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AR125581A1 - Anticuerpos multiespecíficos y combinaciones de anticuerpos - Google Patents

Anticuerpos multiespecíficos y combinaciones de anticuerpos

Info

Publication number
AR125581A1
AR125581A1 ARP210103378A ARP210103378A AR125581A1 AR 125581 A1 AR125581 A1 AR 125581A1 AR P210103378 A ARP210103378 A AR P210103378A AR P210103378 A ARP210103378 A AR P210103378A AR 125581 A1 AR125581 A1 AR 125581A1
Authority
AR
Argentina
Prior art keywords
binds
antibody
binding domain
antibodies
antigen
Prior art date
Application number
ARP210103378A
Other languages
English (en)
Inventor
Joseph Michael David Rastrick
John Paul Silva
Daniel John Lightwood
Ralph Adams
Roger Thomas Palframan
Kerry Louise Tyson
Peter Charles Elliott
Seema Mayank
Andrea Julie Crosby
Emily Mary Cairistine Barry
Seppe Frans Roman Leysen
Zainab Ahdash
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of AR125581A1 publication Critical patent/AR125581A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a anticuerpos que se unen a IL-13 y a IL-22. La invención proporciona anticuerpos multiespecíficos novedosos que se unen tanto a IL-13 como a IL-22 y composiciones que comprenden un anticuerpo que se une a IL-13 y un anticuerpo que se une a IL-22. La invención se refiere, además, a usos terapéuticos de la combinación de anticuerpos anti-IL-13 y anti-IL-22 y anticuerpos multiespecíficos que se unen tanto a IL-13 como a IL-22. Reivindicación 1: Un anticuerpo multiespecífico que comprende al menos dos dominios de unión a antígeno, caracterizado porque un dominio de unión a antígeno se une a IL-13 (“dominio de unión a IL-13”) y el segundo dominio de unión a antígeno se une a IL-22 (“dominio de unión a IL-22”). Reivindicación 88: Una combinación de un anticuerpo que se une a IL13 y la neutraliza y un anticuerpo que se une a IL-22 y la neutraliza para su uso en el tratamiento de una afección inflamatoria de la piel.
ARP210103378A 2020-12-07 2021-12-06 Anticuerpos multiespecíficos y combinaciones de anticuerpos AR125581A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20212128 2020-12-07

Publications (1)

Publication Number Publication Date
AR125581A1 true AR125581A1 (es) 2023-08-02

Family

ID=73740239

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210103378A AR125581A1 (es) 2020-12-07 2021-12-06 Anticuerpos multiespecíficos y combinaciones de anticuerpos

Country Status (16)

Country Link
US (1) US20240067758A1 (es)
EP (1) EP4255926A1 (es)
JP (1) JP2023551981A (es)
KR (1) KR20230117588A (es)
CN (1) CN116670166A (es)
AR (1) AR125581A1 (es)
AU (1) AU2021395729A1 (es)
CA (1) CA3200847A1 (es)
CL (1) CL2023001509A1 (es)
CO (1) CO2023007097A2 (es)
IL (1) IL303295A (es)
MX (1) MX2023006650A (es)
PE (1) PE20231953A1 (es)
TW (1) TW202229340A (es)
WO (1) WO2022122654A1 (es)
ZA (1) ZA202305329B (es)

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EA037960B1 (ru) 2016-04-27 2021-06-15 Эббви Инк. Способ лечения эозинофильного эзофагита с применением антитела против il-13
US20250376535A1 (en) * 2022-06-28 2025-12-11 Beijing Starmab Biomed Technology Ltd Monospecific and multi-specific antibodies
WO2025238133A1 (en) 2024-05-17 2025-11-20 UCB Biopharma SRL Multispecific antibody with binding specificity for il-11 and il-17

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Also Published As

Publication number Publication date
JP2023551981A (ja) 2023-12-13
MX2023006650A (es) 2023-06-21
EP4255926A1 (en) 2023-10-11
IL303295A (en) 2023-07-01
WO2022122654A1 (en) 2022-06-16
CL2023001509A1 (es) 2024-01-19
CN116670166A (zh) 2023-08-29
AU2021395729A1 (en) 2023-07-13
CO2023007097A2 (es) 2023-06-09
TW202229340A (zh) 2022-08-01
US20240067758A1 (en) 2024-02-29
KR20230117588A (ko) 2023-08-08
PE20231953A1 (es) 2023-12-06
AU2021395729A9 (en) 2024-05-30
CA3200847A1 (en) 2022-06-16
ZA202305329B (en) 2024-09-25

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