AR073236A1 - Hidrolasas, acidos nucleicos que las codifican y metodos para prepararlas y el uso de las mismas - Google Patents
Hidrolasas, acidos nucleicos que las codifican y metodos para prepararlas y el uso de las mismasInfo
- Publication number
- AR073236A1 AR073236A1 ARP090103330A ARP090103330A AR073236A1 AR 073236 A1 AR073236 A1 AR 073236A1 AR P090103330 A ARP090103330 A AR P090103330A AR P090103330 A ARP090103330 A AR P090103330A AR 073236 A1 AR073236 A1 AR 073236A1
- Authority
- AR
- Argentina
- Prior art keywords
- methods
- polypeptides
- preparing
- codify
- hydrolases
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 108090000604 Hydrolases Proteins 0.000 title abstract 2
- 102000004157 Hydrolases Human genes 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 239000003921 oil Substances 0.000 abstract 3
- 235000019198 oils Nutrition 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- -1 saturases Proteins 0.000 abstract 3
- 108090001060 Lipase Proteins 0.000 abstract 2
- 102000004882 Lipase Human genes 0.000 abstract 2
- 239000004367 Lipase Substances 0.000 abstract 2
- 235000019421 lipase Nutrition 0.000 abstract 2
- 108010047498 long-chain carboxylesterase Proteins 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 235000010692 trans-unsaturated fatty acids Nutrition 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 239000010775 animal oil Substances 0.000 abstract 1
- 230000002210 biocatalytic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000828 canola oil Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000009884 interesterification Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
- A23D7/04—Working-up
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
- A23D9/02—Other edible oils or fats, e.g. shortenings or cooking oils characterised by the production or working-up
- A23D9/04—Working-up
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
- C11B3/003—Refining fats or fatty oils by enzymes or microorganisms, living or dead
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
- C11C1/04—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis
- C11C1/045—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis using enzymes or microorganisms, living or dead
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
- C11C3/08—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with fatty acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/12—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6418—Fatty acids by hydrolysis of fatty acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6431—Linoleic acids [18:2[n-6]]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6454—Glycerides by esterification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fats And Perfumes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
Abstract
HidroIasas, incluyendo lipasas, saturasas, palmitasas y/o estearatasas y polinucleotidos que las codifican y métodos para preparar y usar estos polinucleotidos y polipéptidos. También polipéptidos, por ejemplo, enzimas, que tienen una actividad de hidrolasa, por ejemplo, lipasas, saturasas, palmitasas y/o estearatasas y métodos para preparar aceites de baja saturacion o de bajo contenido de grasas trans, tales como aceites animales o vegetales de baja saturacion o de bajo contenido de grasas trans, por ejemplo, aceites de soja o canola. Además un método para hidrolizar un aceite o una grasa por dichos polipéptidos, un método para la síntesis biocatalítica de un lípido estructurado así como un método de inter-esterificacion para preparar un alimento, nutriente o un aceite.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/202,204 US8153391B2 (en) | 2008-08-29 | 2008-08-29 | Hydrolases, nucleic acids encoding them and methods for making and using them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073236A1 true AR073236A1 (es) | 2010-10-20 |
Family
ID=41664688
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103330A AR073236A1 (es) | 2008-08-29 | 2009-08-28 | Hidrolasas, acidos nucleicos que las codifican y metodos para prepararlas y el uso de las mismas |
| ARP160102735A AR105958A2 (es) | 2008-08-29 | 2016-09-07 | Métodos para la síntesis biocatalítica de un lípido estructurado, para catalizar una reacción de interesterificación a fin de producir triacilglicéridos, de interesterificación para preparar un alimento, nutriente o un aceite, para producir un 1,3-diacilglicérido (dag) y para hidrolizar un aceite o grasa |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102735A AR105958A2 (es) | 2008-08-29 | 2016-09-07 | Métodos para la síntesis biocatalítica de un lípido estructurado, para catalizar una reacción de interesterificación a fin de producir triacilglicéridos, de interesterificación para preparar un alimento, nutriente o un aceite, para producir un 1,3-diacilglicérido (dag) y para hidrolizar un aceite o grasa |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US8153391B2 (es) |
| EP (1) | EP2329032B1 (es) |
| CN (1) | CN102325891B (es) |
| AR (2) | AR073236A1 (es) |
| BR (1) | BRPI0917220B1 (es) |
| CA (1) | CA2735265C (es) |
| ES (1) | ES2484919T3 (es) |
| MX (1) | MX2011002226A (es) |
| MY (1) | MY162662A (es) |
| PL (1) | PL2329032T3 (es) |
| RU (1) | RU2525675C2 (es) |
| UA (1) | UA101214C2 (es) |
| WO (1) | WO2010024924A2 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| PE20150179A1 (es) * | 2012-06-14 | 2015-02-07 | Bunge Global Innovation Llc | Proceso para la produccion de aceites bajos en acidos grasos saturados |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| CN104087626A (zh) * | 2014-07-07 | 2014-10-08 | 嘉必优生物工程(武汉)有限公司 | 含有2-棕榈酸甘油酯的组合物的制备方法 |
| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
| US20170049121A1 (en) | 2015-08-20 | 2017-02-23 | Bunge Oils, Inc. | High stearic high oleic shortening compositions and methods of making and using the same |
| CN109929820B (zh) * | 2017-12-19 | 2022-10-11 | 丰益(上海)生物技术研发中心有限公司 | 新型的甘油单-二酰酯脂肪酶 |
| CN108034647B (zh) * | 2018-01-31 | 2020-08-04 | 江南大学 | 一种饱和脂肪酸特异性脂肪酶突变体及其应用 |
| JP7359539B2 (ja) * | 2018-03-29 | 2023-10-11 | 日清オイリオグループ株式会社 | 油脂組成物、加熱調理用油脂組成物、加熱調理用油脂組成物の製造方法、並びに、油脂組成物における酸価上昇及び色調上昇の抑制方法 |
| WO2019213754A1 (en) * | 2018-05-07 | 2019-11-14 | Gates Ian D | Method of enzymatic biotransformation of petroleum hydrocarbon |
| US20230250406A1 (en) * | 2018-05-18 | 2023-08-10 | Dsm Ip Assets B.V. | Mutant lipase and use thereof |
| EP3893664A4 (en) * | 2018-12-13 | 2022-09-07 | Cargill, Incorporated | MODIFIED TRIGLYCERIDE WITH OMEGA-3 FATTY ACID RESIDUES |
| EP4211256A1 (en) | 2020-09-07 | 2023-07-19 | Boehringer Ingelheim International Gmbh | Method for detecting contaminating lipase activity |
| US12270747B2 (en) | 2021-04-30 | 2025-04-08 | Root Applied Sciences Inc. | Device for collecting material from air |
| CA3252033A1 (en) | 2022-03-09 | 2023-09-14 | Boehringer Ingelheim International Gmbh | METHOD FOR DETECTING CONTAMINANT CARBOXYLESTERASE ACTIVITY |
| EP4569109A1 (en) * | 2022-08-10 | 2025-06-18 | Boehringer Ingelheim International Gmbh | Artificial mirnas targeting multiple hydrolases |
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| CN102325891B (zh) | 2015-01-07 |
| PL2329032T3 (pl) | 2014-09-30 |
| US20110287496A1 (en) | 2011-11-24 |
| BRPI0917220B1 (pt) | 2018-11-21 |
| MX2011002226A (es) | 2011-04-05 |
| AR105958A2 (es) | 2017-11-29 |
| WO2010024924A3 (en) | 2010-04-29 |
| MY162662A (en) | 2017-06-30 |
| US8541191B2 (en) | 2013-09-24 |
| US20110287136A1 (en) | 2011-11-24 |
| US20100055234A1 (en) | 2010-03-04 |
| CA2735265A1 (en) | 2010-03-04 |
| UA101214C2 (ru) | 2013-03-11 |
| WO2010024924A2 (en) | 2010-03-04 |
| BRPI0917220A2 (pt) | 2015-08-11 |
| US20110281312A1 (en) | 2011-11-17 |
| US20110287495A1 (en) | 2011-11-24 |
| US8227215B2 (en) | 2012-07-24 |
| US20120276618A1 (en) | 2012-11-01 |
| US8349578B2 (en) | 2013-01-08 |
| EP2329032B1 (en) | 2014-04-30 |
| CN102325891A (zh) | 2012-01-18 |
| US8313918B2 (en) | 2012-11-20 |
| CA2735265C (en) | 2019-04-23 |
| US8420342B2 (en) | 2013-04-16 |
| RU2525675C2 (ru) | 2014-08-20 |
| RU2011111747A (ru) | 2012-10-10 |
| ES2484919T3 (es) | 2014-08-12 |
| EP2329032A2 (en) | 2011-06-08 |
| US8153391B2 (en) | 2012-04-10 |
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