AR106262A1 - Alquilación de picolinamidas con cloroacilales sustituidos utilizando un catalizador de éter corona - Google Patents
Alquilación de picolinamidas con cloroacilales sustituidos utilizando un catalizador de éter coronaInfo
- Publication number
- AR106262A1 AR106262A1 ARP160103046A ARP160103046A AR106262A1 AR 106262 A1 AR106262 A1 AR 106262A1 AR P160103046 A ARP160103046 A AR P160103046A AR P160103046 A ARP160103046 A AR P160103046A AR 106262 A1 AR106262 A1 AR 106262A1
- Authority
- AR
- Argentina
- Prior art keywords
- catalyst
- substituted
- chloroacilals
- picolinamides
- group
- Prior art date
Links
- 239000003054 catalyst Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000003426 co-catalyst Substances 0.000 abstract 2
- 229910001502 inorganic halide Inorganic materials 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 abstract 2
- -1 = O Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000008378 aryl ethers Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/08—Halides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0201—Oxygen-containing compounds
- B01J31/0204—Ethers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/44—Allylic alkylation, amination, alkoxylation or analogues
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/001—General concepts, e.g. reviews, relating to catalyst systems and methods of making them, the concept being defined by a common material or method/theory
- B01J2531/002—Materials
- B01J2531/007—Promoter-type Additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/90—Catalytic systems characterized by the solvent or solvent system used
- B01J2531/98—Phase-transfer catalysis in a mixed solvent system containing at least 2 immiscible solvents or solvent phases
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Pharmacology & Pharmacy (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un proceso para la alquilación de picolinamidas con cloroacilales sustituidos, en donde la reacción se realiza en la presencia de un catalizador de fase de transferencia y de un co-catalizador inorgánico de haluro. Reivindicación 1: Un método que incluye los pasos para: reaccionar un picolinamida de la fórmula (1) con un cloroacilal sustituido de la fórmula (2) para producir un compuesto de la fórmula (3), en donde: R¹ es un grupo de alquilo primario o secundario; R² es un heterociclo de 5 - 12 átomos incluyendo 1 - 3 heteroátomos seleccionados de un grupo compuesto por N, O, P, y S con uno o más sustitutos seleccionados de un grupo compuesto por C₁₋₆ alquilo, C₁₋₆ acilo, =O, bencilo, C₁₋₆ alquilo éter, o arilo éter; R³ es un grupo de alquilo primario, secundario, o terciario; y en donde el paso de reacción se realiza en la presencia de un catalizador de transferencia de fase y un co-catalizador de haluro inorgánico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562237844P | 2015-10-06 | 2015-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106262A1 true AR106262A1 (es) | 2017-12-27 |
Family
ID=58447241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160103046A AR106262A1 (es) | 2015-10-06 | 2016-10-05 | Alquilación de picolinamidas con cloroacilales sustituidos utilizando un catalizador de éter corona |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10144728B2 (es) |
| EP (1) | EP3359153B1 (es) |
| JP (2) | JP6975142B2 (es) |
| KR (1) | KR102687147B1 (es) |
| CN (1) | CN108135890B (es) |
| AR (1) | AR106262A1 (es) |
| BR (1) | BR102016023198B8 (es) |
| CA (1) | CA3000198C (es) |
| CO (1) | CO2018003474A2 (es) |
| DK (1) | DK3359153T3 (es) |
| ES (1) | ES2858364T3 (es) |
| HU (1) | HUE052841T2 (es) |
| IL (1) | IL258386B (es) |
| LT (1) | LT3359153T (es) |
| MX (1) | MX2018003875A (es) |
| PL (1) | PL3359153T3 (es) |
| TW (1) | TWI718187B (es) |
| WO (1) | WO2017062362A1 (es) |
| ZA (1) | ZA201802085B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202146007A (zh) * | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480762A (en) * | 1990-11-28 | 1996-01-02 | Fuji Photo Film Co., Ltd. | Method for preparing lithographic printing plate |
| AR037328A1 (es) * | 2001-10-23 | 2004-11-03 | Dow Agrosciences Llc | Compuesto de [7-bencil-2,6-dioxo-1,5-dioxonan-3-il]-4-metoxipiridin-2-carboxamida, composicion que lo comprende y metodo que lo utiliza |
| US6861930B2 (en) | 2001-11-15 | 2005-03-01 | Eaton Corporation | Transfer switch including a circuit breaker housing |
| US7091270B2 (en) * | 2002-01-31 | 2006-08-15 | Bromine Compounds Ltd. | Pentabromobenzyl alkyl ethers and their use as fire retardants |
| US20130060023A1 (en) | 2011-09-07 | 2013-03-07 | Satori Pharmaceuticals, Inc. | Compounds useful for treating neurodegenerative disorders |
| EP2847187A4 (en) * | 2012-05-07 | 2015-10-28 | Dow Agrosciences Llc | MACROCYCLIC PICOLINAMIDE AS FUNGICIDES |
| EP2875024A4 (en) * | 2012-07-20 | 2015-12-23 | Merck Sharp & Dohme | HIV TREATMENT WITH AMIDOSUBSTITUTED PYRIMIDINONE DERIVATIVES |
-
2016
- 2016-10-03 US US15/283,479 patent/US10144728B2/en active Active
- 2016-10-04 JP JP2018516450A patent/JP6975142B2/ja active Active
- 2016-10-04 PL PL16854170T patent/PL3359153T3/pl unknown
- 2016-10-04 CA CA3000198A patent/CA3000198C/en active Active
- 2016-10-04 KR KR1020187010623A patent/KR102687147B1/ko active Active
- 2016-10-04 LT LTEP16854170.4T patent/LT3359153T/lt unknown
- 2016-10-04 MX MX2018003875A patent/MX2018003875A/es unknown
- 2016-10-04 DK DK16854170.4T patent/DK3359153T3/da active
- 2016-10-04 HU HUE16854170A patent/HUE052841T2/hu unknown
- 2016-10-04 WO PCT/US2016/055331 patent/WO2017062362A1/en not_active Ceased
- 2016-10-04 CN CN201680056498.0A patent/CN108135890B/zh active Active
- 2016-10-04 EP EP16854170.4A patent/EP3359153B1/en active Active
- 2016-10-04 ES ES16854170T patent/ES2858364T3/es active Active
- 2016-10-05 AR ARP160103046A patent/AR106262A1/es active IP Right Grant
- 2016-10-05 TW TW105132240A patent/TWI718187B/zh active
- 2016-10-05 BR BR102016023198A patent/BR102016023198B8/pt active IP Right Grant
-
2018
- 2018-03-27 IL IL258386A patent/IL258386B/en active IP Right Grant
- 2018-03-28 ZA ZA2018/02085A patent/ZA201802085B/en unknown
- 2018-03-28 CO CONC2018/0003474A patent/CO2018003474A2/es unknown
-
2021
- 2021-08-11 JP JP2021131000A patent/JP2021185157A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI718187B (zh) | 2021-02-11 |
| CO2018003474A2 (es) | 2018-06-12 |
| LT3359153T (lt) | 2021-03-25 |
| JP2021185157A (ja) | 2021-12-09 |
| WO2017062362A9 (en) | 2017-12-28 |
| EP3359153A4 (en) | 2019-05-08 |
| TW201718560A (zh) | 2017-06-01 |
| BR102016023198B8 (pt) | 2022-09-06 |
| ES2858364T3 (es) | 2021-09-30 |
| CN108135890B (zh) | 2024-07-09 |
| WO2017062362A1 (en) | 2017-04-13 |
| EP3359153A1 (en) | 2018-08-15 |
| KR20180066101A (ko) | 2018-06-18 |
| CA3000198C (en) | 2024-02-27 |
| US20170096414A1 (en) | 2017-04-06 |
| ZA201802085B (en) | 2019-06-26 |
| EP3359153B1 (en) | 2020-12-16 |
| JP2018537407A (ja) | 2018-12-20 |
| BR102016023198B1 (pt) | 2021-06-22 |
| MX2018003875A (es) | 2018-08-16 |
| BR102016023198A2 (pt) | 2017-04-18 |
| HUE052841T2 (hu) | 2021-05-28 |
| CA3000198A1 (en) | 2017-04-13 |
| KR102687147B1 (ko) | 2024-07-24 |
| IL258386B (en) | 2021-02-28 |
| IL258386A (en) | 2018-05-31 |
| DK3359153T3 (da) | 2021-03-08 |
| US10144728B2 (en) | 2018-12-04 |
| PL3359153T3 (pl) | 2021-07-05 |
| JP6975142B2 (ja) | 2021-12-01 |
| CN108135890A (zh) | 2018-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |