AR084915A1 - Proceso para la preparacion de amidas del acido pirazol carboxilico - Google Patents
Proceso para la preparacion de amidas del acido pirazol carboxilicoInfo
- Publication number
- AR084915A1 AR084915A1 ARP120100211A ARP120100211A AR084915A1 AR 084915 A1 AR084915 A1 AR 084915A1 AR P120100211 A ARP120100211 A AR P120100211A AR P120100211 A ARP120100211 A AR P120100211A AR 084915 A1 AR084915 A1 AR 084915A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- oxygen
- compound
- sulfide
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 9
- 239000001301 oxygen Substances 0.000 abstract 9
- 229910052760 oxygen Inorganic materials 0.000 abstract 9
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 7
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical group [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 5
- 239000000460 chlorine Substances 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 3
- 125000004784 trichloromethoxy group Chemical group ClC(O*)(Cl)Cl 0.000 abstract 3
- RLOHOBNEYHBZID-UHFFFAOYSA-N 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid Chemical compound CN1C=C(C(O)=O)C(C(F)F)=N1 RLOHOBNEYHBZID-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/56—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/62—Oximes having oxygen atoms of oxyimino groups esterified
- C07C251/64—Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
- C07C329/04—Esters of monothiocarbonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente se relaciona con un proceso de preparación de ácido 3-difluorometil-1-metil-1H-pirazol-4-carboxílico (9-diclorometileno-1,2,3,4-tetrahidro-1,4-metano-naftaleno-5-il)-amida mediante la acilación del oxígeno de la oxima del compuesto de fórmula (1), en presencia de un solvente y de un agente de acilación de la fórmula: R1-C(X)-Cl; donde X es oxígeno o sulfuro; R1 es cloro si X es oxígeno o sulfuro; o R1 es alcoxi C1-6, CH3-C(=CH2)-O-, fenoxi o triclorometoxi si X es oxígeno; y a) si R1 es cloro y el compuesto de fórmula: R1-C(X)-Cl se agregó al compuesto de fórmula (1); en el que se hace reaccionar el producto obtenido de la fórmula (2) donde X es oxígeno o sulfuro, con el compuesto de fórmula (3); o b) si R1 es cloro y el compuesto de fórmula (1) se agregó al compuesto de fórmula: R1-C(X)-Cl; o R1 es alcoxi C1-6, CH3-C(=CH2)-O-, fenoxi o triclorometoxi si X es oxígeno; en el que se hace reaccionar el producto obtenido de la fórmula (4), donde X es oxígeno o sulfuro; R1 es cloro si X es oxígeno o sulfuro; o R1 es alcoxi C1-6, CH3-C(=CH2)-O-, fenoxi o triclorometoxi si X es oxígeno, con el compuesto de fórmula (3).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11151965 | 2011-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084915A1 true AR084915A1 (es) | 2013-07-10 |
Family
ID=45524566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100211A AR084915A1 (es) | 2011-01-25 | 2012-01-23 | Proceso para la preparacion de amidas del acido pirazol carboxilico |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8895757B2 (es) |
| EP (1) | EP2668166B1 (es) |
| JP (2) | JP6133788B2 (es) |
| KR (1) | KR101851781B1 (es) |
| CN (1) | CN103339113B (es) |
| AR (1) | AR084915A1 (es) |
| AU (1) | AU2012210547B2 (es) |
| BR (1) | BR112013018533A2 (es) |
| CA (1) | CA2824730C (es) |
| CO (1) | CO6751253A2 (es) |
| ES (1) | ES2540211T3 (es) |
| HR (1) | HRP20150658T1 (es) |
| IL (1) | IL227317A (es) |
| MX (1) | MX352697B (es) |
| PL (1) | PL2668166T3 (es) |
| PT (1) | PT2668166E (es) |
| TW (1) | TWI534126B (es) |
| UY (1) | UY33879A (es) |
| WO (1) | WO2012101139A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI534126B (zh) * | 2011-01-25 | 2016-05-21 | 先正達合夥公司 | 用於製備吡唑羧酸醯胺之方法 |
| TWI510472B (zh) | 2012-02-15 | 2015-12-01 | Syngenta Participations Ag | 立體選擇性製備吡唑羧醯胺之方法 |
| WO2018179632A1 (ja) | 2017-03-31 | 2018-10-04 | 日本精工株式会社 | レーザ溶接装置、レーザ加工装置、レーザ溶接方法、軸受の製造方法、機械の製造方法、車両の製造方法、軸受、機械、及び車両 |
| EP4558484A1 (en) | 2022-07-22 | 2025-05-28 | Syngenta Crop Protection AG | Solid form of a heterocyclic amide derivative |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58194853A (ja) * | 1982-05-11 | 1983-11-12 | Showa Denko Kk | シクロヘキセン−アセチルオキシム誘導体 |
| US5093347A (en) | 1991-01-28 | 1992-03-03 | Monsanto Company | 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use |
| CA2626312C (en) * | 2005-10-25 | 2014-10-07 | Hans Tobler | Heterocyclic amide derivatives useful as microbiocides |
| US8227619B2 (en) | 2008-05-14 | 2012-07-24 | Syngenta Limited | Process for the preparation of amides |
| EP2373625B1 (en) * | 2008-12-24 | 2014-10-08 | Syngenta Limited | Methods for the preparation of aryl amides |
| IN2012DN00289A (es) | 2009-08-06 | 2015-05-08 | Syngenta Participations Ag | |
| CN102858749B (zh) | 2010-04-20 | 2014-07-02 | 先正达参股股份有限公司 | 吡唑羧酸酰胺的制备方法 |
| US8519152B2 (en) | 2010-04-20 | 2013-08-27 | Syngenta Crop Protection Llc | Process for the preparation of pyrazole carboxylic acid amides |
| MX2012012004A (es) | 2010-04-20 | 2012-12-17 | Syngenta Participations Ag | Proceso para preparar amidas de acidos carboxilicos pirazolicos. |
| TWI534126B (zh) * | 2011-01-25 | 2016-05-21 | 先正達合夥公司 | 用於製備吡唑羧酸醯胺之方法 |
-
2012
- 2012-01-20 TW TW101102374A patent/TWI534126B/zh active
- 2012-01-23 AR ARP120100211A patent/AR084915A1/es active IP Right Grant
- 2012-01-25 CA CA2824730A patent/CA2824730C/en active Active
- 2012-01-25 ES ES12700859.7T patent/ES2540211T3/es active Active
- 2012-01-25 EP EP12700859.7A patent/EP2668166B1/en active Active
- 2012-01-25 MX MX2013007914A patent/MX352697B/es active IP Right Grant
- 2012-01-25 PT PT127008597T patent/PT2668166E/pt unknown
- 2012-01-25 CN CN201280006384.7A patent/CN103339113B/zh active Active
- 2012-01-25 PL PL12700859T patent/PL2668166T3/pl unknown
- 2012-01-25 UY UY0001033879A patent/UY33879A/es active IP Right Grant
- 2012-01-25 BR BR112013018533A patent/BR112013018533A2/pt active IP Right Grant
- 2012-01-25 JP JP2013549849A patent/JP6133788B2/ja active Active
- 2012-01-25 WO PCT/EP2012/051075 patent/WO2012101139A1/en not_active Ceased
- 2012-01-25 HR HRP20150658TT patent/HRP20150658T1/hr unknown
- 2012-01-25 KR KR1020137022399A patent/KR101851781B1/ko active Active
- 2012-01-25 US US13/981,913 patent/US8895757B2/en active Active
- 2012-01-25 AU AU2012210547A patent/AU2012210547B2/en active Active
-
2013
- 2013-07-04 IL IL227317A patent/IL227317A/en active IP Right Grant
- 2013-07-23 CO CO13173578A patent/CO6751253A2/es unknown
-
2016
- 2016-11-07 JP JP2016217091A patent/JP6419131B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20130310592A1 (en) | 2013-11-21 |
| JP2017071614A (ja) | 2017-04-13 |
| CO6751253A2 (es) | 2013-09-16 |
| MX2013007914A (es) | 2013-08-29 |
| WO2012101139A1 (en) | 2012-08-02 |
| JP6133788B2 (ja) | 2017-05-24 |
| MX352697B (es) | 2017-12-05 |
| TWI534126B (zh) | 2016-05-21 |
| AU2012210547B2 (en) | 2016-04-14 |
| CA2824730C (en) | 2018-10-23 |
| US8895757B2 (en) | 2014-11-25 |
| HRP20150658T1 (hr) | 2015-07-31 |
| AU2012210547A1 (en) | 2013-08-01 |
| JP6419131B2 (ja) | 2018-11-07 |
| JP2014504596A (ja) | 2014-02-24 |
| ES2540211T3 (es) | 2015-07-09 |
| CN103339113A (zh) | 2013-10-02 |
| EP2668166B1 (en) | 2015-05-13 |
| UY33879A (es) | 2012-08-31 |
| TW201245114A (en) | 2012-11-16 |
| KR20140019333A (ko) | 2014-02-14 |
| IL227317A0 (en) | 2013-09-30 |
| EP2668166A1 (en) | 2013-12-04 |
| IL227317A (en) | 2014-11-30 |
| BR112013018533A2 (pt) | 2016-07-12 |
| PT2668166E (pt) | 2015-08-27 |
| PL2668166T3 (pl) | 2015-09-30 |
| CA2824730A1 (en) | 2012-08-02 |
| CN103339113B (zh) | 2015-07-22 |
| KR101851781B1 (ko) | 2018-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |