AR084338A1 - Imidazopiridinas como agentes antivirales del virus sincicial respiratorio - Google Patents
Imidazopiridinas como agentes antivirales del virus sincicial respiratorioInfo
- Publication number
- AR084338A1 AR084338A1 ARP110104743A ARP110104743A AR084338A1 AR 084338 A1 AR084338 A1 AR 084338A1 AR P110104743 A ARP110104743 A AR P110104743A AR P110104743 A ARP110104743 A AR P110104743A AR 084338 A1 AR084338 A1 AR 084338A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- cycloalkyl
- alkoxy
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Composiciones que contienen estos compuestos como un ingrediente activo y procesos para preparar estos compuestos y composiciones.Reivindicación 1: Un compuesto de la fórmula (1), uno de sus profármacos, N-óxidos, sale por adición, aminas cuaternarias, complejos metálicos o una de sus formas estereoquímicamente isoméricas; en donde cada X es, de modo independiente, C o N; cada Y es, de modo independiente, C o N; R1 está presente cuando X = C y R1 está seleccionado del grupo de H, halógeno, alquilo C1-6, cicloalquilo C3-7, alcoxi C1-6, N(R5)2, CO(R6), CH2NH2, CH2OH, CN, C(=NOH)NH2, C(=NOCH3)NH2, C(=NH)NH2, CF3, OCF3 y B(OH)2; B(O-alquilo C1-6)2; R1 está ausente cuando X = N; R2 está seleccionado del grupo que consiste en H, halógeno, -(CR7R8)n-R9, CºC-CH2-R9 y CºC-R9, C=C-R9; R3 está seleccionado del grupo que consiste en H, alquilo C1-10, cicloalquilo C3-7, alquenilo C2-10, SO2-R7 o un anillo saturado de 4 a 6 miembros que contiene un átomo de oxígeno; R4 está presente donde Y es C y está seleccionado del grupo que consiste en H, alquilo C1-6, cicloalquilo C1-6, alcoxi C1-6, CO(R7), CF3 y halógeno; R5 está seleccionado del grupo que consiste en H, alquilo C1-6, COOCH3 y CONHSO2CH3; R6 está seleccionado del grupo que consiste en OH, O(alquilo C1-6), NH2, NHSO2N(alquilo C1-6)2, NHSO2NHCH3, NHSO2(alquilo C1-6), NHSO2(cicloalquilo C3-7) y N(alquilo C1-6)2; R7 y R8 están cada uno seleccionados, de modo independiente, de H, alquilo C1-10, cicloalquilo C3-7 o R7 y R8 tomados juntos, forman un anillo alifático de 4 a 6 miembros que opcionalmente contiene al menos un heteroátomo seleccionado del grupo N, S, O; R9 está seleccionado del grupo que consiste en H, alquilo C1-6, alcoxi C1-6, cicloalquilo C3-7, OH, CN, F, CF2H, CF3, CONR7R8, COOR7, CON(R7)SO2R8, CON(R7)SO2N(R7R8), NR7R8, NR7COOR8, OCOR7, NR7SO2R8, SO2NR7R8, SO2R7 o un anillo saturado de 4 a 6 miembros que contiene un átomo de oxígeno; n es un número entero de 2 a 6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195474 | 2010-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084338A1 true AR084338A1 (es) | 2013-05-08 |
Family
ID=43920326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104743A AR084338A1 (es) | 2010-12-16 | 2011-12-16 | Imidazopiridinas como agentes antivirales del virus sincicial respiratorio |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8846672B2 (es) |
| EP (1) | EP2651934B1 (es) |
| JP (1) | JP5876503B2 (es) |
| KR (1) | KR101876792B1 (es) |
| CN (1) | CN103328472B (es) |
| AR (1) | AR084338A1 (es) |
| AU (1) | AU2011343260B2 (es) |
| CA (1) | CA2822003C (es) |
| EA (1) | EA024681B1 (es) |
| ES (1) | ES2624282T3 (es) |
| TW (1) | TWI541241B (es) |
| WO (1) | WO2012080451A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| DK2864323T3 (en) | 2012-06-15 | 2017-08-14 | Janssen Sciences Ireland Uc | 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2 UNDERIVATIVES SUBSTITUTED BY HETEROCYCLES AS ANTIVIRUS AGENTS AGAINST RESPIRATORY SYNCYTIAL VIRUS |
| AU2013276521A1 (en) * | 2012-06-15 | 2014-12-04 | Janssen Sciences Ireland Uc | 1,3 -dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| AR093020A1 (es) | 2012-10-16 | 2015-05-13 | Janssen R&D Ireland | Compuestos antiviricos para el vsr |
| CN114716426A (zh) | 2013-08-21 | 2022-07-08 | 詹森生物制药有限公司 | 抗病毒化合物 |
| JP2016535043A (ja) | 2013-10-29 | 2016-11-10 | メディヴィル・アクチエボラーグ | キナゾリンベースの呼吸器合胞体ウイルス阻害剤 |
| TWI671299B (zh) | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為ｒｓｖ抗病毒化合物之螺脲化合物 |
| CN106999509A (zh) * | 2014-08-05 | 2017-08-01 | 艾丽奥斯生物制药有限公司 | 用于治疗副粘病毒的联合治疗 |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| KR102667914B1 (ko) | 2015-07-22 | 2024-05-21 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 저해제로서의 벤조다이아제핀 유도체 |
| JP6964343B2 (ja) | 2015-11-20 | 2021-11-10 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ１阻害剤としてのプリノン |
| CN108699077B (zh) | 2016-01-15 | 2021-03-02 | 英安塔制药有限公司 | 作为rsv抑制剂的杂环化合物 |
| NZ756805A (en) | 2017-02-16 | 2025-10-31 | Enanta Pharm Inc | Processes for the preparation of benzodiazepine derivatives |
| WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| US10881666B2 (en) | 2017-09-29 | 2021-01-05 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as RSV inhibitors |
| CN111343990B (zh) | 2017-11-13 | 2023-08-04 | 英安塔制药有限公司 | 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法 |
| CA3099311A1 (en) * | 2018-05-03 | 2019-11-07 | Georgia State University Research Foundation, Inc. | Inhibitors of rsv replication and applications thereof |
| KR20210138684A (ko) | 2019-03-18 | 2021-11-19 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 억제제로서의 벤조디아제핀 유도체 |
| US11572367B2 (en) | 2019-10-04 | 2023-02-07 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| EP4165034A1 (en) | 2020-06-11 | 2023-04-19 | Janssen Sciences Ireland Unlimited Company | Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| AU2022227674A1 (en) | 2021-02-26 | 2023-09-21 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| US12162857B2 (en) | 2022-04-27 | 2024-12-10 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| CN119350428B (zh) * | 2024-12-23 | 2025-03-28 | 江苏长泰药业股份有限公司 | 基于丙酮酸盐的呼吸系统药物增效剂及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2259573A1 (en) | 1996-07-08 | 1998-01-15 | Ruth Richmond Wexler | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin |
| WO2000020400A1 (en) * | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| US6867200B1 (en) * | 1998-12-18 | 2005-03-15 | Axys Pharmaceuticals, Inc. | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors |
| ES2215683T3 (es) | 1999-06-28 | 2004-10-16 | Janssen Pharmaceutica N.V. | Inhibidores de la replicacion del virus sincitial respiratorio. |
| CZ20014574A3 (cs) | 1999-06-28 | 2002-05-15 | Janssen Pharmaceutica N. V. | Inhibitory replikace respiračně syncyciálního viru |
| US6534535B1 (en) | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| AU2003294249A1 (en) * | 2002-11-08 | 2004-06-03 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| AR072008A1 (es) * | 2008-06-13 | 2010-07-28 | Merck & Co Inc | Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38 |
| TWI515187B (zh) * | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
-
2011
- 2011-12-15 TW TW100146388A patent/TWI541241B/zh not_active IP Right Cessation
- 2011-12-16 CN CN201180060279.7A patent/CN103328472B/zh not_active Expired - Fee Related
- 2011-12-16 WO PCT/EP2011/073017 patent/WO2012080451A1/en not_active Ceased
- 2011-12-16 AR ARP110104743A patent/AR084338A1/es active IP Right Grant
- 2011-12-16 ES ES11796711.7T patent/ES2624282T3/es active Active
- 2011-12-16 KR KR1020137016533A patent/KR101876792B1/ko not_active Expired - Fee Related
- 2011-12-16 EA EA201390880A patent/EA024681B1/ru not_active IP Right Cessation
- 2011-12-16 JP JP2013543805A patent/JP5876503B2/ja not_active Expired - Fee Related
- 2011-12-16 EP EP11796711.7A patent/EP2651934B1/en active Active
- 2011-12-16 CA CA2822003A patent/CA2822003C/en active Active
- 2011-12-16 AU AU2011343260A patent/AU2011343260B2/en not_active Ceased
- 2011-12-16 US US13/993,692 patent/US8846672B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA024681B1 (ru) | 2016-10-31 |
| EP2651934A1 (en) | 2013-10-23 |
| KR101876792B1 (ko) | 2018-08-09 |
| KR20140014094A (ko) | 2014-02-05 |
| JP5876503B2 (ja) | 2016-03-02 |
| EP2651934B1 (en) | 2017-02-22 |
| AU2011343260B2 (en) | 2015-03-19 |
| CN103328472A (zh) | 2013-09-25 |
| CN103328472B (zh) | 2015-11-25 |
| EA201390880A1 (ru) | 2013-09-30 |
| US8846672B2 (en) | 2014-09-30 |
| ES2624282T3 (es) | 2017-07-13 |
| CA2822003A1 (en) | 2012-06-21 |
| AU2011343260A1 (en) | 2013-05-02 |
| TWI541241B (zh) | 2016-07-11 |
| TW201307341A (zh) | 2013-02-16 |
| CA2822003C (en) | 2019-04-30 |
| US20130324527A1 (en) | 2013-12-05 |
| JP2013545788A (ja) | 2013-12-26 |
| WO2012080451A1 (en) | 2012-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |