AR094702A1 - Compuestos de azabencimidazol - Google Patents
Compuestos de azabencimidazolInfo
- Publication number
- AR094702A1 AR094702A1 ARP140100515A ARP140100515A AR094702A1 AR 094702 A1 AR094702 A1 AR 094702A1 AR P140100515 A ARP140100515 A AR P140100515A AR P140100515 A ARP140100515 A AR P140100515A AR 094702 A1 AR094702 A1 AR 094702A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- members
- group
- represented
- optionally substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 11
- 125000001424 substituent group Chemical group 0.000 abstract 9
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 6
- -1 -C (O) NR4R5 Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 5
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
Abstract
Compuestos aptos para el tratamiento de trastornos del SNC, metabólicos y autoinmunes. Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1), o una sal de este aceptable desde el punto de vista farmacéutico, en donde: R¹ es representado por un sustituyente seleccionado del grupo que consiste en cicloalquilo C₃₋₁₀, heterocicloalquilo (de 4 a 10 miembros), arilo C₆₋₁₀ y heteroarilo (de 5 a 10 miembros); en donde cicloalquilo C₃₋₁₀, arilo C₆₋₁₀ y heteroarilo (de 5 a 10 miembros) se sustituyen opcionalmente con (R²)ᵇ; y el heterocicloalquilo (de 4 a 10 miembros) se sustituye opcionalmente en 1 a 5 átomos de carbono con un sustituyente seleccionado independientemente del grupo que consiste en halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquil C₁₋₆tio, -C(O)NR⁴R⁵, hidroxi y ciano; y se sustituye opcionalmente, en cada nitrógeno disponible, con alquilo C₁₋₆; R² es representado por un sustituyente seleccionado independientemente del grupo que consiste en halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquil C₁₋₆tio; -C(O)NR⁴R⁵, hidroxi y ciano; R³, si está presente, en cada caso es representado por un sustituyente seleccionado independientemente del grupo que consiste en halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquil C₁₋₆tio, -C(O)NR⁴R⁵, hidroxi y ciano; cada R⁴ y R⁵ es representado por un sustituyente seleccionado independientemente del grupo que consiste en hidrógeno, alquilo C₁₋₆ y cicloalquilo C₃₋₆; cada R⁶ y R⁷ es representado por un sustituyente seleccionado independientemente del grupo que consiste en hidrógeno, alquilo C₁₋₆, -(CH₂)ₘ-cicloalquilo C₃₋₁₀, -(CH₂)ₘ-heterocicloalquilo (de 4 a 10 miembros), -(CH₂)ₘ-arilo C₆₋₁₀ y -(CH₂)ₘ-heteroarilo (de 5 a 10 miembros); en donde alquilo C₁₋₆, cicloalquilo C₃₋₁₀, arilo C₆₋₁₀ y heteroarilo (de 5 a 10 miembros) se sustituyen opcionalmente con 1 a 5 sustituyentes seleccionados independientemente del grupo que consiste en halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquil C₁₋₆tio, -C(O)NR⁴R⁵, hidroxi y ciano; y el heterocicloalquilo (de 4 a 10 miembros) se sustituye opcionalmente en 1 a 5 átomos de carbono con un sustituyente seleccionado independientemente del grupo que consiste en halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquil C₁₋₆tio, -C(O)NR⁴R⁵, hidroxi y ciano; y se sustituye opcionalmente, en cada nitrógeno disponible, con alquilo C₁₋₆; o R⁶ y R⁷, junto con el nitrógeno al que están unidos, forman un heterocicloalquilo (de 4 a 10 miembros), en donde el heterocicloalquilo (de 4 a 10 miembros) se sustituye opcionalmente en 1 a 5 átomos de carbono con un sustituyente seleccionado independientemente del grupo que consiste en halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquil C₁₋₆tio, -C(O)NR⁴R⁵, hidroxi y ciano; a es representado por un entero seleccionado de 0, 1, 2 ó 3; b es representado por un entero seleccionado de 0, 1, 2, 3, 4 ó 5; y m es representado por un entero seleccionado de 0, 1, 2 ó 3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361766268P | 2013-02-19 | 2013-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094702A1 true AR094702A1 (es) | 2015-08-19 |
Family
ID=50151342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100515A AR094702A1 (es) | 2013-02-19 | 2014-02-18 | Compuestos de azabencimidazol |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US9120788B2 (es) |
| EP (1) | EP2958915B1 (es) |
| JP (2) | JP6505023B2 (es) |
| KR (1) | KR20150119370A (es) |
| CN (1) | CN105121439A (es) |
| AP (1) | AP2015008663A0 (es) |
| AR (1) | AR094702A1 (es) |
| AU (1) | AU2014220351A1 (es) |
| BR (1) | BR112015019276A2 (es) |
| CA (1) | CA2900302C (es) |
| CL (1) | CL2015002222A1 (es) |
| CR (1) | CR20150425A (es) |
| CU (1) | CU20150082A7 (es) |
| DO (1) | DOP2015000201A (es) |
| EA (1) | EA201591360A1 (es) |
| EC (1) | ECSP15035278A (es) |
| ES (1) | ES2638850T3 (es) |
| HK (1) | HK1217945A1 (es) |
| IL (1) | IL240672A0 (es) |
| MA (1) | MA38333A1 (es) |
| MD (1) | MD20150071A2 (es) |
| MX (1) | MX2015010714A (es) |
| NI (1) | NI201500112A (es) |
| PE (1) | PE20151332A1 (es) |
| PH (1) | PH12015501755A1 (es) |
| SG (1) | SG11201505878UA (es) |
| TN (1) | TN2015000347A1 (es) |
| TW (1) | TW201443048A (es) |
| UY (1) | UY35333A (es) |
| WO (1) | WO2014128585A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201505878UA (en) | 2013-02-19 | 2015-09-29 | Pfizer | Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders |
| JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
| ES2733502T3 (es) | 2014-08-06 | 2019-11-29 | Pfizer | Compuestos de imidazopiridazina |
| ES2759348T3 (es) | 2015-04-29 | 2020-05-08 | Janssen Pharmaceutica Nv | Imidazopirazinas y pirazolopirimidinas y su utilización como moduladores de receptores AMPA |
| KR20170141769A (ko) | 2015-04-29 | 2017-12-26 | 얀센 파마슈티카 엔.브이. | 인돌론 화합물 및 ampa 수용체 조절제로서의 이의 용도 |
| CN107635970B (zh) | 2015-04-29 | 2021-03-12 | 詹森药业有限公司 | 苯并咪唑酮和苯并噻唑酮化合物以及它们作为ampa受体调节剂的用途 |
| UY36654A (es) | 2015-04-29 | 2016-10-31 | Janssen Pharmaceutica Nv | Azabenzimidazoles con propiedades moduladoras del receptor ampa y composiciones farmacéuticas que los contienen |
| PL3310784T3 (pl) | 2015-06-17 | 2021-03-08 | Pfizer Inc. | Związki tricykliczne i ich zastosowanie jako inhibitory fosfodiesterazy |
| AR107099A1 (es) * | 2015-12-22 | 2018-03-21 | Gruenenthal Gmbh | Compuestos espiro-[indolin heterocicloalcano] como inhibidores de la fosfodiesterasa |
| CN113332292A (zh) * | 2016-02-23 | 2021-09-03 | 辉瑞公司 | 6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物 |
| WO2018036470A1 (zh) * | 2016-08-22 | 2018-03-01 | 南京明德新药研发股份有限公司 | 作为pde4抑制剂的并环类化合物 |
| WO2018234354A1 (en) | 2017-06-20 | 2018-12-27 | Grünenthal GmbH | Novel substituted 3-indole and 3-indazole compounds as phosphodiesterase inhibitors |
| WO2018234353A1 (en) | 2017-06-20 | 2018-12-27 | Grünenthal GmbH | Novel substituted indole and indazole compounds as phosphodiesterase inhibitors |
| EP3643711A1 (en) | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| KR20220100627A (ko) | 2019-11-13 | 2022-07-15 | 니뽄 신야쿠 가부시키가이샤 | 아자벤즈이미다졸 화합물 및 의약 |
| KR102649355B1 (ko) * | 2020-03-31 | 2024-03-19 | 주식회사 엘지화학 | 췌도 이식 보호용 조성물 |
| CN112390750B (zh) * | 2020-11-11 | 2022-03-01 | 常州大学 | 作为选择性磷酸二酯酶2抑制剂的喹啉酮类化合物及其制备方法 |
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- 2014-02-06 CN CN201480009394.5A patent/CN105121439A/zh active Pending
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- 2014-02-06 AU AU2014220351A patent/AU2014220351A1/en not_active Abandoned
- 2014-02-06 KR KR1020157025454A patent/KR20150119370A/ko not_active Ceased
- 2014-02-06 WO PCT/IB2014/058840 patent/WO2014128585A1/en not_active Ceased
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