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AR117921A1 - Cepa modificada de salmonella enterica typhi - Google Patents

Cepa modificada de salmonella enterica typhi

Info

Publication number
AR117921A1
AR117921A1 ARP200100243A ARP200100243A AR117921A1 AR 117921 A1 AR117921 A1 AR 117921A1 AR P200100243 A ARP200100243 A AR P200100243A AR P200100243 A ARP200100243 A AR P200100243A AR 117921 A1 AR117921 A1 AR 117921A1
Authority
AR
Argentina
Prior art keywords
salmonella enterica
serovar
typhi
salmonella
paratyphi
Prior art date
Application number
ARP200100243A
Other languages
English (en)
Original Assignee
Prokarium Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prokarium Ltd filed Critical Prokarium Ltd
Publication of AR117921A1 publication Critical patent/AR117921A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente se relaciona con la modificación de una cepa viva atenuada de Salmonella enterica serovariedad Typhi, donde sus antígenos expuestos en superficie polisacárido y flagelina se pueden convertir, o ser potenciados por otras cepas de Salmonella, incluyendo las serovariedades de S. enterica Paratyphi, Typhimurium y Enteritidis. La presente se relaciona además con cepas modificadas de Salmonella enterica, serovariedad Typhi, que son adecuadas para usar como componentes de una vacuna contra la fiebre entérica y la salmonelosis. Reivindicación 1: Una cepa viva atenuada de Salmonella enterica serovariedad Typhi donde dicha cepa ha sido modificada para expresar los antígenos O del lipopolisacárido O2 y las proteínas flagelares de Salmonella enterica, serovariedad Paratyphi A. Reivindicación 8: Una vacuna que comprende la cepa viva atenuada de acuerdo con las reivindicaciones 1 - 7, para usar a fin de aumentar la inmunogenicidad contra Salmonella enterica, serovariedad Paratyphi A, y para usar en el tratamiento o prevención de la fiebre entérica y la salmonelosis.
ARP200100243A 2019-01-30 2020-01-30 Cepa modificada de salmonella enterica typhi AR117921A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19154550 2019-01-30

Publications (1)

Publication Number Publication Date
AR117921A1 true AR117921A1 (es) 2021-09-01

Family

ID=65443645

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200100243A AR117921A1 (es) 2019-01-30 2020-01-30 Cepa modificada de salmonella enterica typhi

Country Status (10)

Country Link
US (2) US10806778B2 (es)
EP (1) EP3917565A1 (es)
JP (1) JP7657720B2 (es)
KR (1) KR20210142596A (es)
CN (1) CN113412122B (es)
AR (1) AR117921A1 (es)
AU (1) AU2020215254A1 (es)
CA (1) CA3126200A1 (es)
TW (1) TWI842819B (es)
WO (1) WO2020157203A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111057671A (zh) * 2019-12-04 2020-04-24 扬州大学 一种鸡白痢沙门菌单基因无痕敲除减毒株及其制备方法和应用
CN111100938A (zh) * 2019-12-24 2020-05-05 江苏意诺飞生物科技有限公司 人类肠道病原菌感染诊断用乙型副伤寒沙门菌特异性基因探针
EP3922255A1 (en) 2020-06-10 2021-12-15 Prokarium Limited Cancer therapy
GB202009411D0 (en) 2020-06-19 2020-08-05 Prokarium Ltd Autotransporter systems
JP2025531378A (ja) 2022-09-21 2025-09-19 プロカリウム リミテッド 染色体上にランディングパッドが統合されたサルモネラ株
GB202215576D0 (en) 2022-10-21 2022-12-07 Prokarium Ltd Circuit
GB202405780D0 (en) 2024-04-24 2024-06-05 Prokarium Ltd Vacuole escape
WO2025224251A1 (en) * 2024-04-24 2025-10-30 Prokarium Limited Modified microorganisms

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2793673B2 (ja) * 1988-05-05 1998-09-03 アメリカン・サイアナミド・カンパニー 組み換えフラジエリンのワクチン
US6130082A (en) 1988-05-05 2000-10-10 American Cyanamid Company Recombinant flagellin vaccines
GR950300072T1 (en) 1995-10-13 1996-01-31 Schweiz Serum & Impfinst Recombinant live vaccines against Gram-negative enteric pathogens
AU1420897A (en) 1996-12-18 1998-07-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Conjugate vaccine for (salmonella paratyphi) a
GB0327056D0 (en) 2003-11-20 2003-12-24 Cobra Biolog Ltd Plasmid maintenance
US8475810B2 (en) 2005-10-28 2013-07-02 University Of Maryland, Baltimore Attenuated Salmonella enterica serovar paratyphi a and uses thereof
GB201011046D0 (en) 2010-06-30 2010-08-18 Rph Pharmaceuticals Ab Plasmid maintenance
US9011871B2 (en) * 2011-11-07 2015-04-21 University Of Maryland, Baltimore Broad spectrum vaccine against typhoidal and non-typhoidal Salmonella disease
CN104470537B (zh) * 2012-05-23 2017-04-26 美国政府(由卫生和人类服务部的部长所代表) 表达鼠疫耶尔森氏菌F1‑V融合蛋白的伤寒沙门氏菌Ty21a及其用途
CN105734001B (zh) * 2014-12-08 2020-04-07 中国人民解放军军事医学科学院生物工程研究所 一种o抗原糖链延长的甲型副伤寒沙门氏菌及其应用
CN109554311B (zh) * 2018-12-18 2022-01-14 中国农业科学院兰州兽医研究所 一种鼠伤寒沙门氏菌外膜囊泡的提取方法

Also Published As

Publication number Publication date
US10806778B2 (en) 2020-10-20
AU2020215254A1 (en) 2021-08-19
TWI842819B (zh) 2024-05-21
TW202043457A (zh) 2020-12-01
EP3917565A1 (en) 2021-12-08
JP2022523135A (ja) 2022-04-21
WO2020157203A1 (en) 2020-08-06
KR20210142596A (ko) 2021-11-25
CA3126200A1 (en) 2020-08-06
CN113412122A (zh) 2021-09-17
JP7657720B2 (ja) 2025-04-07
US20220249645A1 (en) 2022-08-11
US20200237887A1 (en) 2020-07-30
CN113412122B (zh) 2025-07-08

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