AR062424A1 - Formulacion en aerosol para la inhalacion de beta - agonistas - Google Patents
Formulacion en aerosol para la inhalacion de beta - agonistasInfo
- Publication number
- AR062424A1 AR062424A1 ARP070103672A ARP070103672A AR062424A1 AR 062424 A1 AR062424 A1 AR 062424A1 AR P070103672 A ARP070103672 A AR P070103672A AR P070103672 A ARP070103672 A AR P070103672A AR 062424 A1 AR062424 A1 AR 062424A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- enantiomers
- halogen
- means hydrogen
- pharmacologically tolerable
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000443 aerosol Substances 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- 150000001450 anions Chemical class 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229940092705 beclomethasone Drugs 0.000 abstract 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 abstract 1
- 229960004436 budesonide Drugs 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229960003728 ciclesonide Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000013583 drug formulation Substances 0.000 abstract 1
- 229960002714 fluticasone Drugs 0.000 abstract 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- YXJYBPXSEKMEEJ-UHFFFAOYSA-N phosphoric acid;sulfuric acid Chemical compound OP(O)(O)=O.OS(O)(=O)=O YXJYBPXSEKMEEJ-UHFFFAOYSA-N 0.000 abstract 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 abstract 1
- 229960001860 salicylate Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Formulacion para la inhalacion. Uso y kit. Reivindicacion 1: Formulacion medicamentosa que contiene como principio activo uno o varios compuestos de la formula general 1 en los que R1 significa hidrogeno, alquilo C1-4, O-alquilo C1-4 o halogeno; R2 significa hidrogeno, alquilo C1-4, O-alquilo C1-4 o halogeno; R3 significa hidrogeno, alquilo C1-4, O-alquilo C1-4, halogeno, OH, -O-alquiIen C1-4-COOH u O-alquilen C1-4-COO-alquilo C1-4; X significa un anion de carga negativa simple o multiple, con preferencia un anion de carga negativa simple o multiple seleccionado del grupo compuesto por cloruro, bromuro, yoduro, sulfato fosfato, metansulfonato, nitrato, maleato, acetato, benzoato, citrato, salicilato, trifluoroacetato, fumarato, tartrato, oxalato, succinato, benzoato y p-toluensulfonato, eventualmente en forma de sus tautomeros, enantiomeros, mezclas de los enantiomeros, racematos, solvatos o hidratos: un principio activo 2 seleccionado del grupo consistente en budesonida, beclometasona, fluticasona, ciclesonida o un metabolito del mismo, eventualmente en forma de sus tautomeros, enantiomeros, mezclas de los enantiomeros, racematos, solvatos o hidratos; al menos un ácido farmacologicamente tolerable o un sistema tampon farmacologicamente tolerable, eventualmente otros coadyuvantes farmacologicamente tolerables, así como en calidad de disolvente agua, etanol o una mezcla de agua y etanol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06119129 | 2006-08-18 | ||
| EP07101128 | 2007-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062424A1 true AR062424A1 (es) | 2008-11-05 |
Family
ID=39082381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103672A AR062424A1 (es) | 2006-08-18 | 2007-08-17 | Formulacion en aerosol para la inhalacion de beta - agonistas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080041370A1 (es) |
| EP (1) | EP2054034A2 (es) |
| JP (1) | JP2010501021A (es) |
| KR (1) | KR20090040922A (es) |
| AR (1) | AR062424A1 (es) |
| AU (1) | AU2007285746A1 (es) |
| BR (1) | BRPI0715692A2 (es) |
| CA (1) | CA2660480A1 (es) |
| CO (1) | CO6150123A2 (es) |
| EA (1) | EA200900267A1 (es) |
| IL (1) | IL197024A0 (es) |
| MX (1) | MX2009001553A (es) |
| NO (1) | NO20090410L (es) |
| PE (1) | PE20080607A1 (es) |
| TW (1) | TW200817010A (es) |
| UY (1) | UY30543A1 (es) |
| WO (1) | WO2008020056A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| US20050255050A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Powder formulations for inhalation, comprising enantiomerically pure beta agonists |
| DK1917253T3 (da) * | 2005-08-15 | 2015-03-30 | Boehringer Ingelheim Int | Fremgangsmåde til fremstilling af betamimetika |
| BR112014003061A2 (pt) | 2011-08-12 | 2017-02-21 | Boehringer Ingelheim Vetmedica Gmbh | composição farmacêutica com sabor mascarado |
| WO2014016548A2 (en) | 2012-07-27 | 2014-01-30 | Cipla Limited | Pharmaceutical composition |
| WO2014096116A1 (en) | 2012-12-21 | 2014-06-26 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical formulation comprising ciclesonide |
| BR112015010842B1 (pt) * | 2012-12-21 | 2021-03-30 | Boehringer Ingelheim Vetmedica Gmbh | Uso da ciclesonida para o tratamento de doença das vias respiratórias em cavalos |
| US9944618B2 (en) | 2013-03-14 | 2018-04-17 | Mayo Foundation For Medical Education And Research | Inhibiting neurotransmitter reuptake |
| RS59613B1 (sr) | 2014-06-18 | 2020-01-31 | Boehringer Ingelheim Vetmedica Gmbh | Muskarinski antagonisti i njihove kombinacije za lečenje bolesti disajnih puteva kod konja |
| JP7189766B2 (ja) | 2015-10-09 | 2022-12-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | マイクロ構造コンポーネントのコーティング方法 |
| CN115397417A (zh) * | 2020-04-16 | 2022-11-25 | 广州谷森制药有限公司 | 含有噻托溴铵和奥达特罗的可吸入溶液制剂 |
| US20210322309A1 (en) * | 2020-04-16 | 2021-10-21 | Cai Gu Huang | Inhalable Formulation of a Solution Containing Olodaterol |
| WO2021262648A1 (en) * | 2020-06-23 | 2021-12-30 | Anovent Pharmaceutical (U.S.), Llc | Preparation of a pharmaceutical composition of olodaterol and budesonide |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3134590A1 (de) * | 1981-09-01 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue benzo-heterocyclen |
| KR890000664B1 (ko) * | 1981-10-19 | 1989-03-22 | 바리 안소니 뉴우샘 | 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법 |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| DE10253282A1 (de) * | 2002-11-15 | 2004-05-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung |
| NZ550797A (en) * | 2004-04-22 | 2010-08-27 | Boehringer Ingelheim Int | Pharmaceutical combinations containing 6-hydroxy-8-{1-hydroxy-2-[2-(4-methoxy-phenyl)-1,1-dimethylethylamino]-ethyl}-4H-benzo[1,4]oxazin-3-one for treating respiratory diseases |
| DE102004024452A1 (de) * | 2004-05-14 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation von Betaagonisten |
-
2007
- 2007-08-15 UY UY30543A patent/UY30543A1/es not_active Application Discontinuation
- 2007-08-16 EP EP07819951A patent/EP2054034A2/de not_active Withdrawn
- 2007-08-16 PE PE2007001103A patent/PE20080607A1/es not_active Application Discontinuation
- 2007-08-16 CA CA002660480A patent/CA2660480A1/en not_active Abandoned
- 2007-08-16 EA EA200900267A patent/EA200900267A1/ru unknown
- 2007-08-16 US US11/839,817 patent/US20080041370A1/en not_active Abandoned
- 2007-08-16 KR KR1020097005574A patent/KR20090040922A/ko not_active Withdrawn
- 2007-08-16 WO PCT/EP2007/058515 patent/WO2008020056A2/de not_active Ceased
- 2007-08-16 BR BRPI0715692-8A patent/BRPI0715692A2/pt not_active Application Discontinuation
- 2007-08-16 MX MX2009001553A patent/MX2009001553A/es not_active Application Discontinuation
- 2007-08-16 JP JP2009525029A patent/JP2010501021A/ja active Pending
- 2007-08-16 AU AU2007285746A patent/AU2007285746A1/en not_active Abandoned
- 2007-08-17 TW TW096130612A patent/TW200817010A/zh unknown
- 2007-08-17 AR ARP070103672A patent/AR062424A1/es unknown
-
2009
- 2009-01-28 NO NO20090410A patent/NO20090410L/no not_active Application Discontinuation
- 2009-02-12 IL IL197024A patent/IL197024A0/en unknown
- 2009-03-18 CO CO09028166A patent/CO6150123A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0715692A2 (pt) | 2013-08-06 |
| CO6150123A2 (es) | 2010-04-20 |
| JP2010501021A (ja) | 2010-01-14 |
| NO20090410L (no) | 2009-03-02 |
| WO2008020056A2 (de) | 2008-02-21 |
| EP2054034A2 (de) | 2009-05-06 |
| PE20080607A1 (es) | 2008-07-17 |
| UY30543A1 (es) | 2008-03-31 |
| KR20090040922A (ko) | 2009-04-27 |
| WO2008020056A3 (de) | 2008-09-12 |
| AU2007285746A1 (en) | 2008-02-21 |
| CA2660480A1 (en) | 2008-02-21 |
| US20080041370A1 (en) | 2008-02-21 |
| TW200817010A (en) | 2008-04-16 |
| MX2009001553A (es) | 2009-04-17 |
| IL197024A0 (en) | 2009-11-18 |
| EA200900267A1 (ru) | 2009-08-28 |
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