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ATE221884T1 - Wasserlösliche azole als breitspektrum-antifungus - Google Patents

Wasserlösliche azole als breitspektrum-antifungus

Info

Publication number
ATE221884T1
ATE221884T1 AT99926304T AT99926304T ATE221884T1 AT E221884 T1 ATE221884 T1 AT E221884T1 AT 99926304 T AT99926304 T AT 99926304T AT 99926304 T AT99926304 T AT 99926304T AT E221884 T1 ATE221884 T1 AT E221884T1
Authority
AT
Austria
Prior art keywords
antifungus
water soluble
broad spectrum
soluble azoles
azoles
Prior art date
Application number
AT99926304T
Other languages
English (en)
Inventor
Lieven Meerpoel
Leo Jacobus Jozef Backx
Der Veken Louis Jozef Elis Van
Frank Christopher Odds
Jan Heeres
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE221884T1 publication Critical patent/ATE221884T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT99926304T 1998-05-14 1999-05-06 Wasserlösliche azole als breitspektrum-antifungus ATE221884T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201588A EP0957101A1 (de) 1998-05-14 1998-05-14 Wasserlösliche Azole als Breitspektrum-antifungus
PCT/EP1999/003243 WO1999058530A1 (en) 1998-05-14 1999-05-06 Water soluble azoles as broad-spectrum antifungals

Publications (1)

Publication Number Publication Date
ATE221884T1 true ATE221884T1 (de) 2002-08-15

Family

ID=8233724

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99924942T ATE238296T1 (de) 1998-05-14 1999-05-06 Wasserlösliche azole als breitspektrum-antifungus
AT99926304T ATE221884T1 (de) 1998-05-14 1999-05-06 Wasserlösliche azole als breitspektrum-antifungus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99924942T ATE238296T1 (de) 1998-05-14 1999-05-06 Wasserlösliche azole als breitspektrum-antifungus

Country Status (31)

Country Link
US (2) US6448244B1 (de)
EP (3) EP0957101A1 (de)
JP (2) JP2002514646A (de)
KR (2) KR100575147B1 (de)
CN (2) CN1137118C (de)
AR (2) AR016482A1 (de)
AT (2) ATE238296T1 (de)
AU (2) AU758876B2 (de)
BG (2) BG64388B1 (de)
BR (2) BR9910448A (de)
CA (2) CA2331141C (de)
CO (1) CO5021227A1 (de)
CZ (2) CZ298702B6 (de)
DE (2) DE69907171T2 (de)
DK (1) DK1077976T3 (de)
EE (2) EE04346B1 (de)
ES (2) ES2182531T3 (de)
HR (2) HRP20000740B1 (de)
HU (2) HUP0102031A3 (de)
IL (2) IL139649A (de)
MY (2) MY120248A (de)
NO (2) NO319760B1 (de)
NZ (2) NZ507965A (de)
PL (2) PL194085B1 (de)
PT (1) PT1077976E (de)
SI (1) SI1077976T1 (de)
SK (2) SK286156B6 (de)
TR (2) TR200003322T2 (de)
TW (2) TWI259835B (de)
WO (2) WO1999058530A1 (de)
ZA (2) ZA200007173B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (de) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Wasserlösliche Azole als Breitspektrum-antifungus
RU2002126272A (ru) * 2000-03-07 2004-08-10 Рэнбакси Лабораториз Лимитед (In) Производные азолов в качестве терапевтических агентов против грибковых инфекций
EP1413301A1 (de) * 2002-10-24 2004-04-28 Bayer CropScience SA Antimykotische Medikamente auf der Basis von Arylamidinderivaten
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
EP2571871B1 (de) * 2010-05-19 2017-06-21 Sandoz AG Verfahren zur Herstellung von chiralen Triazolonen
US9346791B2 (en) 2011-09-07 2016-05-24 The Johns Hopkins University Itraconazole analogs and use thereof
US11028078B2 (en) 2011-09-07 2021-06-08 The Johns Hopkins University Itraconazole analogs and use thereof
AU2014274830B2 (en) * 2013-06-07 2017-11-09 The California Institute For Biomedical Research Small molecule inhibitors of fibrosis
PL3227277T3 (pl) 2014-12-05 2020-08-10 Pulmocide Limited Związek przeciwgrzybiczy
WO2016094570A1 (en) * 2014-12-10 2016-06-16 The California Institute For Biomedical Research Small molecule inhibitors of fibrosis
CN107635988B (zh) 2015-05-21 2021-06-18 普尔莫赛德有限公司 抗真菌的苯甲酰胺类衍生物或其可药用盐
CN105237392B (zh) * 2015-11-24 2017-12-12 辽宁渤大化工有限公司 芳烷基水杨酸及其衍生物的制备方法
US11390613B2 (en) 2017-08-20 2022-07-19 University Of Connecticut Azole analogues and methods of use thereof
WO2021030174A1 (en) 2019-08-09 2021-02-18 University Of Connecticut Truncated itraconazole analogues and methods of use thereof
GB201917867D0 (en) 2019-12-06 2020-01-22 Pulmocide Ltd Polymorphs
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CZ286619B6 (cs) * 1992-03-18 2000-05-17 Janssen Pharmaceutica N. V. Stereoisomerické formy itrakonazolu a saperkonazolu, způsob jejich výroby, jejich komplexy, způsob výroby těchto komplexů, farmaceutické přípravky a způsob jejich výroby
TW377349B (en) * 1993-12-21 1999-12-21 Schering Corp Tetrahydrofuran antifungals
JP3764750B2 (ja) * 1994-01-24 2006-04-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 水溶性アゾール抗真菌剤
FI98688C (fi) * 1994-07-20 1997-07-25 Nokia Telecommunications Oy Menetelmä lyhytsanomalähetyksen käynnistämiseksi solukkoradiojärjestelmässä, solukkoradiojärjestelmä sekä solukkoradiojärjestelmän tilaajarekisteri
DE69628117T2 (de) * 1995-06-02 2004-04-01 Schering Corp. Antifungale tetrahydrofurane
EP0837859B1 (de) * 1995-06-19 2003-08-13 Schering Corporation Antifungale tetrahydrofurane
SI0958289T1 (en) 1997-02-11 2004-12-31 Janssen Pharmaceutica N.V. Amino acid ester containing azole antifungals
EP0957101A1 (de) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Wasserlösliche Azole als Breitspektrum-antifungus

Also Published As

Publication number Publication date
NO20005713L (no) 2001-01-11
SK16812000A3 (sk) 2001-08-06
BG104717A (en) 2001-07-31
CO5021227A1 (es) 2001-03-27
MY122147A (en) 2006-03-31
PT1077976E (pt) 2002-12-31
EE04346B1 (et) 2004-08-16
TR200003323T2 (tr) 2001-02-21
NZ507966A (en) 2002-10-25
HRP20000741A2 (en) 2001-06-30
WO1999058530A1 (en) 1999-11-18
HUP0102031A2 (hu) 2002-05-29
DE69902461D1 (de) 2002-09-12
CZ20004109A3 (en) 2001-05-16
BG64388B1 (bg) 2004-12-30
SK16822000A3 (sk) 2001-07-10
AU4361599A (en) 1999-11-29
BR9910448A (pt) 2001-01-02
ATE238296T1 (de) 2003-05-15
CZ299481B6 (cs) 2008-08-13
KR20010042852A (ko) 2001-05-25
ZA200007459B (en) 2002-09-13
NO20005712L (no) 2000-12-07
TWI259835B (en) 2006-08-11
EE200000651A (et) 2002-04-15
TW572899B (en) 2004-01-21
BG104933A (en) 2001-10-31
NO319760B1 (no) 2005-09-12
HUP0103536A3 (en) 2002-08-28
HRP20000740A2 (en) 2001-10-31
CA2331187C (en) 2008-11-18
JP2002514645A (ja) 2002-05-21
HUP0102031A3 (en) 2002-10-28
BG64954B1 (bg) 2006-10-31
AU4141799A (en) 1999-11-29
NO20005713D0 (no) 2000-11-13
CA2331187A1 (en) 1999-11-18
SK286156B6 (sk) 2008-04-07
EP1077976B1 (de) 2002-08-07
TR200003322T2 (tr) 2001-02-21
PL344047A1 (en) 2001-09-24
DE69902461T2 (de) 2003-04-10
DE69907171D1 (de) 2003-05-28
KR20010041480A (ko) 2001-05-25
US6384030B1 (en) 2002-05-07
CA2331141A1 (en) 1999-11-18
CN1300287A (zh) 2001-06-20
KR100575147B1 (ko) 2006-05-03
EP1077975B1 (de) 2003-04-23
DK1077976T3 (da) 2002-12-02
AR016482A1 (es) 2001-07-04
NO319851B1 (no) 2005-09-19
AR016480A1 (es) 2001-07-04
PL194086B1 (pl) 2007-04-30
CZ20004108A3 (en) 2001-05-16
HUP0103536A2 (hu) 2002-07-29
IL139649A0 (en) 2002-02-10
ZA200007173B (en) 2002-03-04
EE200000657A (et) 2002-04-15
IL139649A (en) 2004-09-27
NO20005712D0 (no) 2000-11-13
AU751135B2 (en) 2002-08-08
DE69907171T2 (de) 2004-02-05
HRP20000741B1 (hr) 2009-02-28
JP2002514646A (ja) 2002-05-21
KR100593395B1 (ko) 2006-06-28
EE04311B1 (et) 2004-06-15
NZ507965A (en) 2002-05-31
AU758876B2 (en) 2003-04-03
HK1032781A1 (en) 2001-08-03
MY120248A (en) 2005-09-30
CZ298702B6 (cs) 2007-12-27
SI1077976T1 (en) 2003-02-28
SK285763B6 (sk) 2007-07-06
CN1137118C (zh) 2004-02-04
CA2331141C (en) 2008-10-28
ES2182531T3 (es) 2003-03-01
IL139647A0 (en) 2002-02-10
HK1033312A1 (en) 2001-08-24
PL344037A1 (en) 2001-09-24
US6448244B1 (en) 2002-09-10
EP1077976A1 (de) 2001-02-28
WO1999058529A1 (en) 1999-11-18
PL194085B1 (pl) 2007-04-30
EP1077975A1 (de) 2001-02-28
HRP20000740B1 (en) 2003-12-31
BR9911057A (pt) 2001-02-06
CN1135229C (zh) 2004-01-21
CN1300288A (zh) 2001-06-20
EP0957101A1 (de) 1999-11-17
ES2198915T3 (es) 2004-02-01

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