AR116906A1 - Derivados de heteroarilo bicíclico - Google Patents
Derivados de heteroarilo bicíclicoInfo
- Publication number
- AR116906A1 AR116906A1 ARP190103631A ARP190103631A AR116906A1 AR 116906 A1 AR116906 A1 AR 116906A1 AR P190103631 A ARP190103631 A AR P190103631A AR P190103631 A ARP190103631 A AR P190103631A AR 116906 A1 AR116906 A1 AR 116906A1
- Authority
- AR
- Argentina
- Prior art keywords
- halogen
- compounds
- lower alkyl
- bicyclic heteroaryl
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente proporciona compuestos heteroarilo bicíclicos que tienen la fórmula general (1), en donde R¹, Ar, n y m son como se describen en el presente documento, composiciones que incluyen los compuestos, procesos de fabricación de los compuestos y métodos de uso de los compuestos. Reivindicación 1: Un compuesto de fórmula (1), donde R¹ es halógeno, alquilo inferior, alquilo inferior sustituido con halógeno, alcoxi inferior o alcoxi inferior sustituido con halógeno, y R¹ puede ser diferente si n = 2 ó 3; m es 1, 2 ó 3; n es 1, 2 ó 3; Ar es un grupo heteroarilo de seis miembros, seleccionado de los compuestos de fórmula (2) y (3), donde R² es hidrógeno, halógeno, alquilo inferior, alquilo inferior sustituido con halógeno o alcoxi inferior; R³ es hidrógeno o halógeno; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18212199 | 2018-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR116906A1 true AR116906A1 (es) | 2021-06-23 |
Family
ID=64665266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190103631A AR116906A1 (es) | 2018-12-13 | 2019-12-12 | Derivados de heteroarilo bicíclico |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US12195470B2 (es) |
| EP (2) | EP3894411B1 (es) |
| JP (2) | JP7566745B2 (es) |
| KR (1) | KR102910810B1 (es) |
| CN (2) | CN117946116A (es) |
| AR (1) | AR116906A1 (es) |
| AU (1) | AU2019395774B2 (es) |
| BR (1) | BR112021009443A2 (es) |
| CA (1) | CA3117870A1 (es) |
| CL (1) | CL2021001547A1 (es) |
| CO (1) | CO2021006837A2 (es) |
| CR (1) | CR20210305A (es) |
| DK (1) | DK3894411T3 (es) |
| ES (1) | ES2986688T3 (es) |
| FI (1) | FI3894411T3 (es) |
| HR (1) | HRP20241097T1 (es) |
| HU (1) | HUE067669T2 (es) |
| IL (2) | IL310081A (es) |
| LT (1) | LT3894411T (es) |
| MA (1) | MA54447B1 (es) |
| MX (1) | MX2021006761A (es) |
| MY (1) | MY208077A (es) |
| PE (1) | PE20211776A1 (es) |
| PH (1) | PH12021551387A1 (es) |
| PL (1) | PL3894411T3 (es) |
| PT (1) | PT3894411T (es) |
| RS (1) | RS65821B1 (es) |
| SG (1) | SG11202103340PA (es) |
| SI (1) | SI3894411T1 (es) |
| TW (1) | TWI831892B (es) |
| UA (1) | UA129650C2 (es) |
| WO (1) | WO2020120521A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS65821B1 (sr) * | 2018-12-13 | 2024-09-30 | Hoffmann La Roche | Derivati 7-fenoksi-n-(3-azabiciklo[3.2.1]oktan-8-il)-6,7-dihidro-5h-pirolo[1,2-b][1,2,4]triazol-2-amina i srodna jedinjenja kao modulatori gama-sekretaze za lečenje alchajmerove bolesti |
| AU2019412747B8 (en) | 2018-12-27 | 2025-04-24 | F. Hoffmann-La Roche Ag | Process for the preparation exo-tert-butyl N-(3-azabicyclo[3.2.1]octan-8-yl)carbamate |
| WO2024260932A2 (en) | 2023-06-19 | 2024-12-26 | F. Hoffmann-La Roche Ag | Process for the preparation of a chiral pyrrolo triazole alcohol |
| WO2025228863A1 (en) | 2024-05-03 | 2025-11-06 | F. Hoffmann-La Roche Ag | Dose regimen for a 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivative |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994349A (en) | 1997-10-27 | 1999-11-30 | Howard University | 3-carboalkoxy-2, 3-dihydro-1H-phenothiazin-4[10H]-one derivatives |
| EP1422217A3 (en) | 1998-04-01 | 2004-06-16 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| AU2528900A (en) | 1999-02-12 | 2000-08-29 | Nortran Pharmaceuticals Inc. | Cycloalkyl amine compounds and uses thereof |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| AU5289600A (en) | 1999-05-25 | 2000-12-12 | Neurogen Corporation | 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands |
| WO2001032170A1 (en) | 1999-09-13 | 2001-05-10 | Swope David M | Composition and method for decreasing neurologic symptomatology |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7499263B2 (en) | 2005-08-30 | 2009-03-03 | Doosan Infracore Co., Ltd. | Mobile power source cable connection system and method |
| US8703753B2 (en) | 2005-09-15 | 2014-04-22 | Biomas Ltd. | Use of tellurium compounds for the treatment of actinic keratosis |
| RU2009140182A (ru) | 2007-05-11 | 2011-06-20 | Ф. Хоффманн-Ля Рош Аг (Ch) | Гетариланилины в качестве модуляторов для бета-амилоида |
| NZ584716A (en) | 2007-10-19 | 2011-12-22 | Janssen Pharmaceutica Nv | PIPERIDINYL AND PIPERAZINYL MODULATORS OF gamma-SECRETASE |
| RU2011123862A (ru) | 2008-11-13 | 2012-12-20 | Шеринг Корпорейшн | Модуляторы гамма-секретазы |
| CN102333777B (zh) | 2009-02-26 | 2014-06-25 | 卫材R&D管理有限公司 | 含氮的稠合杂环化合物及其作为β淀粉样蛋白生成抑制剂的用途 |
| WO2010138901A1 (en) | 2009-05-29 | 2010-12-02 | Biogen Idec Ma Inc | Carboxylic acid-containing compounds, derivatives thereof, and related methods of use |
| CN102484127B (zh) | 2009-09-04 | 2015-07-15 | 惠普开发有限公司 | 基于混合金属价键化合物的记忆电阻 |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| US8703763B2 (en) * | 2011-03-02 | 2014-04-22 | Hoffmann-La Roche Inc. | Bridged piperidine derivatives |
| AU2012285931B2 (en) | 2011-07-15 | 2017-01-12 | Cellzome Limited | Novel substituted indole derivatives as gamma secretase modulators |
| US9637491B2 (en) | 2012-10-19 | 2017-05-02 | Origenis Gmbh | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors |
| JP6831372B2 (ja) * | 2015-09-09 | 2021-02-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 架橋ピペリジン誘導体 |
| JP6872550B2 (ja) | 2015-12-10 | 2021-05-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 架橋されたピペリジン誘導体 |
| JP7012715B2 (ja) | 2016-06-27 | 2022-01-28 | エフ．ホフマン－ラ ロシュ アーゲー | γ－セクレターゼモジュレーターとしてのトリアゾロピリジン |
| AR109829A1 (es) | 2016-09-29 | 2019-01-30 | Hoffmann La Roche | Derivados de piperidina puenteados |
| JP7111704B2 (ja) * | 2016-11-01 | 2022-08-02 | エフ．ホフマン－ラ ロシュ アーゲー | 二環式ヘテロアリール誘導体 |
| WO2018087018A1 (en) * | 2016-11-08 | 2018-05-17 | F. Hoffmann-La Roche Ag | Phenoxytriazoles |
| KR20190098998A (ko) | 2016-12-16 | 2019-08-23 | 파이프라인 테라퓨틱스, 아이엔씨. | 달팽이관 시냅스질환의 치료 방법 |
| WO2019141832A1 (en) * | 2018-01-22 | 2019-07-25 | F. Hoffmann-La Roche Ag | Triazolo-azepine derivatives |
| RS65821B1 (sr) * | 2018-12-13 | 2024-09-30 | Hoffmann La Roche | Derivati 7-fenoksi-n-(3-azabiciklo[3.2.1]oktan-8-il)-6,7-dihidro-5h-pirolo[1,2-b][1,2,4]triazol-2-amina i srodna jedinjenja kao modulatori gama-sekretaze za lečenje alchajmerove bolesti |
-
2019
- 2019-12-11 RS RS20240883A patent/RS65821B1/sr unknown
- 2019-12-11 HU HUE19824250A patent/HUE067669T2/hu unknown
- 2019-12-11 CN CN202311792520.6A patent/CN117946116A/zh active Pending
- 2019-12-11 IL IL310081A patent/IL310081A/en unknown
- 2019-12-11 PL PL19824250.5T patent/PL3894411T3/pl unknown
- 2019-12-11 PE PE2021000726A patent/PE20211776A1/es unknown
- 2019-12-11 SI SI201930802T patent/SI3894411T1/sl unknown
- 2019-12-11 HR HRP20241097TT patent/HRP20241097T1/hr unknown
- 2019-12-11 FI FIEP19824250.5T patent/FI3894411T3/fi active
- 2019-12-11 IL IL283823A patent/IL283823B2/en unknown
- 2019-12-11 US US17/413,413 patent/US12195470B2/en active Active
- 2019-12-11 EP EP19824250.5A patent/EP3894411B1/en active Active
- 2019-12-11 JP JP2021533563A patent/JP7566745B2/ja active Active
- 2019-12-11 MA MA54447A patent/MA54447B1/fr unknown
- 2019-12-11 EP EP24177200.3A patent/EP4424370A3/en active Pending
- 2019-12-11 LT LTEPPCT/EP2019/084538T patent/LT3894411T/lt unknown
- 2019-12-11 SG SG11202103340PA patent/SG11202103340PA/en unknown
- 2019-12-11 PH PH1/2021/551387A patent/PH12021551387A1/en unknown
- 2019-12-11 MY MYPI2021001956A patent/MY208077A/en unknown
- 2019-12-11 CN CN201980076253.8A patent/CN113179641B/zh active Active
- 2019-12-11 AU AU2019395774A patent/AU2019395774B2/en active Active
- 2019-12-11 KR KR1020217017774A patent/KR102910810B1/ko active Active
- 2019-12-11 BR BR112021009443-1A patent/BR112021009443A2/pt unknown
- 2019-12-11 WO PCT/EP2019/084538 patent/WO2020120521A1/en not_active Ceased
- 2019-12-11 ES ES19824250T patent/ES2986688T3/es active Active
- 2019-12-11 CR CR20210305A patent/CR20210305A/es unknown
- 2019-12-11 PT PT198242505T patent/PT3894411T/pt unknown
- 2019-12-11 MX MX2021006761A patent/MX2021006761A/es unknown
- 2019-12-11 UA UAA202103248A patent/UA129650C2/uk unknown
- 2019-12-11 CA CA3117870A patent/CA3117870A1/en active Pending
- 2019-12-11 DK DK19824250.5T patent/DK3894411T3/da active
- 2019-12-12 AR ARP190103631A patent/AR116906A1/es unknown
- 2019-12-12 TW TW108145480A patent/TWI831892B/zh active
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2021
- 2021-05-24 CO CONC2021/0006837A patent/CO2021006837A2/es unknown
- 2021-06-11 CL CL2021001547A patent/CL2021001547A1/es unknown
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2024
- 2024-10-02 JP JP2024173048A patent/JP2025000919A/ja active Pending
- 2024-11-25 US US18/959,369 patent/US20250326758A1/en active Pending
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