MX2018003875A - Alquilacion de picolinamidas con cloroacilales sustituidos con el uso de un catalizador de eter de corona. - Google Patents
Alquilacion de picolinamidas con cloroacilales sustituidos con el uso de un catalizador de eter de corona.Info
- Publication number
- MX2018003875A MX2018003875A MX2018003875A MX2018003875A MX2018003875A MX 2018003875 A MX2018003875 A MX 2018003875A MX 2018003875 A MX2018003875 A MX 2018003875A MX 2018003875 A MX2018003875 A MX 2018003875A MX 2018003875 A MX2018003875 A MX 2018003875A
- Authority
- MX
- Mexico
- Prior art keywords
- chloroacylals
- picolinamides
- alkylation
- substituted
- utilizing
- Prior art date
Links
- 230000029936 alkylation Effects 0.000 title abstract 2
- 238000005804 alkylation reaction Methods 0.000 title abstract 2
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003054 catalyst Substances 0.000 title 1
- 150000003983 crown ethers Chemical class 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003426 co-catalyst Substances 0.000 abstract 1
- 229910001502 inorganic halide Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/08—Halides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0201—Oxygen-containing compounds
- B01J31/0204—Ethers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/44—Allylic alkylation, amination, alkoxylation or analogues
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/001—General concepts, e.g. reviews, relating to catalyst systems and methods of making them, the concept being defined by a common material or method/theory
- B01J2531/002—Materials
- B01J2531/007—Promoter-type Additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/90—Catalytic systems characterized by the solvent or solvent system used
- B01J2531/98—Phase-transfer catalysis in a mixed solvent system containing at least 2 immiscible solvents or solvent phases
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Pharmacology & Pharmacy (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un proceso para la alquilación de picolinamidas con cloroacilales sustituidos para producir una estructura de la Fórmula (III), en donde la reacción se realiza en la presencia de un catalizador de transferencia de fase y un cocatalizador de haluro inorgánico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562237844P | 2015-10-06 | 2015-10-06 | |
| PCT/US2016/055331 WO2017062362A1 (en) | 2015-10-06 | 2016-10-04 | Alkylation of picolinamides with substituted chloroacylals utilizing a crown ether catalyst |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018003875A true MX2018003875A (es) | 2018-08-16 |
Family
ID=58447241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018003875A MX2018003875A (es) | 2015-10-06 | 2016-10-04 | Alquilacion de picolinamidas con cloroacilales sustituidos con el uso de un catalizador de eter de corona. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10144728B2 (es) |
| EP (1) | EP3359153B1 (es) |
| JP (2) | JP6975142B2 (es) |
| KR (1) | KR102687147B1 (es) |
| CN (1) | CN108135890B (es) |
| AR (1) | AR106262A1 (es) |
| BR (1) | BR102016023198B8 (es) |
| CA (1) | CA3000198C (es) |
| CO (1) | CO2018003474A2 (es) |
| DK (1) | DK3359153T3 (es) |
| ES (1) | ES2858364T3 (es) |
| HU (1) | HUE052841T2 (es) |
| IL (1) | IL258386B (es) |
| LT (1) | LT3359153T (es) |
| MX (1) | MX2018003875A (es) |
| PL (1) | PL3359153T3 (es) |
| TW (1) | TWI718187B (es) |
| WO (1) | WO2017062362A1 (es) |
| ZA (1) | ZA201802085B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202146007A (zh) * | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司(alpelisib)與6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯啶-3-基]氧苯基]-8,9-二氫-7h-苯并[7]輪烯-2-羧酸之組合 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480762A (en) * | 1990-11-28 | 1996-01-02 | Fuji Photo Film Co., Ltd. | Method for preparing lithographic printing plate |
| AR037328A1 (es) * | 2001-10-23 | 2004-11-03 | Dow Agrosciences Llc | Compuesto de [7-bencil-2,6-dioxo-1,5-dioxonan-3-il]-4-metoxipiridin-2-carboxamida, composicion que lo comprende y metodo que lo utiliza |
| US6861930B2 (en) | 2001-11-15 | 2005-03-01 | Eaton Corporation | Transfer switch including a circuit breaker housing |
| US7091270B2 (en) * | 2002-01-31 | 2006-08-15 | Bromine Compounds Ltd. | Pentabromobenzyl alkyl ethers and their use as fire retardants |
| US20130060023A1 (en) | 2011-09-07 | 2013-03-07 | Satori Pharmaceuticals, Inc. | Compounds useful for treating neurodegenerative disorders |
| EP2847187A4 (en) * | 2012-05-07 | 2015-10-28 | Dow Agrosciences Llc | MACROCYCLIC PICOLINAMIDE AS FUNGICIDES |
| EP2875024A4 (en) * | 2012-07-20 | 2015-12-23 | Merck Sharp & Dohme | HIV TREATMENT WITH AMIDOSUBSTITUTED PYRIMIDINONE DERIVATIVES |
-
2016
- 2016-10-03 US US15/283,479 patent/US10144728B2/en active Active
- 2016-10-04 JP JP2018516450A patent/JP6975142B2/ja active Active
- 2016-10-04 PL PL16854170T patent/PL3359153T3/pl unknown
- 2016-10-04 CA CA3000198A patent/CA3000198C/en active Active
- 2016-10-04 KR KR1020187010623A patent/KR102687147B1/ko active Active
- 2016-10-04 LT LTEP16854170.4T patent/LT3359153T/lt unknown
- 2016-10-04 MX MX2018003875A patent/MX2018003875A/es unknown
- 2016-10-04 DK DK16854170.4T patent/DK3359153T3/da active
- 2016-10-04 HU HUE16854170A patent/HUE052841T2/hu unknown
- 2016-10-04 WO PCT/US2016/055331 patent/WO2017062362A1/en not_active Ceased
- 2016-10-04 CN CN201680056498.0A patent/CN108135890B/zh active Active
- 2016-10-04 EP EP16854170.4A patent/EP3359153B1/en active Active
- 2016-10-04 ES ES16854170T patent/ES2858364T3/es active Active
- 2016-10-05 AR ARP160103046A patent/AR106262A1/es active IP Right Grant
- 2016-10-05 TW TW105132240A patent/TWI718187B/zh active
- 2016-10-05 BR BR102016023198A patent/BR102016023198B8/pt active IP Right Grant
-
2018
- 2018-03-27 IL IL258386A patent/IL258386B/en active IP Right Grant
- 2018-03-28 ZA ZA2018/02085A patent/ZA201802085B/en unknown
- 2018-03-28 CO CONC2018/0003474A patent/CO2018003474A2/es unknown
-
2021
- 2021-08-11 JP JP2021131000A patent/JP2021185157A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI718187B (zh) | 2021-02-11 |
| CO2018003474A2 (es) | 2018-06-12 |
| LT3359153T (lt) | 2021-03-25 |
| JP2021185157A (ja) | 2021-12-09 |
| WO2017062362A9 (en) | 2017-12-28 |
| EP3359153A4 (en) | 2019-05-08 |
| TW201718560A (zh) | 2017-06-01 |
| BR102016023198B8 (pt) | 2022-09-06 |
| ES2858364T3 (es) | 2021-09-30 |
| CN108135890B (zh) | 2024-07-09 |
| WO2017062362A1 (en) | 2017-04-13 |
| EP3359153A1 (en) | 2018-08-15 |
| KR20180066101A (ko) | 2018-06-18 |
| CA3000198C (en) | 2024-02-27 |
| US20170096414A1 (en) | 2017-04-06 |
| ZA201802085B (en) | 2019-06-26 |
| AR106262A1 (es) | 2017-12-27 |
| EP3359153B1 (en) | 2020-12-16 |
| JP2018537407A (ja) | 2018-12-20 |
| BR102016023198B1 (pt) | 2021-06-22 |
| BR102016023198A2 (pt) | 2017-04-18 |
| HUE052841T2 (hu) | 2021-05-28 |
| CA3000198A1 (en) | 2017-04-13 |
| KR102687147B1 (ko) | 2024-07-24 |
| IL258386B (en) | 2021-02-28 |
| IL258386A (en) | 2018-05-31 |
| DK3359153T3 (da) | 2021-03-08 |
| US10144728B2 (en) | 2018-12-04 |
| PL3359153T3 (pl) | 2021-07-05 |
| JP6975142B2 (ja) | 2021-12-01 |
| CN108135890A (zh) | 2018-06-08 |
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