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AR081797A1 - Derivados de pirrolidinona heteroaromaticas fusionadas, composiciones farmaceuticas que las contienen y uso de las mismas para tratar afecciones del sistema inmune y la inflamacion - Google Patents

Derivados de pirrolidinona heteroaromaticas fusionadas, composiciones farmaceuticas que las contienen y uso de las mismas para tratar afecciones del sistema inmune y la inflamacion

Info

Publication number
AR081797A1
AR081797A1 ARP100104923A AR081797A1 AR 081797 A1 AR081797 A1 AR 081797A1 AR P100104923 A ARP100104923 A AR P100104923A AR 081797 A1 AR081797 A1 AR 081797A1
Authority
AR
Argentina
Prior art keywords
independently selected
alkyl
inflammation
heteroaryl
halo
Prior art date
Application number
Other languages
English (en)
Inventor
Yasuyoshi Arikawa
Victoria Feher
Betty Lam
Zhe Nie
Qing Dong
Benjamin Jones
Christopher Smith
Masashi Takahashi
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43618073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR081797(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR081797A1 publication Critical patent/AR081797A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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  • Otolaryngology (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula (1), o su sal aceptable para uso farmacéutico, donde: G se selecciona de N y C(R5); L1 y L2 se seleccionan cada uno de ellos independientemente de NH y un enlace; R1 y R2 se seleccionan cada uno de ellos independientemente de hidrógeno, halo, alquilo C1-3, y haloalquilo C1-3, o R1 y R2, junto con el átomo al cual están unidos, forman un cicloalquilo C3-6; R3 se selecciona de alquilo C2-6, cicloalquilo C3-8, heterocicloalquilo C2-5, y heteroarilo C1-9, cada uno opcionalmente sustituido con uno a cinco sustituyentes independientemente seleccionados de halo, oxo, -NO2, -CN, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, haloalquenilo C2-6, haloalquinilo C2-6, R6, y R7; R4 se selecciona de cicloalquilo C3-8, heterociclilo C2-5, arilo C6-14 y heteroarilo C1-9, cada uno opcionalmente sustituido con uno a cinco sustituyentes independientemente seleccionados de halo, oxo, -CN, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, haloalquenilo C2-6, haloalquinilo C2-6, R6, y R7; R5 se selecciona de hidrógeno, halo, OH, CN, alquilo C1-4, heterociclilo C2-5, heteroarilo C1-5, y R6, donde el resto heterociclilo tiene 3 a 6 átomos del anillo y el resto heteroarilo tiene 5 ó 6 átomos del anillo, y los restos heterociclilo y heteroarilo están cada uno de ellos opcionalmente sustituidos con uno a cuatro sustituyentes seleccionados independientemente de halo, NO2, -CN, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, haloalquilo C1-4, haloalquenilo C2-4, haloalquinilo C2-4, R6, y R7; cada R6 se selecciona independientemente de OR7, -N(R7)R8, -NR7C(O)R8, -C(O)R7, -C(O)OR7, -C(O)N(R7)R8, -C(O)N(R7)OR8, -C(O)N(R7)S(O)2R8, -N(R7)S(O)2R8, -S(O)nR7, y -S(O)2N(R7)R8; cada R7 y R8 se selecciona independientemente de hidrogeno o de alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6-(CH2)m-, aril C6-14-(CH2)m-, heterociclilo C2-5-(CH2)m-, y heteroaril C1-9-(CH2)m-, cada uno de ellos opcionalmente sustituido con uno a cinco sustituyentes independientemente seleccionados de halo, oxo, NO2, -CN, alquilo C1-6, haloalquilo C1-6 y R9; cada R9 se selecciona independientemente de OR10, -N(R10)R11, -N(R10)C(O)R11, -C(O)R10, -C(O)OR10, -C(O)N(R10)R11, -C(O)N(R7)OR8, -C(O)N(R10)S(O)2R11, -NR10S(O)2R11, -S(O)nR10, y -S(O)2N(R10)R11; cada R10 y R11 se selecciona independientemente de hidrógeno y alquilo C1-6; cada n se selecciona independientemente de 0, 1 y 2; y cada m se selecciona independientemente de 0, 1, 2, 3, y 4; donde cada uno de los restos heteroarilo antes mencionados tiene uno a cuatro heteroátomos seleccionados independientemente de N, O, y S, y cada uno de los restos heterociclilo antes mencionados está saturado o parcialmente insaturado y tiene uno o dos heteroátomos independientemente seleccionados de N, O y S.
ARP100104923 2009-12-23 2010-12-22 Derivados de pirrolidinona heteroaromaticas fusionadas, composiciones farmaceuticas que las contienen y uso de las mismas para tratar afecciones del sistema inmune y la inflamacion AR081797A1 (es)

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