AR077973A1 - Anticuerpos anti-cdcp1 humanizados - Google Patents
Anticuerpos anti-cdcp1 humanizadosInfo
- Publication number
- AR077973A1 AR077973A1 ARP100103121A ARP100103121A AR077973A1 AR 077973 A1 AR077973 A1 AR 077973A1 AR P100103121 A ARP100103121 A AR P100103121A AR P100103121 A ARP100103121 A AR P100103121A AR 077973 A1 AR077973 A1 AR 077973A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- seq
- chain variable
- variable domain
- humanized anti
- Prior art date
Links
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 101000737742 Homo sapiens CUB domain-containing protein 1 Proteins 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 102000051487 human CDCP1 Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Métodos para su produccion, composiciones farmacéuticas que contienen dichos anticuerpos; los usos de los mismos para el tratamiento del cáncer; ácido nucleico que codifican el anticuerpo divulgado; vectores de expresion y célula hospedante. Reivindicacion 1: Un anticuerpo que se une específicamente a la CDCP1 humana, que contiene un dominio variable de cadena larga (VH) de la SEQ ID NO: 1 y un dominio variable de cadena corta (VL) de la SEQ ID NO: 2 del anticuerpo CUB4 (n° de deposito DSM ACC2551), caracterizado por estar humanizado y contener en dicha secuencia VH: una usina (K) en la posicion 57 en lugar de la treonina (T) y una valina (V) en la posicion 60 en lugar de la prolina (P).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09011046 | 2009-08-28 | ||
| EP10000972 | 2010-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077973A1 true AR077973A1 (es) | 2011-10-05 |
Family
ID=43086176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103121A AR077973A1 (es) | 2009-08-28 | 2010-08-26 | Anticuerpos anti-cdcp1 humanizados |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8394928B2 (es) |
| EP (1) | EP2470567A1 (es) |
| JP (1) | JP5647687B2 (es) |
| KR (1) | KR101495407B1 (es) |
| CN (1) | CN102482357B (es) |
| AR (1) | AR077973A1 (es) |
| AU (1) | AU2010288879A1 (es) |
| BR (1) | BR112012004221A2 (es) |
| CA (1) | CA2770161A1 (es) |
| CL (1) | CL2012000524A1 (es) |
| CO (1) | CO6511201A2 (es) |
| CR (1) | CR20120038A (es) |
| EC (1) | ECSP12011701A (es) |
| IL (1) | IL217919A0 (es) |
| MA (1) | MA33537B1 (es) |
| MX (1) | MX2012002458A (es) |
| NZ (1) | NZ597664A (es) |
| PE (1) | PE20121063A1 (es) |
| RU (1) | RU2571207C2 (es) |
| SG (1) | SG178886A1 (es) |
| TW (1) | TWI412375B (es) |
| UA (1) | UA106890C2 (es) |
| WO (1) | WO2011023389A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201113037A (en) * | 2009-08-28 | 2011-04-16 | Hoffmann La Roche | Antibodies against CDCP1 for the treatment of cancer |
| TWI412375B (zh) * | 2009-08-28 | 2013-10-21 | Roche Glycart Ag | 人類化抗ｃｄｃｐ１抗體 |
| BR112013019083A2 (pt) | 2011-02-10 | 2017-04-04 | Roche Glycart Ag | combinação de (a) um imunoconjugado, composição farmacêutica, uso de (a) um imunoconjugado, método de tratamento de uma doença em um individuo, método de estímulo de função celular efetora em um indivíduo e kit destinado ao tratamento de uma doença. |
| JP6290209B2 (ja) | 2012-08-07 | 2018-03-07 | ロシュ グリクアート アーゲー | 低下した及び増加したエフェクター機能を有するように操作された２つの抗体を含む組成物。 |
| EP2928923B1 (en) | 2012-12-10 | 2020-01-22 | Biogen MA Inc. | Anti-blood dendritic cell antigen 2 antibodies and uses thereof |
| WO2014172448A2 (en) * | 2013-04-17 | 2014-10-23 | Anaptysbio, Inc. | Antibodies directed against activin receptor type ii (actrii) |
| WO2015082446A1 (en) | 2013-12-02 | 2015-06-11 | F. Hoffmann-La Roche Ag | Treatment of cancer using an anti-cdcp1 antibody and a taxane |
| MX2016009653A (es) | 2014-01-24 | 2017-03-27 | Henry M Jackson Found Advancement Military Medicine Inc | Anticuerpos contra glicoproteina f de virus hendra y nipah. |
| WO2015200522A2 (en) * | 2014-06-25 | 2015-12-30 | Integrated Biotherapeutics, Inc. | Monoclonal antibodies directed against envelope glycoproteins from multiple filovirus species |
| WO2018112334A1 (en) | 2016-12-16 | 2018-06-21 | Bluefin Biomedicine, Inc. | Anti-cub domain-containing protein 1 (cdcp1) antibodies, antibody drug conjugates, and methods of use thereof |
| US10928391B2 (en) * | 2017-06-06 | 2021-02-23 | The Cleveland Clinic Foundation | CD318 as a marker for, and CD318 inhibition as a treatment for, autoimmune disease |
| US11603412B2 (en) | 2017-10-25 | 2023-03-14 | The Regents Of The University Of California | Antibodies against CDCP1 for the treatment and detection of cancer |
| US12371507B2 (en) | 2018-11-09 | 2025-07-29 | Beth Israel Deaconess Medical Center | CDCP1 antibodies and antibody drug conjugates |
| US20230174662A1 (en) | 2019-02-01 | 2023-06-08 | Fondazione Per L'istituto Oncologico Di Ricerca (Ior) | Methods of treating castrate-resistant prostate cancer |
| CN115176013B (zh) | 2019-12-27 | 2024-06-07 | 凯奥目生物科学株式会社 | 抗cdcp1抗体 |
| CN117264055A (zh) * | 2022-06-14 | 2023-12-22 | 上海恒润达生生物科技股份有限公司 | 一种特异性结合人cd318的vhh抗体或其抗原结合片段及其制备方法和应用 |
| AU2023286928A1 (en) | 2022-06-20 | 2025-01-02 | Sichuan Huiyu Pharmaceutical Co., Ltd. | Antibody and use thereof |
| AU2023306656A1 (en) | 2022-07-15 | 2025-01-23 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
| KR20240057529A (ko) * | 2022-10-24 | 2024-05-03 | 주식회사 노벨티노빌리티 | 신규 항-cdcp1 항체 및 이의 용도 |
| WO2025199124A1 (en) * | 2024-03-19 | 2025-09-25 | Tavotek Lab Inc | Antibodies targeting cd318 (cdcp1) and uses thereof |
| WO2025207944A1 (en) * | 2024-03-29 | 2025-10-02 | Sidewinder Therapeutics, Inc. | Fgfr3-iiib-binding antibodies |
| WO2025262641A1 (en) | 2024-06-19 | 2025-12-26 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| DE69726003T2 (de) * | 1996-07-16 | 2004-08-26 | Andreas Plückthun | Immunglobulin-superfamilie domainen und fragmente mit erhöhter löslichkeit |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| ES2569919T3 (es) | 1999-04-09 | 2016-05-13 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de una molécula inmunofuncional |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| CN1329061A (zh) | 2000-06-19 | 2002-01-02 | 上海博德基因开发有限公司 | 一种新的多肽——人g蛋白亚基9.46和编码这种多肽的多核苷酸 |
| EP1301533A1 (de) | 2000-07-07 | 2003-04-16 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Tumorassoziiertes antigen (b345), gekennzeichnet durch eine aminosäuresequenz wie in seq. id. no. 4 |
| EP2180044A1 (en) * | 2001-08-03 | 2010-04-28 | GlycArt Biotechnology AG | Antibody glycosylation variants having increased anti-body-dependent cellular cytotoxicity |
| PL213948B1 (pl) | 2001-10-25 | 2013-05-31 | Genentech Inc | Kompozycje zawierajace glikoproteine, czasteczka kwasu nukleinowego kodujaca te glikoproteine, komórka gospodarza, sposób wytwarzania glikoproteiny, kompozycja do zastosowania do leczenia, zastosowanie kompozycji i zestaw zawierajacy kompozycje |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| DE10242146A1 (de) * | 2002-09-04 | 2004-03-18 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Antikörper zur Identifizierung und/oder Isolierung von hämatopoetischen Stammzellen |
| ATE475708T1 (de) | 2003-01-22 | 2010-08-15 | Glycart Biotechnology Ag | Fusionskonstrukte und deren verwendung zur produktion von antikörpern mit erhöhter fc rezeptor bindungsaffinität und effektorfunktion |
| WO2004074481A1 (en) | 2003-02-19 | 2004-09-02 | Novartis Ag | Glycorpotein antigen sima135 expressed in metastatic human tumor cells |
| WO2005011735A1 (en) | 2003-07-29 | 2005-02-10 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| JP2007503206A (ja) | 2003-08-22 | 2007-02-22 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 変更されたエフェクター機能を有する改良された抗体およびその抗体を産生する方法 |
| AU2004273791A1 (en) | 2003-09-05 | 2005-03-31 | Genentech, Inc. | Antibodies with altered effector functions |
| GB0324656D0 (en) | 2003-10-22 | 2003-11-26 | Celltech R&D Ltd | A protein involved in ovarian cancer |
| ES2708095T3 (es) | 2003-11-05 | 2019-04-08 | Roche Glycart Ag | Anticuerpos de CD20 con afinidad de unión a receptor de Fc y función efectora incrementadas |
| US20080008719A1 (en) * | 2004-07-10 | 2008-01-10 | Bowdish Katherine S | Methods and compositions for the treatment of prostate cancer |
| US7632497B2 (en) | 2004-11-10 | 2009-12-15 | Macrogenics, Inc. | Engineering Fc Antibody regions to confer effector function |
| TW200720289A (en) | 2005-04-01 | 2007-06-01 | Hoffmann La Roche | Antibodies against CCR5 and uses thereof |
| US8008443B2 (en) | 2005-04-26 | 2011-08-30 | Medimmune, Llc | Modulation of antibody effector function by hinge domain engineering |
| JP5315489B2 (ja) | 2005-04-26 | 2013-10-16 | アール クレア アンド カンパニー | エフェクター機能が増強されたヒトＩｇＧ抗体を作製する方法 |
| US20070031419A1 (en) * | 2005-06-30 | 2007-02-08 | Applera Corporation | Methods and compositions for treating diseases targeting CDCP1 |
| KR101379568B1 (ko) | 2005-08-26 | 2014-04-08 | 로슈 글리카트 아게 | 변형된 세포 신호 활성을 가진 개질된 항원 결합 분자 |
| JP2007112734A (ja) | 2005-10-19 | 2007-05-10 | Chugai Pharmaceut Co Ltd | 抗ｃｄｃｐ１抗体を含有する癌細胞増殖抑制剤 |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| TWI412375B (zh) * | 2009-08-28 | 2013-10-21 | Roche Glycart Ag | 人類化抗ｃｄｃｐ１抗體 |
-
2010
- 2010-08-25 TW TW099128526A patent/TWI412375B/zh not_active IP Right Cessation
- 2010-08-26 PE PE2012000273A patent/PE20121063A1/es not_active Application Discontinuation
- 2010-08-26 CN CN201080037452.7A patent/CN102482357B/zh not_active Expired - Fee Related
- 2010-08-26 WO PCT/EP2010/005244 patent/WO2011023389A1/en not_active Ceased
- 2010-08-26 MX MX2012002458A patent/MX2012002458A/es active IP Right Grant
- 2010-08-26 NZ NZ597664A patent/NZ597664A/xx not_active IP Right Cessation
- 2010-08-26 UA UAA201203442A patent/UA106890C2/uk unknown
- 2010-08-26 SG SG2012013397A patent/SG178886A1/en unknown
- 2010-08-26 BR BR112012004221A patent/BR112012004221A2/pt not_active IP Right Cessation
- 2010-08-26 US US12/868,845 patent/US8394928B2/en not_active Expired - Fee Related
- 2010-08-26 CA CA2770161A patent/CA2770161A1/en not_active Abandoned
- 2010-08-26 KR KR1020127007820A patent/KR101495407B1/ko not_active Expired - Fee Related
- 2010-08-26 RU RU2012111708/10A patent/RU2571207C2/ru not_active IP Right Cessation
- 2010-08-26 JP JP2012525932A patent/JP5647687B2/ja not_active Expired - Fee Related
- 2010-08-26 AU AU2010288879A patent/AU2010288879A1/en not_active Abandoned
- 2010-08-26 EP EP10748062A patent/EP2470567A1/en not_active Withdrawn
- 2010-08-26 AR ARP100103121A patent/AR077973A1/es unknown
-
2012
- 2012-01-20 CR CR20120038A patent/CR20120038A/es unknown
- 2012-02-02 IL IL217919A patent/IL217919A0/en unknown
- 2012-02-27 MA MA34651A patent/MA33537B1/fr unknown
- 2012-02-28 EC ECSP12011701 patent/ECSP12011701A/es unknown
- 2012-02-28 CL CL2012000524A patent/CL2012000524A1/es unknown
- 2012-02-29 CO CO12035757A patent/CO6511201A2/es active IP Right Grant
- 2012-12-20 US US13/721,553 patent/US9346886B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9346886B2 (en) | 2016-05-24 |
| TWI412375B (zh) | 2013-10-21 |
| KR101495407B1 (ko) | 2015-02-24 |
| RU2571207C2 (ru) | 2015-12-20 |
| PE20121063A1 (es) | 2012-08-09 |
| CL2012000524A1 (es) | 2012-08-17 |
| US20110052582A1 (en) | 2011-03-03 |
| CN102482357B (zh) | 2014-06-11 |
| HK1167412A1 (en) | 2012-11-30 |
| BR112012004221A2 (pt) | 2016-11-29 |
| US8394928B2 (en) | 2013-03-12 |
| MA33537B1 (fr) | 2012-08-01 |
| JP2013502904A (ja) | 2013-01-31 |
| ECSP12011701A (es) | 2012-03-30 |
| SG178886A1 (en) | 2012-04-27 |
| CR20120038A (es) | 2012-04-18 |
| AU2010288879A1 (en) | 2012-02-02 |
| EP2470567A1 (en) | 2012-07-04 |
| RU2012111708A (ru) | 2013-10-10 |
| JP5647687B2 (ja) | 2015-01-07 |
| MX2012002458A (es) | 2012-03-14 |
| KR20120089658A (ko) | 2012-08-13 |
| WO2011023389A1 (en) | 2011-03-03 |
| TW201110983A (en) | 2011-04-01 |
| CA2770161A1 (en) | 2011-03-03 |
| US20130209455A1 (en) | 2013-08-15 |
| UA106890C2 (uk) | 2014-10-27 |
| IL217919A0 (en) | 2012-03-29 |
| CO6511201A2 (es) | 2012-08-31 |
| NZ597664A (en) | 2013-03-28 |
| CN102482357A (zh) | 2012-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR077973A1 (es) | Anticuerpos anti-cdcp1 humanizados | |
| AR124240A2 (es) | Un anticuerpo biespecífico anti-vegf / anti-ang-2, ácido nucleico, vector de expresión, célula huésped y un método de preparación del anticuerpo | |
| AR126242A2 (es) | Tratamiento del cáncer utilizando receptores de antígenos quiméricos | |
| AR106184A1 (es) | Proteínas de unión a pd-1 y sus métodos de uso | |
| MX2019002268A (es) | Anticuerpo monoclonal anti-pd1, composicion farmaceutica de este y uso de este. | |
| AR064333A1 (es) | Anticuerpo anti-tslp de diseno | |
| AR094271A1 (es) | Anticuerpos anti-gdf15 | |
| PE20180480A1 (es) | Anticuerpos de factor xi y metodos de uso | |
| AR103162A1 (es) | Anticuerpos anti-c5 y métodos para su uso | |
| AR101669A1 (es) | Constructos de anticuerpos para cdh19 y cd3 | |
| AR072167A1 (es) | Anticuerpos contra il-6 humano y sus usos | |
| AR102698A1 (es) | Anticuerpos contra cd73 y sus usos | |
| CL2016000438A1 (es) | Anticuerpos humanizados que se unen específicamente al receptor del factor estimulante de colonias 1 (csf-1r); ácidos nucleicos; vectores de expresión, células huéspedes; procesos de producción; composiciones farmacéuticas; usos y métodos de tratamiento terapéutico para el tratamiento del cáncer y de la enfermedad fibrótica | |
| AR085091A1 (es) | Anticuerpos anti-kit y sus usos | |
| AR102239A1 (es) | Anticuerpos anti-ox40 humanizados y sus usos | |
| AR110017A1 (es) | Anticuerpos de pd-1 y usos de estos | |
| PE20181044A1 (es) | Anticuerpos anti-pd-1 y composiciones | |
| AR080793A1 (es) | Anticuerpos biespecificos | |
| PE20181054A1 (es) | Anticuerpos anti-cd19 humano humanizados y metodos de utilizacion | |
| AR108066A1 (es) | Receptores quiméricos para cll-1 y métodos de uso de los mismos | |
| BR112012021327B8 (pt) | anticorpo monoclonal anti-her2 humanizado, método de preparação e uso do mesmo. | |
| MX2014005728A (es) | Anticuerpos especificos para antigeno de la superficie celular de trofoblasto-2 y sus usos. | |
| CL2012000914A1 (es) | Anticuerpos monoclonales que se unen especificamente a la region c-terminal de progastrina. uso para la preparacion de un medicamento util en el tratamiento de cancer colorectal. | |
| CR20140029A (es) | Proteínas de unión a antígeno de tnf-alfa con unión a fcrn incrementada | |
| AR077972A1 (es) | Anticuerpos contra cdcp1 destinados al tratamiento del cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |