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AR093921A1 - Derivados de indol carboxamida como antagonistas del receptor p2x7 - Google Patents

Derivados de indol carboxamida como antagonistas del receptor p2x7

Info

Publication number
AR093921A1
AR093921A1 ARP130104631A ARP130104631A AR093921A1 AR 093921 A1 AR093921 A1 AR 093921A1 AR P130104631 A ARP130104631 A AR P130104631A AR P130104631 A ARP130104631 A AR P130104631A AR 093921 A1 AR093921 A1 AR 093921A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
cycloalkyl
halogen
mono
Prior art date
Application number
ARP130104631A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR093921A1 publication Critical patent/AR093921A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P35/00—Antineoplastic agents
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
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  • Biomedical Technology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
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  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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Abstract

A su preparación y a su uso como compuestos farmacéuticamente activos. Reivindicación 1: Un compuesto de fórmula (1), en donde R¹ representa un grupo heteroarilo o arilo, donde los grupos están independientemente no sustituidos, mono-, di- o tri-sustituidos, en donde los sustituyentes están independientemente seleccionados del grupo que consiste en alquilo C₁₋₄, cicloalquilo C₃₋₆, alcoxi C₁₋₄, fluoroalquilo C₁₋₃, fluoroalcoxi C₁₋₃, hidroxi, halógeno y fenoxi; R² representa heterociclilo, el cual está insustituido, mono- o di-sustituido, en donde los sustituyentes se seleccionan independientemente de alquilo C₁₋₄, alquilcarbonilo C₁₋₄, alcoxicarbonilo C₁₋₄, alquilsulfonilo C₁₋₄ y halógeno; heterocicliloxi; cicloalquilo C₃₋₆, el cual está insustituido o mono- o di-sustituido con halógeno; cicloalquiloxi C₃₋₆; N-cicloalquil C₃₋₆-amino; N-cicloalquil C₃₋₆-metil-amino; alquilo C₃₋₆; alcoxi C₂₋₆; N-alquilamino C₁₋₄; N,N-di-[alquil C₁₋₄]-amino; o N-arilmetil-N-alquil C₁₋₄-amino; R³ representa hidrógeno o halógeno; R⁴ representa hidrógeno, fluoro, cloro, alquilo C₁₋₄, alcoxi C₁₋₄, alquil C₁₋₄-carbonilo, hidroxi-alquilo C₁₋₄, hidroxi-alcoxi C₂₋₄, alcoxi C₁₋₂-alquilo C₁₋₄ o alcoxi C₁₋₄-alcoxi C₂₋₄; R⁵ representa hidrógeno o alquilo C₁₋₄; y R⁶ representa fluoro, cloro, metilo, etilo o fluoroalquilo C₁₋₂; o una sal de dicho compuesto.
ARP130104631A 2012-12-12 2013-12-11 Derivados de indol carboxamida como antagonistas del receptor p2x7 AR093921A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12196711 2012-12-12

Publications (1)

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AR093921A1 true AR093921A1 (es) 2015-06-24

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US (1) US9718774B2 (es)
EP (1) EP2931717B1 (es)
JP (1) JP6295269B2 (es)
KR (1) KR102232742B1 (es)
CN (1) CN104812749B (es)
AR (1) AR093921A1 (es)
AU (1) AU2013356850B2 (es)
BR (1) BR112015013463B1 (es)
CA (1) CA2890886C (es)
CL (1) CL2015001529A1 (es)
EA (1) EA029644B1 (es)
ES (1) ES2618056T3 (es)
IL (1) IL239295A0 (es)
MA (1) MA38192B1 (es)
MX (1) MX368044B (es)
PH (1) PH12015501339A1 (es)
PL (1) PL2931717T3 (es)
SG (1) SG11201504369SA (es)
TW (1) TWI612034B (es)
WO (1) WO2014091415A1 (es)
ZA (1) ZA201504974B (es)

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BR112015013463A2 (pt) 2017-11-14
IL239295A0 (en) 2015-07-30
ZA201504974B (en) 2017-11-29
EP2931717B1 (en) 2016-12-07
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MX368044B (es) 2019-09-17
EA029644B1 (ru) 2018-04-30
PH12015501339A1 (en) 2015-09-02
CA2890886A1 (en) 2014-06-19
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