[go: up one dir, main page]

AR111178A1 - INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL - Google Patents

INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL

Info

Publication number
AR111178A1
AR111178A1 ARP180100585A ARP180100585A AR111178A1 AR 111178 A1 AR111178 A1 AR 111178A1 AR P180100585 A ARP180100585 A AR P180100585A AR P180100585 A ARP180100585 A AR P180100585A AR 111178 A1 AR111178 A1 AR 111178A1
Authority
AR
Argentina
Prior art keywords
inhibitor
apoptosis signal
regulatory kinase
compound
formula
Prior art date
Application number
ARP180100585A
Other languages
Spanish (es)
Inventor
Gregory Notte
Julie Farand
Kassibla Eloide Dempah
Jennifer Lynne Alleva
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR111178A1 publication Critical patent/AR111178A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporciona un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo para uso en el tratamiento de esteatohepatitis no alcohólica, hepatitis alcohólica, hipertensión arterial pulmonar, insuficiencia cardiaca con fracción de eyección conservada y enfermedad renal diabética. También se proporcionan formas amorfas y cristalinas del compuesto de fórmula (1) y sales, co-cristales, solvatos e hidratos del mismo.A compound of formula (1), or a pharmaceutically acceptable salt thereof is provided for use in the treatment of non-alcoholic steatohepatitis, alcoholic hepatitis, pulmonary arterial hypertension, heart failure with preserved ejection fraction and diabetic kidney disease. Amorphous and crystalline forms of the compound of formula (1) and salts, co-crystals, solvates and hydrates thereof are also provided.

ARP180100585A 2017-03-14 2018-03-14 INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL AR111178A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762471300P 2017-03-14 2017-03-14

Publications (1)

Publication Number Publication Date
AR111178A1 true AR111178A1 (en) 2019-06-12

Family

ID=61750538

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180100585A AR111178A1 (en) 2017-03-14 2018-03-14 INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL

Country Status (6)

Country Link
AR (1) AR111178A1 (en)
BR (1) BR102018004862A2 (en)
JO (1) JOP20180017A1 (en)
TW (1) TW201840551A (en)
UY (1) UY37631A (en)
WO (1) WO2018169742A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598347B (en) 2009-07-13 2017-09-11 基利科學股份有限公司 Inhibitor of kinases that regulate apoptosis signaling
AU2018266911C1 (en) 2017-05-12 2022-10-20 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10597382B2 (en) 2017-08-28 2020-03-24 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2019213244A1 (en) 2018-05-02 2019-11-07 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2019213239A1 (en) 2018-05-02 2019-11-07 Enanta Pharmaceuticals Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN110818683B (en) * 2018-08-10 2023-04-14 中国科学院上海药物研究所 2-pyridine substituted urea structure small molecular compound and its synthesis and application
WO2020041417A1 (en) 2018-08-22 2020-02-27 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11345699B2 (en) 2018-11-19 2022-05-31 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020198214A1 (en) 2019-03-25 2020-10-01 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
KR20230021075A (en) * 2020-06-04 2023-02-13 큐라센 테라퓨틱스, 인코포레이티드 Forms and Compositions of Beta Adrenergic Agonists
WO2023125904A1 (en) * 2021-12-30 2023-07-06 苏州晶云药物科技股份有限公司 Crystal form of azacyclobutyl nicotinic acid compound and preparation method therefor
CN119055775A (en) * 2022-07-30 2024-12-03 中国医学科学院阜外医院 Use of Jun inhibitors in the preparation of drugs for treating heart failure with preserved ejection fraction
CN117054652B (en) * 2023-08-04 2024-05-17 南京医科大学 A biomarker for assisting detection of myocardial hypertrophy and its application
CN118252938B (en) * 2024-01-24 2025-02-11 中国医学科学院阜外医院 Use of an agent for inhibiting or knocking out Jun gene expression for treating heart failure with preserved ejection fraction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598347B (en) 2009-07-13 2017-09-11 基利科學股份有限公司 Inhibitor of kinases that regulate apoptosis signaling
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
UY34573A (en) 2012-01-27 2013-06-28 Gilead Sciences Inc QUINASE INHIBITOR REGULATING THE APOPTOSIS SIGNAL
US20150342943A1 (en) 2014-06-03 2015-12-03 Gilead Sciences, Inc. Methods of treating liver disease
TW201618781A (en) 2014-08-13 2016-06-01 吉李德科學股份有限公司 Methods of treating pulmonary hypertension
MA41252A (en) * 2014-12-23 2017-10-31 Gilead Sciences Inc SOLID FORMS OF AN ASK 1 INHIBITOR

Also Published As

Publication number Publication date
JOP20180017A1 (en) 2019-01-30
UY37631A (en) 2018-09-28
BR102018004862A2 (en) 2019-01-02
TW201840551A (en) 2018-11-16
WO2018169742A1 (en) 2018-09-20

Similar Documents

Publication Publication Date Title
AR111178A1 (en) INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL
AR106237A2 (en) HETEROCYCLIC INHIBITORS OF ASPARTIL PROTEASA, ITS PHARMACEUTICALLY ACCEPTABLE SALTS
ECSP24026637A (en) 3-(5-HYDROXY-1-OXOISOINDOLIN-2-IL)PIPERIDINE-2,6-DIONE DERIVATIVES
ECSP20013248A (en) DERIVATIVES OF 3- (1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME
MX2021009764A (en) 3-(1-OXOISOINDOLIN-2-IL)PIPERIDINE-2,6-DIONA SUBSTITUTE DERIVATIVES AND USES THEREOF.
AR117920A1 (en) HUMAN IMMUNODEFICIENCY VIRUS REPLICATION INHIBITORS
CL2021002244A1 (en) Jak inhibitor compound and use thereof
AR108768A2 (en) PIRIDINE AND PIRAZOL COMPOUNDS AND THEIR USES FOR HEMOGLOBIN MODULATION
AR078411A1 (en) IMIDAZOLIL VINYL COMPOUND AND PHARMACEUTICAL COMPOSITION THAT INCLUDES IT
BR112015031864A2 (en) pyrimidinedione compounds against cardiac conditions
MX376856B (en) EXTENDED-RELEASE DOSAGE FORMS FOR A JAK 1 (JANUS KINASE 1) INHIBITOR.
MA38078A1 (en) Pyridine derivative
AR124688A2 (en) A PYRIMIDINE SULFONAMIDE OR A TAUTOMER THEREOF, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
CL2021003342A1 (en) Disubstituted pyrazole compounds as ketohexokinase inhibitors.
EA201891780A1 (en) DERIVATIVES OF SULPHONAMIDE AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS
MX2019013626A (en) Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof.
CR20210085A (en) 2,6 diamino pyridine compounds
AR111806A1 (en) DERIVATIVES OF INDOL N-SUBSTITUTED
DE60306539D1 (en) Non-nucleoside inhibitors of the reverse transcriptase
CR20140462A (en) SALTS OF 5 - [(1R) -2 - ({2- [4- (2,2-DIFLUORO-2-PHENYLETOXI) PHENYL] ETIL} AMINO) -1-HYDROXYETY] -8-HYDROQUINOLIN-2 (1H) - ONA
MX2019005803A (en) DERIVATIVE OF PYRID [3,4-D] PYRIMIDINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALT.
CO6361939A2 (en) 5- (2- {[6- (2, 2-DIFLUORO-2-PHENYLETOXI) HEXIL] AMINO} -1-HYDROXYETHYL) -8-HYDROXYQUINOLIN-2 (IH) -ONA FOR PULMONARY TREATMENT
MX2021008632A (en) Cyclic molecules as bruton's tyrosine kinase inhibitor.
MX2017000634A (en) Inhibitors of the renal outer medullary potassium channel.
AR099766A1 (en) INHIBITORS OF KINASE ASSOCIATED WITH ADAPTER 1, COMPOSITIONS THAT INCLUDE THEM AND METHODS TO USE THEM

Legal Events

Date Code Title Description
FB Suspension of granting procedure