AU5326598A - New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them - Google Patents

New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

Info

Publication number: AU5326598A
Authority: AU; Australia
Prior art keywords: camptothecin; medicaments; pharmaceutical compositions; compositions containing; new analogues
Prior art date: 1996-12-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU53265/98A

Other versions

AU734485B2 (en

Inventor

Dennis Bigg

Olivier Lavergne

Francesc Pla Rodas

Jacques Pommier

Gerard Ulibarri

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ipsen Pharma SAS

Original Assignee

Ipsen Pharma SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-20

Filing date

1997-12-05

Publication date

1998-07-17

1997-12-05 Application filed by Ipsen Pharma SAS filed Critical Ipsen Pharma SAS

1998-07-17 Publication of AU5326598A publication Critical patent/AU5326598A/en

2001-06-14 Application granted granted Critical

2001-06-14 Publication of AU734485B2 publication Critical patent/AU734485B2/en

2009-03-26 Assigned to IPSEN PHARMA S.A.S reassignment IPSEN PHARMA S.A.S Request to Amend Deed and Register Assignors: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

2017-12-05 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AU53265/98A 1996-12-20 1997-12-05 New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them Ceased AU734485B2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR96/15774		1996-12-20
FR9615774A FR2757514B1 (en)	1996-12-20	1996-12-20	NOVEL CAMPTOTHECIN ANALOGS, PREPARATION METHODS, USE THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR1997/002218 WO1998028305A1 (en)	1996-12-20	1997-12-05	Novel counterparts of camptothecin, their application as medicine and pharmaceutical compositions containing them

Publications (2)

Publication Number	Publication Date
AU5326598A true AU5326598A (en)	1998-07-17
AU734485B2 AU734485B2 (en)	2001-06-14

Family

ID=9498938

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU53265/98A Ceased AU734485B2 (en)	1996-12-20	1997-12-05	New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

Country Status (25)

Country	Link
EP (1)	EP0946567B1 (en)
JP (2)	JP3576175B2 (en)
KR (1)	KR100516874B1 (en)
CN (1)	CN1097056C (en)
AR (1)	AR008543A1 (en)
AT (1)	ATE248177T1 (en)
AU (1)	AU734485B2 (en)
BR (1)	BR9714170A (en)
CA (1)	CA2275351C (en)
CZ (1)	CZ299795B6 (en)
DE (1)	DE69724453T2 (en)
DK (1)	DK0946567T3 (en)
ES (1)	ES2206761T3 (en)
FR (1)	FR2757514B1 (en)
HU (1)	HUP9904210A3 (en)
MX (1)	MXPA99005776A (en)
MY (1)	MY119473A (en)
NO (1)	NO326464B1 (en)
NZ (1)	NZ335939A (en)
PL (1)	PL188181B1 (en)
PT (1)	PT946567E (en)
RU (1)	RU2194051C2 (en)
UA (1)	UA57758C2 (en)
WO (1)	WO1998028305A1 (en)
ZA (1)	ZA9711129B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2790261B1 (en) *	1999-02-26	2004-09-10	Sod Conseils Rech Applic	NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS AND PROCESSES FOR THEIR PREPARATION
FR2768431B1 (en) *	1997-08-29	2000-03-24	Sod Conseils Rech Applic	NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS, A NEW OPTICALLY PURE SYNTHESIS INTERMEDIATE AND PROCESS FOR PREPARING THE SAME
US6291676B1 (en) *	1999-03-03	2001-09-18	University Of Kentucky Research Foundation	Water-soluble derivatives of camptothecin/homocamptothecin
US6207832B1 (en)	1999-04-09	2001-03-27	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
AU3455100A (en) *	1999-05-28	2000-12-18	Nippon Chemiphar Co. Ltd.	Process for the preparation of 2-halo-3-(3-quinolyl)propionic acid derivatives
US6372906B1 (en)	2001-04-12	2002-04-16	University Of Pittsburgh	Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en)	2001-08-27	2004-04-20	University Of Pittsburgh	Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
US20040077674A1 (en) *	2002-03-01	2004-04-22	Curran Dennis P.	Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
AR046579A1 (en) *	2003-11-12	2005-12-14	Smithkline Beecham Corp	TOPOTECAN CRYSTAL COMPOSITE, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE TO PREPARE IT AND ITS USE TO PREPARE SUCH PHARMACEUTICAL COMPOSITION
ITRM20040288A1 (en) *	2004-06-11	2004-09-11	Sigma Tau Ind Farmaceuti	USE OF 7-T-BUTOXYIMINOMETHYL CAMPTOTECIN FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF UTERUS NEOPLASIES.
EP1794127A1 (en) *	2004-09-21	2007-06-13	Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.)	Novel processes for the production of useful intermediates
CN102746314B (en) *	2011-04-18	2016-07-06	华东师范大学	Containing stablizing the camptothecine compounds of 7 yuan of lactonic rings, preparation method and purposes
CN114539292B (en) *	2022-01-28	2023-08-29	遵义医药高等专科学校	A novel podophyllotoxin splicing anti-tumor active molecular compound and its preparation method and application
WO2023232145A1 (en) *	2022-06-02	2023-12-07	华东师范大学	Small molecule of homocamptothecins and use thereof
WO2024230752A1 (en) *	2023-05-08	2024-11-14	甘李药业股份有限公司	Camptothecin derivative, linker, ligand-drug conjugate and medical use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0615547B2 (en) *	1988-01-20	1994-03-02	株式会社ヤクルト本社	Novel camptothecin derivative
US5391745A (en) *	1992-07-23	1995-02-21	Sloan-Kettering Institute For Cancer Research	Methods of preparation of camptothecin analogs
EP0835258B1 (en) *	1995-06-21	2002-09-25	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Novel camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

1996
- 1996-12-20 FR FR9615774A patent/FR2757514B1/en not_active Expired - Fee Related
1997
- 1997-05-12 UA UA99063449A patent/UA57758C2/en unknown
- 1997-12-05 KR KR10-1999-7005603A patent/KR100516874B1/en not_active Expired - Fee Related
- 1997-12-05 JP JP52844898A patent/JP3576175B2/en not_active Expired - Fee Related
- 1997-12-05 PL PL97334125A patent/PL188181B1/en not_active IP Right Cessation
- 1997-12-05 DE DE69724453T patent/DE69724453T2/en not_active Expired - Lifetime
- 1997-12-05 HU HU9904210A patent/HUP9904210A3/en unknown
- 1997-12-05 AU AU53265/98A patent/AU734485B2/en not_active Ceased
- 1997-12-05 CN CN97180815A patent/CN1097056C/en not_active Expired - Fee Related
- 1997-12-05 RU RU99115829/04A patent/RU2194051C2/en not_active IP Right Cessation
- 1997-12-05 CA CA002275351A patent/CA2275351C/en not_active Expired - Fee Related
- 1997-12-05 PT PT97950236T patent/PT946567E/en unknown
- 1997-12-05 AT AT97950236T patent/ATE248177T1/en active
- 1997-12-05 DK DK97950236T patent/DK0946567T3/en active
- 1997-12-05 CZ CZ0220599A patent/CZ299795B6/en not_active IP Right Cessation
- 1997-12-05 MX MXPA99005776A patent/MXPA99005776A/en not_active IP Right Cessation
- 1997-12-05 EP EP97950236A patent/EP0946567B1/en not_active Expired - Lifetime
- 1997-12-05 WO PCT/FR1997/002218 patent/WO1998028305A1/en not_active Ceased
- 1997-12-05 ES ES97950236T patent/ES2206761T3/en not_active Expired - Lifetime
- 1997-12-05 NZ NZ335939A patent/NZ335939A/en not_active IP Right Cessation
- 1997-12-05 BR BR9714170-4A patent/BR9714170A/en not_active Application Discontinuation
- 1997-12-10 ZA ZA9711129A patent/ZA9711129B/en unknown
- 1997-12-17 MY MYPI97006088A patent/MY119473A/en unknown
- 1997-12-19 AR ARP970106043A patent/AR008543A1/en active IP Right Grant
1999
- 1999-06-18 NO NO19992998A patent/NO326464B1/en not_active IP Right Cessation
2003
- 2003-11-26 JP JP2003395513A patent/JP2004115535A/en not_active Withdrawn

Also Published As

Publication number	Publication date
CN1097056C (en)	2002-12-25
ATE248177T1 (en)	2003-09-15
HUP9904210A3 (en)	2000-09-28
ES2206761T3 (en)	2004-05-16
UA57758C2 (en)	2003-07-15
NZ335939A (en)	2000-04-28
JP2001505922A (en)	2001-05-08
EP0946567B1 (en)	2003-08-27
DE69724453T2 (en)	2004-06-09
HK1024695A1 (en)	2000-10-20
ZA9711129B (en)	1999-05-03
WO1998028305A1 (en)	1998-07-02
JP3576175B2 (en)	2004-10-13
CA2275351A1 (en)	1998-07-02
DE69724453D1 (en)	2003-10-02
RU2194051C2 (en)	2002-12-10
MXPA99005776A (en)	2004-08-31
NO326464B1 (en)	2008-12-08
DK0946567T3 (en)	2003-12-22
CN1241191A (en)	2000-01-12
PL188181B1 (en)	2004-12-31
MY119473A (en)	2005-05-31
NO992998D0 (en)	1999-06-18
FR2757514A1 (en)	1998-06-26
CA2275351C (en)	2008-10-14
AU734485B2 (en)	2001-06-14
KR20000069608A (en)	2000-11-25
BR9714170A (en)	2000-02-29
HUP9904210A2 (en)	2000-05-28
FR2757514B1 (en)	1999-02-12
PT946567E (en)	2004-01-30
JP2004115535A (en)	2004-04-15
KR100516874B1 (en)	2005-09-26
NO992998L (en)	1999-08-18
CZ220599A3 (en)	1999-09-15
CZ299795B6 (en)	2008-11-26
AR008543A1 (en)	2000-01-19
EP0946567A1 (en)	1999-10-06
PL334125A1 (en)	2000-02-14

Publication	Publication Date	Title
ZA9811796B (en)	1999-06-29	New tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them.
AU3080895A (en)	1996-02-16	Novel piperazides derived from arylpiperazine, processes for their preparation, their use as medicaments and pharmaceutical compositions comprising them
AU4867697A (en)	1998-05-15	Oxadiazoles, processes for preparing them and their use as pharmaceutical compositions
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AU2498597A (en)	1997-11-12	New benzazepine derivatives, medicaments containing the same and their use to prepare medicaments
HUP0001508A3 (en)	2003-01-28	4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them
HUP9601566A3 (en)	1998-01-28	Therapeutic tetrahydro-isoquinolin derivatives, their intermediates and pharmaceutical compositions containing the active component
AU5278196A (en)	1996-10-16	New taxoids, their preparation and pharmaceutical compositions containing them
HUP9900413A3 (en)	2002-02-28	Use of coralyne derivatives, new coralyne derivatives and use thereof, pharmaceutical compositions containing these new coralyne derivatives
HUP0002272A3 (en)	2002-03-28	Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use
IL111533A0 (en)	1995-01-24	Quinoxalinedione derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
HUP9904694A3 (en)	2001-12-28	Spiropyrrolidine derivatives, their use and pharmaceutical compositions containing them
AU5326498A (en)	1998-07-17	Prodrug forms and new analogues of camptothecin, their use as medicaments
AU5326598A (en)	1998-07-17	New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
ZA9557B (en)	1996-01-05	Optionally substituted phenylimidazolidines their preparation process and intermediates their use as medicaments and the pharmaceutical compositions containing them
AU5339594A (en)	1994-05-09	Novel taxane derivatives, their preparation and pharmaceutical compositions containing them
AU2030297A (en)	1997-09-22	Taxoids, preparation thereof and pharmaceutical compositions containing same
HU9700955D0 (en)	1997-07-28	Substituted 2-naphtoylguanidine derivatives, their production, their use and pharmaceutical compositions containing them
AU8147094A (en)	1995-05-29	Novel taxoids, their preparation and pharmaceutical compositions containing them
AU8146994A (en)	1995-05-29	Novel taxicine derivatives, their preparation and pharmaceutical compositions containing them
AU2741795A (en)	1996-01-04	Taxoids, preparation thereof and pharmaceutical compositions containing them
HUP9800631A3 (en)	1998-12-28	4-aminotetrahydrobenzisoxazole or -isothiazole derivatives, pharmaceutical compositions containing them and their use for the preparation of pharmaceutical compositions
IL164513A0 (en)	2005-12-18	Pyrazolopyrimidines, pharmaceutical compositions containing them, and their use in the preparation of medicaments
HUP9802590A3 (en)	2001-08-28	Indan-, benzothiophene-, benzofuran- and indolesulfonamide derivatives, their use and pharmaceutical compositions containing them
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Legal Events

Date	Code	Title	Description
2001-10-11	FGA	Letters patent sealed or granted (standard patent)