AR073283A1 - Derivados de heteroarilamida y su uso como activadores de glucokinasa - Google Patents
Derivados de heteroarilamida y su uso como activadores de glucokinasaInfo
- Publication number
- AR073283A1 AR073283A1 ARP090103462A ARP090103462A AR073283A1 AR 073283 A1 AR073283 A1 AR 073283A1 AR P090103462 A ARP090103462 A AR P090103462A AR P090103462 A ARP090103462 A AR P090103462A AR 073283 A1 AR073283 A1 AR 073283A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halo
- alkylamino
- optionally substituted
- independently
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- -1 thiazolo [5,4-b] pyridinyl Chemical group 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006594 (C1-C3) alkylsulfony group Chemical group 0.000 abstract 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 102000030595 Glucokinase Human genes 0.000 abstract 1
- 108010021582 Glucokinase Proteins 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Composiciones farmacéuticas de los mismos; y métodos para tratar enfermedades, trastornos o afecciones mediadas por glucoquinasa. Reivindicacion 1: Un compuesto de formula (1) en la que cada uno de X, Y, y Z es independientemente C(R ) o N, donde R es H, halo, alquilo C1-3, halo-sustituido, alquilo C1-6 o alcoxi C1-6, y X, Y y Z no son todos N; R1 es H, alquilo C1-6, alquilo C1-3 halo-sustituido, -S(O)2(R1a) o C(O)R1a, donde R1a es alquilo C1-6, cicloalquilo C3-6, alquilamino C1-3 o dialquilamino C1-3; R2 es cicloalquilo C3-6 o heterociclo de 5 a 6 miembros que contiene un heteroátomo de N, O o S; donde dicho cicloalquilo y dicho heterociclo están opcionalmente sustituidos con uno a dos sustituyentes, siendo cada uno independientemente halo, alquilo C1-6, alcoxi C1-6, -CF3 o ciano; R3 es H o alquilo C1-6; y R4 es quinolinilo, tiazolo[5,4-b]piridinilo o heteroarilo de 5 a 6 miembros que contiene de uno a dos heteroátomos N y opcionalmente un heteroátomo O o S, donde dichos heteroarilo, quinolinilo y tiazolo[5,4-b]piridinilo están opcionalmente sustituidos con uno a dos R4a, donde cada R4a es independientemente alquilo C1-6 opcionalmente sustituido con uno a tres hidroxi, -CF3, ciano, alcoxi C1-6, halo, amino, alquilamino C1-3, di-alquilamino C1-3, -CO2R4b, -alquil C1-6-CO2R4b, -C(O)N(R4b)2, -P(O)(OR4)2, -alquil C1-6-P(O)(OR4b)2, -P(O)(OR4b)-alquilo C1-3, alquilsulfonilo C1-3, -SO3H, -NHC(O)R4c o arilalquilo C1-6, donde el arilo de dicho arilalquilo está opcionalmente sustituido con alquilo C1-6, -CF3 ciano, alcoxi C1-6, halo, amino, alquilamino C1-3 o di-alquilamino C1-3; R4b en cada caso es independientemente hidrogeno, alquilo C1-6 o bencilo; y R4c en cada caso es independientemente CO2H o alquilo C1-6 opcionalmente sustituido con uno a tres hidroxi; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9605608P | 2008-09-11 | 2008-09-11 | |
| US23257809P | 2009-08-10 | 2009-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073283A1 true AR073283A1 (es) | 2010-10-28 |
Family
ID=41228587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103462A AR073283A1 (es) | 2008-09-11 | 2009-09-09 | Derivados de heteroarilamida y su uso como activadores de glucokinasa |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US7977367B2 (es) |
| EP (1) | EP2344458A1 (es) |
| JP (2) | JP4907746B2 (es) |
| KR (1) | KR101258331B1 (es) |
| CN (1) | CN102216276A (es) |
| AP (1) | AP2011005613A0 (es) |
| AR (1) | AR073283A1 (es) |
| AU (1) | AU2009290474A1 (es) |
| BR (1) | BRPI0918128A2 (es) |
| CA (1) | CA2735184C (es) |
| CL (1) | CL2011000478A1 (es) |
| CO (1) | CO6361937A2 (es) |
| CR (1) | CR20110103A (es) |
| DO (1) | DOP2011000076A (es) |
| EA (1) | EA201100311A1 (es) |
| EC (1) | ECSP11010885A (es) |
| GE (1) | GEP20135793B (es) |
| IL (1) | IL211411A0 (es) |
| MA (1) | MA32627B1 (es) |
| MX (1) | MX2011002613A (es) |
| NI (1) | NI201100050A (es) |
| NZ (1) | NZ591366A (es) |
| PA (1) | PA8842101A1 (es) |
| PE (1) | PE20110303A1 (es) |
| SV (1) | SV2011003855A (es) |
| TW (1) | TWI382026B (es) |
| UY (1) | UY32098A (es) |
| WO (1) | WO2010029461A1 (es) |
| ZA (1) | ZA201101364B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2799157A1 (en) * | 2009-05-06 | 2010-11-11 | Xianqi Kong | Ammo acid derivatives for the treatment of neuropathic pain |
| AU2011235212B2 (en) | 2010-03-31 | 2014-07-31 | The Scripps Research Institute | Reprogramming cells |
| KR20130130737A (ko) * | 2010-11-11 | 2013-12-02 | 사노피 | ３（６아미노피리딘３일）２아크릴산 유도체의 제조방법 |
| WO2013113782A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113719A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds ii |
| WO2013113787A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| AR089884A1 (es) | 2012-02-03 | 2014-09-24 | Basf Se | Compuestos fungicidas de pirimidina |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| IN2014DN07224A (es) | 2012-02-03 | 2015-04-24 | Basf Se | |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113781A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds i |
| WO2013135672A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
| JP2015512891A (ja) | 2012-03-13 | 2015-04-30 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 殺菌性ピリミジン化合物 |
| HUE037765T2 (hu) | 2012-07-04 | 2018-09-28 | Agro Kanesho Co Ltd | 2-Aminonikotinsav-észter-származék és ezt hatóanyagként tartalmazó baktericid |
| WO2014142255A1 (ja) | 2013-03-14 | 2014-09-18 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3018126A4 (en) | 2013-07-03 | 2016-12-07 | Takeda Pharmaceuticals Co | HETEROCYCLIC CONNECTION |
| EP3018123B1 (en) | 2013-07-03 | 2023-05-10 | Takeda Pharmaceutical Company Limited | Amide compound |
| EP2878339A1 (en) | 2013-12-02 | 2015-06-03 | Siena Biotech S.p.A. | SIP3 antagonists |
| AR099677A1 (es) | 2014-03-07 | 2016-08-10 | Sumitomo Chemical Co | Compuesto heterocíclico fusionado y su uso para el control de plagas |
| EP3487862A1 (en) | 2016-07-22 | 2019-05-29 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
| TW201840578A (zh) * | 2017-02-22 | 2018-11-16 | 以色列商亞當阿甘公司 | 製備甲基膦酸丁基酯的方法 |
| GB201714777D0 (en) | 2017-09-14 | 2017-11-01 | Univ London Queen Mary | Agent |
| CN109134535B (zh) * | 2018-10-22 | 2021-03-19 | 江苏长青农化股份有限公司 | 一种甲基磷酸酯的制备方法 |
| US20230321123A1 (en) * | 2020-08-25 | 2023-10-12 | Helmholtz-Zentrum für Infektionsforschung GmbH | INHIBITORS OF PSEUDOMONAS AERUGINOSA VIRULENCE FACTOR LasB |
| CA3219084A1 (en) | 2021-07-08 | 2023-01-12 | Ishihara Sangyo Kaisha, Ltd. | Nematicidal composition |
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- 2009-08-28 AU AU2009290474A patent/AU2009290474A1/en not_active Abandoned
- 2009-08-28 WO PCT/IB2009/053773 patent/WO2010029461A1/en not_active Ceased
- 2009-08-28 PE PE2011000617A patent/PE20110303A1/es not_active Application Discontinuation
- 2009-08-28 CA CA2735184A patent/CA2735184C/en not_active Expired - Fee Related
- 2009-08-28 KR KR1020117005658A patent/KR101258331B1/ko not_active Expired - Fee Related
- 2009-08-28 CN CN2009801445796A patent/CN102216276A/zh active Pending
- 2009-08-28 EA EA201100311A patent/EA201100311A1/ru unknown
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- 2009-08-28 EP EP09787045A patent/EP2344458A1/en not_active Withdrawn
- 2009-08-28 BR BRPI0918128A patent/BRPI0918128A2/pt not_active IP Right Cessation
- 2009-08-28 JP JP2011526597A patent/JP4907746B2/ja not_active Expired - Fee Related
- 2009-09-09 UY UY0001032098A patent/UY32098A/es not_active Application Discontinuation
- 2009-09-09 AR ARP090103462A patent/AR073283A1/es not_active Application Discontinuation
- 2009-09-09 US US12/556,086 patent/US7977367B2/en not_active Expired - Fee Related
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