[go: up one dir, main page]

AR111178A1 - Inhibidor de la quinasa reguladora de la señal de apoptosis - Google Patents

Inhibidor de la quinasa reguladora de la señal de apoptosis

Info

Publication number
AR111178A1
AR111178A1 ARP180100585A ARP180100585A AR111178A1 AR 111178 A1 AR111178 A1 AR 111178A1 AR P180100585 A ARP180100585 A AR P180100585A AR P180100585 A ARP180100585 A AR P180100585A AR 111178 A1 AR111178 A1 AR 111178A1
Authority
AR
Argentina
Prior art keywords
inhibitor
apoptosis signal
regulatory kinase
compound
formula
Prior art date
Application number
ARP180100585A
Other languages
English (en)
Inventor
Gregory Notte
Julie Farand
Kassibla Eloide Dempah
Jennifer Lynne Alleva
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR111178A1 publication Critical patent/AR111178A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporciona un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo para uso en el tratamiento de esteatohepatitis no alcohólica, hepatitis alcohólica, hipertensión arterial pulmonar, insuficiencia cardiaca con fracción de eyección conservada y enfermedad renal diabética. También se proporcionan formas amorfas y cristalinas del compuesto de fórmula (1) y sales, co-cristales, solvatos e hidratos del mismo.
ARP180100585A 2017-03-14 2018-03-14 Inhibidor de la quinasa reguladora de la señal de apoptosis AR111178A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762471300P 2017-03-14 2017-03-14

Publications (1)

Publication Number Publication Date
AR111178A1 true AR111178A1 (es) 2019-06-12

Family

ID=61750538

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180100585A AR111178A1 (es) 2017-03-14 2018-03-14 Inhibidor de la quinasa reguladora de la señal de apoptosis

Country Status (6)

Country Link
AR (1) AR111178A1 (es)
BR (1) BR102018004862A2 (es)
JO (1) JOP20180017A1 (es)
TW (1) TW201840551A (es)
UY (1) UY37631A (es)
WO (1) WO2018169742A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
AU2018266911C1 (en) 2017-05-12 2022-10-20 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10597382B2 (en) 2017-08-28 2020-03-24 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2019213244A1 (en) 2018-05-02 2019-11-07 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2019213239A1 (en) 2018-05-02 2019-11-07 Enanta Pharmaceuticals Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN110818683B (zh) * 2018-08-10 2023-04-14 中国科学院上海药物研究所 2-吡啶取代脲结构小分子化合物及其合成和应用
WO2020041417A1 (en) 2018-08-22 2020-02-27 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11345699B2 (en) 2018-11-19 2022-05-31 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020198214A1 (en) 2019-03-25 2020-10-01 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
KR20230021075A (ko) * 2020-06-04 2023-02-13 큐라센 테라퓨틱스, 인코포레이티드 베타 아드레날린성 작용제의 형태 및 조성물
WO2023125904A1 (zh) * 2021-12-30 2023-07-06 苏州晶云药物科技股份有限公司 氮杂环丁基烟酸类化合物的晶型及其制备方法
CN119055775A (zh) * 2022-07-30 2024-12-03 中国医学科学院阜外医院 Jun抑制剂在制备用于治疗射血分数保留的心衰的药物中的用途
CN117054652B (zh) * 2023-08-04 2024-05-17 南京医科大学 一种用于辅助检测心肌肥厚的生物标志物及其应用
CN118252938B (zh) * 2024-01-24 2025-02-11 中国医学科学院阜外医院 抑制或敲除Jun基因表达的试剂用于治疗射血分数保留的心衰的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
US20150342943A1 (en) 2014-06-03 2015-12-03 Gilead Sciences, Inc. Methods of treating liver disease
TW201618781A (zh) 2014-08-13 2016-06-01 吉李德科學股份有限公司 治療肺高血壓之方法
MA41252A (fr) * 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1

Also Published As

Publication number Publication date
JOP20180017A1 (ar) 2019-01-30
UY37631A (es) 2018-09-28
BR102018004862A2 (pt) 2019-01-02
TW201840551A (zh) 2018-11-16
WO2018169742A1 (en) 2018-09-20

Similar Documents

Publication Publication Date Title
AR111178A1 (es) Inhibidor de la quinasa reguladora de la señal de apoptosis
AR106237A2 (es) Inhibidores heterocíclicos de la aspartil proteasa, sus sales farmacéuticamente aceptables
ECSP24026637A (es) Derivados de 3-(5-hidroxi-1-oxoisoindolin-2-il)piperidina-2,6-diona
ECSP20013248A (es) Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
MX2021009764A (es) Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona sustituidos y usos de los mismos.
AR117920A1 (es) Inhibidores de la replicación del virus de la inmunodeficiencia humana
CL2021002244A1 (es) Compuesto inhibidor de jak y uso del mismo
AR108768A2 (es) Compuestos de piridina y pirazol y sus usos para la modulación de hemoglobina
AR078411A1 (es) Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende
BR112015031864A2 (pt) compostos de pirimidinadiona contra as condições cardíacas
MX376856B (es) Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
MA38078A1 (fr) Dérivé de pyridine
AR124688A2 (es) Una pirimidina sulfonamida o un tautómero del mismo, o una sal farmacéuticamente aceptable del mismo
CL2021003342A1 (es) Compuestos de pirazol disustituidos como inhibidores de cetohexoquinasa.
EA201891780A1 (ru) Производные сульфонамида и содержащие их фармацевтические композиции
MX2019013626A (es) Modo de accion dual novedoso de activadores de guanilato ciclasa solubles e inhibidores de fosfodiesterasa y usos de los mismos.
CR20210085A (es) Compuestos de 2,6-diaminopiridina
AR111806A1 (es) Derivados de indol n-sustituidos
DE60306539D1 (de) Nicht-nukleosidische inhibitoren der reverse transkriptase
CR20140462A (es) Sales de 5-[(1r)-2-({2-[4-(2,2-difluoro-2-feniletoxi)fenil]etil} amino) -1-hidroxietil]-8-hidroquinolin-2(1h)-ona
MX2019005803A (es) Derivado de pirido[3,4-d]pirimidina y su sal farmaceuticamente aceptable.
CO6361939A2 (es) 5- (2-{ [6- (2, 2-difluoro-2-feniletoxi) hexil] amino} -1-hidroxietil) -8-hidroxiquinolin-2 (ih)-ona para el tratamiento pulmonar
MX2021008632A (es) Moléculas cíclicas como inhibidores de la tirosina cinasa de bruton.
MX2017000634A (es) Inhibidores del canal de potasio medularmente externo renal.
AR099766A1 (es) Inhibidores de la quinasa asociada al adaptador 1, composiciones que los comprenden y métodos para utilizarlos

Legal Events

Date Code Title Description
FB Suspension of granting procedure