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AR063081A1 - Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentos - Google Patents

Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentos

Info

Publication number
AR063081A1
AR063081A1 ARP070104342A ARP070104342A AR063081A1 AR 063081 A1 AR063081 A1 AR 063081A1 AR P070104342 A ARP070104342 A AR P070104342A AR P070104342 A ARP070104342 A AR P070104342A AR 063081 A1 AR063081 A1 AR 063081A1
Authority
AR
Argentina
Prior art keywords
group
substituted
heterocyclyl
alkyl
nr2r3
Prior art date
Application number
ARP070104342A
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English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
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Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR063081A1 publication Critical patent/AR063081A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A—HUMAN NECESSITIES
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Gynecology & Obstetrics (AREA)

Abstract

Compuestos de 3-aza-biciclo [3.1.0] hexano y su uso en la preparacion de medicamentos. Estos compuestos son utiles en trastornos del sueno, como insomnio, apicea del sueno, dolor neuropático y trastornos neurologicos y psiquiátricos. Reivindicacion 1: Un compuesto de formula (1) donde X representa C(O) o SO2; A representa arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido o está independientemente mono- o di-sustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, cicloalquilo C3-6, alquinilo C2-6, hidroxi-alquilo C1-4, hidroxi-alquinilo C2-6, trimetilsilil-etinilo, cicloalquil C3-6-etinilo, alcoxi C1-4, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, C(O)NR2R3 y halogeno; B representa un átomo de hidrogeno o un grupo arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido o está independientemente mono-, di- o trisustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, cicloalquilo C3-6, alcoxi C1-4, rnetoxi-alcoxi C1-4, ciano, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, C(O)NR2R3 y halogeno; o B representa un grupo 2,3-dihidro-benzo[1 ,4]dioxinilo; o A y B juntos representan un grupo tricíclico; n representa 0 o 1; R1 representa arilo o heterociclilo, donde el arilo o heterociclilo no está sustituido está independientemente mono-, di- o tri-sustituido, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alquinilo C2-6, cicloalquilo C3-6, alcoxi C1-4, alquil C1-4-tio, halogeno, hidroxi, ciano, trifluorometilo, trifluorometoxi, NR2R3, N(R2)C(O)R3, COOR2 y C(O)NR2R3, o R1 representa un grupo heterociclil-etenilo, heterociclil-alquilo C1-4 o ariloxialquilo C1-4, donde dichos grupos no están sustituidos o están independientemente mono- o di-sustituidos en la porcion arilo o heterociclilo, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alcoxi C1-4, halogeno, trifluorometilo, trifluorometoxi y NR2R3, o R1 representa un grupo 2,3-dihidro-benzofuranilo, benzo[1,3jdioxolilo, 2,3-dihidro-benzo[1,4]dioxinilo, 4-oxo- 4H-cromenilo, 2H-cromenilo, cromanilo, 4H-benzo[1,3]dioxinilo, 2,3-dihidro-tieno[3,4-b][1,4]dioxinilo, morfolin-4-il-fenilo, piperazin-1-il-fenilo, 3,4-dihidro-2H-benzo[1,4]oxazinilo, 3-oxo-3,4-dihidro-2H-benzo[1,4]oxazinilo o 2,3,6,7-tetrahidro- benzo[1,2-b;4,5-b']difuranilo, donde dichos grupos no están sustituidos o están independientemente mono- o di-sustituidos, donde los sustituyentes se seleccionan independientemente del grupo que consiste en alquilo C1-4, alcoxi C1-4 y halogeno; R2 representa hidrogeno o alquilo C1-4; y R3 representa hidrogeno o alquilo C1-4; o una sal farmacéuticamente aceptable de dicho compuesto.
ARP070104342A 2006-09-29 2007-10-01 Derivados de 3- aza- biciclo [3.1.0] hexano y su uso para la preparacion de medicamentos AR063081A1 (es)

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IB2006053570 2006-09-29

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AR063081A1 true AR063081A1 (es) 2008-12-23

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Country Link
US (1) US20100016401A1 (es)
EP (1) EP2079690B1 (es)
JP (1) JP2010504957A (es)
KR (1) KR20090077051A (es)
CN (1) CN101522618A (es)
AR (1) AR063081A1 (es)
AT (1) ATE481383T1 (es)
CA (1) CA2662612A1 (es)
CL (1) CL2007002809A1 (es)
DE (1) DE602007009284D1 (es)
ES (1) ES2350460T3 (es)
TW (1) TW200823227A (es)
WO (1) WO2008038251A2 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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