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AR102266A1 - Inhibidores de aldosterona sintasa - Google Patents

Inhibidores de aldosterona sintasa

Info

Publication number
AR102266A1
AR102266A1 ARP150103319A ARP150103319A AR102266A1 AR 102266 A1 AR102266 A1 AR 102266A1 AR P150103319 A ARP150103319 A AR P150103319A AR P150103319 A ARP150103319 A AR P150103319A AR 102266 A1 AR102266 A1 AR 102266A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
heterocyclyl
groups
sintasa
Prior art date
Application number
ARP150103319A
Other languages
English (en)
Inventor
Yu Hui
Surprenant Simon
Nemoto Peter
Meyers Kenneth
Hornberger Keith
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54352516&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR102266(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR102266A1 publication Critical patent/AR102266A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/54Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto, caracterizado porque tiene la fórmula (1) en donde: R¹ se selecciona de -C(O)NH₂, -C(O)NH(CH₃) y -CN; R² es -(X)-R⁴, en donde -(X)- es un enlace, -CH₂- u -O-; y R⁴ se selecciona de H; alquilo C₁₋₃, opcionalmente sustituido con uno a cuatro grupos seleccionados de -F y -OH; halógeno; -CN; -SO₂-alquilo C₁₋₃; -C(O)N(alquil C₁₋₃)₂, siempre que -(X)- no sea -O-; -NHC(O)R⁵ o -N(CH₃)C(O)R⁵, siempre que -(X)- sea -CH₂- y en donde R⁵ se selecciona de cicloalquilo C₃₋₆ y alquilo C₁₋₃, opcionalmente sustituido con uno a tres grupos -F; -NHSO₂-alquilo C₁₋₃; -CH(ciclopropil)NHSO₂-alquilo C₁₋₃; -OCH₂C(O)N(alquilo C₁₋₃)₂, siempre que -(X)- sea -CH₂-; -S(=O)(=NH)CH₃, siempre que -(X)- sea -CH₂-; heterociclilo seleccionado de tetrahidropiranilo, tetrahidrofuranilo, pirrolidinilo, 1,1-dioxo[1,2]-tiazina, morfolinilo, oxazolidinilo, piperidinilo, azetidinilo, en donde dicho heterociclilo está opcionalmente sustituido con uno a tres grupos seleccionados de -C(O)alquilo C₁₋₃, halógeno, -OH, oxo y alquilo C₁₋₃; -C(O)-heterociclilo, siempre que -(X)- sea -CH₂, en donde dicho heterociclilo se selecciona de morfolin-4-ilo, pirrolidin-1-ilo y piperidin-1-ilo, opcionalmente sustituido con uno o dos grupos seleccionados de -F y -OH; cicloalquilo C₃₋₆ opcionalmente sustituido con -CN u -OH; y fenilo, opcionalmente sustituido con -SO₂NH₂; y R³ es H o alquilo C₁₋₃ opcionalmente sustituido con -OH; o R² y R³ forman juntos un anillo cicloalquilo fusionado de cinco miembros opcionalmente sustituido con -OH; o una de sus sales o estereoisómeros.
ARP150103319A 2014-10-15 2015-10-14 Inhibidores de aldosterona sintasa AR102266A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462064234P 2014-10-15 2014-10-15

Publications (1)

Publication Number Publication Date
AR102266A1 true AR102266A1 (es) 2017-02-15

Family

ID=54352516

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103319A AR102266A1 (es) 2014-10-15 2015-10-14 Inhibidores de aldosterona sintasa

Country Status (33)

Country Link
US (1) US9745289B2 (es)
EP (1) EP3207039B1 (es)
JP (1) JP6279812B2 (es)
KR (1) KR102441634B1 (es)
CN (1) CN107108587B (es)
AP (1) AP2017009829A0 (es)
AR (1) AR102266A1 (es)
AU (1) AU2015333611B2 (es)
CA (1) CA2964754C (es)
CL (1) CL2017000827A1 (es)
CO (1) CO2017003305A2 (es)
CY (1) CY1121650T1 (es)
DK (1) DK3207039T3 (es)
EA (1) EA031766B1 (es)
ES (1) ES2724555T3 (es)
HR (1) HRP20190896T1 (es)
HU (1) HUE043783T2 (es)
IL (1) IL251200B (es)
LT (1) LT3207039T (es)
ME (1) ME03381B (es)
MX (1) MX369025B (es)
NZ (1) NZ729688A (es)
PE (1) PE20170696A1 (es)
PH (1) PH12017500595B1 (es)
PL (1) PL3207039T3 (es)
PT (1) PT3207039T (es)
RS (1) RS58651B1 (es)
SG (1) SG11201701850UA (es)
SI (1) SI3207039T1 (es)
TR (1) TR201907755T4 (es)
TW (1) TWI731842B (es)
UA (1) UA118717C2 (es)
WO (1) WO2016061161A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9890171B2 (en) * 2014-12-02 2018-02-13 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors
FI3562487T3 (fi) * 2016-12-29 2023-12-14 Ji Xing Pharmaceuticals Hong Kong Ltd Metalloentsyymi-inhibiittoriyhdisteitä
US11958818B2 (en) 2019-05-01 2024-04-16 Boehringer Ingelheim International Gmbh (R)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate
KR20230093251A (ko) 2020-09-10 2023-06-27 프리시릭스 엔.브이. Fap에 대한 항체 단편
KR20240122521A (ko) 2021-12-14 2024-08-12 베링거 인겔하임 인터내셔날 게엠베하 만성 신장 질환 치료용 알도스테론 신타아제 억제제
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting
WO2025261526A1 (zh) * 2024-06-21 2025-12-26 上海翰森生物医药科技有限公司 双稠环类化合物、及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR073629A1 (es) * 2008-10-07 2010-11-17 Schering Corp Analogos de benzodioxano moduladores de receptores adrenergicos alfa 2c, composiciones farmaceuticas que los contienen y uso de los mismos para tratar enfermedades respiratorias, alergicas, cardiacas, parkinson y/o alzheimer, entre otras
SI2429995T1 (sl) * 2009-05-15 2014-05-30 Novartis Ag Arilpiridini kot inhibitorji aldosteron sintaze
SG11201402199QA (en) * 2011-11-30 2014-09-26 Hoffmann La Roche New bicyclic dihydroisoquinoline-1-one derivatives
US9550750B2 (en) * 2012-10-05 2017-01-24 Merck Sharp & Dohme Corp. Indoline compounds as aldosterone synthase inhibitors
EP2958562B1 (en) * 2013-02-22 2025-09-10 Merck Sharp & Dohme LLC Antidiabetic bicyclic compounds
US9181272B2 (en) * 2013-04-30 2015-11-10 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors
EP3172212B1 (en) * 2014-07-24 2018-06-13 Boehringer Ingelheim International GmbH Aldosterone synthase inhibitors

Also Published As

Publication number Publication date
MX2017004852A (es) 2017-06-22
CA2964754C (en) 2023-01-24
PH12017500595B1 (en) 2020-11-25
TWI731842B (zh) 2021-07-01
RS58651B1 (sr) 2019-05-31
IL251200A0 (en) 2017-05-29
US9745289B2 (en) 2017-08-29
PT3207039T (pt) 2019-06-04
LT3207039T (lt) 2019-05-10
ME03381B (me) 2020-01-20
SG11201701850UA (en) 2017-04-27
IL251200B (en) 2019-05-30
CL2017000827A1 (es) 2017-11-03
AU2015333611B2 (en) 2020-02-06
CN107108587B (zh) 2020-05-22
TR201907755T4 (tr) 2019-06-21
US20160108026A1 (en) 2016-04-21
CA2964754A1 (en) 2016-04-21
CY1121650T1 (el) 2020-07-31
UA118717C2 (uk) 2019-02-25
PL3207039T3 (pl) 2019-08-30
JP6279812B2 (ja) 2018-02-14
ES2724555T3 (es) 2019-09-12
EA201790830A1 (ru) 2017-09-29
AU2015333611A1 (en) 2017-03-23
EA031766B1 (ru) 2019-02-28
HRP20190896T1 (hr) 2019-07-12
CN107108587A (zh) 2017-08-29
CO2017003305A2 (es) 2017-07-19
TW201629048A (zh) 2016-08-16
MX369025B (es) 2019-10-25
AP2017009829A0 (en) 2017-03-31
EP3207039B1 (en) 2019-03-06
KR102441634B1 (ko) 2022-09-13
PH12017500595A1 (en) 2017-08-30
EP3207039A1 (en) 2017-08-23
PE20170696A1 (es) 2017-06-07
WO2016061161A1 (en) 2016-04-21
JP2017531016A (ja) 2017-10-19
DK3207039T3 (en) 2019-04-23
NZ729688A (en) 2020-05-29
BR112017005859A2 (pt) 2017-12-26
KR20170066651A (ko) 2017-06-14
SI3207039T1 (sl) 2019-05-31
HUE043783T2 (hu) 2019-09-30

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