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AR130506A1 - Anticuerpos anti-lair1 humano - Google Patents

Anticuerpos anti-lair1 humano

Info

Publication number
AR130506A1
AR130506A1 ARP230102472A ARP230102472A AR130506A1 AR 130506 A1 AR130506 A1 AR 130506A1 AR P230102472 A ARP230102472 A AR P230102472A AR P230102472 A ARP230102472 A AR P230102472A AR 130506 A1 AR130506 A1 AR 130506A1
Authority
AR
Argentina
Prior art keywords
antibody
antibodies
human lair1
human
lair1
Prior art date
Application number
ARP230102472A
Other languages
English (en)
Inventor
Julian Davies
Scott Charles Potter
Andrew Charles Vendel
Wei Wang
Reid Martin Renny Feldman
Shireen Syrah Khan
Monica Macal
Ramirez Maria Elena Ayala
Original Assignee
Lilly Co Eli
Trex Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Trex Bio Inc filed Critical Lilly Co Eli
Publication of AR130506A1 publication Critical patent/AR130506A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente descripción se relaciona con anticuerpos que se unen a LAIR1 humano (“anticuerpos anti-LAIR1 humano” o “anticuerpos anti-LAIR1 humano”), composiciones que comprenden dichos anticuerpos anti-LAIR1 humano y métodos para usar dichos anticuerpos anti-LAIR1 humano. Reivindicación 1: Un anticuerpo que se une a LAIR1 humano, en donde el anticuerpo comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), en donde la VH comprende regiones determinantes de complementariedad de la cadena pesada HCDR1, HCDR2, y HCDR3, y la VL comprende regiones determinantes de complementariedad de la cadena ligera LCDR1, LCDR2, y LCDR3, en donde HCDR1 comprende la sec. con núm. de ident.: 1, HCDR2 comprende la sec. con núm. de ident.: 2, HCDR3 comprende la sec. con núm. de ident.: 3, LCDR1 comprende la sec. con núm. de ident.: 4, LCDR2 comprende la sec. con núm. de ident.: 5, y LCDR3 comprende la sec. con núm. de ident.: 6. Reivindicación 17: Un ácido nucleico que comprende una secuencia que codifica la sec. con núm. de ident.: 9, 25, 10, 21, 27 o 22. Reivindicación 18: Un vector que comprende el ácido nucleico de la reivindicación 17. Reivindicación 27: Un proceso para producir un anticuerpo que comprende cultivar la célula de una cualquiera de las reivindicaciones 23 a 26 en condiciones tales que se exprese el anticuerpo y recuperar el anticuerpo expresado del medio de cultivo. Reivindicación 28: Un anticuerpo producido mediante el proceso de la reivindicación 27. Reivindicación 29: Una composición farmacéutica que comprende el anticuerpo de una cualquiera de las reivindicaciones 1 a 16 o 28, y un excipiente, diluyente o portador farmacéuticamente aceptable.
ARP230102472A 2022-09-16 2023-09-15 Anticuerpos anti-lair1 humano AR130506A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202263375936P 2022-09-16 2022-09-16

Publications (1)

Publication Number Publication Date
AR130506A1 true AR130506A1 (es) 2024-12-11

Family

ID=90275943

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230102472A AR130506A1 (es) 2022-09-16 2023-09-15 Anticuerpos anti-lair1 humano

Country Status (17)

Country Link
US (1) US20240101670A1 (es)
EP (1) EP4587475A2 (es)
JP (1) JP2025532639A (es)
KR (1) KR20250080868A (es)
CN (1) CN120202223A (es)
AR (1) AR130506A1 (es)
AU (1) AU2023342134A1 (es)
CA (1) CA3267700A1 (es)
CL (1) CL2025000695A1 (es)
CO (1) CO2025003205A2 (es)
CR (1) CR20250130A (es)
DO (1) DOP2025000059A (es)
IL (1) IL319594A (es)
MX (1) MX2025003065A (es)
PE (1) PE20251693A1 (es)
TW (1) TW202426500A (es)
WO (1) WO2024059789A2 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018204986B2 (en) * 2017-01-02 2024-08-01 The Board Of Regents Of The University Of Texas System Anti-LAIR1 antibodies and their uses

Also Published As

Publication number Publication date
CL2025000695A1 (es) 2025-07-04
US20240101670A1 (en) 2024-03-28
CR20250130A (es) 2025-07-01
WO2024059789A2 (en) 2024-03-21
MX2025003065A (es) 2025-08-01
IL319594A (en) 2025-05-01
CO2025003205A2 (es) 2025-06-06
EP4587475A2 (en) 2025-07-23
DOP2025000059A (es) 2025-06-30
AU2023342134A1 (en) 2025-04-03
WO2024059789A3 (en) 2024-05-16
KR20250080868A (ko) 2025-06-05
TW202426500A (zh) 2024-07-01
PE20251693A1 (es) 2025-07-02
JP2025532639A (ja) 2025-10-01
CA3267700A1 (en) 2024-03-21
CN120202223A (zh) 2025-06-24

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