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AR124289A1 - Composiciones de agentes de unión a antígenos de guanilato ciclasa c (gcc) y métodos de uso de estos - Google Patents

Composiciones de agentes de unión a antígenos de guanilato ciclasa c (gcc) y métodos de uso de estos

Info

Publication number
AR124289A1
AR124289A1 ARP210103413A ARP210103413A AR124289A1 AR 124289 A1 AR124289 A1 AR 124289A1 AR P210103413 A ARP210103413 A AR P210103413A AR P210103413 A ARP210103413 A AR P210103413A AR 124289 A1 AR124289 A1 AR 124289A1
Authority
AR
Argentina
Prior art keywords
seq
hcdr1
hcdr2
hcdr3
cdr
Prior art date
Application number
ARP210103413A
Other languages
English (en)
Inventor
Gary Shapiro
Xingyue He
Mei Rosa Ng
Juan Franco Elena De
Steven Vance
Original Assignee
Takeda Pharmaceuticals Co
Crescendo Biologics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co, Crescendo Biologics Ltd filed Critical Takeda Pharmaceuticals Co
Publication of AR124289A1 publication Critical patent/AR124289A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G01N33/575—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

Se describen agentes de unión a antígenos (p. ej., anticuerpos de domino único) que se unen a la guanilato ciclasa C (GCC). También se describen ácidos nucleicos, vectores de expresión recombinantes, células hospedadoras, fragmentos de unión a antígenos, y composiciones farmacéuticas que comprenden estos agentes de unión a antígenos y fragmentos de estos. La invención también proporciona métodos terapéuticos para usar los anticuerpos y moléculas de unión a antígenos proporcionados en la presente. Reivindicación 1: Un agente de unión a la guanilato ciclasa C (GCC) que comprende: una región variable de cadena pesada (VH) con secuencias de región de determinación de la complementariedad (CDR) de HYYWS (HCDR1) (SEQ ID Nº 8), RIYPSGSTSYNPSLKS (HCDR2) (SEQ ID Nº 11) y DRSTGWSEWNSDL (HCDR3) (SEQ ID Nº 16); una región variable de cadena pesada (VH) con secuencias de región de determinación de la complementariedad (CDR) de RYWMS (HCDR1) (SEQ ID Nº 9), KIRHDGGEKYYVDSVKG (HCDR2) (SEQ ID Nº 12) y DYTRDV (HCDR3) (SEQ ID Nº 17); una región variable de cadena pesada (VH) con secuencias de región de determinación de la complementariedad (CDR) de RYWMT (HCDR1) (SEQ ID Nº 10), KIKYDGSEKYYADSVKG (HCDR2) (SEQ ID Nº 13) y DYNKDY (HCDR3) (SEQ ID Nº 18); una región variable de cadena pesada (VH) con secuencias de región de determinación de la complementariedad (CDR) de RYWMT (HCDR1) (SEQ ID Nº 10), KIRHDGGEKYYPDSVKG (HCDR2) (SEQ ID Nº 14) y DYNKDL (HCDR3) (SEQ ID Nº 19) o una región variable de cadena pesada (VH) con secuencias de región de determinación de la complementariedad (CDR) de RYWMT (HCDR1) (SEQ ID Nº 10), KIRHDGGEKYYADSVKG (HCDR2) (SEQ ID Nº 15) y DYNKDY (HCDR3) (SEQ ID Nº 18). Reivindicación 4: El agente de unión a GCC de una cualquiera de las reivindicaciones anteriores, en donde la región VH comprende una secuencia de aminoácidos que es al menos 95% idéntica a una cualquiera de las SEQ ID Nº 1, 20, 21, 26, 27, ó 28.
ARP210103413A 2020-12-09 2021-12-09 Composiciones de agentes de unión a antígenos de guanilato ciclasa c (gcc) y métodos de uso de estos AR124289A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063123333P 2020-12-09 2020-12-09

Publications (1)

Publication Number Publication Date
AR124289A1 true AR124289A1 (es) 2023-03-15

Family

ID=80119244

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210103413A AR124289A1 (es) 2020-12-09 2021-12-09 Composiciones de agentes de unión a antígenos de guanilato ciclasa c (gcc) y métodos de uso de estos

Country Status (16)

Country Link
US (1) US20240033359A1 (es)
EP (1) EP4259165A1 (es)
JP (1) JP2023552852A (es)
KR (1) KR20230130641A (es)
CN (1) CN117015388A (es)
AR (1) AR124289A1 (es)
AU (1) AU2021397404A1 (es)
CA (1) CA3204692A1 (es)
CL (2) CL2023001667A1 (es)
CO (1) CO2023009126A2 (es)
EC (1) ECSP23050865A (es)
IL (1) IL303541A (es)
MX (1) MX2023006773A (es)
PE (1) PE20240368A1 (es)
TW (1) TW202237639A (es)
WO (1) WO2022123307A1 (es)

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TW202519263A (zh) * 2019-03-21 2025-05-16 美商再生元醫藥公司 含有抗il-33抗體之穩定調配物
CN117720660A (zh) * 2022-09-19 2024-03-19 广东菲鹏制药股份有限公司 抗人鸟苷酸环化酶c抗体及其试剂盒和应用
KR20250075590A (ko) * 2022-09-28 2025-05-28 레전드 바이오테크 아일랜드 리미티드 Gcc를 표적으로 하는 항체 및 키메라 항원 수용체 및 이의 사용 방법
CN115894697B (zh) * 2022-12-09 2023-08-29 华道(上海)生物医药有限公司 一种抗鸟苷酸环化酶2c的纳米抗体及其应用

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Also Published As

Publication number Publication date
AU2021397404A9 (en) 2025-03-06
ECSP23050865A (es) 2023-08-31
AU2021397404A1 (en) 2023-07-27
US20240033359A1 (en) 2024-02-01
EP4259165A1 (en) 2023-10-18
IL303541A (en) 2023-08-01
CO2023009126A2 (es) 2023-09-18
JP2023552852A (ja) 2023-12-19
MX2023006773A (es) 2023-10-16
CA3204692A1 (en) 2022-06-16
CL2025001723A1 (es) 2025-09-05
WO2022123307A1 (en) 2022-06-16
KR20230130641A (ko) 2023-09-12
CN117015388A (zh) 2023-11-07
PE20240368A1 (es) 2024-03-04
CL2023001667A1 (es) 2023-12-01
TW202237639A (zh) 2022-10-01

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