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AR110405A1 - Compuestos - Google Patents

Compuestos

Info

Publication number
AR110405A1
AR110405A1 ARP170103598A ARP170103598A AR110405A1 AR 110405 A1 AR110405 A1 AR 110405A1 AR P170103598 A ARP170103598 A AR P170103598A AR P170103598 A ARP170103598 A AR P170103598A AR 110405 A1 AR110405 A1 AR 110405A1
Authority
AR
Argentina
Prior art keywords
alkyl
halogen
group
independently selected
amino
Prior art date
Application number
ARP170103598A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
C4 Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, C4 Therapeutics Inc filed Critical Hoffmann La Roche
Publication of AR110405A1 publication Critical patent/AR110405A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Reivindicación 1: Compuesto de fórmula (1), en la que R¹ se selecciona cada uno independientemente entre el grupo que consiste en i) amino, ii) alquilo C₁₋₆, iii) alcoxi C₁₋₆, iv) ciano, v) halógeno, vi) halógenoalquilo C₁₋₆, vii) halógenoalcoxi C₁₋₆, y viii) hidroxi; R² se selecciona cada uno independientemente entre el grupo que consiste en i) amino, ii) arilo sustituido con (R³)ₖ, iii) alquilo C₁₋₆, iv) alcoxi C₁₋₆, v) alquinilo C₂₋₆ sustituido con (R⁵)ₚ, vi) ciano, vii) halógeno, viii) halógenoalquilo C₁₋₆, ix) halógenoalcoxi C₁₋₆, x) heteroarilo sustituido con (R⁴)ₗ, xi) heterociclilo sustituido con (R⁷)ʳ y xii) hidroxi; R³ se selecciona cada uno independientemente entre el grupo que consiste en i) amino, ii) alquilo C₁₋₆, iii) alcoxi C₁₋₆, iv) ciano, v) halógeno, vi) halógenoalquilo C₁₋₆, vii) halógenoalcoxi C₁₋₆, y viii) hidroxi; R⁴ se selecciona cada uno independientemente entre el grupo que consiste en i) amino, ii) alquilo C₁₋₆, iii) alcoxi C₁₋₆, iv) ciano, v) halógeno, vi) halógenoalquilo C₁₋₆, vii) halógenoalcoxi C₁₋₆, viii) heterociclilo sustituido con (R⁸)ₛ, y ix) hidroxi; R⁵ se selecciona independientemente entre el grupo que consiste en i) heteroarilo sustituido con (R⁶)q, y ii) alquilo C₁₋₆; R⁶ se selecciona independientemente entre el grupo que consiste en i) amino, y ii) alquilo C₁₋₆; R⁷ se selecciona independientemente entre el grupo que consiste en i) amino, y ii) alquilo C₁₋₆; R⁸ se selecciona independientemente entre el grupo que consiste en i) amino, y ii) alquilo C₁₋₆; Het es heteroarilo; k es 0, 1, 2 ó 3; l es 0, 1 ó 2; n es 0, 1, 2 ó 3; m es 0, 1 ó 2; p es 0, 1 ó 2; q es 0, 1 ó 2; r es 0, 1 ó 2; s es 0, 1 ó 2; o una sal farmacéuticamente aceptable del mismo.
ARP170103598A 2016-12-22 2017-12-20 Compuestos AR110405A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16206394 2016-12-22

Publications (1)

Publication Number Publication Date
AR110405A1 true AR110405A1 (es) 2019-03-27

Family

ID=57777430

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170103598A AR110405A1 (es) 2016-12-22 2017-12-20 Compuestos

Country Status (7)

Country Link
US (2) US10882848B2 (es)
EP (1) EP3558967B1 (es)
JP (1) JP7076453B2 (es)
CN (1) CN110325528B (es)
AR (1) AR110405A1 (es)
TW (1) TW201834651A (es)
WO (1) WO2018115218A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101911090B1 (ko) * 2011-12-27 2018-10-25 두산인프라코어 주식회사 인양력 증대 자세교정 장치
CN107406442B (zh) 2014-12-23 2021-08-17 达纳－法伯癌症研究所公司 作为egfr抑制剂的新的嘧啶和治疗病症的方法
MA48946A (fr) * 2017-06-02 2020-04-08 C4 Therapeutics Inc Composés
WO2019164947A1 (en) 2018-02-20 2019-08-29 Dana-Farber Cancer Institute, Inc. Inhibitors of egfr and methods of use thereof
WO2019246541A1 (en) 2018-06-21 2019-12-26 Dana-Farber Cancer Institute, Inc. Inhibitors of egfr and methods of use thereof
CA3103166A1 (en) * 2018-06-29 2020-01-02 F. Hoffmann-La Roche Ag Compounds
WO2020051235A1 (en) 2018-09-04 2020-03-12 C4 Therapeutics, Inc. Compounds for the degradation of brd9 or mth1
EP3935050B1 (en) 2019-03-06 2024-10-02 C4 Therapeutics, Inc. Heterocyclic compounds for medical treatment
EP3986407A4 (en) * 2019-06-21 2023-07-19 Dana-Farber Cancer Institute, Inc. ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF
EP3986565B1 (en) * 2019-06-21 2023-08-30 F. Hoffmann-La Roche AG New egfr inhibitors
PT3986897T (pt) * 2019-06-21 2023-10-23 Hoffmann La Roche Inibidor do egfr para o tratamento do cancro
CN120004861A (zh) 2019-11-11 2025-05-16 达纳-法伯癌症研究所股份有限公司 变构egfr抑制剂及其使用方法
AR120799A1 (es) * 2019-12-20 2022-03-16 Hoffmann La Roche 2-[4-cloro-6-[2-[4-[[4-(hidroximetil)-1-piperidil]metil]fenil]etinil]-1-oxoisoindolin-2-il]-2-(6,7-dihidro-5h-pirrolo[1,2-c]imidazol-1-il)-n-tiazol-2-il-acetamida como inhibidor de egfr
AR120800A1 (es) * 2019-12-20 2022-03-16 Hoffmann La Roche Derivados de 6,7-dihidro-5h-pirrolo[1,2-c]imidazol como inhibidores de egfr
WO2021127561A1 (en) 2019-12-20 2021-06-24 C4 Therapeutics, Inc. Isoindolinone and indazole compounds for the degradation of egfr
CA3167899A1 (en) 2020-02-14 2021-08-19 Xiangyong LIU Quinolyl phosphine oxide compound, and composition and application thereof
CN116600806A (zh) * 2020-12-01 2023-08-15 豪夫迈·罗氏有限公司 新的吲唑衍生物
WO2022117475A1 (en) * 2020-12-01 2022-06-09 F. Hoffmann-La Roche Ag New indazole derivatives
AU2021393722A1 (en) * 2020-12-01 2023-04-13 F. Hoffmann-La Roche Ag New indazole acetylene derivatives
US20250129047A1 (en) 2021-07-04 2025-04-24 Newave Pharmaceutical Inc. Isoquinoline derivatives as mutant egfr modulators and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2049518B1 (en) * 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.
CN102093339B (zh) * 2010-12-09 2013-06-12 天津药物研究院 一类嘧啶衍生物的制备及用途
CN102060848B (zh) * 2010-12-09 2013-09-18 天津药物研究院 芳香胺取代的嘧啶衍生物的制备及用途
US10385019B2 (en) * 2015-06-30 2019-08-20 Dana-Farber Cancer Institute, Inc. Inhibitors of EGFR and methods of use thereof

Also Published As

Publication number Publication date
EP3558967A1 (en) 2019-10-30
US20210070739A1 (en) 2021-03-11
US11708354B2 (en) 2023-07-25
US20190308955A1 (en) 2019-10-10
TW201834651A (zh) 2018-10-01
US10882848B2 (en) 2021-01-05
WO2018115218A1 (en) 2018-06-28
JP7076453B2 (ja) 2022-05-27
JP2020502246A (ja) 2020-01-23
CN110325528B (zh) 2022-10-11
CN110325528A (zh) 2019-10-11
EP3558967B1 (en) 2022-03-02

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