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MX2021004288A - Nuevo proceso para la sintesis de derivados de piperazinil-etoxi-bromofenilo y su aplicacion en la produccion de compuestos que los contienen. - Google Patents

Nuevo proceso para la sintesis de derivados de piperazinil-etoxi-bromofenilo y su aplicacion en la produccion de compuestos que los contienen.

Info

Publication number
MX2021004288A
MX2021004288A MX2021004288A MX2021004288A MX2021004288A MX 2021004288 A MX2021004288 A MX 2021004288A MX 2021004288 A MX2021004288 A MX 2021004288A MX 2021004288 A MX2021004288 A MX 2021004288A MX 2021004288 A MX2021004288 A MX 2021004288A
Authority
MX
Mexico
Prior art keywords
synthesis
derivates
bromophenyl
piperazinyl
ethoxy
Prior art date
Application number
MX2021004288A
Other languages
English (en)
Inventor
Christophe Hardouin
Louis-Philippe Beauregard
Martial Bertrand
Pascall Giguere
Bruno Schiavi
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MX2021004288A publication Critical patent/MX2021004288A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Proceso para la síntesis industrial del compuesto de la fórmula (I): (ver Fórmula).
MX2021004288A 2018-10-15 2019-10-14 Nuevo proceso para la sintesis de derivados de piperazinil-etoxi-bromofenilo y su aplicacion en la produccion de compuestos que los contienen. MX2021004288A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18306354 2018-10-15
PCT/EP2019/077729 WO2020078875A1 (en) 2018-10-15 2019-10-14 New process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them

Publications (1)

Publication Number Publication Date
MX2021004288A true MX2021004288A (es) 2021-05-31

Family

ID=63965576

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004288A MX2021004288A (es) 2018-10-15 2019-10-14 Nuevo proceso para la sintesis de derivados de piperazinil-etoxi-bromofenilo y su aplicacion en la produccion de compuestos que los contienen.

Country Status (14)

Country Link
US (1) US11512062B2 (es)
EP (1) EP3867233A1 (es)
JP (1) JP7448532B2 (es)
KR (1) KR102825242B1 (es)
CN (1) CN112930340B (es)
AR (1) AR116635A1 (es)
AU (1) AU2019362310B2 (es)
CA (1) CA3115608A1 (es)
EA (1) EA202190989A1 (es)
IL (1) IL282094B2 (es)
MA (1) MA53897A (es)
MX (1) MX2021004288A (es)
TW (1) TWI856981B (es)
WO (1) WO2020078875A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024520801A (ja) 2021-06-11 2024-05-24 ギリアード サイエンシーズ， インコーポレイテッド Ｍｃｌ－１阻害剤と抗がん剤との組み合わせ
CA3222752A1 (en) 2021-06-11 2022-12-15 Gilead Sciences, Inc. Combination mcl-1 inhibitors with anti-body drug conjugates

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401824A (en) * 1982-03-08 1983-08-30 The Upjohn Company Benzopyran compounds, derivatives of prostaglandins
US6867203B2 (en) * 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
GB0500029D0 (en) 2005-01-04 2005-02-09 Univ Belfast Basic ionic liquids
US7759337B2 (en) 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
CA2624166A1 (en) * 2005-10-11 2007-04-26 Intermune, Inc. Inhibitors of viral replication
JP5079265B2 (ja) * 2006-06-13 2012-11-21 ポリプラスチックス株式会社 安定化ポリアセタール樹脂の製造方法
WO2010148649A1 (en) 2009-06-26 2010-12-29 Glaxo Group Limited 5-membered heteroaryl derivatives used as sphingosine 1-phosphate receptor agonists
TWI472331B (zh) 2009-11-11 2015-02-11 Sumitomo Dainippon Pharma Co Ltd ８－氮雙環〔３‧２‧１〕辛烷－８－羧醯胺衍生物
CN108456206A (zh) 2011-06-17 2018-08-28 流体公司 利用碳酸二烷基酯季铵化来合成杂离子化合物
TWI464242B (zh) * 2012-10-26 2014-12-11 Ind Tech Res Inst 負介電異方性液晶化合物、液晶顯示器、與光電裝置
KR102006994B1 (ko) * 2013-03-28 2019-08-02 주식회사 삼양사 신규 페난트렌 화합물, 이의 제조방법 및 이를 이용한 유기전자소자
WO2015024203A1 (en) 2013-08-20 2015-02-26 Leo Pharma A/S Novel neurokinin 1 receptor antagonist compounds ii
FR3015483B1 (fr) 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TN2016000452A1 (en) * 2014-04-25 2018-04-04 Pfizer Heteroaromatic compounds and their use as dopamine d1 ligands.
JP6635949B2 (ja) 2014-06-04 2020-01-29 トーマス・ヘレデイズ・スティフテルス・フォー・メディシンスク・フォルスクニング 炎症性および自己免疫性の病気の処置のためのｍｔｈ１阻害剤
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10106553B2 (en) 2016-04-11 2018-10-23 Janssen Pharmaceutica Nv Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
KR101891263B1 (ko) * 2016-07-20 2018-08-23 주식회사 엘지화학 신규한 헤테로고리 화합물 및 이를 포함하는 유기발광 소자
IL266198B2 (en) * 2016-10-28 2023-11-01 Servier Lab Liposomal formulation for use in cancer treatment
CN107573360B (zh) 2017-10-27 2019-08-09 都创(上海)医药科技有限公司 一种多靶点小分子化合物s63845的制备方法
JP2021164585A (ja) * 2020-04-07 2021-10-14 株式会社サンセイアールアンドディ 遊技機

Also Published As

Publication number Publication date
CN112930340B (zh) 2025-01-07
AU2019362310A1 (en) 2021-05-13
CN112930340A (zh) 2021-06-08
CA3115608A1 (en) 2020-04-23
EA202190989A1 (ru) 2021-07-05
AR116635A1 (es) 2021-05-26
MA53897A (fr) 2022-01-19
AU2019362310B2 (en) 2024-10-24
US11512062B2 (en) 2022-11-29
WO2020078875A1 (en) 2020-04-23
BR112021006467A2 (pt) 2021-07-13
JP7448532B2 (ja) 2024-03-12
US20210380549A1 (en) 2021-12-09
TWI856981B (zh) 2024-10-01
IL282094A (en) 2021-05-31
JP2022512694A (ja) 2022-02-07
EP3867233A1 (en) 2021-08-25
TW202033506A (zh) 2020-09-16
IL282094B2 (en) 2025-03-01
IL282094B1 (en) 2024-11-01
KR102825242B1 (ko) 2025-06-24
KR20210076094A (ko) 2021-06-23
NZ774813A (en) 2024-07-26

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