DE29916231U1 - Multivitamin and mineral preparation - Google Patents

Description

SAMSON & PARTNER

PATENT ATTORNEYS · EUROPEAN PATENT ATTORNEYS · EUROPEAN TRADE MARK ATTORNEYS
OUR REF DATE

R1874002DEU00Tb September 15, 1999

Tu/18/ba

Applicant:

Dr. Jobst Renner Renner■see pharmacy Nymphenburg Street 174

80634 Munich

Multivitamin and mineral supplement Description

The invention relates to a multivitamin and mineral preparation.

There are many reasons why the body's supply of vitamins and minerals from food alone is often not sufficient. The best-known example is the proverbial southern German goiter, which is caused by iodine deficiency. These also include:

Impairment of the body's own defenses against bacterial and viral infections;
Deficiency symptoms resulting from stomach and intestinal diseases with nutritional disorders;

- increased need for vitamins and minerals during pregnancy and breastfeeding;

Diets, e.g. sick diet, fasting diet, one-sided diet;

- Skin diseases and skin problems such as dry, flaky and cracked skin, skin blemishes

(acne), chapped corners of the mouth and dry, cracked lips;

- Brittle nails; it has been repeatedly observed that nail growth is promoted by certain vitamins and minerals and the nail substance is strengthened;

- Age-related problems, e.g. decrease in physical and mental mobility;

- Loss of performance due to physical and mental stress;

- loss of appetite and weight loss;

States of exhaustion, e.g. during recovery after a long illness or due to physical and mental overload;

- physical activity, e.g. prevention of sore muscles and replenishment of minerals that are excreted in increased amounts in sweat;

- antibiotic treatment;

- Estrogen treatment, e.g. with the pill or during menopause;

- in children with loss of appetite, weakness or lack of weight gain.

In all these cases, additional intake of vitamins and minerals is recommended.

There are very different recommendations regarding the amounts of vitamins and minerals that should be consumed per day. The following are the minimum doses recommended by the USA (Recommended Dietary Allowances (RDA) published in Nutrition Health Reports) for pregnant or breastfeeding women. It should be stressed that these RDAs are only a guideline for the minimum intake and that higher doses may be required in individual cases. These values are then compared with the average intake of vitamins and minerals recommended by the European Federation of Associations of Health Product Manufacturers (1995) under

entitled "Essential Nutrients in Supplements".

US RDA average intake from food

Vitamin C: Vitamin E: Vitamin Bl: Vitamin B2: Vitamin B5: Vitamin B6: Vitamin B12: Folic acid: Biotin: Vitamin D3: Vitamin A:

95mg

12mg

1.6mg

1.8mg

4-7mg

2.2mg

2.6 ^g

/zg*

30-100mg

5 /ig**

RE

57.6mg

9.3 mg 1.7 mg 2. 0 mg 6. 0 mg

2.4 mg 7.2 /ig 300 μg

37.5mg

2.9 /g

1012 RE

Calcium: Magnesium: Iron: Zinc: Manganese: Copper: Molybdenum: Iodine: Selenium:

0 0mg

355mg

3 0 mg

19mg

2-5mg

1.5-3mg

75-200 μg

200 /kg

917mg

308mg

13.2mg

11.1mg

4.6mg

1.5mg

128 /ig

225 /day***

* This value for folic acid is a value for women who do not belong to a risk group. For women who want to have children and who have a risk factor (e.g. diabetes, taking antiepileptic drugs), a dose of up to 5 mg folic acid is recommended. ** RDA of the EU

*** The supply of iodine depends to a large extent on the region. In southern Germany, for example, iodine intake is insufficient

The values in this table show that the minimum vitamin and mineral intake for some of the vitamins and minerals listed above is not guaranteed by the average dietary intake, for example in the case of pregnancy. For other values, the recommended dose is just about achieved by the average dietary intake. However, if an unbalanced diet, including an unbalanced nutrition, is added to the risk potential of pregnancy, the intake of the vitamins and minerals in question can quickly fall below the recommended minimum dose.

If you want to be sure that your body is receiving the recommended amounts of vitamins and minerals in the case of one of the above-mentioned risk factors for vitamin and mineral deficiency, e.g. during pregnancy, you usually have to resort to several preparations, possibly even to individual preparations, which is not only annoying because of the number of tablets or capsules you have to take, but also expensive.

The purpose of this invention is therefore to create a multivitamin and mineral preparation that combines the most important vitamins and minerals in doses that ensure an adequate supply of the body with them when taken once or twice a day.

This task is solved by a multivitamin and mineral preparation that contains:

Vitamin C (as Ca-ascorbate): 100-200 mg

Vitamin E (DL-X-tocopherol acetate): 70-130 mg

Vitamin Bl (Thiamine Chloride HCl): 20-80 mg

Vitamin B2 (riboflavin): 20-80 mg

Vitamin B3 (nicotinamide): 20-80 mg

Vitamin B5 (as Ca pantothenate): 20-80 mg

Vitamin B6 (pyridoxine HCl): 20- 80 mg Vitamin B12 (cyanocobalamin): 0.08-0.15 mg Inositol: 20 -80 mg Folic acid: 0.3-0.5 mg Biotin: 0.03-0.08 mg Vitamin D3 (cholecalciferol): 300-500 I .E. Vitamin A (retinol palmitate): 1000-50001 .E. Calcium hydrogen sulfate: 70-150 mg Magne s i umox i d 30- 80 mg Iron(II) sulfate 25- 40 mg Zinc sulfate 12- 18 mg Manganese(II) sulfate 0-3 mg Copper sulfate 0-3 mg Sodium molybdate 160 M9 Potassium iodide 0.08-0.12 mg Selenium yeast 30-50 mg

Particularly preferred is a preparation that contains:

vitamin C (as Ca-ascorbate): 150 mg Vitamin E (DL-X-Tocopherol Acetate): 50 mg Vitamin B12 (Thiamine chloride HCl): 50 mg Vitamin B2 (Riboflavin): 50 mg Vitamin B3 (Nicotinamide): 50 mg Vitamin B5 (as Ca-pantothenate): 50 mg Vitamin B6 (Pyridoxine HCl): 50 mg Vitamin B12 (Cyanocobalamin): 0.1 mg Inositol: 50 mg Folic acid: 0.4 mg Biotin: 0.05 mg Vitamin D3 (Cholecalciferol): 400 I .E. Vitamin A (Retinol palmitate): 1.1 - 2.2 mg

Calcium hydrogen sulfate: Magnesium oxide Iron(II) sulfate

(= 2000-4000 IU)

100 mg (= 2 9.4 mg Ca) 50 mg 33 mg (= 10 mg Fe)

i ·&igr;··
ϕϕϕ ϕ Zinc sulfate φ φ φ % ΦΦΦ· mg (= 6 mg Zn) ϕϕ♦ Manganese(II) sulfate ? * φ ? ? ? ???? ?? ? mg ϕ ϕ
φφφ φφφ Copper sulfate φ φ φ φ φ Φ Φ
Φ Φ ·Φ; mg Sodium molybdate 6 Potassium iodide 16.5 mg Selenium yeast 2 mg (= 50 μιη) len) 1 160 &ogr;,&igr; 50

Some of the above values are significantly higher than the US RDA (particularly when the vitamin and mineral preparation according to the invention is taken twice daily). As already mentioned above, the RDA values given are a minimum recommendation and in individual cases a much higher intake may be advisable. However, this intake must be within the safe dosage range of the vitamins and minerals, as some of them have undesirable side effects when overdosed. To prove that the multivitamin and mineral preparation in question is within these limits, the values published by the European Federation of Association of Health Product Manufacturers (see above) as safe for intake as a dietary supplement are given below:

Vitamin C 2 00 0 mg

Vitamin E 800mg

Vitamin Bl no limit

Vitamin B2 no limit

Vitamin B3 not specified

Vitamin B5 no limit

Vitamin B6 200mg

Vitamin B12 no limit

Inositol not specified

Folic acid 5 mg*

Biotin no limit

Vitamin D3 10 /tbsp

Vitamin A 2.3 0 mg

Calcium 1500 mg

Magnesium 350 mg Iron (total daily intake incl.

Iron from food) 60 mg

Zinc 15 mg

Manganese 15 mg

Copper mg

Molybdenum 20 0 μg

Iodine 500 ^g

Selenium 200 ug

* This value was taken from the article "Folic acid protects: Too little known among pregnant women" in the magazine "BABY and the first years", September 1999, page 19, Wort und Bild Verlag, Munich.

If the salts used in the preparation according to the invention are converted to their metal or other trace element content, it is found that when the preparation according to the invention is taken twice daily, the values recommended as the maximum safe dose are not exceeded.

The invention therefore provides a preparation that allows a simpler and significantly more cost-effective administration of vitamins and minerals than with conventional preparations of this type and is also safe when dosed as intended.

0 The preparation according to the invention can be used in hard or, preferably, soft gelatin capsules.

For this purpose, the components listed above are filled into the capsules using a conventional dosing and filling device.

The capsules should be dark colored and stored protected from light, as some of the ingredients are light-sensitive.

Claims (2)

1. Multivitamin and mineral supplement containing:
Vitamin C (as Ca-ascorbate): 100-200 mg
Vitamin E (DL-≙-tocopherol acetate): 70-130 mg
Vitamin B1 (Thiamine Chloride HCl): 20-80 mg
Vitamin B2 (riboflavin): 20-80 mg
Vitamin B3 (nicotinamide): 20-80 mg
Vitamin B5 (as Ca pantothenate): 20-80 mg
Vitamin B6 (Pyridoxine HCl): 20-80 mg
Vitamin B12 (cyanocobalamin): 0.08-0.15 mg
Inositol: 20-80 mg
Folic acid: 0.3-0.5 mg
Biotin: 0.03-0.08 mg
Vitamin D3 (cholecalciferol): 300-500 IU
Vitamin A (retinol palmitate): 1000-5000 IU
Calcium hydrogen sulfate: 70-150 mg
Magnesium oxide: 30-80 mg
Iron(II) sulfate: 25-40 mg
Zinc sulfate: 12-18 mg
Manganese(II) sulfate: 0-3 mg
Copper sulfate: 0-3 mg
Sodium molybdate: 160 µg
Potassium iodide: 0.08-0.12 mg
Selenium yeast: 30-50 mg. 2. Preparation according to claim 1, which contains:
Vitamin C (as Ca-ascorbate): 150 mg
Vitamin E (DL-≙-tocopherol acetate): 50 mg
Vitamin B1 (Thiamine Chloride HCl): 50 mg
Vitamin B2 (riboflavin): 50 mg
Vitamin B3 (nicotinamide): 50 mg
Vitamin B5 (as Ca pantothenate): 50 mg
Vitamin B6 (Pyridoxine HCl): 50 mg
Vitamin B12 (cyanocobalamin): 0.1 mg
Inositol: 50 mg
Folic acid: 0.4 mg
Biotin: 0.05 mg
Vitamin D3 (cholecalciferol): 400 IU
Vitamin A (retinol palmitate): 1.1-2.2 mg (= 2000-4000 IU)
Calcium hydrogen sulfate: 100 mg (= 29.4 mg Ca)
Magnesium oxide: 50 mg
Iron(II) sulfate: 33 mg (= 10 mg Fe)
Zinc sulfate: 16.5 mg (= 6 mg Zn)
Manganese(II) sulfate: 2 mg
Copper sulfate: 1 mg
Sodium molybdate: 160 µg
Potassium iodide: 0.1 mg
Selenium yeast 50 mg (= 50 µg selenium).