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AR077119A1 - Tratamiento de sofocos, sintomas vasomotores y sudores nocturnos con precursores de esteroides sexuales en combinacion con moduladores selectivos del receptor de estrogenos. composicion farmaceutica. conjunto de elementos. - Google Patents

Tratamiento de sofocos, sintomas vasomotores y sudores nocturnos con precursores de esteroides sexuales en combinacion con moduladores selectivos del receptor de estrogenos. composicion farmaceutica. conjunto de elementos.

Info

Publication number
AR077119A1
AR077119A1 ARP100102137A ARP100102137A AR077119A1 AR 077119 A1 AR077119 A1 AR 077119A1 AR P100102137 A ARP100102137 A AR P100102137A AR P100102137 A ARP100102137 A AR P100102137A AR 077119 A1 AR077119 A1 AR 077119A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
night sweats
vasomotor symptoms
derivative
estrogen receptor
Prior art date
Application number
ARP100102137A
Other languages
English (en)
Inventor
Fernand Labrie
Original Assignee
Endorech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43306950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR077119(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Endorech Inc filed Critical Endorech Inc
Publication of AR077119A1 publication Critical patent/AR077119A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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Abstract

Método para la reduccion o eliminacion de la incidencia de sofocos, síntomas vasomotores y sudores nocturnos al tiempo que disminuye el riesgo de sufrir de cáncer de mama, uterino o de endometrio y que además tiene un efecto beneficioso por inhibicion del desarrollo de osteoporosis, hipercolesterolemia, hiperlipidemia, aterosclerosis, hipertension, resistencia a insulina, diabetes tipo 2, pérdida de masa muscular, adiposidad, mal de Alzheimer, pérdida de cognicion, pérdida de memoria o sequedad vaginal, en animales de sangre caliente susceptibles, inclusive seres humanos, que comprenden la administracion de una cantidad de un precursor de esteroides sexuales, en particular dehidroepiandrosterona (DHEA), y un antiestrogeno o un modulador selectivo del receptor de estrogenos, en particular compuestos de la estructura general (1). Reivindicacion 3: Una composicion farmacéutica para reducir o eliminar síntomas seleccionados del grupo que consiste de sofocos, síntomas vasomotores y sudores nocturnos, caracterizada porque comprende: a) un excipiente, diluyente o vehículo farmacéuticamente aceptable; b) al menos un precursor de esteroides sexuales o una prodroga del mismo; y c) al menos un modulador selectivo del receptor de estrogenos o un antiestrogeno o una prodroga de cualquiera de ellos; en donde dicha composicion farmacéutica se provee en un envase que dirige el uso de dicha composicion en la reduccion o eliminacion de al menos un síntoma seleccionado del grupo que consiste de sofocos, síntomas vasomotores y sudores nocturnos. Reivindicacion 35: La composicion farmacéutica de la reivindicacion 3, caracterizada porque el modulador selectivo del receptor de estrogenos se selecciona del grupo que consiste de un derivado de trifeniletileno, un derivado indol, un derivado de benzopirano, Tamoxifeno, Toremifeno, CC 8490, SERM 3471, HMR 3339, HMR 3656, Raloxifeno, LY 335124, LY 326315, Arzoxifeno (LY 353381), SH 646, Pipendoxifeno (ERA 923), Bazedoxifeno (TSE 424, WAY 140424), Oporia (Lasoxifeno) y un derivado centcromano.
ARP100102137A 2009-06-16 2010-06-16 Tratamiento de sofocos, sintomas vasomotores y sudores nocturnos con precursores de esteroides sexuales en combinacion con moduladores selectivos del receptor de estrogenos. composicion farmaceutica. conjunto de elementos. AR077119A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18754909P 2009-06-16 2009-06-16
US12/791,174 US20100317635A1 (en) 2009-06-16 2010-06-01 Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators

Publications (1)

Publication Number Publication Date
AR077119A1 true AR077119A1 (es) 2011-08-03

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ARP100102137A AR077119A1 (es) 2009-06-16 2010-06-16 Tratamiento de sofocos, sintomas vasomotores y sudores nocturnos con precursores de esteroides sexuales en combinacion con moduladores selectivos del receptor de estrogenos. composicion farmaceutica. conjunto de elementos.

Country Status (20)

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US (4) US20100317635A1 (es)
EP (3) EP3178480A1 (es)
JP (4) JP2012530074A (es)
KR (10) KR20210048609A (es)
CN (3) CN104352504A (es)
AR (1) AR077119A1 (es)
AU (1) AU2010262722A1 (es)
BR (1) BRPI1011561A2 (es)
CA (2) CA2765446A1 (es)
CL (1) CL2011003172A1 (es)
EA (1) EA201200016A1 (es)
HK (1) HK1204550A1 (es)
IL (2) IL216963A (es)
MA (1) MA33434B1 (es)
MX (1) MX338290B (es)
NZ (1) NZ597583A (es)
SG (3) SG177497A1 (es)
TW (1) TWI612044B (es)
WO (1) WO2010145010A1 (es)
ZA (1) ZA201109198B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8268806B2 (en) 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions
EP2580210B1 (en) 2010-06-10 2017-03-01 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
CN103796643B (zh) * 2011-07-19 2016-06-22 潘塔希生物科学股份有限公司 含有脱氢表雄酮(dhea)的片剂
EP2791132A4 (en) 2011-12-14 2015-08-05 Seragon Pharmaceuticals Inc ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
AP2014007657A0 (en) 2011-12-16 2014-05-31 Olema Pharmaceuticals Inc Novel benzopyran compounds, compositions and uses thereof
WO2013134311A1 (en) * 2012-03-07 2013-09-12 Ligand Pharmaceuticals, Inc. Steroid hormone and cholesterol pathways as one unified homestatic system
WO2014008159A1 (en) * 2012-07-03 2014-01-09 The University Of North Carolina At Chapel Hill Selective estrogen receptor degraders for treatment of tamoxifen resistant tumors
WO2014203129A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Combinations of benzopyran compounds, compositions and uses thereof
WO2014203132A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Substituted benzopyran compounds, compositions and uses thereof
CN103739456A (zh) * 2013-12-03 2014-04-23 镇江圣安医药有限公司 2-（对-（（z-4-氯-1,2-二苯基-1-丁烯基）苯氧基）乙醇的新型衍生物及其应用
US9744177B2 (en) * 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM
US10391071B2 (en) 2015-04-28 2019-08-27 Cutech Srl Compositions comprising valerian extracts
SG10201913001SA (en) * 2015-10-27 2020-03-30 Sun Pharma Advanced Res Co Ltd Novel heterocyclic antiestrogens
JP6790222B2 (ja) * 2016-03-25 2020-11-25 羅欣薬業（上海）有限公司Ｌｕｏｘｉｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ （Ｓｈａｎｇｈａｉ） Ｃｏ．， Ｌｔｄ． エストロゲン受容体ダウンレギュレーターとしての置換インドール化合物
JP7131773B2 (ja) * 2016-04-29 2022-09-06 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ホルモン受容体に関連する転写活性の標的尺度
CA3064371A1 (en) * 2016-05-20 2017-11-23 Azure Biotech, Inc. Vaginal delivery systems containing selective estrogen receptor modulator (serm) and uses thereof
EP3681478B1 (en) * 2017-09-11 2025-09-10 Atossa Therapeutics, Inc. Topical compositions and methods for treatment
TWI793165B (zh) 2017-09-11 2023-02-21 美商阿托薩醫療公司 製造及使用因多昔芬(endoxifen)之方法
US12201591B2 (en) 2019-07-03 2025-01-21 Atossa Therapeutics, Inc. Sustained release compositions of endoxifen
WO2022203097A1 (ko) * 2021-03-24 2022-09-29 디어젠 주식회사 스트레스 과립의 조절제인 atxn2를 제어하여 tdp-43 단백질의 과잉생산을 억제하는 중추신경계질환의 예방 및 치료 조성물

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US60503A (en) 1866-12-18 Improvement in olaips foe gluing the tips on billiard cues
US3797444A (en) * 1971-04-19 1974-03-19 H Stubbs Towing guide
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
DE3333240A1 (de) * 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen Mittel zur transdermalen applikation von arzneimittelwirkstoffen
CA1254514A (en) 1984-06-29 1989-05-23 Eugene Roberts Method for promoting nerve regeneration
US4725439A (en) 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4624665A (en) * 1984-10-01 1986-11-25 Biotek, Inc. Method of transdermal drug delivery
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US4816258A (en) 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US5064654A (en) * 1989-01-11 1991-11-12 Ciba-Geigy Corporation Mixed solvent mutually enhanced transdermal therapeutic system
US5162037A (en) * 1988-04-01 1992-11-10 Whitson Laboratories, Inc. Magnetically influenced homeopathic pharmaceutical formulations, methods of their preparation and methods of their administration
US5154922A (en) * 1988-12-01 1992-10-13 Schering Corporation Compositions for transdermal delivery of estradiol
US5071644A (en) * 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
US5292730A (en) 1990-08-29 1994-03-08 Humanetics Corporation Modulation of immune system with Δ5-androstenes
US5707983A (en) 1990-08-29 1998-01-13 Humanetics Corporation Treatment of alzheimer's disease and modulation of immune system with Δ5-androstenes
US6060503A (en) 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
US5776923A (en) * 1993-01-19 1998-07-07 Endorecherche, Inc. Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
WO1994016709A2 (en) 1993-01-19 1994-08-04 Endorecherche Inc. Therapeutic uses and delivery systems of dehydroepiandrosterone
AU6513196A (en) 1995-07-11 1997-02-10 Ansaldo Volund A/S A stirling machine
US5883118A (en) 1996-01-11 1999-03-16 Nova Nordisk A/S Prostatic carcinoma
AU1367297A (en) 1996-01-11 1997-08-01 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical comp osition for the treatment or prophylaxis of menopausal symptoms
US5726202A (en) 1996-01-11 1998-03-10 Novo Nordisk A/S Benign prostatic hypertrophy
US5747059A (en) 1996-01-11 1998-05-05 Novo Nordisk A/S Atrophy of skin/mucous membrane
AU1367197A (en) 1996-01-11 1997-08-01 Novo Nordisk A/S Use of the l-enantiomer of centchroman for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of breast cancer
WO1997032837A1 (en) 1996-03-06 1997-09-12 Sumitomo Pharmaceuticals Co., Ltd. Nonsteroidal estrogen derivatives
TW397821B (en) 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
ATE206701T1 (de) 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
US6150381A (en) 1998-06-09 2000-11-21 R.J. Reynolds Tobacco Company Methods of treating microbial infection and therapeutic formulations therefor
ID27922A (id) * 1998-06-11 2001-05-03 Endorech Inc KOMPOSISI FARMASETIKAL DAN PENGGUNAAN DARI ANDROST-5-ENA-3β, 17β-DIOL
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
AU5181200A (en) * 1999-06-04 2000-12-28 General Hospital Corporation, The Pharmaceutical formulations for treating postmenopausal and perimenopausal women, and their use
TR200403328T2 (tr) * 1999-07-06 2005-03-21 Endorecherche, Inc. Kilo alımını tedavi ve/veya önleme metotları.
AU7896100A (en) * 1999-10-14 2001-04-23 Endorecherche Inc. Selective estrogen receptor modulators in the treatment or reduction of the riskof acquiring hypertension, cardiovascular diseases, and insulin resistance
GB0000313D0 (en) 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
SK9592002A3 (en) * 2000-01-28 2003-12-02 Endorech Inc A method for reduction or elimination of the incidence of menopausal symptoms, method of treatment or decreasing the risk of an acquiring disease, a pharmaceutical composition and a kit
US20040198706A1 (en) 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US20050131005A1 (en) * 2002-04-30 2005-06-16 Jiabing Wang 4-azasteroid derivatives as androgen receptor modulators
AU2003227412A1 (en) 2002-10-01 2004-04-23 Dainippon Pharmaceutical Co., Ltd. Spiro compounds, medicinal compositions containing the same and intermediates of the compounds
US20040121991A1 (en) 2002-12-20 2004-06-24 Araneo Barbara A. Dehydroepiandrosterone (DHEA) congeners for prevention and/or treatment of ulcers
AR046639A1 (es) 2003-11-21 2005-12-14 Schering Corp Combinaciones terapeuticas de anticuerpo anti- igfr1
ATE476428T1 (de) * 2004-01-22 2010-08-15 Lilly Co Eli Selektive modulatoren des östrogenrezeptors zur behandlung von vasomotorischen symptomen
EP1761270A1 (en) * 2004-06-23 2007-03-14 Merck & Co., Inc. Estrogen receptor modulators
CN106138065A (zh) * 2004-10-20 2016-11-23 恩多研究公司 性甾体前体单独或与选择性雌激素受体调节剂联合用于预防和治疗绝经后女性的性功能障碍
EP1957109A2 (en) * 2005-12-02 2008-08-20 Sirtris Pharmaceuticals, Inc. Modulators of cdc2-like kinases (clks) and methods of use thereof
CN101489563A (zh) 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
US8268806B2 (en) * 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions
AU2012204083C1 (en) 2007-08-10 2015-02-05 Myriel Pharmaceuticals, Llc DHEA compositions for treating menopause
US9744177B2 (en) 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM

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