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AR062564A1 - Compuestos heterociclicos utiles para prevenir y/o tratar enfermedades y trastornos mediados por tnf-alfa y/o por mk2,tales como enfermedades autoinmunes, inflamacion y artritis, composiciones farmaceuticas que los contienen y metodo de preparacion. - Google Patents

Compuestos heterociclicos utiles para prevenir y/o tratar enfermedades y trastornos mediados por tnf-alfa y/o por mk2,tales como enfermedades autoinmunes, inflamacion y artritis, composiciones farmaceuticas que los contienen y metodo de preparacion.

Info

Publication number
AR062564A1
AR062564A1 ARP070103811A ARP070103811A AR062564A1 AR 062564 A1 AR062564 A1 AR 062564A1 AR P070103811 A ARP070103811 A AR P070103811A AR P070103811 A ARP070103811 A AR P070103811A AR 062564 A1 AR062564 A1 AR 062564A1
Authority
AR
Argentina
Prior art keywords
alkyl
amino
aryl
cycloalkyl
hetero
Prior art date
Application number
ARP070103811A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37836874&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR062564(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR062564A1 publication Critical patent/AR062564A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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Abstract

Reivindicacion 1: Un compuesto de la formula (1) o una sal farmacéuticamente aceptable o un éster farmacéuticamente aceptable y disociable, o una sal de adicion de ácido del mismo: en donde: Rl se selecciona a partir de: halogeno, ciano, hidroxilo, mercapto, (arilo, aril-alquilo C1-6, arilalquenilo C2-6, hetero-arilo monociclico, hetero-aril-alquilo C1-6, hetero-aril-alquenilo C2-6, aril-amino, hetero-aril-amino, ariloxilo, hetero-ariloxilo, alquilo C1-6, cicloalquilo C3-7, alcoxilo C1-6, alquilo C1-6-amino, alquenilo C2-6, alquinilo C2-6, hetero-cicloalquilo, hetero-cicloalquil-alquilo C1-6, hetero cicloalquil-alquenilo C2-6, hetero-cicloalquilamino, hetero-cicloalquiloxilo, amino) opcionalmente sustituido, en donde los sustituyentes opcionales sobre R1 se seleccionan a partir de halogeno, ciano, hidroxilo, mercapto, sulfonilo, amino, alquilo C1-6-amino, di-alquilo C1-6-amino, arilo, hetero-arilo monocíclico, alquilo C1-6, alcoxilo C1-6, cicloalquilo C3-7, heterocicloalquilo C3-7, carboxilo, carbonil-alquilo C1-7, cada uno de los cuales, donde sea aplicable, puede estar opcionalmente sustituido por alquilo C1-6, cicloalquilo C3-7, cicloalquilo C3-7, hetero-cicloalquilo C3-7, alcoxilo C1-6, alquenilo C1-6, alquinilo C1-6, halogeno, hidroxilo, mercapto, ciano, amino, hetero-cicloalquilo C3-7-carbonilo; cada uno de los cuales, donde sea aplicable, puede estar opcionalmente sustituido por alquilo C1-6, cicloalquilo C3-7, cicloalquilo C3-7, hetero- cicloalquilo C3-7, alcoxilo C1-6, alquenilo C1-6, alquinilo C1-6, halogeno, hidroxilo, mercapto, ciano, amino, hetero-cicloalquilo C3-7-carbonilo; X es O, S o NOH; R2 representa el grupo -C(A)(Q)-Y, en donde Q es H o alquilo C1-6; A es H o alquilo C1-6; Y es amino, amino-oxilo, hidroxilo, alcoxilo C1-6, alquilo C1-6-amino o hidrazina, que en cada caso pueden estar opcionalmente sustituidos, seleccionándose los sustituyentes opcionales sobre Y a partir de alquilo C1-6, halogeno, hidroxilo; R3 es -OH, -OR4 o -NHR4, en donde R4 es H o alquilo C1-6; o R2 y R3 se unen para denotar colectivamente el grupo -R2-R3- para formar un anillo de 5, 6, o 7 miembros, seleccionándose el grupo colectivo -R2-R3- a partir de: -(CH2)nNR5-, -CH2ONH-, -(CH2)n- , -CH=N-NH-, -(CH2)n-NR6-NH- en donde R5 se selecciona a partir de H o (alquilo C1-6, aril-alquilo C1-6, hetero-aril-alquilo C1-6, cicloalquilo C3-7-alquilo C1-6, heterocicloalquilo C3-7-alquilo C1-6) opcionalmente sustituido; siendo los sustituyentes opcionales sobre R5 uno o más grupos independientemente seleccionados a partir de halogeno, alquilo C1-6, alcoxilo C1-6, amino, trifluoro-metilo, sulfonilo, hidroxilo; y R6 se selecciona a partir de H o alquilo C1-6 opcionalmente sustituido, carbonilo, sulfonilo; siendo los sustituyentes opcionales sobre R6 uno o más grupos independientemente seleccionados a partir de alquilo C1-6, alcoxilo inferior, amino, alquil-amino, hidroxilo; en donde n es 1, 2 o 3; y R7 se selecciona a partir de H y alquilo C1-6 opcionalmente sustituido, seleccionándose los sustituyentes opcionales a partir de amino, hidroxilo, halogeno, y carboxilo.
ARP070103811A 2006-08-30 2007-08-28 Compuestos heterociclicos utiles para prevenir y/o tratar enfermedades y trastornos mediados por tnf-alfa y/o por mk2,tales como enfermedades autoinmunes, inflamacion y artritis, composiciones farmaceuticas que los contienen y metodo de preparacion. AR062564A1 (es)

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CL2007002499A1 (es) 2006-08-30 2008-03-14 Phenomix Corp Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes.
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
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WO2013033657A2 (en) 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York CaMKII, IP3R, CALCINEURIN, P38 AND MK2/3 INHIBITORS TO TREAT METABOLIC DISTURBANCES OF OBESITY
AU2014238443A1 (en) 2013-03-15 2015-07-30 Celgene Car Llc MK2 inhibitors and uses thereof
JP2016530209A (ja) 2013-09-17 2016-09-29 ファーマケア，インク． ビニルオートタキシン阻害剤化合物
WO2015042052A1 (en) 2013-09-17 2015-03-26 Pharmakea, Inc. Heterocyclic vinyl autotaxin inhibitor compounds
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