AR085203A1 - Inhibidores benzimidazol del virus sincitial respiratorio - Google Patents
Inhibidores benzimidazol del virus sincitial respiratorioInfo
- Publication number
- AR085203A1 AR085203A1 ARP110104739A ARP110104739A AR085203A1 AR 085203 A1 AR085203 A1 AR 085203A1 AR P110104739 A ARP110104739 A AR P110104739A AR P110104739 A ARP110104739 A AR P110104739A AR 085203 A1 AR085203 A1 AR 085203A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- cycloalkyl
- alkyl
- cr6r7
- so2ch3
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 150000001556 benzimidazoles Chemical class 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 150000004696 coordination complex Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000005544 phthalimido group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Bencimidazoles que tienen actividad inhibidora sobre la replicación de RSV, composiciones que contienen estos compuestos como ingrediente activo y procesos para preparar estos compuestos y composiciones. Reivindicación 1: Un compuesto representado por la fórmula (1), un profármaco, N-óxido, sal de adición, amina cuaternaria, complejo metálico, o una forma isómerica según la estereoquímica del mismo; donde cada X es de manera independiente C o N; R¹ es H; R² se selecciona del grupo compuesto por Br y Cl; R³ es -(CR⁶R⁷)ₙ-R⁸; R⁴ se selecciona del grupo compuesto por H, cicloalquilo C₃₋₇, alquenilo C₂₋₁₀, -(CR⁶R⁷)ₙ-R⁸, -CH₂-p-fluorofenilo, CH₂CF₃ y -SO₂CH₃; R⁵ está presente donde X es C, por el cual cada R⁵ se selecciona, cada una independientemente, del grupo compuesto por H, alquilo C₁₋₆, alcoxi C₁₋₆, halógeno, y CN; R⁵ está ausente cuando X es N; R⁶ y R⁷ son elegidos cada uno de manera independiente de H y alquilo C₁₋₁₀, cicloalquilo C₃₋₇, o R⁶ y R⁷ tomados juntos forman un anillo alifático o aromático de 5 a 6 miembros que opcionalmente contiene uno o más heteroátomos seleccionados del grupo N, S, O; R⁸ se selecciona del grupo compuesto por H, OH, CF₃, CHF₂, F, Cl, SO₂CH₃, SO₂-cicloalquilo C₃₋₇, NR⁶SO₂R⁶, SO₂NR⁶R⁷, NR⁶SO₂-cicloalquilo C₃₋₇, CN, NR⁶R⁷, COOH, COOR⁶, CONR⁶R⁷, OCO-alquilo C₁₋₆, CONR⁶SO₂R⁷, CONHR⁶SO₂R⁷, CONHR⁶SO₂NR⁶R⁷CONR⁶SO₂NR⁶R⁷, ftalimido o un anillo alifático o aromático de 5 a 6 miembros que opcionalmente contiene uno o más heteroátomos seleccionados del grupo N, S, O; n es un número entero que tiene un valor que va de 1 a 6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195467 | 2010-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR085203A1 true AR085203A1 (es) | 2013-09-18 |
Family
ID=43875271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104739A AR085203A1 (es) | 2010-12-16 | 2011-12-16 | Inhibidores benzimidazol del virus sincitial respiratorio |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8865705B2 (es) |
| EP (1) | EP2651903B1 (es) |
| JP (1) | JP6005656B2 (es) |
| KR (1) | KR101876240B1 (es) |
| CN (2) | CN103313974A (es) |
| AR (1) | AR085203A1 (es) |
| AU (1) | AU2011343255B2 (es) |
| BR (1) | BR112013012137A2 (es) |
| CA (1) | CA2821999C (es) |
| CL (1) | CL2013001713A1 (es) |
| CY (1) | CY1117751T1 (es) |
| DK (1) | DK2651903T3 (es) |
| EA (1) | EA022972B1 (es) |
| ES (1) | ES2576180T3 (es) |
| HK (1) | HK1247616A1 (es) |
| HR (1) | HRP20160650T1 (es) |
| HU (1) | HUE029247T2 (es) |
| IL (1) | IL225640A (es) |
| MX (1) | MX340030B (es) |
| MY (1) | MY156641A (es) |
| NZ (1) | NZ609450A (es) |
| PH (1) | PH12013500796A1 (es) |
| PL (1) | PL2651903T3 (es) |
| PT (1) | PT2651903E (es) |
| SG (1) | SG190766A1 (es) |
| SI (1) | SI2651903T1 (es) |
| TW (1) | TWI530495B (es) |
| UA (1) | UA112298C2 (es) |
| WO (1) | WO2012080446A1 (es) |
| ZA (1) | ZA201304424B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| US20150166533A1 (en) * | 2012-06-15 | 2015-06-18 | Janssen R&D Ireland | Novel 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| DK2864323T3 (en) | 2012-06-15 | 2017-08-14 | Janssen Sciences Ireland Uc | 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2 UNDERIVATIVES SUBSTITUTED BY HETEROCYCLES AS ANTIVIRUS AGENTS AGAINST RESPIRATORY SYNCYTIAL VIRUS |
| WO2014009302A1 (en) * | 2012-07-10 | 2014-01-16 | F. Hoffmann-La Roche Ag | Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| AR093020A1 (es) | 2012-10-16 | 2015-05-13 | Janssen R&D Ireland | Compuestos antiviricos para el vsr |
| EP2948444B1 (en) * | 2013-01-28 | 2016-12-07 | Janssen Sciences Ireland UC | Quinoxalinones and dihydroquinoxalinones as respiratory syncytial virus antiviral agents |
| CN105392787B (zh) * | 2013-05-14 | 2017-11-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚 |
| EP2997028A1 (en) | 2013-05-14 | 2016-03-23 | F.Hoffmann-La Roche Ag | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| RU2016105969A (ru) * | 2013-08-15 | 2017-09-20 | Ф. Хоффманн-Ля Рош Аг | Новые азаоксоиндолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции |
| CN114716426A (zh) | 2013-08-21 | 2022-07-08 | 詹森生物制药有限公司 | 抗病毒化合物 |
| WO2015065336A1 (en) * | 2013-10-29 | 2015-05-07 | Medivir Ab | Respiratory syncytial virus inhibitors |
| TWI671299B (zh) | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為ｒｓｖ抗病毒化合物之螺脲化合物 |
| CN106999509A (zh) * | 2014-08-05 | 2017-08-01 | 艾丽奥斯生物制药有限公司 | 用于治疗副粘病毒的联合治疗 |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| KR102667914B1 (ko) | 2015-07-22 | 2024-05-21 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 저해제로서의 벤조다이아제핀 유도체 |
| CN108699077B (zh) | 2016-01-15 | 2021-03-02 | 英安塔制药有限公司 | 作为rsv抑制剂的杂环化合物 |
| NZ756805A (en) | 2017-02-16 | 2025-10-31 | Enanta Pharm Inc | Processes for the preparation of benzodiazepine derivatives |
| WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| US10881666B2 (en) | 2017-09-29 | 2021-01-05 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as RSV inhibitors |
| CN111343990B (zh) | 2017-11-13 | 2023-08-04 | 英安塔制药有限公司 | 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法 |
| KR20210138684A (ko) | 2019-03-18 | 2021-11-19 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 억제제로서의 벤조디아제핀 유도체 |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| US11572367B2 (en) | 2019-10-04 | 2023-02-07 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| EP4165034A1 (en) | 2020-06-11 | 2023-04-19 | Janssen Sciences Ireland Unlimited Company | Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| AU2022227674A1 (en) | 2021-02-26 | 2023-09-21 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| US12162857B2 (en) | 2022-04-27 | 2024-12-10 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| WO2024174953A1 (zh) * | 2023-02-21 | 2024-08-29 | 苏州隆博泰药业有限公司 | 苯并咪唑类衍生物及其医药用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2259573A1 (en) | 1996-07-08 | 1998-01-15 | Ruth Richmond Wexler | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of factor xa and of thrombin |
| WO2000020400A1 (en) | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| ES2215683T3 (es) | 1999-06-28 | 2004-10-16 | Janssen Pharmaceutica N.V. | Inhibidores de la replicacion del virus sincitial respiratorio. |
| CZ20014574A3 (cs) | 1999-06-28 | 2002-05-15 | Janssen Pharmaceutica N. V. | Inhibitory replikace respiračně syncyciálního viru |
| US6534535B1 (en) | 1999-08-12 | 2003-03-18 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| AU2003294249A1 (en) | 2002-11-08 | 2004-06-03 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
-
2011
- 2011-12-15 TW TW100146390A patent/TWI530495B/zh not_active IP Right Cessation
- 2011-12-16 AR ARP110104739A patent/AR085203A1/es active IP Right Grant
- 2011-12-16 PT PT118020544T patent/PT2651903E/pt unknown
- 2011-12-16 EA EA201390888A patent/EA022972B1/ru not_active IP Right Cessation
- 2011-12-16 PL PL11802054.4T patent/PL2651903T3/pl unknown
- 2011-12-16 CA CA2821999A patent/CA2821999C/en active Active
- 2011-12-16 UA UAA201305027A patent/UA112298C2/uk unknown
- 2011-12-16 CN CN2011800602778A patent/CN103313974A/zh active Pending
- 2011-12-16 HU HUE11802054A patent/HUE029247T2/en unknown
- 2011-12-16 BR BR112013012137A patent/BR112013012137A2/pt not_active Application Discontinuation
- 2011-12-16 MX MX2013006886A patent/MX340030B/es active IP Right Grant
- 2011-12-16 US US13/993,107 patent/US8865705B2/en active Active
- 2011-12-16 DK DK11802054.4T patent/DK2651903T3/da active
- 2011-12-16 WO PCT/EP2011/073008 patent/WO2012080446A1/en not_active Ceased
- 2011-12-16 NZ NZ609450A patent/NZ609450A/en not_active IP Right Cessation
- 2011-12-16 SI SI201130853A patent/SI2651903T1/sl unknown
- 2011-12-16 CN CN201710103106.8A patent/CN107417683A/zh active Pending
- 2011-12-16 EP EP11802054.4A patent/EP2651903B1/en active Active
- 2011-12-16 ES ES11802054.4T patent/ES2576180T3/es active Active
- 2011-12-16 AU AU2011343255A patent/AU2011343255B2/en not_active Ceased
- 2011-12-16 HR HRP20160650TT patent/HRP20160650T1/hr unknown
- 2011-12-16 MY MYPI2013001281A patent/MY156641A/en unknown
- 2011-12-16 SG SG2013026711A patent/SG190766A1/en unknown
- 2011-12-16 PH PH1/2013/500796A patent/PH12013500796A1/en unknown
- 2011-12-16 KR KR1020137016944A patent/KR101876240B1/ko not_active Expired - Fee Related
- 2011-12-16 JP JP2013543799A patent/JP6005656B2/ja not_active Expired - Fee Related
-
2013
- 2013-04-09 IL IL225640A patent/IL225640A/en active IP Right Grant
- 2013-06-13 CL CL2013001713A patent/CL2013001713A1/es unknown
- 2013-06-14 ZA ZA2013/04424A patent/ZA201304424B/en unknown
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2016
- 2016-06-22 CY CY20161100561T patent/CY1117751T1/el unknown
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2018
- 2018-05-31 HK HK18107115.5A patent/HK1247616A1/zh unknown
Also Published As
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