AR108864A1 - Agentes antibacterianos - Google Patents
Agentes antibacterianosInfo
- Publication number
- AR108864A1 AR108864A1 ARP170101736A ARP170101736A AR108864A1 AR 108864 A1 AR108864 A1 AR 108864A1 AR P170101736 A ARP170101736 A AR P170101736A AR P170101736 A ARP170101736 A AR P170101736A AR 108864 A1 AR108864 A1 AR 108864A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- optionally substituted
- heterocycloalkyl
- haloalkyl
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 14
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 7
- 125000001072 heteroaryl group Chemical group 0.000 abstract 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 6
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D331/00—Heterocyclic compounds containing rings of less than five members, having one sulfur atom as the only ring hetero atom
- C07D331/04—Four-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), o una sal aceptable farmacéuticamente, hidrato, solvato, profármaco, estereoisómero, o tautómero del mismo, donde: X es S(O)q o NR⁶; A es C₆₋₁₀ arilo, heteroarilo, C₃₋₇ cicloalquilo, C₄₋₇ cicloalquenilo, o heterocicloalquilo, donde el arilo, heteroarilo, cicloalquilo, cicloalquenilo, o heterocicloalquilo está sustituido opcionalmente con uno o más R⁷; B es -CºC=R³, -CºC-CºC-R³, -CºC-CH=CH-R³, C₁₋₄ alquilo, C₁₋₄ haloalquilo, -OR⁸, -S(O)ʳR⁸, halógeno, C₆₋₁₀ arilo, heteroarilo, o -SF₅, donde el arilo o heteroarilo está sustituido opcionalmente con R²; R¹ es H, C₁₋₄ alquilo, C₂₋₄ alquenilo, C₂₋₄ alquinilo, C₁₋₄ alcoxi, C₁₋₄ haloalquilo, C₁₋₄ haloalcoxi, -(CH₂)ₘ-C₃₋₇ cicloalquilo, -(CH₂)ₘ-heterocicloalquilo, -O(CH₂)ₘ-C₃₋₇ cicloalquilo, -O(CH₂)ₘ-heterocicloalquilo, halógeno, -S(O)ₚ-C₁₋₄ alquilo, -OH, -(CH₂)ₙNH₂, -(CH₂)ₙ-C₁₋₄ alquilamino, o -(CH₂)ₙ-C₁₋₄ dialquilamino; R² es C₁₋₄ alquilo, C₁₋₄ alcoxi, C₁₋₄ haloalquilo, C₁₋₄ haloalcoxi, halógeno, -OH, -NH₂, o -CN; R³ es H, C₁₋₄ alquilo, C₃₋₇ cicloalquilo, heterocicloalquilo, o heteroarilo, donde el alquilo está sustituido opcionalmente con uno o más R⁴, y donde el cicloalquilo, heterocicloalquilo, o heteroarilo está sustituido opcionalmente con uno o más R⁵; cada R⁴ es en forma independiente en cada caso -OH, -NH₂, C₁₋₄ alcoxi, C₁₋₄ alquilamino, o C₁₋₄ dialquilamino; cada R⁵ es en forma independiente en cada caso C₁₋₄ alquilo, C₁₋₄ haloalquilo, C₁₋₄ alcoxi, C₁₋₄ haloalcoxi, halógeno, C₁₋₄ hidroxialquilo, -C(O)H, -C(=O)C₁₋₄ alquilo, -OH, -NH₂, C₁₋₄ alquilamino, C₁₋₄ dialquilamino, o -S(O)ₚ-C₁₋₄ alquilo; R⁶ es H, C₁₋₄ alquilo, C₁₋₄ hidroxialquilo, -C(O)H, -C(O)C₁₋₄ alquilo, -S(O)ʳ-C₁₋₄ alquilo, o -C(O)OC₁₋₄ alquilo; cada R⁷ es en forma independiente en cada caso C₁₋₄ alquilo, C₁₋₄ alcoxi, C₁₋₄ haloalquilo, C₁₋₄ haloalcoxi, o halógeno; o dos R⁷ en átomos adyacentes junto con los átomos a los que están unidos forman un anillo C₆₋₁₀ arilo opcionalmente sustituido con uno o más R⁹; o dos R⁷ en átomos adyacentes junto con los átomos a los que están unidos forman un anillo heteroarilo opcionalmente sustituido con uno o más R⁹; o dos R⁷ en átomos adyacentes junto con los átomos a los que están unidos forman un anillo C₄₋₈ cicloalquilo opcionalmente sustituido con uno o más R⁹; o dos R⁷ en átomos adyacentes junto con los átomos a los que están unidos forman un anillo heterocicloalquilo opcionalmente sustituido con uno o más R⁹; R⁸ es C₁₋₄ alquilo, C₂₋₄ alquenilo, C₂₋₄ alquinilo, C₁₋₄ haloalquilo, o C₃₋₆ cicloalquilo, donde el alquilo, alquenilo, o alquinilo está sustituido opcionalmente con uno o más sustituyentes seleccionados entre el grupo que consiste en C₃₋₇ cicloalquilo y heterocicloalquilo; cada R⁹ es en forma independiente en cada caso C₁₋₄ alquilo, C₁₋₄ alcoxi, C₁₋₄ haloalquilo, C₁₋₄ haloalcoxi, o halógeno; cada R’ es C₁₋₄ alquilo; o es 1 ó 2; s es 0, 1, ó 2; cada q, p, y r es en forma independiente en cada caso 0, 1, ó 2; y cada m y n es en forma independiente en cada caso 0, 1, 2, ó 3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662353910P | 2016-06-23 | 2016-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR108864A1 true AR108864A1 (es) | 2018-10-03 |
Family
ID=59276882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170101736A AR108864A1 (es) | 2016-06-23 | 2017-06-22 | Agentes antibacterianos |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR108864A1 (es) |
| TW (1) | TW201803847A (es) |
| WO (1) | WO2017223349A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016201288A1 (en) | 2015-06-12 | 2016-12-15 | Brown University | Novel antibacterial compounds and methods of making and using same |
| CN108358887B (zh) * | 2018-03-20 | 2020-12-22 | 富乐马鸿凯（大连）医药有限公司 | 一种光学纯的含硫四元杂环药物中间体的合成 |
| CN110283745B (zh) * | 2019-06-27 | 2021-05-11 | 浙江工业大学 | 医院不动杆菌fk2及其在降解有机污染物中的应用 |
| US11555010B2 (en) | 2019-07-25 | 2023-01-17 | Brown University | Diamide antimicrobial agents |
| CN110563611B (zh) | 2019-09-19 | 2021-02-02 | 中国医学科学院医药生物技术研究所 | 一种异羟肟酸类衍生物及其制备方法和应用 |
| CN113604408B (zh) * | 2021-09-06 | 2023-08-22 | 浙江树人学院（浙江树人大学） | 莫德斯托斯不动杆菌hyy-1及其在降解有机污染物中的应用 |
| CN116730870B (zh) * | 2023-08-08 | 2023-10-13 | 中国医学科学院医药生物技术研究所 | 异羟肟酸类化合物或其可药用盐、及其用途和制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998018754A1 (en) | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof |
| US6716878B1 (en) | 1999-04-09 | 2004-04-06 | Vernalis (Oxford) Limited | Antimicrobial agents |
| ES2387803T3 (es) | 2003-01-08 | 2012-10-02 | Novartis Vaccines And Diagnostics, Inc. | Agentes antibacterianos |
| US7998961B2 (en) | 2006-08-31 | 2011-08-16 | Schering Corporation | Hydantoin derivatives useful as antibacterial agents |
| JP5227304B2 (ja) | 2007-02-28 | 2013-07-03 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
| CA2691987C (en) | 2007-06-12 | 2016-08-16 | Achaogen, Inc. | Antibacterial agents |
| EP2307365B1 (en) | 2008-06-25 | 2013-03-27 | Merck Sharp & Dohme Corp. | Synthesis and use of heterocyclic antibacterial agents |
| EP2315746A1 (en) | 2008-08-04 | 2011-05-04 | Schering Corporation | Urea derivatives as antibacterial agents |
| WO2010024356A1 (ja) | 2008-08-27 | 2010-03-04 | 大正製薬株式会社 | ナフチリジン－ｎ－オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| EP2334636A2 (en) | 2008-09-19 | 2011-06-22 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2011005355A1 (en) | 2009-05-07 | 2011-01-13 | Achaogen, Inc. | Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria |
| EP2488489A2 (en) | 2009-10-13 | 2012-08-22 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| US8664401B2 (en) | 2009-12-16 | 2014-03-04 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| NZ603198A (en) | 2010-04-20 | 2013-10-25 | Taisho Pharmaceutical Co Ltd | Novel hydroxamic acid derivative |
| EP2638006A1 (en) | 2010-11-10 | 2013-09-18 | Achaogen, Inc. | Hydroxamic acid derivatives and their use in the treatment of bacterial infections |
| WO2013039947A1 (en) | 2011-09-12 | 2013-03-21 | Achaogen, Inc. | Polymorphs of n-((s)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1r,2r)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide |
| EP2847162A1 (en) | 2012-05-09 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| EP2847168A1 (en) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
-
2017
- 2017-06-22 AR ARP170101736A patent/AR108864A1/es unknown
- 2017-06-22 WO PCT/US2017/038815 patent/WO2017223349A1/en not_active Ceased
- 2017-06-22 TW TW106120880A patent/TW201803847A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017223349A1 (en) | 2017-12-28 |
| TW201803847A (zh) | 2018-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |