AR078411A1 - Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende - Google Patents
Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR078411A1 AR078411A1 ARP100101403A ARP100101403A AR078411A1 AR 078411 A1 AR078411 A1 AR 078411A1 AR P100101403 A ARP100101403 A AR P100101403A AR P100101403 A ARP100101403 A AR P100101403A AR 078411 A1 AR078411 A1 AR 078411A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- pharmaceutical composition
- imidazolil
- vinyl
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de vinil imidazolilo que es (E)-2-(4-(2-(5-(1-(3,5-dicloropiridin-4-il)etoxi)-1H-indazol-3-il)vinil)-1H-pirazol-1-il)etanol, o una sal del mismo farmacéuticamente aceptable. Preferentemente, el compuesto es (R)-(E)-2(4-(2-(5-(1-(3,5-dicloropiridin-4-il)etoxi)-1H-indazol-3-il)vinil)- 1H-pirazol-1-il)etanol, o una sal del mismo farmacéuticamente aceptable. Una composicion farmacéutica que comprende dicho compuesto o su sal en combinacion con un portador, diluyente o excipiente farmacéuticamente aceptable. Dicho compuesto o su sal es para uso en terapia, preferiblemente para el tratamiento de cáncer. Dicho cáncer se selecciona de cáncer de pulmon de célula no pequena, cáncer gástrico y mieloma multiple.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17629009P | 2009-05-07 | 2009-05-07 | |
| US30141610P | 2010-02-04 | 2010-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078411A1 true AR078411A1 (es) | 2011-11-09 |
Family
ID=42238704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101403A AR078411A1 (es) | 2009-05-07 | 2010-04-27 | Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US8268869B2 (es) |
| EP (1) | EP2427449B1 (es) |
| JP (1) | JP5555314B2 (es) |
| KR (1) | KR101373910B1 (es) |
| CN (1) | CN102421769B (es) |
| AR (1) | AR078411A1 (es) |
| AU (1) | AU2010246114B2 (es) |
| BR (1) | BRPI1013748A2 (es) |
| CA (1) | CA2760535C (es) |
| CL (1) | CL2011002781A1 (es) |
| CO (1) | CO6450624A2 (es) |
| CR (1) | CR20110580A (es) |
| DK (1) | DK2427449T3 (es) |
| EA (1) | EA018149B1 (es) |
| EC (1) | ECSP11011441A (es) |
| ES (1) | ES2408117T3 (es) |
| HN (1) | HN2011002809A (es) |
| HR (1) | HRP20130323T1 (es) |
| IL (1) | IL216004A (es) |
| JO (1) | JO2860B1 (es) |
| MA (1) | MA33244B1 (es) |
| ME (1) | ME01462B (es) |
| MX (1) | MX2011011342A (es) |
| MY (1) | MY160390A (es) |
| NZ (1) | NZ595553A (es) |
| PE (2) | PE20120812A1 (es) |
| PL (1) | PL2427449T3 (es) |
| PT (1) | PT2427449E (es) |
| RS (1) | RS52795B (es) |
| SG (1) | SG175909A1 (es) |
| SI (1) | SI2427449T1 (es) |
| TW (1) | TWI382982B (es) |
| UA (1) | UA104756C2 (es) |
| WO (1) | WO2010129509A1 (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3062B1 (ar) * | 2010-10-05 | 2017-03-15 | Lilly Co Eli | R)-(e)-2-(4-(2-(5-(1-(3، 5-داي كلورو بيريدين-4-يل)إيثوكسي)-1h-إندازول-3-يل)?ينيل)-1h-بيرازول-1-يل)إيثانول بلوري |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| JP6107812B2 (ja) | 2012-03-08 | 2017-04-05 | アステラス製薬株式会社 | 新規ｆｇｆｒ３融合体 |
| NZ702747A (en) | 2012-06-13 | 2017-03-31 | Incyte Holdings Corp | Substituted tricyclic compounds as fgfr inhibitors |
| US20150203589A1 (en) | 2012-07-24 | 2015-07-23 | The Trustees Of Columbia University In The City Of New York | Fusion proteins and methods thereof |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| JP2016515508A (ja) | 2013-03-15 | 2016-05-30 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 融合タンパク質及びその方法 |
| LT2986610T (lt) | 2013-04-19 | 2018-04-10 | Incyte Holdings Corporation | Bicikliniai heterociklai, kaip fgfr inhibitoriai |
| CN103819396B (zh) * | 2014-02-26 | 2016-06-15 | 四川大学 | 一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| EP3925979A3 (en) | 2014-12-23 | 2022-03-23 | The Trustees of Columbia University in the City of New York | Fgfr-tacc fusion proteins and methods thereof |
| SG10201913036RA (en) | 2015-02-20 | 2020-02-27 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CN105906621A (zh) * | 2015-04-06 | 2016-08-31 | 四川百利药业有限责任公司 | 用作fgfr抑制剂的乙醇类化合物 |
| WO2016187767A1 (en) * | 2015-05-25 | 2016-12-01 | Hutchison Medipharma Limited | Pharmaceutical compositions and use thereof |
| WO2017024968A1 (zh) * | 2015-08-07 | 2017-02-16 | 南京明德新药研发股份有限公司 | 作为fgfr和vegfr抑制剂的乙烯基化合物 |
| JP6549311B2 (ja) | 2015-08-20 | 2019-07-24 | 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． | インドール誘導体、その調製方法および医薬におけるその使用 |
| CN107459519A (zh) | 2016-06-06 | 2017-12-12 | 上海艾力斯医药科技有限公司 | 稠合嘧啶哌啶环衍生物及其制备方法和应用 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EP4309737A3 (en) | 2018-05-04 | 2024-03-27 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| EP3788046B1 (en) | 2018-05-04 | 2025-12-10 | Incyte Corporation | Salts of an fgfr inhibitor |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN114072387B (zh) * | 2019-11-06 | 2024-03-08 | 暨南大学 | 吲唑类化合物及其药用组合物和应用 |
| KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021138391A1 (en) * | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| JP7511294B2 (ja) * | 2020-08-11 | 2024-07-05 | ホーナン メディノ ファーマシューティカル テクノロジー カンパニー リミテッド | Ｆｇｆｒ阻害剤化合物及びその使用 |
| US12065494B2 (en) | 2021-04-12 | 2024-08-20 | Incyte Corporation | Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| AR126101A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| CN116554148B (zh) * | 2022-12-13 | 2025-01-28 | 药康众拓(北京)医药科技有限公司 | 一种乙烯基吲唑类氘代fgfr抑制剂药物及用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| HU230787B1 (en) | 2000-09-11 | 2018-05-02 | Novartis Vaccines & Diagnostics Inc | Quinolinone derivatives as tyrosine kinase inhibitors |
| JP4383870B2 (ja) * | 2001-10-17 | 2009-12-16 | 協和発酵キリン株式会社 | 線維芽細胞増殖因子受容体自己リン酸化を阻害するキノリン誘導体およびキナゾリン誘導体並びにそれらを含有する医薬組成物 |
| IL164209A0 (en) * | 2002-05-31 | 2005-12-18 | Eisai Co Ltd | Pyrazole derivatives and pharmaceutical compositions containing the same |
| DE10342503A1 (de) * | 2003-09-12 | 2005-04-14 | Merck Patent Gmbh | Benzyl-Benzimidazolylderivate |
| EA200601985A1 (ru) | 2004-05-26 | 2007-04-27 | Пфайзер Лимитед | Новые производные индазола и индолона и их применение в качестве фармацевтических средств |
| WO2007058626A1 (en) | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Indazole compounds |
| EP1963320A1 (en) * | 2005-12-07 | 2008-09-03 | OSI Pharmaceuticals, Inc. | Pyrrolopyridine kinase inhibiting compounds |
| SI2120932T1 (sl) | 2006-12-20 | 2014-09-30 | Nerviano Medical Sciences S.R.L. | Indazolni derivati kot kinazni inhibitorji za zdravljenje raka |
| US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| TW200911262A (en) | 2007-06-05 | 2009-03-16 | Schering Corp | Novel compounds that are ERK inhibitors |
| DE102007028521A1 (de) | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | Indazolamidderivate |
| WO2009099982A1 (en) * | 2008-02-04 | 2009-08-13 | Osi Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
-
2010
- 2010-04-27 AR ARP100101403A patent/AR078411A1/es unknown
- 2010-04-27 JO JO2010130A patent/JO2860B1/en active
- 2010-04-29 TW TW099113702A patent/TWI382982B/zh not_active IP Right Cessation
- 2010-05-04 DK DK10717402.1T patent/DK2427449T3/da active
- 2010-05-04 AU AU2010246114A patent/AU2010246114B2/en not_active Ceased
- 2010-05-04 MY MYPI2011005296A patent/MY160390A/en unknown
- 2010-05-04 MA MA34312A patent/MA33244B1/fr unknown
- 2010-05-04 PL PL10717402T patent/PL2427449T3/pl unknown
- 2010-05-04 JP JP2012509889A patent/JP5555314B2/ja not_active Expired - Fee Related
- 2010-05-04 RS RS20130207A patent/RS52795B/sr unknown
- 2010-05-04 ES ES10717402T patent/ES2408117T3/es active Active
- 2010-05-04 MX MX2011011342A patent/MX2011011342A/es active IP Right Grant
- 2010-05-04 HR HRP20130323AT patent/HRP20130323T1/hr unknown
- 2010-05-04 PE PE2011001877A patent/PE20120812A1/es not_active Application Discontinuation
- 2010-05-04 WO PCT/US2010/033487 patent/WO2010129509A1/en not_active Ceased
- 2010-05-04 CN CN201080020264.3A patent/CN102421769B/zh not_active Expired - Fee Related
- 2010-05-04 PT PT107174021T patent/PT2427449E/pt unknown
- 2010-05-04 CA CA2760535A patent/CA2760535C/en not_active Expired - Fee Related
- 2010-05-04 ME MEP-2013-32A patent/ME01462B/me unknown
- 2010-05-04 UA UAA201112804A patent/UA104756C2/uk unknown
- 2010-05-04 KR KR1020117026320A patent/KR101373910B1/ko not_active Expired - Fee Related
- 2010-05-04 BR BRPI1013748A patent/BRPI1013748A2/pt not_active IP Right Cessation
- 2010-05-04 SI SI201030191T patent/SI2427449T1/sl unknown
- 2010-05-04 NZ NZ595553A patent/NZ595553A/xx not_active IP Right Cessation
- 2010-05-04 EA EA201171367A patent/EA018149B1/ru not_active IP Right Cessation
- 2010-05-04 US US12/773,186 patent/US8268869B2/en not_active Expired - Fee Related
- 2010-05-04 SG SG2011081627A patent/SG175909A1/en unknown
- 2010-05-04 PE PE2016000013A patent/PE20160124A1/es not_active Application Discontinuation
- 2010-05-04 EP EP10717402A patent/EP2427449B1/en active Active
-
2011
- 2011-10-21 HN HN2011002809A patent/HN2011002809A/es unknown
- 2011-10-27 IL IL216004A patent/IL216004A/en not_active IP Right Cessation
- 2011-11-04 CO CO11150245A patent/CO6450624A2/es active IP Right Grant
- 2011-11-07 CR CR20110580A patent/CR20110580A/es unknown
- 2011-11-07 CL CL2011002781A patent/CL2011002781A1/es unknown
- 2011-11-07 EC EC2011011441A patent/ECSP11011441A/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR078411A1 (es) | Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende | |
| EA201390275A1 (ru) | Кристаллический (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпиридин-4-ил)этокси)-1h-индазол-3-ил)винил)-1h-пиразол-1-ил)этанол | |
| CL2009000228A1 (es) | Compuestos derivados de 7,8-dihidropirido[4,3-d]pirimidin con un sustituyente oximico, inhibidores de hsp90; y composicion farmaceutica que comprene a dichos compuestos. | |
| UA99621C2 (xx) | Похідні піридазинону$производные пиридазинона | |
| MX376856B (es) | Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1). | |
| CL2008002369A1 (es) | Compuestos derivados de piridin-3-il-oxipiridin-2-il-amino, inhibidores de alk5; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del cancer. | |
| EA201070395A1 (ru) | Ингибиторы polo-подобных киназ | |
| CU20160109A7 (es) | Compuestos de indazol como inhibidores de irak4 | |
| WO2009105513A8 (en) | Novel compounds and methods for therapy | |
| MX2015012432A (es) | Inhibidores piridinicos de la cinasa cdk9. | |
| CL2009000906A1 (es) | Compuestos derivados de 4-imidazolil y 4-triazolil de 2-(6-(4-cicloalquilpiperazin-1-il)pirimidin-4-il)-1h-pirazol-3(2h)ona inhibidores de hif-prolil-4-hidroxilasas; procedimiento de preparacion; composicion farmaceutica; y uso del compuesto en el tratamiento de enfermedades cardiovasculares, renales y hematologicas. | |
| EA201100334A1 (ru) | Бициклические производные триазола для лечения опухолей | |
| CL2009000915A1 (es) | Compuestos derivados de 1-ciano-3-pirrolidinil-bencenosulfonamidas, inhibidores de catepsina c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de una enfermedad pulmonar obstructiva cronica (copd). | |
| NO20083923L (no) | Pyrazolkinoloner er potente parp-inhibitorer | |
| TNSN08529A1 (en) | Inhibitors of akt (protein kinase b) | |
| CL2007003251A1 (es) | Compuestos derivados de 1h-pirazoles sustituidos, inhibidores de reacciones catalizadas por una quinasa; su procedimiento de preparacion; composicion farmaceutica; compuestos intermediarios; uso de los compuestos principales, utiles en el tratamiento del cancer. | |
| MX2015012386A (es) | Inhibidores de la cinasa cdk9. | |
| DOP2018000134A (es) | Compuestos de 1,3,4-tiadiazol y su uso en el tratamiento del cáncer | |
| CL2018003107A1 (es) | Procedimiento para la preparación de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo | |
| EA201000613A1 (ru) | Тризамещенные пиперидины | |
| ES2531159T3 (es) | Compuestos y métodos para el tratamiento del cáncer | |
| EA201000720A1 (ru) | 4,4-дизамещённые пиперидины как ингибиторы ренина | |
| NO20063943L (no) | Kombinasjon av voriconazol og en antifungal CYP2C19 inhibitor | |
| DK2089030T3 (da) | Middel til profylakse eller behandling af alkoholafhængighed eller lægemiddelafhængighed | |
| CL2008001390A1 (es) | (e)-n-(4nitrobenciliden)-1-(piperidin-4-il)metanamina; proceso de preparacion; y uso dicho compuesto para preparar el compuesto 2-(4-((((1-metil-1h-indol-3-il)metil)amino)metil)piperidin-1-il)-n-((tetrahidro-2h-piran-2-il)oxi)pirimidin-5-carboxamida. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |