviosyl-transferase in the conversion of ascarbose-homologous in acarbose and in the preparation of acarbose-homologous
TW201217533A (en) * 2010-08-04 2012-05-01 Bayer Pharma AG Genomics of actinoplanes utahensis
CN106167814B (en) * 2016-08-31 2019-08-09 河北华荣制药有限公司 A method of improving acarbose fermentation unit
CN106566796B (en) * 2016-10-28 2020-11-10 上海交通大学 Genetic manipulation system of acarbose-producing strain Actinoplanes spp.
EP4045520A1 (en) * 2019-10-16 2022-08-24 Bayer Aktiengesellschaft Methods for the improved formation of acarbose
CN112592878B (en) * 2020-12-25 2022-08-26 上海交通大学 Method for enhancing expression of positive regulatory protein gene to improve acarbose fermentation level
CN113444670A (en) * 2021-07-28 2021-09-28 山东鲁抗医药股份有限公司 Screening method and culture method of high-activity acarbose producing strain

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19507214A1 (en) * 1995-03-02 1996-10-31 Bayer Ag Acarbose biosynthesis genes from Actinoplanes sp., Process for their isolation and their use
DE19622783A1 (en) * 1996-06-07 1997-12-11 Hoechst Ag Isolation of the biosynthetic genes for pseudo-oligosaccharides from Streptomyces glaucescens GLA.O and their use

Also Published As

Publication number Publication date
NO994164D0 (en) 1999-08-27
CN1249001A (en) 2000-03-29
WO1998038313A1 (en) 1998-09-03
DE19708127A1 (en) 1998-09-03
BG103672A (en) 2000-05-31
IL131433A0 (en) 2001-01-28
CA2282735A1 (en) 1998-09-03
EP0968294A1 (en) 2000-01-05
BR9807640A (en) 2000-03-21
CZ9903054A3 (en) 1999-11-17
ZA981659B (en) 1998-09-10
HUP0000889A2 (en) 2000-07-28
KR20000075777A (en) 2000-12-26
PL335369A1 (en) 2000-04-25
AU6296898A (en) 1998-09-18

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Legal Events

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