AU2002218746A1 - Composition comprising folic acid and zinc for improving male fertility - Google Patents
Composition comprising folic acid and zinc for improving male fertilityInfo
- Publication number
- AU2002218746A1 AU2002218746A1 AU2002218746A AU1874602A AU2002218746A1 AU 2002218746 A1 AU2002218746 A1 AU 2002218746A1 AU 2002218746 A AU2002218746 A AU 2002218746A AU 1874602 A AU1874602 A AU 1874602A AU 2002218746 A1 AU2002218746 A1 AU 2002218746A1
- Authority
- AU
- Australia
- Prior art keywords
- zinc
- composition
- folic acid
- male fertility
- improving male
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title abstract 4
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title abstract 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract 2
- 230000035558 fertility Effects 0.000 title abstract 2
- 229960000304 folic acid Drugs 0.000 title abstract 2
- 235000019152 folic acid Nutrition 0.000 title abstract 2
- 239000011724 folic acid Substances 0.000 title abstract 2
- 239000011701 zinc Substances 0.000 title abstract 2
- 229910052725 zinc Inorganic materials 0.000 title abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 abstract 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 abstract 1
- 229930003779 Vitamin B12 Natural products 0.000 abstract 1
- 229930003471 Vitamin B2 Natural products 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229960003237 betaine Drugs 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 229940091250 magnesium supplement Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract 1
- 229960002477 riboflavin Drugs 0.000 abstract 1
- 239000013545 self-assembled monolayer Substances 0.000 abstract 1
- 210000000582 semen Anatomy 0.000 abstract 1
- 235000019163 vitamin B12 Nutrition 0.000 abstract 1
- 239000011715 vitamin B12 Substances 0.000 abstract 1
- 235000019164 vitamin B2 Nutrition 0.000 abstract 1
- 239000011716 vitamin B2 Substances 0.000 abstract 1
- 235000019158 vitamin B6 Nutrition 0.000 abstract 1
- 239000011726 vitamin B6 Substances 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
A composition for improving the fertility of a male, and/or for improving the quality of the semen produced by a male includes at least one source of folic acid, preferably 0.05-8 mg; at least one source of zinc, preferably 5-50 mg; and optionally one or more of vitamin B12, magnesium, betaine, choline, SAM, vitamin B2, and Vitamin B6; and/or optionally one or more carriers, excipients and/or adjuvants.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/610,536 US6576634B1 (en) | 2000-07-07 | 2000-07-07 | Pharmaceutical or dietetic preparation for improvement of fertility and sperm quality |
| US09/610,536 | 2000-07-07 | ||
| PCT/NL2001/000521 WO2002003974A2 (en) | 2000-07-07 | 2001-07-09 | Composition comprising folic acid and zinc for improving male fertility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002218746A1 true AU2002218746A1 (en) | 2002-01-21 |
Family
ID=24445408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002218746A Abandoned AU2002218746A1 (en) | 2000-07-07 | 2001-07-09 | Composition comprising folic acid and zinc for improving male fertility |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6576634B1 (en) |
| EP (1) | EP1299105B1 (en) |
| AT (1) | ATE273052T1 (en) |
| AU (1) | AU2002218746A1 (en) |
| DE (1) | DE60104853T2 (en) |
| ES (1) | ES2225625T3 (en) |
| WO (1) | WO2002003974A2 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6576634B1 (en) * | 2000-07-07 | 2003-06-10 | N.V. Nutricia | Pharmaceutical or dietetic preparation for improvement of fertility and sperm quality |
| AU2003237488A1 (en) * | 2002-01-22 | 2003-09-02 | Equine2, Inc. | Method of increasing fertility and athletic performance in horses |
| CH696628A5 (en) * | 2002-02-26 | 2007-08-31 | Eprova Ag | Use of folate suitable for the manufacture of a preparation for the prevention and treatment of inflammation and inflammation-associated diseases, in particular for influencing the |
| FR2884692B1 (en) * | 2005-04-21 | 2009-08-14 | Formquest Ltd | FOOD SUPPLEMENT COMPRISING AN ASSOCIATION OF ANTIOXIDANT AGENTS AND CARNITINE, OBTAINED BY ENDOGENEOUS OR EXOGENOUS SYNTHESIS, AS AID FOR FERTILITY IN MAN AND WOMEN |
| US20070060620A1 (en) * | 2005-09-09 | 2007-03-15 | John Sefton | Use of RAR retinoid agonists to increase sperm count and sperm mobility in males |
| US20070114476A1 (en) * | 2005-11-04 | 2007-05-24 | Williams Christopher P | Low radiocarbon nucleotide and amino acid dietary supplements |
| WO2008136793A1 (en) | 2007-05-03 | 2008-11-13 | Williams Christopher P | Low radiocarbon dietary supplements and methods of making same |
| US8512761B2 (en) | 2006-01-27 | 2013-08-20 | Yale University | Fast acting inhibitor of gastric acid secretion |
| SI1976532T1 (en) * | 2006-01-27 | 2016-04-29 | Yale University | Fast acting inhibitor of gastric acid secretion |
| AT503219B1 (en) | 2006-02-03 | 2008-07-15 | Annerl Brigitte | COMBINATION PREPARATION BASED ON ANTIOXIDANTS TO IMPROVE THE SEED QUALITY |
| BRPI0717439A2 (en) | 2006-10-18 | 2013-11-19 | Periness Ltd | PHARMACEUTICAL COMPOSITION, AND METHODS FOR TREATING MALE SUBFERTILITY, FOR DETERMINING A FERTLITY STATUS IN A MALE SEX, FOR ASSISTED REPRODUCTION TECHNIQUE FOR A SPECULAR SPULLET REPRODUCTION FOR CULLED SPLIT USE IN AN AUXILIARY REPRODUCTION TECHNIQUE. |
| DE102007053369A1 (en) | 2007-11-09 | 2009-07-02 | Alzchem Trostberg Gmbh | Use of a preparation containing a creatine-component and a further component of e.g. L-carnitine, acetyl-L-carnitine, arginine, glutathione, vitamin C and vitamin E, as a dietary supplement for improving the male fertility in vertebrates |
| HUP0800237A2 (en) * | 2008-04-11 | 2010-03-01 | Istvan Szabo | Modification of sperm motility and storing |
| US8377454B2 (en) * | 2009-05-01 | 2013-02-19 | Parviz Gharagozloo | Treating male infertility secondary to sperm oxidative stress |
| FR2964834B1 (en) * | 2010-09-21 | 2012-09-28 | Marc Cohen | ANTI-OXIDIZING COMPOSITION FOR PREVENTING INFERTILITY IN MAN |
| ES2575828B1 (en) | 2014-12-31 | 2017-07-07 | Universidad De León | Use of probiotics in increasing male fertility |
| CN106036823A (en) * | 2016-05-23 | 2016-10-26 | 沈阳迪格医疗科技有限公司 | Health-care product and preparation method thereof |
| BE1032231B1 (en) * | 2023-12-15 | 2025-07-14 | Curafyt Bv | COMPOSITION FOR USE IN THE TREATMENT OF OVULATION SUB- OR INFERTILITY IN EQUINES |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5063226A (en) * | 1988-07-15 | 1991-11-05 | University Of Florida | Use of supplemental dietary riboflavin to increase fertility and/or prolificacy in animals |
| GB2268871A (en) * | 1992-07-04 | 1994-01-26 | Bio Nutritional Health Service | Composition for use as a food or food supplement |
| US5700590A (en) * | 1994-01-10 | 1997-12-23 | Abbott Laboratories | Nutritional formula with ribo-nucleotides |
| DE19605153A1 (en) * | 1996-02-13 | 1997-08-14 | Pfeiffer Erich Gmbh & Co Kg | Discharge device for media and method for producing a discharge device or the like. |
| EP0891719A1 (en) * | 1997-07-14 | 1999-01-20 | N.V. Nutricia | Nutritional composition containing methionine |
| US6207190B1 (en) * | 1998-08-13 | 2001-03-27 | Chronorx, Llc | Dosage forms for the treatment of the chronic glaucomas |
| ZA994697B (en) * | 1998-09-09 | 2000-01-31 | Pharmachoice Healthcare Pty Lt | Pharmaceutical formulation. |
| DE29916231U1 (en) * | 1999-09-15 | 2000-02-17 | Renner, Jobst, Dr., 81479 München | Multivitamin and mineral preparation |
| US6420342B1 (en) * | 2000-05-08 | 2002-07-16 | N.V. Nutricia | Nutritional preparation comprising ribose and medical use thereof |
| ES2258426T3 (en) * | 2000-06-16 | 2006-09-01 | Matthias Dr. Med. Rath | COMPOSITION FOR THE PREVENTION OF DISEASES OF SMOOTH MUSCLES THAT INCLUDE ASCORBATE, ARGININE AND MAGNESIUM. |
| US6576634B1 (en) * | 2000-07-07 | 2003-06-10 | N.V. Nutricia | Pharmaceutical or dietetic preparation for improvement of fertility and sperm quality |
| US6995166B1 (en) * | 2000-09-27 | 2006-02-07 | Everett Laboratories, Inc. | Method and composition for supplementation of nutritional deficiencies in renal patients |
-
2000
- 2000-07-07 US US09/610,536 patent/US6576634B1/en not_active Expired - Lifetime
-
2001
- 2001-07-09 EP EP01984142A patent/EP1299105B1/en not_active Expired - Lifetime
- 2001-07-09 DE DE60104853T patent/DE60104853T2/en not_active Expired - Fee Related
- 2001-07-09 ES ES01984142T patent/ES2225625T3/en not_active Expired - Lifetime
- 2001-07-09 AU AU2002218746A patent/AU2002218746A1/en not_active Abandoned
- 2001-07-09 WO PCT/NL2001/000521 patent/WO2002003974A2/en not_active Ceased
- 2001-07-09 AT AT01984142T patent/ATE273052T1/en not_active IP Right Cessation
-
2003
- 2003-05-15 US US10/438,322 patent/US20040058014A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002003974A2 (en) | 2002-01-17 |
| EP1299105B1 (en) | 2004-08-11 |
| US6576634B1 (en) | 2003-06-10 |
| DE60104853D1 (en) | 2004-09-16 |
| ES2225625T3 (en) | 2005-03-16 |
| DE60104853T2 (en) | 2005-08-18 |
| WO2002003974A3 (en) | 2003-01-23 |
| US20040058014A1 (en) | 2004-03-25 |
| EP1299105A2 (en) | 2003-04-09 |
| ATE273052T1 (en) | 2004-08-15 |
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