AR131186A2 - Proceso para producir derivado de diazabiciclooctano y su intermediario - Google Patents
Proceso para producir derivado de diazabiciclooctano y su intermediarioInfo
- Publication number
- AR131186A2 AR131186A2 ARP230103205A ARP230103205A AR131186A2 AR 131186 A2 AR131186 A2 AR 131186A2 AR P230103205 A ARP230103205 A AR P230103205A AR P230103205 A ARP230103205 A AR P230103205A AR 131186 A2 AR131186 A2 AR 131186A2
- Authority
- AR
- Argentina
- Prior art keywords
- producing
- diazabiciclooctone
- derivative
- isoindol
- dioxo
- Prior art date
Links
- -1 2,5-dioxopyrrolidin-1-yl Chemical group 0.000 abstract 4
- NFDXQGNDWIPXQL-UHFFFAOYSA-N 1-cyclooctyldiazocane Chemical class C1CCCCCCC1N1NCCCCCC1 NFDXQGNDWIPXQL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención proporciona un proceso para producir un derivado de diazabiciclooctano representado por la fórmula (IV) y sus intermediarios, Esquema (1), (en donde P es un grupo protector NH capaz de ser removido con ácido; R¹ es 2,5-dioxopirrolidin-1-ilo, 1,3-dioxo-3a,4,7,7a-tetrahidro-1H-isoindol-2(3H)-ilo, 1,3-dioxohexahidro-1H-isoindol-2(3H)-ilo o 3,5-dioxo-4-azatriciclo[5,2,1,0²,⁶]dec-8-en-4-ilo; R² es hidrógeno, ClCO- o Cl₃COCO-; R³ es alquilo C₁₋₆ o heterociclilo o forma un anillo heterocíclico de 3 a 7 miembros junto con el -O-NH- al que está unido; y OBn es benciloxi).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013197110 | 2013-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR131186A2 true AR131186A2 (es) | 2025-02-26 |
Family
ID=52743343
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140103525A AR097744A1 (es) | 2013-09-24 | 2014-09-24 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103209A AR131190A2 (es) | 2013-09-24 | 2023-11-28 | Derivado de diazabiciclooctano intermediario |
| ARP230103205A AR131186A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103208A AR131189A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103207A AR131188A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140103525A AR097744A1 (es) | 2013-09-24 | 2014-09-24 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103209A AR131190A2 (es) | 2013-09-24 | 2023-11-28 | Derivado de diazabiciclooctano intermediario |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230103208A AR131189A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103207A AR131188A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10000491B2 (es) |
| EP (1) | EP3050883B1 (es) |
| JP (1) | JP6453222B2 (es) |
| KR (1) | KR102239725B1 (es) |
| CN (2) | CN107501264A (es) |
| AR (5) | AR097744A1 (es) |
| AU (1) | AU2014324302B2 (es) |
| BR (1) | BR112016006246B8 (es) |
| CA (1) | CA2924953C (es) |
| DK (1) | DK3050883T3 (es) |
| ES (1) | ES2793201T3 (es) |
| HK (1) | HK1244487A1 (es) |
| HU (1) | HUE049027T2 (es) |
| IL (1) | IL244740B (es) |
| MX (2) | MX372585B (es) |
| MY (2) | MY193210A (es) |
| NZ (1) | NZ718009A (es) |
| RU (1) | RU2719480C2 (es) |
| SG (1) | SG11201602256UA (es) |
| TW (1) | TWI644908B (es) |
| WO (1) | WO2015046207A1 (es) |
| ZA (1) | ZA201602053B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2857401B8 (en) * | 2012-05-30 | 2019-11-20 | Meiji Seika Pharma Co., Ltd. | NOVEL ß-LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME |
| US10000491B2 (en) | 2013-09-24 | 2018-06-19 | Meiji Seika Pharma Co., Ltd. | Process for producing diazabicyclooctane derivative and intermediate thereof |
| NZ719568A (en) * | 2013-10-08 | 2018-06-29 | Meiji Seika Pharma Co Ltd | Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative |
| AU2015355970B2 (en) | 2014-12-05 | 2020-05-21 | Meiji Seika Pharma Co., Ltd. | Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation |
| CA2944306C (en) | 2015-10-30 | 2023-11-14 | The Toronto-Dominion Bank | Validating encrypted data from a multi-layer token |
| US11216808B2 (en) | 2015-11-04 | 2022-01-04 | The Toronto-Dominion Bank | Token-based system for excising data from databases |
| JP2020011901A (ja) * | 2016-10-20 | 2020-01-23 | 協和キリン株式会社 | ピロリジン化合物の製造方法 |
| CN106699756B (zh) * | 2016-12-30 | 2019-10-29 | 淄博鑫泉医药技术服务有限公司 | β内酰胺酶抑制剂阿维巴坦的合成方法 |
| CN111447924A (zh) | 2017-09-27 | 2020-07-24 | 费多拉制药公司 | 二氮杂二环辛烷衍生物的药物形式及其制备方法 |
| WO2019064071A1 (en) | 2017-09-27 | 2019-04-04 | F. Hoffmann-La Roche Ag | CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| WO2019064066A1 (en) | 2017-09-27 | 2019-04-04 | F. Hoffmann-La Roche Ag | PHARMACEUTICAL FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| CN109678856B (zh) * | 2017-10-18 | 2020-09-25 | 新发药业有限公司 | 一种阿维巴坦中间体的制备方法 |
| CN111373033A (zh) | 2017-11-23 | 2020-07-03 | 豪夫迈·罗氏有限公司 | 脯氨酸羟化酶及其相关用途、方法和产品 |
| US11957690B2 (en) | 2018-07-16 | 2024-04-16 | Brown University | Chromogenic beta-lactamase substrate |
| CN119707784A (zh) * | 2018-09-21 | 2025-03-28 | 株式会社Api | 氨基酸衍生物的制备方法 |
| US12195755B2 (en) | 2019-05-20 | 2025-01-14 | Brown University | Placental lipid bilayer for cell-free molecular interaction studies |
| US11751775B2 (en) | 2019-08-30 | 2023-09-12 | DePuy Synthes Products, Inc. | Electrical device for monitoring, prevention, and treatment of implant infections |
| US12509559B2 (en) | 2019-10-28 | 2025-12-30 | Brown University | Bacterial beta-lactamase responsive hydrogels |
| CN121021508A (zh) * | 2025-10-29 | 2025-11-28 | 北京耀诚惠仁科技有限公司 | β-内酰胺酶抑制剂中间体共晶或盐及其制备方法和应用 |
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| JP6023800B2 (ja) | 2011-06-17 | 2016-11-09 | アストラゼネカ アクチボラグ | ｔｒａｎｓ−７−オキソ−６−（スルホオキシ）−１，６−ジアザビシクロ［３，２，１］オクタン−２−カルボキサミドとその塩が含まれる複素環式化合物を製造するための方法 |
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| PT2872510T (pt) | 2011-08-30 | 2017-03-01 | Wockhardt Ltd | Derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infeções bacterianas |
| AU2012310136B2 (en) | 2011-09-13 | 2016-07-07 | Wockhardt Limited | Nitrogen containing compounds and their use |
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| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| EP2857401B8 (en) | 2012-05-30 | 2019-11-20 | Meiji Seika Pharma Co., Ltd. | NOVEL ß-LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME |
| US10000491B2 (en) | 2013-09-24 | 2018-06-19 | Meiji Seika Pharma Co., Ltd. | Process for producing diazabicyclooctane derivative and intermediate thereof |
| NZ719568A (en) | 2013-10-08 | 2018-06-29 | Meiji Seika Pharma Co Ltd | Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative |
-
2014
- 2014-09-24 US US15/023,976 patent/US10000491B2/en active Active
- 2014-09-24 WO PCT/JP2014/075203 patent/WO2015046207A1/ja not_active Ceased
- 2014-09-24 EP EP14847854.8A patent/EP3050883B1/en active Active
- 2014-09-24 ES ES14847854T patent/ES2793201T3/es active Active
- 2014-09-24 DK DK14847854.8T patent/DK3050883T3/da active
- 2014-09-24 BR BR112016006246A patent/BR112016006246B8/pt active IP Right Grant
- 2014-09-24 MY MYPI2019004461A patent/MY193210A/en unknown
- 2014-09-24 CA CA2924953A patent/CA2924953C/en active Active
- 2014-09-24 SG SG11201602256UA patent/SG11201602256UA/en unknown
- 2014-09-24 TW TW103132937A patent/TWI644908B/zh active
- 2014-09-24 MX MX2019006550A patent/MX372585B/es unknown
- 2014-09-24 MY MYPI2016700980A patent/MY176278A/en unknown
- 2014-09-24 MX MX2016003867A patent/MX367578B/es active IP Right Grant
- 2014-09-24 NZ NZ718009A patent/NZ718009A/en unknown
- 2014-09-24 HU HUE14847854A patent/HUE049027T2/hu unknown
- 2014-09-24 AU AU2014324302A patent/AU2014324302B2/en active Active
- 2014-09-24 JP JP2015539238A patent/JP6453222B2/ja active Active
- 2014-09-24 CN CN201710665418.8A patent/CN107501264A/zh active Pending
- 2014-09-24 RU RU2016115767A patent/RU2719480C2/ru active
- 2014-09-24 CN CN201480052097.9A patent/CN105555787B/zh active Active
- 2014-09-24 AR ARP140103525A patent/AR097744A1/es active IP Right Grant
- 2014-09-24 KR KR1020167009769A patent/KR102239725B1/ko active Active
-
2016
- 2016-03-23 IL IL244740A patent/IL244740B/en active IP Right Grant
- 2016-03-29 ZA ZA2016/02053A patent/ZA201602053B/en unknown
- 2016-06-24 HK HK18103950.2A patent/HK1244487A1/zh unknown
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2017
- 2017-06-05 US US15/613,620 patent/US10000492B2/en active Active
-
2023
- 2023-11-28 AR ARP230103209A patent/AR131190A2/es unknown
- 2023-11-28 AR ARP230103205A patent/AR131186A2/es unknown
- 2023-11-28 AR ARP230103208A patent/AR131189A2/es unknown
- 2023-11-28 AR ARP230103207A patent/AR131188A2/es unknown
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