AR117738A2 - Neurotoxinas recombinantes de clostridium botulinum - Google Patents
Neurotoxinas recombinantes de clostridium botulinumInfo
- Publication number
- AR117738A2 AR117738A2 ARP190103867A ARP190103867A AR117738A2 AR 117738 A2 AR117738 A2 AR 117738A2 AR P190103867 A ARP190103867 A AR P190103867A AR P190103867 A ARP190103867 A AR P190103867A AR 117738 A2 AR117738 A2 AR 117738A2
- Authority
- AR
- Argentina
- Prior art keywords
- protein
- clostridium botulinum
- nucleotide sequence
- chain bont
- recombinant neurotoxins
- Prior art date
Links
- 241000193155 Clostridium botulinum Species 0.000 title 1
- 239000002581 neurotoxin Substances 0.000 title 1
- 231100000618 neurotoxin Toxicity 0.000 title 1
- 108030001720 Bontoxilysin Proteins 0.000 abstract 3
- 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente proporciona una secuencia de ácidos nucleicos que comprende una secuencia de nucleótidos contiguos, donde dicha secuencia de nucleótidos contiguos tiene por lo menos 90% de identidad de secuencia con la secuencia de ácidos nucleicos de SEC ID Nº 1, y donde dicha secuencia de nucleótidos contiguos codifica una proteína BoNT/E1 de una sola cadena. La presente provee además métodos para producir la proteína BoNT/E1 de una sola cadena soluble en una célula huésped de E. coli, junto con métodos para producir la proteína BoNT/E1 de dos cadenas soluble.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201219602A GB201219602D0 (en) | 2012-10-31 | 2012-10-31 | Recombinant clostridium botulinum neurotoxins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR117738A2 true AR117738A2 (es) | 2021-08-25 |
Family
ID=47358958
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103981A AR093309A1 (es) | 2012-10-31 | 2013-10-31 | Neurotoxinas recombinantes de clostridium botulinum |
| ARP190103867A AR117738A2 (es) | 2012-10-31 | 2019-12-26 | Neurotoxinas recombinantes de clostridium botulinum |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103981A AR093309A1 (es) | 2012-10-31 | 2013-10-31 | Neurotoxinas recombinantes de clostridium botulinum |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10030238B2 (es) |
| EP (3) | EP3673914B1 (es) |
| JP (2) | JP2019068823A (es) |
| KR (2) | KR102264478B1 (es) |
| CN (2) | CN110499321A (es) |
| AR (2) | AR093309A1 (es) |
| AU (3) | AU2013340610B2 (es) |
| BR (1) | BR112015005384A2 (es) |
| CA (1) | CA2885519A1 (es) |
| DK (2) | DK3326644T3 (es) |
| EA (1) | EA201590794A8 (es) |
| ES (2) | ES2788199T3 (es) |
| GB (1) | GB201219602D0 (es) |
| HU (2) | HUE048802T2 (es) |
| IL (1) | IL237623B (es) |
| IN (1) | IN2015MN00436A (es) |
| MX (2) | MX367080B (es) |
| NO (1) | NO2914282T3 (es) |
| NZ (1) | NZ705575A (es) |
| PL (2) | PL3326644T3 (es) |
| PT (2) | PT2914282T (es) |
| SG (2) | SG10201701140WA (es) |
| TW (3) | TWI673361B (es) |
| UA (1) | UA118837C2 (es) |
| WO (1) | WO2014068317A1 (es) |
| ZA (1) | ZA201501449B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201219602D0 (en) * | 2012-10-31 | 2012-12-12 | Syntaxin Ltd | Recombinant clostridium botulinum neurotoxins |
| RU2746736C2 (ru) * | 2015-03-26 | 2021-04-20 | Президент Энд Феллоуз Оф Гарвард Колледж | Сконструированный ботулинический нейротоксин |
| WO2017063743A1 (en) | 2015-10-14 | 2017-04-20 | Merz Pharma Gmbh & Co. Kgaa | Improvements to ultrasound-based therapy of photoaged tissue |
| EP3423084B1 (en) | 2016-03-02 | 2021-09-01 | Merz Pharma GmbH & Co. KGaA | Composition comprising botulinum toxin |
| EP3263710A1 (en) * | 2016-07-01 | 2018-01-03 | Ipsen Biopharm Limited | Production of activated clostridial neurotoxins |
| WO2018039506A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Engineered botulinum neurotoxin |
| RU2762607C2 (ru) | 2016-09-13 | 2021-12-21 | Аллерган, Инк. | Стабилизированные небелковые композиции клостридиального токсина |
| US11952601B2 (en) | 2017-06-20 | 2024-04-09 | Merz Pharma Gmbh & Co. Kgaa | Recombinant botulinum toxin with increased duration of effect |
| ES2930237T3 (es) | 2017-07-06 | 2022-12-09 | Merz Pharma Gmbh & Co Kgaa | Neurotoxinas botulínicas recombinantes nuevas con mayor duración de efectos |
| EP3694489A4 (en) | 2017-10-11 | 2021-06-30 | Illustris Pharmaceuticals, Inc. | METHOD AND COMPOSITION OF TOPICAL ADMINISTRATION |
| CN119020332A (zh) * | 2018-01-29 | 2024-11-26 | 益普生生物制药有限公司 | 切割非神经元snare的肉毒杆菌神经毒素 |
| WO2019158745A1 (de) * | 2018-02-16 | 2019-08-22 | Bontana Therapies Gmbh | Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung |
| GB201815844D0 (en) * | 2018-09-28 | 2018-11-14 | Ipsen Biopharm Ltd | Therapeutic & comestic uses of botulinum neurotoxin serotype e |
| GB202011055D0 (en) | 2020-07-17 | 2020-09-02 | Ipsen Bioinnovation Ltd | Treatment of post-operative pain |
| GB202015618D0 (en) * | 2020-10-01 | 2020-11-18 | Ipsen Biopharm Ltd | Method for producing beta-trypsin |
| CN115819526A (zh) * | 2022-12-02 | 2023-03-21 | 海雅美生物技术(珠海)有限公司 | 一种重组肉毒杆菌神经毒素及其制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6967088B1 (en) | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
| NZ308772A (en) * | 1995-05-17 | 1999-04-29 | Du Pont | Recombinant baculovirus insecticides |
| WO2000002524A2 (en) | 1998-07-10 | 2000-01-20 | U.S. Army Medical Research Institute Of Infectious Diseases | Botulinum neurotoxin vaccine |
| KR100876060B1 (ko) | 1999-08-25 | 2008-12-26 | 알러간, 인코포레이티드 | 활성화가능한 재조합 신경독 |
| US7374896B2 (en) | 2001-08-28 | 2008-05-20 | Allergan, Inc. | GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity |
| US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
| US20110111483A1 (en) * | 2004-06-30 | 2011-05-12 | Allergan, Inc. | Optimizing Expression of Active Botulinum Toxin Type E |
| US7825233B2 (en) * | 2004-06-30 | 2010-11-02 | Allergan, Inc. | Optimizing expression of active Botulinum Toxin type E |
| GB2416122A (en) * | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| DE102004043009A1 (de) * | 2004-09-06 | 2006-03-23 | Toxogen Gmbh | Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen |
| DE102005002978B4 (de) | 2005-01-21 | 2013-04-25 | Merz Pharma Gmbh & Co. Kgaa | Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form |
| MXPA06009853A (es) * | 2005-03-03 | 2007-03-29 | Allergan Inc | Medios para bacteria de clostridium y procesos para obtener una toxina clostridial. |
| ES2369558T3 (es) * | 2005-09-19 | 2011-12-01 | Allergan, Inc. | Toxinas clostridiales y toxinas clostridiales activables. |
| US20070218084A1 (en) * | 2005-12-30 | 2007-09-20 | Fondazione Pierfranco E Luisa Mariani- Onlus | Method for the Mapping of the Epileptogenic Focus in the Pre-Surgical Evaluation of Patients with Intractable Epilepsy |
| JP2009543558A (ja) * | 2006-07-11 | 2009-12-10 | アラーガン、インコーポレイテッド | 増強した転位置能力および増強したターゲティング活性を有する改変クロストリジウム毒素 |
| WO2009014854A1 (en) * | 2007-07-26 | 2009-01-29 | Allergan, Inc. | Methods of activiting clostridial toxins |
| KR20160103551A (ko) | 2008-12-10 | 2016-09-01 | 알러간, 인코포레이티드 | 클로스트리디움 독소 약제학적 조성물 |
| GB0903006D0 (en) * | 2009-02-23 | 2009-04-08 | Syntaxin Ltd | Modified non-cytotoxic proteases |
| CN102481351B (zh) * | 2009-04-14 | 2015-05-13 | Mcw研究基金会股份有限公司 | 工程改造的肉毒杆菌神经毒素 |
| SG181772A1 (en) * | 2009-12-16 | 2012-07-30 | Allergan Inc | Modified clostridial toxins comprising an integrated protease cleavage site-binding domain |
| WO2012112434A1 (en) | 2011-02-14 | 2012-08-23 | Allergan, Inc. | Inhibiting aberrant blood vessel formation using retargeted endopeptidases |
| GB201219602D0 (en) * | 2012-10-31 | 2012-12-12 | Syntaxin Ltd | Recombinant clostridium botulinum neurotoxins |
| GB201407525D0 (en) * | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
| WO2018039506A1 (en) * | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Engineered botulinum neurotoxin |
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2012
- 2012-10-31 GB GB201219602A patent/GB201219602D0/en not_active Ceased
-
2013
- 2013-10-31 TW TW107110108A patent/TWI673361B/zh not_active IP Right Cessation
- 2013-10-31 EP EP20153122.5A patent/EP3673914B1/en active Active
- 2013-10-31 EP EP17201198.3A patent/EP3326644B1/en active Active
- 2013-10-31 AU AU2013340610A patent/AU2013340610B2/en not_active Ceased
- 2013-10-31 IN IN436MUN2015 patent/IN2015MN00436A/en unknown
- 2013-10-31 NO NO13811605A patent/NO2914282T3/no unknown
- 2013-10-31 BR BR112015005384A patent/BR112015005384A2/pt not_active Application Discontinuation
- 2013-10-31 SG SG10201701140WA patent/SG10201701140WA/en unknown
- 2013-10-31 EA EA201590794A patent/EA201590794A8/ru unknown
- 2013-10-31 ES ES17201198T patent/ES2788199T3/es active Active
- 2013-10-31 MX MX2015005156A patent/MX367080B/es active IP Right Grant
- 2013-10-31 SG SG11201502372SA patent/SG11201502372SA/en unknown
- 2013-10-31 WO PCT/GB2013/052845 patent/WO2014068317A1/en not_active Ceased
- 2013-10-31 PT PT138116058T patent/PT2914282T/pt unknown
- 2013-10-31 AR ARP130103981A patent/AR093309A1/es active IP Right Grant
- 2013-10-31 ES ES13811605.8T patent/ES2662402T3/es active Active
- 2013-10-31 CA CA2885519A patent/CA2885519A1/en not_active Abandoned
- 2013-10-31 DK DK17201198.3T patent/DK3326644T3/da active
- 2013-10-31 CN CN201910795176.3A patent/CN110499321A/zh active Pending
- 2013-10-31 PT PT172011983T patent/PT3326644T/pt unknown
- 2013-10-31 NZ NZ705575A patent/NZ705575A/en not_active IP Right Cessation
- 2013-10-31 TW TW108125708A patent/TW202012622A/zh unknown
- 2013-10-31 DK DK13811605.8T patent/DK2914282T3/en active
- 2013-10-31 US US14/427,234 patent/US10030238B2/en active Active
- 2013-10-31 KR KR1020207026658A patent/KR102264478B1/ko active Active
- 2013-10-31 TW TW102139558A patent/TWI626307B/zh not_active IP Right Cessation
- 2013-10-31 CN CN201380047542.8A patent/CN104755098A/zh active Pending
- 2013-10-31 HU HUE17201198A patent/HUE048802T2/hu unknown
- 2013-10-31 EP EP13811605.8A patent/EP2914282B1/en active Active
- 2013-10-31 PL PL17201198T patent/PL3326644T3/pl unknown
- 2013-10-31 KR KR1020157010099A patent/KR102188539B1/ko active Active
- 2013-10-31 UA UAA201502159A patent/UA118837C2/uk unknown
- 2013-10-31 HU HUE13811605A patent/HUE036764T2/hu unknown
- 2013-10-31 PL PL13811605T patent/PL2914282T3/pl unknown
-
2015
- 2015-03-03 ZA ZA2015/01449A patent/ZA201501449B/en unknown
- 2015-03-08 IL IL237623A patent/IL237623B/en active IP Right Grant
- 2015-04-23 MX MX2019009222A patent/MX2019009222A/es unknown
-
2018
- 2018-05-21 AU AU2018203556A patent/AU2018203556B2/en not_active Ceased
- 2018-12-10 JP JP2018230980A patent/JP2019068823A/ja not_active Ceased
-
2019
- 2019-12-26 AR ARP190103867A patent/AR117738A2/es unknown
-
2020
- 2020-02-05 JP JP2020017612A patent/JP2020078321A/ja active Pending
- 2020-09-30 AU AU2020244481A patent/AU2020244481A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |