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AR078544A1 - Procedimiento de cultivo de celulas de mamiferos para la produccion de proteinas - Google Patents

Procedimiento de cultivo de celulas de mamiferos para la produccion de proteinas

Info

Publication number
AR078544A1
AR078544A1 ARP100103638A ARP100103638A AR078544A1 AR 078544 A1 AR078544 A1 AR 078544A1 AR P100103638 A ARP100103638 A AR P100103638A AR P100103638 A ARP100103638 A AR P100103638A AR 078544 A1 AR078544 A1 AR 078544A1
Authority
AR
Argentina
Prior art keywords
proteins
protein product
production
cultivation
cell cultures
Prior art date
Application number
ARP100103638A
Other languages
English (en)
Inventor
Zhengjian Li
Ying Jing
Yueming Qian
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43823459&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR078544(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR078544A1 publication Critical patent/AR078544A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Procedimientos y procesos para la produccion de proteínas, en particular de glucoproteínas, mediante el cultivo de células animales o de mamífero, preferentemente, pero no limitados a, cultivos celulares semicontinuos. En un aspecto, los procedimientos comprenden la adicion de compuesto glucocorticoide durante el periodo de cultivo. La adicion de compuesto glucocorticoide mantiene una viabilidad alta de los cultivos celulares y puede proporcionar un aumento en la titulacion final de producto proteico y una calidad alta de producto proteico, tal como se determina, por ejemplo, por medio del contenido de acido siálico en la proteína producida. La consistencia en la calidad del producto proteico, producido de manera recombinante, es un requisito para la aprobacion regulatoria del mismo para ser empleado como agente terapéutico y/o profiláctico.
ARP100103638A 2009-10-06 2010-10-06 Procedimiento de cultivo de celulas de mamiferos para la produccion de proteinas AR078544A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27834309P 2009-10-06 2009-10-06

Publications (1)

Publication Number Publication Date
AR078544A1 true AR078544A1 (es) 2011-11-16

Family

ID=43823459

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100103638A AR078544A1 (es) 2009-10-06 2010-10-06 Procedimiento de cultivo de celulas de mamiferos para la produccion de proteinas

Country Status (26)

Country Link
US (3) US9540426B2 (es)
EP (1) EP2486048B2 (es)
JP (1) JP2013506436A (es)
KR (1) KR20120100973A (es)
CN (1) CN102753572A (es)
AR (1) AR078544A1 (es)
AU (1) AU2010303590B2 (es)
BR (1) BR112012007854A2 (es)
CA (1) CA2777050C (es)
CO (1) CO6531436A2 (es)
CY (1) CY1118734T1 (es)
DK (1) DK2486048T4 (es)
EA (2) EA028491B1 (es)
ES (1) ES2613269T5 (es)
HR (1) HRP20170269T4 (es)
HU (1) HUE031867T2 (es)
IL (1) IL219124A (es)
LT (1) LT2486048T (es)
MX (1) MX2012003654A (es)
PL (1) PL2486048T5 (es)
PT (1) PT2486048T (es)
RS (1) RS55727B2 (es)
SI (2) SI2486048T1 (es)
SM (2) SMT201700116T1 (es)
TW (1) TW201118176A (es)
WO (1) WO2011044180A1 (es)

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Also Published As

Publication number Publication date
CO6531436A2 (es) 2012-09-28
US10030064B2 (en) 2018-07-24
PL2486048T3 (pl) 2017-07-31
US9540426B2 (en) 2017-01-10
CA2777050C (en) 2016-12-20
CY1118734T1 (el) 2017-07-12
EA025604B1 (ru) 2017-01-30
US10059754B2 (en) 2018-08-28
IL219124A (en) 2017-10-31
EP2486048B1 (en) 2016-11-23
TW201118176A (en) 2011-06-01
CN102753572A (zh) 2012-10-24
AU2010303590B2 (en) 2016-07-07
MX2012003654A (es) 2012-04-30
SI2486048T1 (sl) 2017-02-28
JP2013506436A (ja) 2013-02-28
WO2011044180A1 (en) 2011-04-14
DK2486048T4 (da) 2020-03-30
RS55727B1 (sr) 2017-07-31
SMT201700116T1 (it) 2017-03-08
EA201270469A1 (ru) 2012-10-30
HRP20170269T1 (hr) 2017-04-07
IL219124A0 (en) 2012-06-28
AU2010303590A1 (en) 2012-05-03
PL2486048T5 (pl) 2020-07-13
BR112012007854A2 (pt) 2016-11-22
LT2486048T (lt) 2017-02-10
US20170129937A1 (en) 2017-05-11
EA201490631A1 (ru) 2016-05-31
HUE031867T2 (en) 2017-09-28
CA2777050A1 (en) 2011-04-14
SMT201700116B (it) 2017-03-08
PT2486048T (pt) 2017-02-06
SI2486048T2 (sl) 2020-04-30
DK2486048T3 (en) 2017-02-27
ES2613269T5 (es) 2020-08-03
ES2613269T3 (es) 2017-05-23
EA028491B1 (ru) 2017-11-30
KR20120100973A (ko) 2012-09-12
US20110081679A1 (en) 2011-04-07
EP2486048B2 (en) 2019-12-25
US20170129936A1 (en) 2017-05-11
EP2486048A1 (en) 2012-08-15
RS55727B2 (sr) 2020-09-30
HRP20170269T4 (hr) 2020-04-03

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