AU2009248997A1 - Triazine compounds as PI3 kinase and mTOR inhibitors - Google Patents

Triazine compounds as PI3 kinase and mTOR inhibitors Download PDF

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Publication number: AU2009248997A1
Authority: AU; Australia
Prior art keywords: phenyl; azabicyclo; oxa; triazin; urea
Prior art date: 2008-05-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2009248997A

Other languages

English (en)

Inventor

Semiramis Ayral-Kaloustian

Zecheng Chen

Kevin J Curran

Christoph M Dehnhardt

Efren G Delos Santos

Osvaldo Dos Santos

Ariamala Gopalsamy

Joshua A Kaplan

Tarek S Mansour

David J Richard

Mengxiao Shi

Aranapakam M Venkatesan

Jeroen C Verheijen

Arie Zask

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

Original Assignee

Wyeth LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-05-23

Filing date

2009-05-21

Publication date

2009-11-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40911929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2009248997(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-05-21 Application filed by Wyeth LLC filed Critical Wyeth LLC

2009-11-26 Publication of AU2009248997A1 publication Critical patent/AU2009248997A1/en

Status Abandoned legal-status Critical Current

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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Hematology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AU2009248997A 2008-05-23 2009-05-21 Triazine compounds as PI3 kinase and mTOR inhibitors Abandoned AU2009248997A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US5566108P	2008-05-23	2008-05-23
US61/055,661		2008-05-23
PCT/US2009/044784 WO2009143317A1 (en)	2008-05-23	2009-05-21	Triazine compounds as p13 kinase and mtor inhibitors

Publications (1)

Publication Number	Publication Date
AU2009248997A1 true AU2009248997A1 (en)	2009-11-26

Family

ID=40911929

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU2009248997A Abandoned AU2009248997A1 (en)	2008-05-23	2009-05-21	Triazine compounds as PI3 kinase and mTOR inhibitors
AU2009248993A Active AU2009248993C1 (en)	2008-05-23	2009-05-21	Triazine compounds as PI3 kinase and mTOR inhibitors

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AU2009248993A Active AU2009248993C1 (en)	2008-05-23	2009-05-21	Triazine compounds as PI3 kinase and mTOR inhibitors

Country Status (43)

Country	Link
US (8)	US8039469B2 (es)
EP (3)	EP2294072B1 (es)
JP (2)	JP2011520979A (es)
KR (1)	KR101331341B1 (es)
CN (2)	CN104230831B (es)
AP (2)	AP2010005452A0 (es)
AR (2)	AR071909A1 (es)
AU (2)	AU2009248997A1 (es)
BR (1)	BRPI0912294B8 (es)
CA (2)	CA2721692C (es)
CL (2)	CL2009001273A1 (es)
CO (1)	CO6311070A2 (es)
CR (1)	CR11757A (es)
CU (1)	CU23887B1 (es)
CY (2)	CY1118879T1 (es)
DK (2)	DK3216793T3 (es)
DO (1)	DOP2010000315A (es)
EA (1)	EA020317B1 (es)
EC (2)	ECSP10010624A (es)
ES (2)	ES2625467T3 (es)
GE (1)	GEP20125589B (es)
HR (2)	HRP20170637T1 (es)
HU (1)	HUE043331T2 (es)
IL (2)	IL209060A (es)
LT (2)	LT3216793T (es)
MA (1)	MA32319B1 (es)
ME (1)	ME01111B (es)
MX (1)	MX2010012808A (es)
MY (1)	MY155653A (es)
NI (1)	NI201000198A (es)
NZ (1)	NZ588526A (es)
PA (2)	PA8828101A1 (es)
PE (2)	PE20091943A1 (es)
PL (1)	PL3216793T3 (es)
PT (2)	PT2294072T (es)
RS (2)	RS58724B1 (es)
SA (1)	SA109300314B1 (es)
SI (2)	SI2294072T1 (es)
TR (1)	TR201906123T4 (es)
TW (2)	TWI389906B (es)
UA (1)	UA99361C2 (es)
WO (2)	WO2009143317A1 (es)
ZA (1)	ZA201007204B (es)

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ES2554513T3 (es)	2008-05-23	2015-12-21	Novartis Ag	Derivados de quinolinas y quinoxalinas como inhibidores de la proteína tirosina quinasa
US10022381B2 (en) *	2008-05-23	2018-07-17	Pfizer Inc.	Triazine compounds as PI3 kinase and mTOR inhibitors
AP2010005452A0 (en) *	2008-05-23	2010-12-31	Wyeth Llc	Triazine compounds as P13 kinase and MTOR inhibitors.
GB2465405A (en) *	2008-11-10	2010-05-19	Univ Basel	Triazine, pyrimidine and pyridine analogues and their use in therapy
WO2010096619A1 (en) *	2009-02-23	2010-08-26	Wyeth Llc	Process, purification and crystallization of 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
RU2011143359A (ru)	2009-03-27	2013-05-10	Патвэй Терапьютикс, Инк.	Примидинил- и 1,3,5-триазинилбензимидазолсульфонамиды и их применение в терапии рака
UY32582A (es)	2009-04-28	2010-11-30	Amgen Inc	Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
WO2011005119A1 (en)	2009-07-07	2011-01-13	Pathway Therapeutics Limited	Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
EP2467137A1 (en) *	2009-08-19	2012-06-27	Ambit Biosciences Corporation	Biaryl compounds and methods of use thereof
WO2011087812A1 (en) *	2009-12-21	2011-07-21	Vanderbilt University	Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective m1 agonists and methods of making and using same
EA201290876A1 (ru)	2010-03-05	2013-03-29	Президент Энд Феллоуз Оф Гарвард Колледж	Композиции индуцированных дендритных клеток и их использование
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PE20091943A1 (es)	2009-12-19
US9174963B2 (en)	2015-11-03
US20130005723A1 (en)	2013-01-03
JP2011520979A (ja)	2011-07-21
IL209061A0 (en)	2011-01-31
IL209060A0 (en)	2011-01-31
LT3216793T (lt)	2019-05-10
EA020317B1 (ru)	2014-10-30
US8217036B2 (en)	2012-07-10
US8575159B2 (en)	2013-11-05
BRPI0912294B1 (pt)	2019-11-12
CN104230831B (zh)	2016-08-24
HK1157328A1 (en)	2012-06-29
WO2009143313A1 (en)	2009-11-26
CY1121699T1 (el)	2020-07-31
ECSP10010623A (es)	2010-12-30
US20150011752A1 (en)	2015-01-08
PE20091957A1 (es)	2009-12-30
LT2294072T (lt)	2017-06-12
AP2010005453A0 (en)	2010-12-31
US20130109670A1 (en)	2013-05-02
IL209060A (en)	2014-05-28
AR071909A1 (es)	2010-07-21
ES2625467T3 (es)	2017-07-19
PA8828201A1 (es)	2009-12-16
SI2294072T1 (sl)	2017-05-31
PL3216793T3 (pl)	2019-09-30
US20140248239A1 (en)	2014-09-04
KR20110002485A (ko)	2011-01-07
DOP2010000315A (es)	2010-12-15
US20130315865A1 (en)	2013-11-28
DK3216793T3 (da)	2019-05-06
US20090304692A1 (en)	2009-12-10
BRPI0912294B8 (pt)	2021-05-25
AU2009248993C1 (en)	2013-10-03
ZA201007204B (en)	2011-12-28
HUE043331T2 (hu)	2019-08-28
US8445486B2 (en)	2013-05-21
US8039469B2 (en)	2011-10-18
TW201011010A (en)	2010-03-16
CA2721710A1 (en)	2009-11-26
TW201008949A (en)	2010-03-01
TWI389906B (zh)	2013-03-21
EA201071232A1 (ru)	2011-06-30
CL2009001273A1 (es)	2009-11-27
TR201906123T4 (tr)	2019-05-21
AU2009248993A1 (en)	2009-11-26
PT3216793T (pt)	2019-05-30
CA2721692A1 (en)	2009-11-26
MY155653A (en)	2015-11-13
SI3216793T1 (sl)	2019-06-28
CR11757A (es)	2010-11-30
JP4948677B2 (ja)	2012-06-06
PT2294072T (pt)	2017-05-29
AP2010005452A0 (en)	2010-12-31
EP2300483A1 (en)	2011-03-30
PA8828101A1 (es)	2009-12-16
HRP20190680T1 (hr)	2019-06-14
RS58724B1 (sr)	2019-06-28
US20110312955A1 (en)	2011-12-22
MA32319B1 (fr)	2011-05-02
HK1203199A1 (en)	2015-10-23
RS55960B1 (sr)	2017-09-29
DK2294072T3 (en)	2017-05-15
ECSP10010624A (es)	2010-12-30
KR101331341B1 (ko)	2013-11-19
AR071908A1 (es)	2010-07-21
EP2294072B1 (en)	2017-03-29
CA2721692C (en)	2014-01-14
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CU23887B1 (es)	2013-04-19
CU20100229A7 (es)	2011-11-15
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EP2294072A1 (en)	2011-03-16
EP3216793A1 (en)	2017-09-13
EP3216793B1 (en)	2019-03-27
US8748421B2 (en)	2014-06-10
BRPI0912294A2 (pt)	2015-10-20
CO6311070A2 (es)	2011-08-22
NZ588526A (en)	2012-08-31
CN102036995B (zh)	2014-09-17
CY1118879T1 (el)	2018-01-10
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Publication	Publication Date	Title
AU2009248993B2 (en)	2011-07-07	Triazine compounds as PI3 kinase and mTOR inhibitors
US10022381B2 (en)	2018-07-17	Triazine compounds as PI3 kinase and mTOR inhibitors
HK1203199B (en)	2017-09-15	Triazine compounds as pi3 kinase and mtor inhibitors
HK1157328B (en)	2015-07-17	Triazine compounds as pi3 kinase and mtor inhibitors

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