AR074474A1 - Inhibidores ns5a de vhc - Google Patents
Inhibidores ns5a de vhcInfo
- Publication number
- AR074474A1 AR074474A1 ARP090104678A ARP090104678A AR074474A1 AR 074474 A1 AR074474 A1 AR 074474A1 AR P090104678 A ARP090104678 A AR P090104678A AR P090104678 A ARP090104678 A AR P090104678A AR 074474 A1 AR074474 A1 AR 074474A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- heteroaryl
- independently
- heterocyclyl
- cycloalkyl
- Prior art date
Links
- 101800001014 Non-structural protein 5A Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 16
- 125000000623 heterocyclic group Chemical group 0.000 abstract 15
- 125000003118 aryl group Chemical group 0.000 abstract 12
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 11
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 10
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000001589 carboacyl group Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000003367 polycyclic group Polymers 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos, composiciones farmacéuticas y medicamentos para el tratamiento de hepatitis C. Reivindicación 1: Un compuesto que tiene la fórmula (1) donde A y A' se seleccionan independientemente del grupo formado por una ligadura simple, -(CR2)n-O-(CR2)p-, -(CR2)n-N(RN)-(CR2)p-, -(CR2)n-S(O)k-N(RN)-(CR2)p-, -(CR2)n-C(O)-N(RN)-(CR2)p-, -(CR2)n-N(RN)-C(O)-N(RN)-(CR2)p-, -(CR2)n-C(O)-O-(CR2)p-, -(CR2)n-N(RN)-S(O)k-N(RN)-(CR2)p- y -(CR2)n-N(RN)-C(O)-O-(CR2)p- y un grupo heteroarilo seleccionado del grupo de fórmulas (2), donde X1 es CH2, NH, O ó S; Y1, Y2 y Z1 son cada uno independientemente CH o N; X2 es NH, O ó S; V es -CH2-CH2-, -CH=CH-, -N=CH-, -(CH2)a-N(RN)-(CH2)b- o -(CH2)a-O-(CH2)b-, donde a y b son independientemente 0, 1, 2 ó 3 con la condición de que a y b no son ambos 0; el resto de fórmula (3) incluye opcionalmente 1 ó 2 N como heteroátomos en el residuo fenilo, los carbonos del grupo heteroarilo están cada uno independientemente opcionalmente sustituidos con un sustituyente seleccionado del grupo formado por OH, -CN, -NO2, halógeno, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclilo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoilo, sulfonilo sustituido, sulfonato, sulfonamido y amino, los N, si presentes, del grupo heteroarilo están cada uno independientemente opcionalmente sustituidos con un sustituyente seleccionado del grupo formado por -OH, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclilo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoilo, sulfonilo sustituido, sulfonato y sulfonamido; a y b son independientemente 1, 2 ó 3; c y d son independientemente 1 ó 2; n y p son independientemente 0, 1, 2 ó 3; k es 0, 1 ó 2; cada R se relaciona independientemente del grupo formado por H, -OH, -CN, -NO2, halógeno, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclilo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoilo, sulfonilo sustituido, sulfonato, sulfonamido y amino; cada RN se selecciona independientemente del grupo formado por hidrógeno, -OH, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclilo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoilo, sulfonilo sustituido, sulfonato, y sulfonamido y donde para cada A y A', B puede estar ligado a cualquier lado de A y A', de modo que cuando A o A' es por ejemplo un resto de fórmula (4), entonces A-B-A' puede ser cualquiera de los restos del grupo de fórmulas (5); B es Q o Q-Q, donde Q se selecciona independientemente del grupo formado por un grupo cicloalquilo, grupo cicloalquenilo, heterociclilo, grupo arilo o heteroarilo, con la condición que sólo un Q es un anillo aromático de 6 miembros cuando B es Q-Q y con la condición de que cuando B es Q-Q, entonces cualquier Q que s un policiclilo está conectado al resto de la molécula a través de solo un ciclo del policiclilo; Rc, Rd, Re y Rf se seleccionan cada uno independientemente del grupo formado por H, alquilo C1-8, heteroalquilo C1-8, aralquilo y un anillo de 4 a 8 miembros que puede ser cicloalquilo, heterociclilo, heteroarilo o arilo, donde, cada heteroátomo, si presente, es independientemente N, O ó S, cada uno de Rc, Rd, Re y Rf puede estar opcionalmente sustituido por alquilo C1-8, heteroalquilo C1-8, aralquilo o un anillo de 4 a 8 miembros que puede ser cicloalquilo, heterociclilo, heteroarilo o arilo y donde cada heteroátomo, si presente, es independientemente N, O ó S, Rc y Rd se unen opcionalmente para formar un heterociclo de 4 a 8 miembros fusionado opcionalmente con otro anillo heterocíclico o heteroarilo de 3 a 6 miembros, y Re y Rf se unen opcionalmente para formar un heterociclo de 4 a 8 miembros fusionado opcionalmente con otro anillo heterociclilo o heteroarilo de 3 a 6 miembros; Y e Y' son cada uno independientemente C o N; y Z y Z' se seleccionan independientemente del grupo formado por H, alquilo C1-8, heteroalquilo C1-8, cicloalquilo, heterociclilo, arilo, heteroarilo, aralquilo, 1-3 aminoácidos, -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-NR7-(CR42)t-R8, -U-(CR42)t-R8 y -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-O-(CR42)t-R8, donde U se selecciona del grupo formado por -C(O)-, -C(S)- y -S(O)2-, cada R4, R5 y R7 se selecciona independientemente del grupo formado por H, alquilo C1-8, heteroalquilo C1-8, cicloalquilo, heterociclilo, arilo, heteroarilo y aralquilo; R8 se selecciona independientemente del grupo formado por H, alquilo C1-8, heteroalquilo C1-8, cicloalquilo, heterociclilo, arilo, heteroarilo, aralquilo, -C(O)-R81, -C(S)-R81-C(O)-O-R81, -C(O)-N-R812, -S(O)2-R81 y -S(O)2-N-R812, donde cada R81 se selecciona independientemente del grupo formado por H, alquilo C1-8, heteroalquilo C1-8, cicloalquilo, heterociclilo, arilo, heteroarilo y aralquilo, opcionalmente, R7 y R8 forman conjuntamente un anillo de 4-7 miembros, cada t es independientemente 0, 1, 2, 3 ó 4, y u es 0, 1 ó 2.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11972308P | 2008-12-03 | 2008-12-03 | |
| US17359009P | 2009-04-28 | 2009-04-28 | |
| US18295209P | 2009-06-01 | 2009-06-01 | |
| PCT/US2009/066467 WO2010065681A1 (en) | 2008-12-03 | 2009-12-02 | Inhibitors of hcv ns5a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074474A1 true AR074474A1 (es) | 2011-01-19 |
Family
ID=42233598
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104678A AR074474A1 (es) | 2008-12-03 | 2009-12-03 | Inhibidores ns5a de vhc |
| ARP090104677A AR080264A1 (es) | 2008-12-03 | 2009-12-03 | Inhibidores ns5a de vhc |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104677A AR080264A1 (es) | 2008-12-03 | 2009-12-03 | Inhibidores ns5a de vhc |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8865756B2 (es) |
| EP (3) | EP2373168A4 (es) |
| JP (2) | JP2012510525A (es) |
| KR (1) | KR20110098779A (es) |
| CN (2) | CN102300462B (es) |
| AR (2) | AR074474A1 (es) |
| AU (2) | AU2009322387A1 (es) |
| BR (1) | BRPI0922364A2 (es) |
| CA (2) | CA2750577A1 (es) |
| CL (1) | CL2011001332A1 (es) |
| CO (1) | CO6390076A2 (es) |
| EA (1) | EA201190007A1 (es) |
| IL (2) | IL213278A0 (es) |
| MX (1) | MX2011005896A (es) |
| NZ (2) | NZ593808A (es) |
| PE (1) | PE20120207A1 (es) |
| SG (2) | SG171891A1 (es) |
| TW (2) | TWI472526B (es) |
| WO (2) | WO2010065681A1 (es) |
| ZA (1) | ZA201104911B (es) |
Families Citing this family (160)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| SI2373172T1 (sl) * | 2008-12-03 | 2013-12-31 | Presidio Pharmaceuticals, Inc. | Inhibitorji HCV NS5A |
| CN102245604A (zh) | 2008-12-23 | 2011-11-16 | 雅培制药有限公司 | 抗病毒化合物 |
| CA2740193A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| US8314135B2 (en) | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
| US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US8420686B2 (en) | 2009-02-17 | 2013-04-16 | Enanta Pharmaceuticals, Inc. | Linked diimidazole antivirals |
| TWI438200B (zh) | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| US8637561B2 (en) * | 2009-02-17 | 2014-01-28 | Enanta Pharmaceuticals, Inc. | Linked diimidazole derivatives |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8242156B2 (en) | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| KR20130130875A (ko) * | 2009-02-27 | 2013-12-02 | 이난타 파마슈티칼스, 인코포레이티드 | Ｃ형 간염 바이러스 억제제 |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8426458B2 (en) * | 2009-02-27 | 2013-04-23 | Enanta Pharmaceuticals, Inc. | Hepatitis C Virus inhibitors |
| AU2013204195B2 (en) * | 2009-02-27 | 2016-09-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8507522B2 (en) * | 2009-03-06 | 2013-08-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| CA2756255A1 (en) | 2009-03-27 | 2010-09-30 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic hcv inhibitors |
| TWI476190B (zh) * | 2009-03-30 | 2015-03-11 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2010120935A1 (en) * | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
| JP2012526834A (ja) | 2009-05-12 | 2012-11-01 | シェーリング コーポレイション | ウイルス疾患治療に有用な縮合型三環式アリール化合物 |
| PE20120509A1 (es) | 2009-05-13 | 2012-05-09 | Gilead Sciences Inc | Derivados 9,9 difluoro-9h-fluoreno que tiene actividad antiviral |
| EP2435424B1 (en) * | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| CA2762885A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis c |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| PL2455376T3 (pl) | 2009-06-11 | 2015-06-30 | Abbvie Bahamas Ltd | Związki heterocykliczne jako inhibitory wirusa zapalenia wątroby typu C (HCV) |
| US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| EP2454254A2 (en) | 2009-07-16 | 2012-05-23 | Vertex Pharmaceuticals Incorporated | Benzimidazole analogues for the treatment or prevention of flavivirus infections |
| CN102471327A (zh) | 2009-07-21 | 2012-05-23 | 吉里德科学公司 | 黄病毒科病毒的抑制剂 |
| RU2538507C2 (ru) * | 2009-08-07 | 2015-01-10 | Тиботек Фармасьютикалз | Фенилэтинильные производные в качестве ингибиторов вируса гепатита с |
| CA2768638A1 (en) | 2009-08-07 | 2011-02-10 | Tibotec Pharmaceuticals | Bis-benzimidazole derivatives as hepatitis c virus inhibitors |
| CN102482260A (zh) | 2009-09-03 | 2012-05-30 | 泰博特克药品公司 | 双-苯并咪唑衍生物 |
| CN102480971B (zh) | 2009-09-04 | 2014-11-26 | 杨森制药公司 | 化合物 |
| US8501714B2 (en) | 2009-09-09 | 2013-08-06 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| US9156818B2 (en) | 2009-09-11 | 2015-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8822700B2 (en) | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8759332B2 (en) | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8927709B2 (en) | 2009-09-11 | 2015-01-06 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8703938B2 (en) | 2009-09-11 | 2014-04-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| WO2011031934A1 (en) * | 2009-09-11 | 2011-03-17 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
| US8815928B2 (en) | 2009-09-11 | 2014-08-26 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
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| AU2006274861B2 (en) * | 2005-07-29 | 2012-11-08 | Medivir Ab | Macrocyclic inhibitors of hepatitis C virus |
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| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| WO2008073461A2 (en) * | 2006-12-11 | 2008-06-19 | Wyeth | Ion channel modulators |
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| CN101280196B (zh) * | 2008-06-03 | 2011-01-26 | 西安近代化学研究所 | 四环液晶化合物 |
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| US8383094B2 (en) | 2008-10-01 | 2013-02-26 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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2009
- 2009-12-02 AU AU2009322387A patent/AU2009322387A1/en not_active Abandoned
- 2009-12-02 PE PE2011001155A patent/PE20120207A1/es not_active Application Discontinuation
- 2009-12-02 BR BRPI0922364A patent/BRPI0922364A2/pt not_active IP Right Cessation
- 2009-12-02 CN CN200980155944.3A patent/CN102300462B/zh not_active Expired - Fee Related
- 2009-12-02 CA CA2750577A patent/CA2750577A1/en not_active Abandoned
- 2009-12-02 NZ NZ593808A patent/NZ593808A/en not_active IP Right Cessation
- 2009-12-02 EP EP09831084A patent/EP2373168A4/en not_active Withdrawn
- 2009-12-02 EP EP13189259.8A patent/EP2774927A1/en not_active Withdrawn
- 2009-12-02 EP EP20090831071 patent/EP2373167A4/en not_active Withdrawn
- 2009-12-02 SG SG2011039799A patent/SG171891A1/en unknown
- 2009-12-02 KR KR1020117015471A patent/KR20110098779A/ko not_active Ceased
- 2009-12-02 EA EA201190007A patent/EA201190007A1/ru unknown
- 2009-12-02 JP JP2011539670A patent/JP2012510525A/ja active Pending
- 2009-12-02 JP JP2011539662A patent/JP2012510523A/ja active Pending
- 2009-12-02 CN CN200980155930.1A patent/CN102300461B/zh not_active Expired - Fee Related
- 2009-12-02 NZ NZ593806A patent/NZ593806A/en not_active IP Right Cessation
- 2009-12-02 WO PCT/US2009/066467 patent/WO2010065681A1/en not_active Ceased
- 2009-12-02 US US13/132,604 patent/US8865756B2/en not_active Expired - Fee Related
- 2009-12-02 CA CA2745119A patent/CA2745119A1/en not_active Abandoned
- 2009-12-02 MX MX2011005896A patent/MX2011005896A/es not_active Application Discontinuation
- 2009-12-02 WO PCT/US2009/066451 patent/WO2010065668A1/en not_active Ceased
- 2009-12-02 US US13/132,606 patent/US9120779B2/en not_active Expired - Fee Related
- 2009-12-02 SG SG2011039781A patent/SG171890A1/en unknown
- 2009-12-02 AU AU2009322400A patent/AU2009322400A1/en not_active Abandoned
- 2009-12-03 AR ARP090104678A patent/AR074474A1/es unknown
- 2009-12-03 AR ARP090104677A patent/AR080264A1/es unknown
- 2009-12-03 TW TW98141406A patent/TWI472526B/zh not_active IP Right Cessation
- 2009-12-03 TW TW098141404A patent/TWI494309B/zh not_active IP Right Cessation
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2011
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- 2011-06-02 CL CL2011001332A patent/CL2011001332A1/es unknown
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