MX2019007349A - Vacuna combinada para cerdos. - Google Patents
Vacuna combinada para cerdos.Info
- Publication number
- MX2019007349A MX2019007349A MX2019007349A MX2019007349A MX2019007349A MX 2019007349 A MX2019007349 A MX 2019007349A MX 2019007349 A MX2019007349 A MX 2019007349A MX 2019007349 A MX2019007349 A MX 2019007349A MX 2019007349 A MX2019007349 A MX 2019007349A
- Authority
- MX
- Mexico
- Prior art keywords
- pigs
- pcv2
- prrsv
- vaccine
- combined vaccine
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 241000282887 Suidae Species 0.000 title 1
- 241001673669 Porcine circovirus 2 Species 0.000 abstract 3
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 abstract 2
- 229940001442 combination vaccine Drugs 0.000 abstract 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 abstract 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 abstract 1
- 239000007764 o/w emulsion Substances 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 229940032094 squalane Drugs 0.000 abstract 1
- 229940042585 tocopherol acetate Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se relaciona con una vacuna combinada para cerdo, que comprende antígenos no replicadores del circovirus porcino tipo 2 (PCV2), y del virus del síndrome reproductivo y respiratorio porcino (PRRSV) vivo; la vacuna combinada está formulada como una emulsión de aceite en agua, y es adyuvada con escualano y acetato de vitamina E. Se encontró que esta vacuna combinada es inmunológicamente efectiva contra todos los patógenos: PCV2, y PRRSV.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16206789 | 2016-12-23 | ||
| EP17157828 | 2017-02-24 | ||
| PCT/EP2017/084376 WO2018115435A1 (en) | 2016-12-23 | 2017-12-22 | Combination vaccine for swine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019007349A true MX2019007349A (es) | 2019-09-05 |
| MX388128B MX388128B (es) | 2025-03-19 |
Family
ID=60955042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019007349A MX388128B (es) | 2016-12-23 | 2017-12-22 | Vacuna combinada para cerdos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11065324B2 (es) |
| EP (1) | EP3558351B1 (es) |
| JP (1) | JP6931059B2 (es) |
| KR (1) | KR102632419B1 (es) |
| CN (1) | CN110087678B (es) |
| BR (1) | BR112019012504A2 (es) |
| CA (1) | CA3045563C (es) |
| DK (1) | DK3558351T3 (es) |
| ES (1) | ES2906854T3 (es) |
| MX (1) | MX388128B (es) |
| PL (1) | PL3558351T3 (es) |
| RU (1) | RU2761453C2 (es) |
| WO (1) | WO2018115435A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1968630T3 (pl) | 2005-12-29 | 2018-08-31 | Boehringer Ingelheim Vetmedica, Inc. | Multiwalentne immunogenne kompozycje PCV2 |
| US12239702B2 (en) | 2017-12-04 | 2025-03-04 | Intervet Inc. | Vaccination with replicon particles and oil adjuvant |
| GB2619625B (en) * | 2019-05-20 | 2024-04-03 | Soligenix Inc | Compositions and Methods of Manufacturing Trivalent Filovirus Vaccines |
| KR20220062345A (ko) * | 2019-09-12 | 2022-05-16 | 인터벳 인터내셔널 비.브이. | 피내 투여용 복합 백신 |
| JP7681023B2 (ja) | 2019-12-18 | 2025-05-21 | インターベット インターナショナル ベー． フェー． | クリプトスポリジウム症ワクチン |
| AR124849A1 (es) | 2021-02-11 | 2023-05-10 | Intervet Int Bv | Vacuna para mycoplasma bovis |
| WO2023072805A1 (en) | 2021-10-25 | 2023-05-04 | Intervet International B.V. | A vaccine for the protection of piglets against swine influenza a virus infection |
| EP4452315A1 (en) | 2021-12-24 | 2024-10-30 | Intervet International B.V. | Stable emulsions of antigens |
| CN117100851A (zh) * | 2023-10-23 | 2023-11-24 | 成都依思康生物科技有限公司 | 一种佐剂、疫苗组合物及其制备方法和应用 |
| WO2025093740A1 (en) | 2023-11-03 | 2025-05-08 | Intervet International B.V. | Recombinant pyolysin protein |
| WO2025262123A1 (en) | 2024-06-19 | 2025-12-26 | Intervet International B.V. | Veterinary vaccines against enteric diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0382271B1 (en) * | 1989-02-04 | 1994-12-21 | Akzo Nobel N.V. | Tocols as adjuvant in vaccine |
| ES2367194T3 (es) * | 2005-11-04 | 2011-10-31 | Novartis Vaccines And Diagnostics S.R.L. | Cambio del equilibrio th1/th2 en vacunas contra la gripe fraccionadas con adyuvantes. |
| TW200908994A (en) * | 2007-04-20 | 2009-03-01 | Glaxosmithkline Biolog Sa | Vaccine |
| TWI449533B (zh) | 2008-04-18 | 2014-08-21 | Intervet Int Bv | 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）、豬肺炎黴漿菌（Ｍｙｃｏｐｌａｓｍａ ｈｙｏｐｎｅｕｍｏｎｉａｅ）及豬環狀病毒（Ｐｏｒｃｉｎｅ ｃｉｒｃｏ ｖｉｒｕｓ）用疫苗 |
| ES2552383T3 (es) | 2009-02-10 | 2015-11-27 | Novartis Ag | Regímenes de vacuna de la gripe para cepas asociadas a pandemias |
| BRPI1011224A2 (pt) | 2009-02-17 | 2016-03-15 | Glaxosmithkline Biolog Sa | vacina contra vírus da dengue inativado com adjuvante livre de alumínio |
| UA114504C2 (uk) * | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
| CA2931139C (en) * | 2013-12-03 | 2023-03-14 | Intervet International B.V. | Swine vaccine against prrs and lawsonia intracellularis |
| CN106999567B (zh) | 2014-12-11 | 2021-08-31 | 英特维特国际股份有限公司 | 用于即用型PCV2/M.hyo组合疫苗的方法 |
| CN105251002B (zh) * | 2015-11-13 | 2019-02-15 | 中国人民解放军第三军医大学 | 一种水包油型纳米乳佐剂及其mrsa纳米乳佐剂疫苗和制备方法 |
-
2017
- 2017-12-22 EP EP17828754.6A patent/EP3558351B1/en active Active
- 2017-12-22 CN CN201780080200.4A patent/CN110087678B/zh active Active
- 2017-12-22 ES ES17828754T patent/ES2906854T3/es active Active
- 2017-12-22 WO PCT/EP2017/084376 patent/WO2018115435A1/en not_active Ceased
- 2017-12-22 DK DK17828754.6T patent/DK3558351T3/da active
- 2017-12-22 BR BR112019012504-3A patent/BR112019012504A2/pt active IP Right Grant
- 2017-12-22 RU RU2019122996A patent/RU2761453C2/ru active
- 2017-12-22 KR KR1020197017612A patent/KR102632419B1/ko active Active
- 2017-12-22 CA CA3045563A patent/CA3045563C/en active Active
- 2017-12-22 US US16/471,606 patent/US11065324B2/en active Active
- 2017-12-22 MX MX2019007349A patent/MX388128B/es unknown
- 2017-12-22 JP JP2019533381A patent/JP6931059B2/ja active Active
- 2017-12-22 PL PL17828754T patent/PL3558351T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019122996A3 (es) | 2021-05-14 |
| DK3558351T3 (da) | 2022-03-21 |
| PL3558351T3 (pl) | 2022-03-21 |
| CA3045563A1 (en) | 2018-06-28 |
| JP6931059B2 (ja) | 2021-09-01 |
| EP3558351B1 (en) | 2022-01-26 |
| JP2020514266A (ja) | 2020-05-21 |
| US20200085935A1 (en) | 2020-03-19 |
| MX388128B (es) | 2025-03-19 |
| EP3558351A1 (en) | 2019-10-30 |
| ES2906854T3 (es) | 2022-04-20 |
| CN110087678B (zh) | 2023-09-26 |
| RU2761453C2 (ru) | 2021-12-08 |
| KR20190099418A (ko) | 2019-08-27 |
| KR102632419B1 (ko) | 2024-01-31 |
| US11065324B2 (en) | 2021-07-20 |
| BR112019012504A2 (pt) | 2019-11-19 |
| RU2019122996A (ru) | 2021-01-25 |
| WO2018115435A1 (en) | 2018-06-28 |
| CN110087678A (zh) | 2019-08-02 |
| CA3045563C (en) | 2022-05-03 |
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