AR117834A1 - Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de síntesis - Google Patents
Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de síntesisInfo
- Publication number
- AR117834A1 AR117834A1 ARP200100124A ARP200100124A AR117834A1 AR 117834 A1 AR117834 A1 AR 117834A1 AR P200100124 A ARP200100124 A AR P200100124A AR P200100124 A ARP200100124 A AR P200100124A AR 117834 A1 AR117834 A1 AR 117834A1
- Authority
- AR
- Argentina
- Prior art keywords
- pcta
- synthesis
- chelating ligand
- gadolinium complex
- complex
- Prior art date
Links
- 229910052688 Gadolinium Inorganic materials 0.000 title abstract 3
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Complejo de gadolinio, procesos para su preparación e intermediarios de obtención del mismo. Reivindicación 1: Complejo de gadolinio de hexaácido de fórmula (1) que consiste en al menos el 80% de un exceso diastereoisomérico que comprende una mezcla de isómeros I-RRR e I-SSS de fórmulas: (4) y (3) respectivamente. Reivindicación 4: Complejo de fórmula (2) que consiste en al menos el 80% de un exceso diastereoisomérico que comprende una mezcla de isómeros II-RRR e II-SSS de fórmulas: (6) y (5) respectivamente. Reivindicación 16: Complejo de fórmula (2) que consiste en al menos el 80% de un exceso diastereoisomérico que comprende una mezcla de isómeros II-RRR e II-SSS de fórmulas: (6) y (5), obtenible por el proceso de acuerdo con una cualquiera de las reivindicaciones 7 a 15. Reivindicación 17: Hexaéster de butilo de fórmula (7).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1900433A FR3091872B1 (fr) | 2019-01-17 | 2019-01-17 | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR117834A1 true AR117834A1 (es) | 2021-08-25 |
Family
ID=67001954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200100124A AR117834A1 (es) | 2019-01-17 | 2020-01-17 | Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de síntesis |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20220098218A1 (es) |
| EP (2) | EP3902799B1 (es) |
| JP (3) | JP7101897B2 (es) |
| KR (2) | KR102593187B1 (es) |
| CN (2) | CN113646309B (es) |
| AR (1) | AR117834A1 (es) |
| AU (2) | AU2020208793B2 (es) |
| BR (2) | BR112021014087B1 (es) |
| CA (2) | CA3126337C (es) |
| CL (1) | CL2021001869A1 (es) |
| CO (1) | CO2021009253A2 (es) |
| DK (2) | DK3902799T3 (es) |
| ES (1) | ES2929699T3 (es) |
| FI (1) | FI3936505T3 (es) |
| FR (1) | FR3091872B1 (es) |
| HR (2) | HRP20221291T1 (es) |
| HU (2) | HUE060073T2 (es) |
| IL (1) | IL284883B2 (es) |
| MA (2) | MA54624A (es) |
| MX (1) | MX2021008654A (es) |
| PH (1) | PH12021551724A1 (es) |
| PL (1) | PL3902799T3 (es) |
| PT (2) | PT3902799T (es) |
| RS (1) | RS65146B1 (es) |
| SG (1) | SG11202107781WA (es) |
| TW (1) | TWI812832B (es) |
| WO (1) | WO2020148431A1 (es) |
| ZA (1) | ZA202104993B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| CN114031513B (zh) * | 2021-11-01 | 2022-07-26 | 中国人民解放军总医院第八医学中心 | 钆塞酸二钠异构体的分离及其在作为mr成像对比剂中的应用 |
| EP4582432A4 (en) * | 2022-09-01 | 2025-12-10 | Theranocure Co Ltd | Novel compound and mri contrast agent comprising same |
| KR102845061B1 (ko) * | 2022-09-01 | 2025-08-13 | 주식회사 테라노큐어 | 신규한 화합물 및 이를 포함하는 mri 조영제 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE4001655A1 (de) | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| EP2786768A1 (en) * | 2013-04-04 | 2014-10-08 | Agfa Healthcare | Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide |
| KR102231121B1 (ko) * | 2013-04-26 | 2021-03-23 | 게르브 | 조영제 제형 및 이와 관련된 제조 방법 |
| CN119039292A (zh) * | 2018-08-06 | 2024-11-29 | 伯拉考成像股份公司 | 基于带有钆的pcta的造影剂 |
| US11370804B2 (en) * | 2019-01-17 | 2022-06-28 | Guerbet | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
| FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| US11426470B2 (en) * | 2019-01-17 | 2022-08-30 | Guerbet | Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method |
-
2019
- 2019-01-17 FR FR1900433A patent/FR3091872B1/fr active Active
-
2020
- 2020-01-17 DK DK20700830.1T patent/DK3902799T3/da active
- 2020-01-17 MA MA054624A patent/MA54624A/fr unknown
- 2020-01-17 CA CA3126337A patent/CA3126337C/fr active Active
- 2020-01-17 MA MA055227A patent/MA55227A/fr unknown
- 2020-01-17 KR KR1020217036450A patent/KR102593187B1/ko active Active
- 2020-01-17 AR ARP200100124A patent/AR117834A1/es unknown
- 2020-01-17 KR KR1020217025765A patent/KR102442900B1/ko active Active
- 2020-01-17 SG SG11202107781WA patent/SG11202107781WA/en unknown
- 2020-01-17 HR HRP20221291TT patent/HRP20221291T1/hr unknown
- 2020-01-17 HR HRP20231161TT patent/HRP20231161T1/hr unknown
- 2020-01-17 CA CA3186302A patent/CA3186302C/fr active Active
- 2020-01-17 US US17/423,589 patent/US20220098218A1/en not_active Abandoned
- 2020-01-17 PL PL20700830.1T patent/PL3902799T3/pl unknown
- 2020-01-17 BR BR112021014087-5A patent/BR112021014087B1/pt active IP Right Grant
- 2020-01-17 PH PH1/2021/551724A patent/PH12021551724A1/en unknown
- 2020-01-17 RS RS20231021A patent/RS65146B1/sr unknown
- 2020-01-17 FI FIEP21190150.9T patent/FI3936505T3/fi active
- 2020-01-17 HU HUE20700830A patent/HUE060073T2/hu unknown
- 2020-01-17 EP EP20700830.1A patent/EP3902799B1/fr active Active
- 2020-01-17 PT PT207008301T patent/PT3902799T/pt unknown
- 2020-01-17 HU HUE21190150A patent/HUE063338T2/hu unknown
- 2020-01-17 BR BR122022025041-6A patent/BR122022025041B1/pt active IP Right Grant
- 2020-01-17 EP EP21190150.9A patent/EP3936505B1/fr active Active
- 2020-01-17 PT PT211901509T patent/PT3936505T/pt unknown
- 2020-01-17 DK DK21190150.9T patent/DK3936505T3/da active
- 2020-01-17 MX MX2021008654A patent/MX2021008654A/es unknown
- 2020-01-17 IL IL284883A patent/IL284883B2/en unknown
- 2020-01-17 WO PCT/EP2020/051142 patent/WO2020148431A1/fr not_active Ceased
- 2020-01-17 AU AU2020208793A patent/AU2020208793B2/en active Active
- 2020-01-17 TW TW109101778A patent/TWI812832B/zh active
- 2020-01-17 ES ES20700830T patent/ES2929699T3/es active Active
- 2020-01-17 JP JP2021541200A patent/JP7101897B2/ja active Active
- 2020-01-17 CN CN202080009659.7A patent/CN113646309B/zh active Active
- 2020-01-17 CN CN202111050874.4A patent/CN113698400B/zh active Active
-
2021
- 2021-07-14 CL CL2021001869A patent/CL2021001869A1/es unknown
- 2021-07-15 ZA ZA2021/04993A patent/ZA202104993B/en unknown
- 2021-07-15 CO CONC2021/0009253A patent/CO2021009253A2/es unknown
- 2021-10-25 JP JP2021173862A patent/JP7503532B2/ja active Active
-
2023
- 2023-01-25 AU AU2023200400A patent/AU2023200400B2/en active Active
-
2024
- 2024-04-11 JP JP2024063851A patent/JP2024088782A/ja active Pending
-
2025
- 2025-05-05 US US19/199,254 patent/US20250270235A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR117834A1 (es) | Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de síntesis | |
| CO2021009261A2 (es) | Complejo de gadolinio y un ligando quelatante derivado de pcta diastereoisoméricamente enriquecido y método de preparación y de purificación | |
| CL2024000373A1 (es) | Compuesto inductor de la degradación de plk1 novedoso | |
| BR112021006229A2 (pt) | composto, composição farmacêutica, e, método para tratamento de um câncer | |
| CL2019003154A1 (es) | Proceso de preparación de un compuesto intermediario de fórmula (vi) para la preparación de compuestos de cannabidiol. (divisional solicitud 201800079) | |
| BR112017020993A2 (pt) | compostos, processo para a síntese de compostos, composição, uso de um composto da fórmula i, método para combater fungos fitopatogênicos, e, semente. | |
| CL2017002637A1 (es) | Compuestos nucleósidos 5'-sustituidos. | |
| DOP2021000017A (es) | Compuestos de pirimidina y composiciones farmaceuticas para prevenir o tratar cánceres que incluyen los mismos | |
| AR116790A1 (es) | PROCEDIMIENTO PARA LA PREPARACIÓN DE 3a-HIDROXI-5a-PREGNAN-20-ONA (BREXANOLONA) | |
| AR098128A1 (es) | Proceso para la preparación de un inhibidor de pde4 | |
| BR112018013985A2 (pt) | glicosídeos de esteviol altamente solúveis | |
| MX2025000971A (es) | Proceso para la sintesis del acido (s)-3-amino-4-(difluorometilenil)ciclopent-1-eno-1-carboxilico | |
| MX2017001459A (es) | Sintesis de fosforamidatos. | |
| BR112018006519A2 (pt) | compostos de fórmula, processo para a síntese de compostos, compostos intermediários x, composição, utilização de um composto de fórmula, método para o combate de fungos e semente | |
| BR112018073490A2 (pt) | 6.7.beta-epóxidos esteroides como intermediários químicos | |
| MX2022002941A (es) | Cristal de derivado de 1,3,5-triazina o solvato del mismo y metodo para producir el mismo. | |
| UY37519A (es) | Fenilamidinas y su uso como fungicidas | |
| CO2021001857A2 (es) | Preparación de intermedio útil para la síntesis de inhibidor de sglt | |
| MX2021012544A (es) | Compuestos novedosos y composiciones farmaceuticas de los mismos para el tratamiento de enfermedades renales. | |
| CO2019007836A2 (es) | Derivados de pirrolotriazina como inhibidor de cinasas | |
| PE20230183A1 (es) | Procesos e intermediario para la preparacion de oxetan-2-ilmetanamina | |
| ZA202006181B (en) | Process for the preparation of iloprost | |
| AR117872A1 (es) | Procesos para la preparación de la forma i del polimorfo de imidacloprid | |
| UY39874A (es) | Compuestos novedosos de estireno y un proceso para la preparación de los mismos. | |
| MX2021004288A (es) | Nuevo proceso para la sintesis de derivados de piperazinil-etoxi-bromofenilo y su aplicacion en la produccion de compuestos que los contienen. |