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AR096015A1 - Conjugados de fármacos con anticuerpos - Google Patents

Conjugados de fármacos con anticuerpos

Info

Publication number
AR096015A1
AR096015A1 ARP140100924A ARP140100924A AR096015A1 AR 096015 A1 AR096015 A1 AR 096015A1 AR P140100924 A ARP140100924 A AR P140100924A AR P140100924 A ARP140100924 A AR P140100924A AR 096015 A1 AR096015 A1 AR 096015A1
Authority
AR
Argentina
Prior art keywords
antibodies
conjugates
drugs
fgfr4
integer
Prior art date
Application number
ARP140100924A
Other languages
English (en)
Inventor
Petropoulos Konstantin
Hu Tiancen
Jenkins David
Bryant Fallecido Batt David
Mosher Rebecca
Haubst Nicole
Toksoz Engin
John Meyer Matthew
Ettenberg Seth
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR096015A1 publication Critical patent/AR096015A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/3023—Lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/565—Complementarity determining region [CDR]
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Abstract

La presente se relaciona con anticuerpos contra los factores de crecimiento de fibroblastos 2 y 4 (anti-FGFR2 y FGFR4), fragmentos de anticuerpos, conjugados de fármacos con anticuerpos, y sus usos para el tratamiento del cáncer. Reivindicación 1: Un conjugado de fármacos con anticuerpos de la fórmula: Ab-(L-(D)ₘ)ₙ en donde Ab es un anticuerpo o fragmento de unión a antígeno del mismo que se une específicamente a ambos FGFR2 y FGFR4 humanos; L es un enlazador; D es una fracción farmacológica; m es un entero de 1 a 8; y n es un entero de 1 a 10.
ARP140100924A 2013-03-13 2014-03-13 Conjugados de fármacos con anticuerpos AR096015A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361780299P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
AR096015A1 true AR096015A1 (es) 2015-12-02

Family

ID=50897870

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140100924A AR096015A1 (es) 2013-03-13 2014-03-13 Conjugados de fármacos con anticuerpos

Country Status (14)

Country Link
US (2) US9498532B2 (es)
EP (1) EP2968592A2 (es)
JP (2) JP2016518332A (es)
KR (1) KR20150130333A (es)
CN (1) CN105188763B (es)
AR (1) AR096015A1 (es)
AU (2) AU2014244060B2 (es)
BR (1) BR112015023418A8 (es)
CA (1) CA2904090A1 (es)
EA (1) EA201591611A1 (es)
MX (1) MX2015012122A (es)
TW (1) TW201444574A (es)
UY (1) UY35399A (es)
WO (1) WO2014160160A2 (es)

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US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9415118B2 (en) * 2013-03-13 2016-08-16 Novartis Ag Antibody drug conjugates
JP6449244B2 (ja) 2013-04-19 2019-01-09 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｆｇｆｒ抑制剤としての二環式複素環
PE20210949A1 (es) 2013-08-01 2021-05-24 Five Prime Therapeutics Inc Anticuerpos anti-fgfr2iiib afucosilados
TWI541022B (zh) * 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
CA2974651A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
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AU2017202150A1 (en) 2017-04-20
CA2904090A1 (en) 2014-10-02
MX2015012122A (es) 2016-11-08
WO2014160160A3 (en) 2015-01-08
TW201444574A (zh) 2014-12-01
US9498532B2 (en) 2016-11-22
EA201591611A1 (ru) 2016-03-31
AU2017202150B2 (en) 2018-12-20
UY35399A (es) 2014-10-31
CN105188763B (zh) 2019-02-19
BR112015023418A8 (pt) 2018-01-23
WO2014160160A2 (en) 2014-10-02
BR112015023418A2 (pt) 2017-11-28
US20140301946A1 (en) 2014-10-09
CN105188763A (zh) 2015-12-23
US20170106095A1 (en) 2017-04-20
AU2014244060A1 (en) 2015-10-01
JP2019193626A (ja) 2019-11-07
AU2014244060B2 (en) 2017-04-20
KR20150130333A (ko) 2015-11-23
EP2968592A2 (en) 2016-01-20

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