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AR073711A1 - Derivados de isoquinolina - Google Patents

Derivados de isoquinolina

Info

Publication number
AR073711A1
AR073711A1 ARP090103762A ARP090103762A AR073711A1 AR 073711 A1 AR073711 A1 AR 073711A1 AR P090103762 A ARP090103762 A AR P090103762A AR P090103762 A ARP090103762 A AR P090103762A AR 073711 A1 AR073711 A1 AR 073711A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
halo
atom
heterocycloalkyl
Prior art date
Application number
ARP090103762A
Other languages
English (en)
Inventor
Stephen Brough
Bryan Roberts
Timothy Jon Luker
Stephen St-Gallay
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR073711A1 publication Critical patent/AR073711A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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Abstract

Los procesos para su preparacion, las composiciones farmacéuticas que los contienen y su uso en terapia, para tratar enfermedades respiratorias. Reivindicacion 1: Un compuesto caracterizado porque es de la formula (1) donde R1 es alquil C1-8 el cual es opcionalmente sustituido con 1 2, 3 o 4 grupos independientemente seleccionados de alquil C1-6, alcoxi C1-6, -halo, -OH, -NH2, -HN(alquil C1-6), -N-di-(alquil C1-6), cicloalquil C3-7, alquil C1-6-cicloalquil C3-7, -alquil C1-6-alcoxi C1-6, o alquil C1-6-hidroxi, y donde un sustituyente R1 alquil C1-6 independiente puede ser opcionalmente fusionado con otro sustituyente R1 alquil C1-6 independiente para formar un anillo carbocíclico saturado el cual puede ser además opcionalmente sustituido; R2 es H, halo, alquil C1-6 y alcoxi C1-6; R3 es (CH2)d-Y y R3 es independientemente opcionalmente sustituido por uno o más alquil C1-6, alcoxi C1-6, -halo, -OH, -NH2, -HN(alquil C1-6), -N-di-(alquil C1-6), cicloalquil C3-7, alquil C1-6-cicloalquil C3-7, -alquil C1-6-hidroxi y alquil C1-6-alcoxi C1-6; Y es seleccionado de heterocicloalquil, O-heterocicloalquil, S-(O)e-heterocicloalquil, S-(O)e-alquil C1-6-heterocicloalquil, -SO2NH-alquil C1-6 y alquil C1-6; d es 0, 1, 2, y 3; e es 0, 1 o 2; R4 y R5 son independientemente seleccionados de H, alquil C1-6, alcoxi C1-6, halo, CF3, y CN; R6 es seleccionado de H, alquil C1-6, alcoxi C1-6 y halo, heterocicloalquil es un anillo cíclico no aromático de 3 a 7 miembros unido a C- o N-, que contiene de 1 a 2 átomos NR7, o un átomo NR7 y un átomo de S o uno de O, o un átomo de S, o un átomo de O; que contiene opcionalmente, cuando sea posible, 1 o 2 enlaces dobles, y donde cualquier átomo de S en un átomo del grupo heterocicloalquil puede opcionalmente ser oxidado hasta SO o SO; R7 H, alquil C1-6 y -C(O)O-alquil C1-6, donde dicho alquil C1-6 puede ser opcionalmente sustituido con alcoxi C1-6, -OH, halo y cicloalquil C3-7, o una sal farmacéuticamente aceptable o N-oxido del mismo.
ARP090103762A 2008-10-01 2009-09-29 Derivados de isoquinolina AR073711A1 (es)

Applications Claiming Priority (2)

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US10176408P 2008-10-01 2008-10-01
US17941709P 2009-05-19 2009-05-19

Publications (1)

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AR073711A1 true AR073711A1 (es) 2010-11-24

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US (1) US8012980B2 (es)
EP (1) EP2344472A4 (es)
JP (1) JP2012504601A (es)
KR (1) KR20110067051A (es)
CN (1) CN102245593A (es)
AR (1) AR073711A1 (es)
AU (1) AU2009300456B2 (es)
BR (1) BRPI0920756A2 (es)
CA (1) CA2737434A1 (es)
MX (1) MX2011003489A (es)
RU (1) RU2512318C2 (es)
TW (1) TW201018665A (es)
UY (1) UY32154A (es)
WO (1) WO2010039079A1 (es)

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RU2479580C2 (ru) 2007-06-27 2013-04-20 Астразенека Аб Производные пиразинона и их применение для лечения легочных заболеваний

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WO2010039079A1 (en) 2010-04-08
UY32154A (es) 2010-04-30
RU2512318C2 (ru) 2014-04-10
MX2011003489A (es) 2011-05-02
EP2344472A4 (en) 2012-11-28
EP2344472A1 (en) 2011-07-20
CA2737434A1 (en) 2010-04-08
US20100099665A1 (en) 2010-04-22
RU2011113437A (ru) 2012-11-10
TW201018665A (en) 2010-05-16
AU2009300456A1 (en) 2010-04-08
BRPI0920756A2 (pt) 2019-09-24
US8012980B2 (en) 2011-09-06

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