[go: up one dir, main page]

PE20081734A1 - Comprimido que comprende 2-[[6-[(3r)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2h)-pirimidinil]metil]-benzonitrilo y celulosa microcristalina - Google Patents

Comprimido que comprende 2-[[6-[(3r)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2h)-pirimidinil]metil]-benzonitrilo y celulosa microcristalina

Info

Publication number
PE20081734A1
PE20081734A1 PE2008000219A PE2008000219A PE20081734A1 PE 20081734 A1 PE20081734 A1 PE 20081734A1 PE 2008000219 A PE2008000219 A PE 2008000219A PE 2008000219 A PE2008000219 A PE 2008000219A PE 20081734 A1 PE20081734 A1 PE 20081734A1
Authority
PE
Peru
Prior art keywords
methyl
tablet
microcrystalline cellulose
benzonitrile
dioxo
Prior art date
Application number
PE2008000219A
Other languages
English (en)
Inventor
Akihiko Ono
Shigeyuki Marunaka
Makoto Fukuta
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39156227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081734(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20081734A1 publication Critical patent/PE20081734A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN COMPRIMIDO QUE COMPRENDE: A) UN GRANULO QUE COMPRENDE 2-[[6-[(3R)-3-AMINO-1-PIPERIDINIL]-3,4-DIHIDRO-3-METIL-2,4-DIOXO-1(2H)-PIRIMIDINIL]METIL]-BENZONITRILO Y CELULOSA MICROCRISTALINA EN UN 5-40% EN PESO; B) UN AUXILIAR DE COMPRESION QUE CONTIENE ESTEARATO DE MAGNESIO Y CELULOSA MICROCRISTALINA EN UN 2-20% EN PESO. DICHO COMPRIMIDO INDUCE FACILMENTE UN PROBLEMA EN LA COMPRESION AL PRENSAR EL COMPRIMIDO EN SU PRODUCCION
PE2008000219A 2007-02-01 2008-01-30 Comprimido que comprende 2-[[6-[(3r)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2h)-pirimidinil]metil]-benzonitrilo y celulosa microcristalina PE20081734A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007023584 2007-02-01

Publications (1)

Publication Number Publication Date
PE20081734A1 true PE20081734A1 (es) 2009-01-19

Family

ID=39156227

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000219A PE20081734A1 (es) 2007-02-01 2008-01-30 Comprimido que comprende 2-[[6-[(3r)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2h)-pirimidinil]metil]-benzonitrilo y celulosa microcristalina

Country Status (11)

Country Link
US (1) US8697125B2 (es)
EP (1) EP2124901B1 (es)
JP (1) JP5284967B2 (es)
AR (1) AR065096A1 (es)
CA (1) CA2677193C (es)
CL (1) CL2008000280A1 (es)
ES (1) ES2639854T3 (es)
HR (1) HRP20171518T1 (es)
PE (1) PE20081734A1 (es)
TW (1) TW200836774A (es)
WO (1) WO2008093878A1 (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
MX2007009317A (es) 2005-02-03 2008-01-30 Gen Hospital Corp Metodo para tratar cancer resistente a gefitinib.
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
CN103110948A (zh) 2005-11-04 2013-05-22 惠氏公司 mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
CN109503584A (zh) 2006-05-04 2019-03-22 勃林格殷格翰国际有限公司 多晶型
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
EP2120885A2 (en) * 2007-03-13 2009-11-25 Takeda Pharmaceutical Company Limited Solid preparation comprising 2-[[6-[(3r)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2h)-pyrimidinyl]methyl]-4-fluorobenzonitrile
PE20090882A1 (es) * 2007-07-19 2009-08-03 Takeda Pharmaceutical Preparacion solida que comprende alogliptina y clorhidrato de metformina
CL2008002427A1 (es) 2007-08-16 2009-09-11 Boehringer Ingelheim Int Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
ES2958968T3 (es) 2008-06-17 2024-02-16 Wyeth Llc Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
SG10202102855RA (en) 2008-08-04 2021-05-28 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
CN102149407A (zh) 2008-09-10 2011-08-10 贝林格尔.英格海姆国际有限公司 治疗糖尿病和相关病症的组合疗法
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102264719A (zh) * 2008-12-23 2011-11-30 桑多斯股份公司 结晶形式的有机化合物
TWI508965B (zh) 2008-12-23 2015-11-21 Boehringer Ingelheim Int 有機化合物的鹽形式
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
UA102429C2 (ru) 2009-02-13 2013-07-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Фармацевтическая композиция, которая включает ингибитор sglt-2, ингибитор дпп-iv и другой антидиабетический агент, и ее применение
JP2012517977A (ja) * 2009-02-13 2012-08-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害剤（リナグリプチン）を任意で他の抗糖尿病薬と組み合わせて含む抗糖尿病薬
HUE061640T2 (hu) 2009-04-06 2023-07-28 Wyeth Llc Gyógykezelési rendszer mellrákhoz neratinib alkalmazásával
JP5732394B2 (ja) * 2009-07-28 2015-06-10 武田薬品工業株式会社 錠剤
ES3029208T3 (en) * 2009-11-09 2025-06-23 Wyeth Llc Tablet formulations of neratinib maleate
EP2504002B1 (en) 2009-11-27 2019-10-09 Boehringer Ingelheim International GmbH Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
WO2011074660A1 (ja) * 2009-12-18 2011-06-23 田辺三菱製薬株式会社 溶出安定性製剤
WO2011136373A1 (ja) * 2010-04-30 2011-11-03 武田薬品工業株式会社 腸溶性錠剤
AU2011249722B2 (en) 2010-05-05 2015-09-17 Boehringer Ingelheim International Gmbh Combination therapy
ES2802243T3 (es) 2010-06-24 2021-01-18 Boehringer Ingelheim Int Terapia para la diabetes
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
AR085689A1 (es) 2011-03-07 2013-10-23 Boehringer Ingelheim Int Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2
JP5874545B2 (ja) * 2011-06-20 2016-03-02 アステラス製薬株式会社 経口投与用医薬組成物
KR101985384B1 (ko) 2011-07-15 2019-06-03 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴나졸린, 이의 제조 및 약제학적 조성물에서의 이의 용도
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
EP4151218A1 (en) 2012-05-14 2023-03-22 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2014051023A1 (ja) * 2012-09-27 2014-04-03 株式会社 三和化学研究所 アナグリプチン含有製剤
CN103877054B (zh) * 2012-12-21 2016-05-25 北大方正集团有限公司 一种苯甲酸阿格列汀片剂及其制备方法
CN103610661B (zh) * 2013-11-22 2017-09-12 威海迪素制药有限公司 一种组合物
CN104721188A (zh) * 2013-12-20 2015-06-24 中美华世通生物医药科技（武汉）有限公司 一种稳定的含苯甲酸阿格列汀的组合物
JP6238921B2 (ja) * 2014-02-17 2017-11-29 大原薬品工業株式会社 イルベサルタンを含有する錠剤
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
CA2987850A1 (en) 2015-06-17 2016-12-22 Hexal Aktiengesellschaft Alogliptin formulation
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合
JP7250305B2 (ja) * 2018-10-02 2023-04-03 共和薬品工業株式会社 メマンチン又はその薬物学的に許容される塩を含む医薬組成物及びその製造方法
JP7340572B2 (ja) * 2021-08-20 2023-09-07 セトラスホールディングス株式会社 酸化マグネシウム錠剤

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200193A (en) * 1987-04-22 1993-04-06 Mcneilab, Inc. Pharmaceutical sustained release matrix and process
JP3836528B2 (ja) * 1995-11-17 2006-10-25 エスエス製薬株式会社 イブプロフェン含有錠剤及びその製造法
ATE299699T1 (de) * 1996-05-20 2005-08-15 Searle Llc Arzneimittel enthaltend oxaprozin natriumsalz, kaliumsalz, oder tris(hydroxymethyl)aminomethansalz
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
JPH1059842A (ja) 1996-08-13 1998-03-03 Lion Corp 錠剤用組成物及び打錠方法
AR016827A1 (es) * 1997-08-22 2001-08-01 Smithkline Beecham Corp PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA
EP0998272B1 (en) * 1997-08-26 2003-05-02 Aventis Pharmaceuticals Inc. Pharmaceutical composition for combination of piperidinoalkanol-decongestant
UA74141C2 (uk) * 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
CN1679556A (zh) 1999-12-08 2005-10-12 法马西亚公司 维得克西组合物
AR029538A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
JP2002179559A (ja) * 2000-10-06 2002-06-26 Takeda Chem Ind Ltd 薄層糖衣錠およびその製造方法
US6645526B2 (en) * 2001-11-13 2003-11-11 Mylan Pharmaceuticals, Inc. Storage stable thyroxine active drug formulations and methods for their production
JP2004189653A (ja) * 2002-12-10 2004-07-08 Yoshio Itabashi イブプロフェン含有錠剤
US20040214804A1 (en) * 2003-04-25 2004-10-28 Pharmacia Corporation Combination of an aldosterone receptor antagonist and an anti-obesity agent
WO2005067976A2 (en) * 2004-01-20 2005-07-28 Novartis Ag Direct compression formulation and process
CN102127057A (zh) * 2004-03-15 2011-07-20 武田药品工业株式会社 二肽基肽酶抑制剂
DE202006000591U1 (de) * 2005-01-20 2006-03-30 Analyze & Realize Ag Gelenkformulierung
US20090215756A1 (en) * 2005-05-18 2009-08-27 Combino Pharm, S.L. Formulations containing losartan and/or its salts
ES2445180T5 (es) 2005-09-14 2022-02-01 Takeda Pharmaceuticals Co Administración de inhibidores de dipeptidil peptidasa
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
WO2007078726A2 (en) * 2005-12-16 2007-07-12 Merck & Co., Inc. Pharmaceutical compositions of combinations of dipeptidyl peptidase-4 inhibitors with metformin

Also Published As

Publication number Publication date
JP5284967B2 (ja) 2013-09-11
ES2639854T3 (es) 2017-10-30
AR065096A1 (es) 2009-05-13
EP2124901B1 (en) 2017-07-19
JP2010517936A (ja) 2010-05-27
CA2677193C (en) 2015-06-30
HRP20171518T1 (hr) 2017-11-17
US8697125B2 (en) 2014-04-15
CA2677193A1 (en) 2008-08-07
US20090318482A1 (en) 2009-12-24
TW200836774A (en) 2008-09-16
CL2008000280A1 (es) 2008-08-18
EP2124901A1 (en) 2009-12-02
WO2008093878A1 (en) 2008-08-07

Similar Documents

Publication Publication Date Title
PE20081734A1 (es) Comprimido que comprende 2-[[6-[(3r)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2h)-pirimidinil]metil]-benzonitrilo y celulosa microcristalina
GB0906579D0 (en) Pharmaceuticals, compositions and methods of making and using the same
PE20140923A1 (es) Preparacion solida que comprende alogliptina y clorhidrato de metformina
AR065698A1 (es) Preparacion solida
GB0518994D0 (en) Adding metadata to a stock content item
DE602007006961D1 (de) Cgrp-rezeptorantagonisten
CA119744S (en) Bottle
MX2009005363A (es) Pirimidinas y su uso como antagonistas del receptor cxcr2.
PH12012501157A1 (en) Anti-her3 antibodies and uses thereof
ATE496051T1 (de) Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten
MY164646A (en) Nicotine lozenge compositions
EP1971366A4 (en) Human anti-IL-23 antibodies, compositions, methods and uses
ATE480524T1 (de) Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten
IL195218A0 (en) 2,4-diamino pyrimidines as cell cycle kinase inhibitors
EA201100306A1 (ru) Производные циклогексиламида и их применение в качестве антагонистов рецептора crf-1
NO20090203L (no) IL-8 receptorantagonist
NO20074544L (no) Inhibering av HER2-losriving med matriksmetalloproteaseantagonister
CL2008003266A1 (es) Compuestos derivados de pirimidindiona y triazindiona sustituidas con cicloguanidina, utiles como antagonista del receptor de procineticina; composicion farmaceutica que comprende dichos compuestos; y uso en el tratamiento de enfermedades gastrointestinales.
MY145644A (en) 5,6-bisaryl-2-pyridine-carboxamide derivatives, preparation and application thereof in therapeutics as urotensin ii receptor antagonists
MX2012001284A (es) Tableta.
PL1987357T3 (pl) Polipeptydy rozpoznawane przez przeciwciała anty-Trichinella oraz ich zastosowanie
TR201909067T4 (tr) Bir sağım başlığı.
BR112017001000A2 (pt) composições de açúcar para preparação de comprimidos por compressão direta
ECSP099673A (es) Formas sólidas de un inhibidor de cinasa raf
EA200601759A1 (ru) Композиции рамиприла

Legal Events

Date Code Title Description
FA Abandonment or withdrawal