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MX2012008533A - Naftiridinas sustituidas y su uso como inhibidores de syk quinasa. - Google Patents

Naftiridinas sustituidas y su uso como inhibidores de syk quinasa.

Info

Publication number
MX2012008533A
MX2012008533A MX2012008533A MX2012008533A MX2012008533A MX 2012008533 A MX2012008533 A MX 2012008533A MX 2012008533 A MX2012008533 A MX 2012008533A MX 2012008533 A MX2012008533 A MX 2012008533A MX 2012008533 A MX2012008533 A MX 2012008533A
Authority
MX
Mexico
Prior art keywords
alkyl
ring
naftiridines
syk
replaced
Prior art date
Application number
MX2012008533A
Other languages
English (en)
Inventor
Matthias Hoffmann
Andreas Schnapp
Georg Dahmann
Gerhard Schaenzle
Sandra Handschuh
Guenter Linz
Dennis Fiegen
Jasna Klicic
Stephen P East
Michael Philip Mazanetz
John Robert Scott
Edward Walker
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42272624&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012008533(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2012008533A publication Critical patent/MX2012008533A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a nuevas naftiridinas sustituidas de fórmula 1, como también a sus sales, diastereómeros, enantiómeros, racematos, hidratos o solvatos farmacológicamente aceptables, (ver fórmula) en la que R1 se selecciona entre -O-R3 o -NR3R4, R3 es alquilo C1-6 que sustituido con R5 y R6, R5 se selecciona entre hidrógeno, alquilo C1-6 lineal o ramificado, alquenilo C2-6, -alquilen C1-6 -O-alquilo C1-3, haloalquilo C1-3, R6 es un anillo X (ver fórmula) donde n es 0 ó 1, y donde es o bien un enlace sencillo o un doble enlace y donde A, B, D y E se seleccionan cada uno independientemente unos de otros de CH2, CH, C, N, NH, O o S y donde el anillo X está unido a la molécula mediante la posición A, B, D o E, donde dicho anillo X puede estar opcionalmente sustituido con uno, dos o tres residuos seleccionados cada uno individualmente entre el grupo que consiste en - oxo, hidroxi, -alquilo C1-3, -haloalquilo C1-3, -O-alquilo C1-3, -alcanol C1-3 y halógeno, y donde R4, R2, R7, R8, R9, R10, R11 y Q pueden tener los significados expuestos en la reivindicación 1, como también composiciones farmacéuticas que contienen estos compuestos.
MX2012008533A 2010-01-29 2011-01-21 Naftiridinas sustituidas y su uso como inhibidores de syk quinasa. MX2012008533A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10152159 2010-01-29
PCT/EP2011/050871 WO2011092128A1 (en) 2010-01-29 2011-01-21 Substituted naphthyridines and their use as syk kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2012008533A true MX2012008533A (es) 2012-08-31

Family

ID=42272624

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008533A MX2012008533A (es) 2010-01-29 2011-01-21 Naftiridinas sustituidas y su uso como inhibidores de syk quinasa.

Country Status (19)

Country Link
US (2) US8969568B2 (es)
EP (1) EP2528915B1 (es)
JP (1) JP5629331B2 (es)
KR (1) KR20120125267A (es)
CN (1) CN102822172A (es)
AR (1) AR080074A1 (es)
AU (1) AU2011209274B8 (es)
BR (1) BR112012018865A2 (es)
CA (1) CA2786245A1 (es)
CL (1) CL2012001807A1 (es)
EA (1) EA201201052A1 (es)
IL (1) IL220553A0 (es)
MX (1) MX2012008533A (es)
NZ (1) NZ600857A (es)
PH (1) PH12012501535A1 (es)
TW (1) TW201139435A (es)
UY (1) UY33205A (es)
WO (1) WO2011092128A1 (es)
ZA (1) ZA201204793B (es)

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BR112012018865A2 (pt) 2010-01-29 2016-04-12 Boehringer Ingelheim Int naftiridinas substituídas e seu uso como inibidores de quinase syk
WO2012167423A1 (en) 2011-06-08 2012-12-13 Hutchison Medipharma Limited Substituted pyridopyrazines as novel syk inhibitors
EA024845B1 (ru) 2011-07-26 2016-10-31 Бёрингер Ингельхайм Интернациональ Гмбх Замещенные хинолины и их применение в качестве лекарственных средств
WO2014086032A1 (en) * 2012-12-07 2014-06-12 Hutchison Medipharma Limited Substituted pyridopyrazines as syk inhibitors
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NZ718576A (en) 2013-10-21 2019-11-29 Genosco Substituted pyrimidine compounds and their use as syk inhibitors
HRP20191364T1 (hr) 2014-03-19 2019-11-01 Boehringer Ingelheim Int Sik-inhibitori tipa heteroarila
WO2017042100A1 (en) 2015-09-11 2017-03-16 Boehringer Ingelheim International Gmbh Pyrazolyl-substituted heteroaryls and their use as medicaments
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US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
TWI870497B (zh) 2019-11-01 2025-01-21 美商奈維特製藥公司 使用mtorc1調節劑的治療方法
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN114315747A (zh) * 2020-09-30 2022-04-12 山东润博生物科技有限公司 一种5,5-二甲基异噁唑烷-3-硫酮的制备方法
KR20220138655A (ko) * 2021-04-06 2022-10-13 주식회사 온코크로스 신장 질환의 예방 또는 치료용 화합물
KR20220138654A (ko) * 2021-04-06 2022-10-13 주식회사 온코크로스 당뇨병의 예방 또는 치료용 화합물
CN113735791A (zh) * 2021-10-14 2021-12-03 杭州欧晨科技有限公司 一种3-溴-5,5-二甲基-4,5-二氢异噁唑的合成方法

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AU2011209274A1 (en) 2012-07-19
CA2786245A1 (en) 2011-08-04
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US20150126503A1 (en) 2015-05-07
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UY33205A (es) 2011-08-31
US9187478B2 (en) 2015-11-17
EP2528915A1 (en) 2012-12-05
JP2013518073A (ja) 2013-05-20
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EA201201052A1 (ru) 2013-02-28
BR112012018865A2 (pt) 2016-04-12
US20120028939A1 (en) 2012-02-02
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