AR079127A1 - Composiciones de daptomicina y metodos relacionados - Google Patents
Composiciones de daptomicina y metodos relacionadosInfo
- Publication number
- AR079127A1 AR079127A1 ARP100104318A AR079127A1 AR 079127 A1 AR079127 A1 AR 079127A1 AR P100104318 A ARP100104318 A AR P100104318A AR 079127 A1 AR079127 A1 AR 079127A1
- Authority
- AR
- Argentina
- Prior art keywords
- daptomycin
- preparation
- solid
- sucrose
- powdered
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Formulaciones de daptomicina en polvo que tienen estabilidad mejorada y tiempos de reconstitucion más rápidos cuando están en estado solido. Algunos ejemplos de las composiciones comprenden daptomicina y sacarosa. Reivindicacion 1: Una preparacion de daptomicina solida con reconstitucion aumentada y estabilidad de daptomicina aumentada en formas en polvo y reconstituida, caracterizada porque la preparacion de daptomicina solida comprende daptomicina, sacarosa, y un agente amortiguador fosfato; en donde: a) la preparacion de daptomicina solida es al menos 92% daptomicina pura, segun se calcula mediante la proporcion de absorbancia (área bajo la curva) a 214 nm para la daptomicina dividido por el área total bajo la curva medida mediante cromatografía líquida de alto rendimiento (HPLC) de la solucion de daptomicina reconstituida a 214 nm de acuerdo a la Tabla 3; y b) la preparacion de daptomicina se puede obtener mediante los pasos de: i) formar una solucion acuosa de daptomicina que comprende 105 mg/ml (10,5% peso en volumen) de daptomicina, 7,1 mg/ml (50 mM) de un agente amortiguador fosfato dibásico de sodio y 150 mg/mI (15% peso en volumen) de sacarosa a un pH de aproximadamente 7,0; y ii) convertir la formulacion de daptomicina acuosa a la preparacion de daptomicina solida.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26378409P | 2009-11-23 | 2009-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079127A1 true AR079127A1 (es) | 2011-12-28 |
Family
ID=44060422
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104318 AR079127A1 (es) | 2009-11-23 | 2010-11-23 | Composiciones de daptomicina y metodos relacionados |
| ARP210102879A AR123846A2 (es) | 2009-11-23 | 2021-10-19 | Composición farmacéutica sólida liofilizada de daptomicina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210102879A AR123846A2 (es) | 2009-11-23 | 2021-10-19 | Composición farmacéutica sólida liofilizada de daptomicina |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US8835382B2 (es) |
| EP (2) | EP3417849A1 (es) |
| JP (3) | JP6041673B2 (es) |
| CN (3) | CN104056250A (es) |
| AR (2) | AR079127A1 (es) |
| AU (1) | AU2010321531C1 (es) |
| BR (1) | BR112012012406B1 (es) |
| CA (1) | CA2781666C (es) |
| CL (2) | CL2012001336A1 (es) |
| CO (1) | CO6541585A2 (es) |
| CR (1) | CR20120271A (es) |
| CY (1) | CY1120854T1 (es) |
| DK (1) | DK2504353T4 (es) |
| DO (1) | DOP2012000140A (es) |
| EC (1) | ECSP12011939A (es) |
| ES (1) | ES2686331T5 (es) |
| FI (1) | FI2504353T4 (es) |
| HR (1) | HRP20181380T4 (es) |
| HU (1) | HUE039967T2 (es) |
| IL (1) | IL219891B (es) |
| LT (1) | LT2504353T (es) |
| MX (1) | MX2012005993A (es) |
| NZ (1) | NZ600118A (es) |
| PE (2) | PE20151717A1 (es) |
| PL (1) | PL2504353T5 (es) |
| PT (1) | PT2504353T (es) |
| RS (1) | RS57566B2 (es) |
| RU (1) | RU2607526C2 (es) |
| SG (1) | SG10201407724YA (es) |
| SI (1) | SI2504353T2 (es) |
| TR (1) | TR201812823T4 (es) |
| TW (2) | TWI548414B (es) |
| WO (1) | WO2011063419A2 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696412B1 (en) | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| US20060014674A1 (en) * | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
| LT2504353T (lt) | 2009-11-23 | 2018-09-25 | Cubist Pharmaceuticals Llc | Lipopeptidų kompozicijos ir susiję būdai |
| WO2012094381A2 (en) | 2011-01-05 | 2012-07-12 | Hospira, Inc. | Spray drying vancomycin |
| WO2012162567A1 (en) * | 2011-05-26 | 2012-11-29 | Cubist Pharmaceuticals, Inc. | Cb-183,315 compositions and related methods |
| CN104168908A (zh) * | 2012-01-12 | 2014-11-26 | 细胞基因公司 | 罗米地新制剂及其用途 |
| CA2881121A1 (en) * | 2012-08-23 | 2014-03-27 | Agila Specialties Private Limited | Improved daptomycin injectable formulation |
| NZ741342A (en) * | 2012-09-11 | 2019-10-25 | Hospira Australia Pty Ltd | Daptomycin formulations and uses thereof |
| CN104027791B (zh) * | 2013-03-06 | 2016-08-10 | 浙江海正药业股份有限公司 | 药物组合物 |
| CN104511011A (zh) * | 2013-09-29 | 2015-04-15 | 山东新时代药业有限公司 | 一种达托霉素无菌粉末及其制备方法 |
| US10647746B2 (en) | 2016-04-08 | 2020-05-12 | Versitech Limited | Antibacterial cyclic lipopeptides |
| US11667674B2 (en) | 2016-04-08 | 2023-06-06 | Versitech Limited | Antibacterial cyclic lipopeptides |
| ES2946600T3 (es) | 2016-10-21 | 2023-07-21 | Xellia Pharmaceuticals Aps | Formulaciones líquidas de daptomicina |
| RU2770366C2 (ru) | 2017-08-31 | 2022-04-15 | Кселлия Фармасьютикалз Апс | Препараты даптомицина |
| CN110339341A (zh) * | 2018-04-03 | 2019-10-18 | 江苏恒瑞医药股份有限公司 | 一种达托霉素或其盐的组合物 |
| CN110548130A (zh) * | 2018-06-04 | 2019-12-10 | 浙江医药股份有限公司新昌制药厂 | 含达托霉素的喷雾干粉及其工业化制备方法 |
| US11058745B1 (en) | 2018-10-04 | 2021-07-13 | Good Health, Llc | Stable liquid pharmaceutical compositions of daptomycin |
| CN111840511A (zh) * | 2019-04-30 | 2020-10-30 | 江苏恒瑞医药股份有限公司 | 一种含有精氨酸的达托霉素或其盐的组合物 |
| JP7582205B2 (ja) * | 2019-12-26 | 2024-11-13 | ニプロ株式会社 | ダプトマイシンを含有する安定した凍結乾燥製剤 |
| AU2021227095B2 (en) | 2020-02-28 | 2024-02-22 | Xellia Pharmaceuticals Aps | Daptomycin formulation |
| AU2021233893A1 (en) | 2020-03-12 | 2022-08-25 | Baxter Healthcare Sa | Daptomycin formulations containing a combination of sorbitol and mannitol |
| US11362190B2 (en) | 2020-05-22 | 2022-06-14 | Raytheon Company | Depletion mode high electron mobility field effect transistor (HEMT) semiconductor device having beryllium doped Schottky contact layers |
| CN114788814B (zh) * | 2021-01-26 | 2023-10-13 | 浙江创新生物有限公司 | 一种高稳定性的注射用达托霉素组合物及其制备方法和其应用 |
| RU2770481C1 (ru) * | 2021-06-25 | 2022-04-18 | федеральное государственное автономное образовательное учреждение высшего образования «Казанский (Приволжский) федеральный университет» (ФГАОУ ВО КФУ) | Способ получения суммарной фракции липопептидов бактерий Bacillus subtilis MG-8 ВКПМ В-12476 и его использование в качестве профилактического средства от болезней сельскохозяйственных птиц |
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| US20110124551A1 (en) | 2009-11-23 | 2011-05-26 | Eagle Pharmaceuticals, Inc. | Formulations of daptomycin |
| LT2504353T (lt) | 2009-11-23 | 2018-09-25 | Cubist Pharmaceuticals Llc | Lipopeptidų kompozicijos ir susiję būdai |
| WO2012061360A2 (en) | 2010-11-01 | 2012-05-10 | Rib-X Pharmaceuticals, Inc. | Pharmaceutical compositions |
| NZ612187A (en) | 2010-12-23 | 2015-07-31 | Alkermes Pharma Ireland Ltd | Multi-api loading prodrugs |
| EP2670418A4 (en) | 2011-02-04 | 2015-06-17 | Aegis Therapeutics Llc | ORAL BIO-AVAILABLE PEPTIDARY MATERIAL COMPOSITIONS AND METHOD THEREFOR |
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2010
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