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AR093106A1 - Silicato de zirconio microporoso para el tratamiento de la hipercalemia - Google Patents

Silicato de zirconio microporoso para el tratamiento de la hipercalemia

Info

Publication number
AR093106A1
AR093106A1 ARP130103842A ARP130103842A AR093106A1 AR 093106 A1 AR093106 A1 AR 093106A1 AR P130103842 A ARP130103842 A AR P130103842A AR P130103842 A ARP130103842 A AR P130103842A AR 093106 A1 AR093106 A1 AR 093106A1
Authority
AR
Argentina
Prior art keywords
ion
value
zirconium silicate
microporous
mixtures
Prior art date
Application number
ARP130103842A
Other languages
English (en)
Inventor
F Guillem Alvaro
Jeffrey Keyser Donald
Original Assignee
Zs Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50485556&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR093106(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zs Pharma Inc filed Critical Zs Pharma Inc
Publication of AR093106A1 publication Critical patent/AR093106A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/0013—Controlling the temperature of the process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B01J19/006—Baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/02—Processes using inorganic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/14—Base exchange silicates, e.g. zeolites
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/20—Silicates
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/025—Silicon compounds without C-silicon linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00054—Controlling or regulating the heat exchange system
    • B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
    • B01J2219/00058—Temperature measurement
    • B01J2219/00063—Temperature measurement of the reactants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00094—Jackets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00761—Details of the reactor
    • B01J2219/00763—Baffles
    • B01J2219/00765—Baffles attached to the reactor wall
    • B01J2219/00768—Baffles attached to the reactor wall vertical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Geology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Combustion & Propulsion (AREA)

Abstract

Composiciones de silicato de zirconio microporoso formuladas para eliminar toxinas, por ejemplo, iones de potasio, del tracto gastrointestinal a una velocidad elevada sin causar efectos secundarios indeseados. Las formulaciones preferidas están diseñadas para evitar un aumento del pH de la orina en pacientes y/o evitar la entrada potencial de partículas en el torrente sanguíneo del paciente. Reivindicación 1: Una composición de silicato de zirconio que comprende un silicato de zirconio de la fórmula (1): AₚMˣZr₁₋ˣSiₙGeʸOₘ (1) caracterizada porque A es un ión de potasio, un ión de sodio, un ión de rubidio, un ión de cesio, un ión de calcio, un ión de magnesio, un ión de hidronio o mezclas de los mismos; M es al menos un metal del marco, en donde el metal del marco es hafnio (4⁺), estaño (4⁺), niobio (5⁺), titanio (4⁺), cerio (4⁺), germanio (4⁺), praseodimio (4⁺), terbio (4⁺) o mezclas de los mismos; p tiene un valor de entre aproximadamente 1 y aproximadamente 20; x tiene un valor de entre 0 y menos que 1; n tiene un valor de entre aproximadamente 0 y aproximadamente 12; y tiene un valor de entre 0 y aproximadamente 12; m tiene un valor de entre aproximadamente 3 y aproximadamente 36 y 1 £ n + y £ 12, en donde la composición comprende ZS-9 y ZS-7 y carece de cantidades detectables de ZS-8.
ARP130103842A 2012-10-22 2013-10-23 Silicato de zirconio microporoso para el tratamiento de la hipercalemia AR093106A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261716956P 2012-10-22 2012-10-22
US201361800182P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
AR093106A1 true AR093106A1 (es) 2015-05-20

Family

ID=50485556

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130103842A AR093106A1 (es) 2012-10-22 2013-10-23 Silicato de zirconio microporoso para el tratamiento de la hipercalemia

Country Status (23)

Country Link
US (2) US8877255B2 (es)
EP (1) EP2882444B1 (es)
JP (1) JP6423795B2 (es)
KR (1) KR102184602B1 (es)
CN (1) CN104797263B (es)
AR (1) AR093106A1 (es)
AU (2) AU2013334776B2 (es)
BR (1) BR112015008962B1 (es)
CA (1) CA2891053C (es)
CL (1) CL2015001014A1 (es)
DK (1) DK2882444T3 (es)
ES (1) ES3053035T3 (es)
FI (1) FI2882444T3 (es)
HR (1) HRP20251373T1 (es)
IL (1) IL237905A (es)
LT (1) LT2882444T (es)
MX (1) MX360684B (es)
PH (1) PH12015500849B1 (es)
PT (1) PT2882444T (es)
RS (1) RS67365B1 (es)
SM (1) SMT202500409T1 (es)
WO (1) WO2014066407A1 (es)
ZA (1) ZA201502186B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60335794D1 (de) 2002-03-29 2011-03-03 Xoma Technology Ltd Multigene vectoren und methoden für eine erhöhte expression von rekombinanten polypeptiden
AU2012214224B2 (en) 2011-02-11 2016-03-17 Zs Pharma, Inc Microporous zirconium silicate for the treatment of hyperkalemia
US9943637B2 (en) 2012-06-11 2018-04-17 ZS Pharma, Inc. Microporous zirconium silicate and its method of production
CA2878832A1 (en) 2012-07-11 2014-01-16 ZS Pharma, Inc. Microporous zirconium silicate for the treatment of hyperkalemia in hypercalcemic patients and improved calcium-containing compositions for the treatment of hyperkalemia
US10695365B2 (en) 2012-10-22 2020-06-30 ZS Pharma, Inc. Microporous zirconium silicate for the treatment of hyperkalemia
RS67365B1 (sr) 2012-10-22 2025-11-28 Zs Pharma Inc Mikroporozni cirkonijum silikat za lečenje hiperkalemije
AU2014248081B2 (en) * 2013-04-05 2019-02-28 ZS Pharma, Inc. Microporous zirconium silicate and diuretics for the reduction of potassium and treatment of chronic kidney and/or chronic heart disease
KR102332954B1 (ko) * 2013-11-08 2021-11-29 제트에스 파마, 인코포레이티드 고칼륨혈증의 치료를 위한 미세다공성 규산지르코늄
US20160038538A1 (en) * 2013-11-08 2016-02-11 ZS Pharma, Inc. Microporous zirconium silicate for the treatment of hyperkalemia
US9592253B1 (en) 2015-10-14 2017-03-14 ZS Pharma, Inc. Extended use zirconium silicate compositions and methods of use thereof
CN117137944A (zh) 2019-03-13 2023-12-01 阿斯利康(瑞典)有限公司 用于血液透析患者中使用的钾结合剂
WO2020198124A1 (en) 2019-03-23 2020-10-01 Muller Dyllan Christopher Device for ion capture
US11964266B2 (en) 2019-07-09 2024-04-23 Uop Llc Process for removing cobalt, lead, cadmium and chromium ions from bodily fluids using metallate ion exchange compositions
US11484875B2 (en) 2019-07-09 2022-11-01 Uop Llc Process for removing mercury ions from bodily fluids using titanium metallate ion exchange compositions
US11577014B2 (en) 2019-07-09 2023-02-14 Uop Llc Process for removing strontium ions from bodily fluids using metallate ion exchange compositions
US12036528B2 (en) 2020-09-30 2024-07-16 Uop Llc Process for removing lead ions from boldily fluids using metallate ion exchange compositions
CN118439624B (zh) * 2024-04-15 2025-01-24 时森海(杭州)医药科技有限公司 一种锆硅酸钠水合物及其制备方法
CN119643609A (zh) * 2025-02-17 2025-03-18 北京华睿鼎信科技有限公司 一种晶相杂质的分析方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3329480A (en) 1963-10-18 1967-07-04 Union Oil Co Crystalline zircono-silicate zeolites
US3947279A (en) 1971-12-23 1976-03-30 Owens-Illinois, Inc. Thermally crystallizable glasses possessing precision controlled crystallization and flow properties and process of producing same
US4581141A (en) 1978-02-27 1986-04-08 Purdue Research Foundation Dialysis material and method for removing uremic substances
FR2444005A1 (fr) 1978-12-15 1980-07-11 Ugine Kuhlmann Procede industriel de fabrication en semi-continu de zeolithe a
US4943545A (en) 1987-06-08 1990-07-24 Mobil Oil Corporation Activation of zeolites
US5032556A (en) 1989-02-21 1991-07-16 Tosoh Corporation Preparation method for zircon powder
US5015453A (en) 1989-04-28 1991-05-14 W. R. Grace & Co.-Conn. Crystalline group IVA metal-containing molecular sieve compositions
JP3265344B2 (ja) 1990-03-16 2002-03-11 東ソー株式会社 ジルコン粉末の合成法
US5338527A (en) 1992-08-20 1994-08-16 Uop Zirconium silicate composition, method of preparation and uses thereof
WO1994010087A1 (en) 1992-10-28 1994-05-11 Crosfield Limited Silicas
US5518707A (en) 1994-10-24 1996-05-21 Uop Metallo germanates
GB9601398D0 (en) 1996-01-24 1996-03-27 Piper Edwina M Composition
WO1998052239A1 (fr) 1997-03-12 1998-11-19 Japan As Represented By Director General Of Agency Of Industrial Science And Technology Separateur pour accumulateur et accumulateur electrique alcalin l'utilisant
IT1283284B1 (it) 1996-03-21 1998-04-16 Eniricerche Spa Zeolite ers-10 e procedimento per la sua preparazione
FR2750893B1 (fr) 1996-07-12 1998-10-30 Elf Aquitaine Procede de synthese de zeolithe avec agitation homogene du milieu, dispositif et application
CA2214495C (en) 1996-09-25 2002-02-05 Daniel L. Woodard Hydrated zirconium silicate composition for purification of nucleic acids
US5891417A (en) * 1997-04-08 1999-04-06 Uop Llc Zirconium silicate and zirconium germanate molecular sieves and process using the same
US5888472A (en) 1997-04-08 1999-03-30 Uop Llc Zirconium silicate molecular sieves and process using the same
US6007790A (en) 1998-08-13 1999-12-28 Uop Llc Family of microporous indium silicate compositions
EP1038580B1 (en) 1999-03-26 2005-05-25 Uop Llc Ammonium ion adsorption process using zirconium silicate and zirconium germanate molecular sieves
US6099737A (en) 1999-03-29 2000-08-08 Uop Llc Process for removing toxins from blood using zirconium metallate or titanium metallate compositions
US6332985B1 (en) 1999-03-29 2001-12-25 Uop Llc Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions
US7041274B2 (en) 1999-10-22 2006-05-09 Intevep, S.A. Aluminosilicate compositions, preparation and use
US20020061521A1 (en) 2000-01-31 2002-05-23 Rosen Craig A. Nucleic acids, proteins, and antibodies
US6379641B1 (en) 2000-05-01 2002-04-30 Uop Llc Microporous rare earth silicates and method of producing same
US6596254B1 (en) 2000-06-12 2003-07-22 Sandia Corporation Niobate-based octahedral molecular sieves
AU2000260501A1 (en) * 2000-07-12 2002-01-21 Uop Llc Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions
WO2002062356A2 (en) 2001-02-06 2002-08-15 Ash Medical Systems, Inc. Monovalent-selective cation exchangers as oral sorbent therapy
US6579460B1 (en) 2001-03-13 2003-06-17 Uop Llc Process and composition for removing toxins from bodily fluids
US6814871B1 (en) 2001-07-13 2004-11-09 Uop Llc Process for removing pollutants from aqueous streams
US6689335B1 (en) 2002-12-19 2004-02-10 Eastman Kodak Company Silver ion sequester and release agent
US6984403B2 (en) 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
EP1695760B1 (en) 2003-12-15 2020-01-01 Asahi Kasei Kabushiki Kaisha Porous formed article and method for production thereof
US7556799B2 (en) 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
US8192758B2 (en) 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
US8282960B2 (en) 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
US7854924B2 (en) 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
MXPA06011270A (es) 2004-03-30 2007-03-08 Ilypsa Inc Composiciones fijadoras de iones.
CA2593525C (en) 2004-12-28 2011-05-10 Renal Solutions, Inc. Method of synthesizing zirconium phosphate particles
US7967984B2 (en) 2005-06-14 2011-06-28 Asahi Kasei Chemicals Corporation Apparatus for water treatment and method of treating water
WO2007041569A1 (en) 2005-09-30 2007-04-12 Ilypsa, Inc. Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
CA2624112A1 (en) 2005-09-30 2007-04-05 Ilypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
US8367112B2 (en) 2006-02-28 2013-02-05 Alkermes Pharma Ireland Limited Nanoparticulate carverdilol formulations
WO2007127390A2 (en) 2006-04-28 2007-11-08 Biolife, L.L.C. Materials and methods for wound treatment
WO2008070072A2 (en) 2006-12-01 2008-06-12 Mutual Pharmaceutical Company, Inc. Carvedilol forms, compositions, and methods of preparation thereof
EP2079660B1 (en) 2007-01-03 2017-01-11 Insilico Co., Ltd. Coordination polymer crystal with porous metal-organic frameworks and preperation method thereof
ES2304890B1 (es) 2007-04-03 2009-10-30 Universidad De Zaragoza Procedimiento de obtencion de esferas de titanosilicato.
DE202009018699U1 (de) 2008-02-26 2012-11-20 Corning Incorporated Läutermittel für Silikatgläser
WO2010022381A1 (en) 2008-08-22 2010-02-25 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
US20110097401A1 (en) 2009-06-12 2011-04-28 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
US8865121B2 (en) 2009-06-18 2014-10-21 Basf Se Organotemplate-free synthetic process for the production of a zeolitic material
US20120070468A1 (en) 2010-09-16 2012-03-22 Uop Llc Removal of toxins from gastrointestinal fluids
AU2012214224B2 (en) 2011-02-11 2016-03-17 Zs Pharma, Inc Microporous zirconium silicate for the treatment of hyperkalemia
JP5982469B2 (ja) 2011-04-08 2016-08-31 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ アシル化触媒の製造方法
US10092688B2 (en) 2011-05-13 2018-10-09 Laura Jean Robinson Medicament kit and method of use
US9527751B2 (en) 2011-11-11 2016-12-27 Basf Se Organotemplate-free synthetic process for the production of a zeolitic material of the CHA-type structure
US20130202524A1 (en) 2012-02-06 2013-08-08 Basf Se Iron- And Copper-Containing Zeolite Beta From Organotemplate-Free Synthesis And Use Thereof In The Selective Catalytic Reduction Of NOx
US9475041B2 (en) 2012-04-24 2016-10-25 Basf Se Zeolitic materials and methods for their preparation using alkenyltrialkylammonium compounds
US9943637B2 (en) 2012-06-11 2018-04-17 ZS Pharma, Inc. Microporous zirconium silicate and its method of production
RS67365B1 (sr) 2012-10-22 2025-11-28 Zs Pharma Inc Mikroporozni cirkonijum silikat za lečenje hiperkalemije

Also Published As

Publication number Publication date
US9913860B2 (en) 2018-03-13
US20150250821A1 (en) 2015-09-10
ZA201502186B (en) 2016-01-27
KR102184602B1 (ko) 2020-11-30
CN104797263B (zh) 2018-02-09
KR20150074053A (ko) 2015-07-01
US20140113002A1 (en) 2014-04-24
AU2013334776A1 (en) 2015-05-07
BR112015008962B1 (pt) 2021-09-21
AU2017251722A1 (en) 2017-11-09
IL237905A (en) 2017-12-31
EP2882444A4 (en) 2016-03-02
CA2891053C (en) 2020-12-01
RS67365B1 (sr) 2025-11-28
BR112015008962A2 (pt) 2017-07-04
MX2015005104A (es) 2015-07-17
AU2013334776B2 (en) 2017-08-31
SMT202500409T1 (it) 2025-11-10
PT2882444T (pt) 2025-11-21
LT2882444T (lt) 2025-11-10
HRP20251373T1 (hr) 2025-12-19
ES3053035T3 (en) 2026-01-16
JP2016505510A (ja) 2016-02-25
EP2882444A1 (en) 2015-06-17
JP6423795B2 (ja) 2018-11-14
PH12015500849B1 (en) 2017-09-06
WO2014066407A1 (en) 2014-05-01
CA2891053A1 (en) 2014-05-01
HK1211494A1 (en) 2016-05-27
MX360684B (es) 2018-11-13
PH12015500849A1 (en) 2015-06-22
FI2882444T3 (fi) 2025-11-05
EP2882444B1 (en) 2025-09-17
US8877255B2 (en) 2014-11-04
DK2882444T3 (da) 2025-11-03
CN104797263A (zh) 2015-07-22
CL2015001014A1 (es) 2015-08-28

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