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AR061584A1 - Uso de 2-aminotetralinas sustituidas para la fabricacion de un medicamento para la prevencion, alivio y/o tratamiento de diversos tipos de dolor - Google Patents

Uso de 2-aminotetralinas sustituidas para la fabricacion de un medicamento para la prevencion, alivio y/o tratamiento de diversos tipos de dolor

Info

Publication number
AR061584A1
AR061584A1 ARP070102756A ARP070102756A AR061584A1 AR 061584 A1 AR061584 A1 AR 061584A1 AR P070102756 A ARP070102756 A AR P070102756A AR P070102756 A ARP070102756 A AR P070102756A AR 061584 A1 AR061584 A1 AR 061584A1
Authority
AR
Argentina
Prior art keywords
alkyl
relief
prevention
treatment
group
Prior art date
Application number
ARP070102756A
Other languages
English (en)
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436802&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR061584(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of AR061584A1 publication Critical patent/AR061584A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Reivindicacion 1: Uso de un compuesto que tiene la formula (1) en donde n es un numero desde 1 a 5; R1 es seleccionado del grupo que consiste de hidrogeno, 3- piridilo, 4-piridilo, fenilo opcionalmente sustituido, formulas (2), en donde X es S, O o NH; R2 es un grupo -OA; y R3 y R4 son cada uno independientemente hidrogeno o un grupo -OA; en donde A es hidrogeno, alquilo, cicloalquilo, arilo, alcoxialquilo, -C(=S)R6, -C(=S)OR6, -C(=S)NR6R7, -S(O)2R6, -S(O)2OR6, -P(O2H)R6, -P(O2H)OR6, CHRR6OC(O)R7, alquilo C1-3-OC(O)R6, -C(OR6)R7R8, -CH-(OR6)R7, C(O)R6, -C(O)NR6R7, o C(O)OR6, en donde R6, R7 y R8 son cada uno independientemente hidrogeno, alquilo, cicloalquilo o arilo; y en donde los sustituyentes alquilo están opcionalmente sustituidos con uno o más átomos de halogeno; R5 es un alquilo C1-3, en donde los compuestos de la formula (1) pueden estar presentes como enantiomeros puros (R o S) o cualquier mezcla de los mismos, incluyendo racematos, o sales, prodrogas o metabolitos de los mismos, farmacéuticamente aceptables, para la preparacion de una composicion farmacéutica para la prevencion, alivio y/o tratamiento de dolor cronico y/o agudo. Reivindicacion 13: Uso de acuerdo con una de las reivindicaciones precedentes, en donde el compuesto es (+/-) 5,6,7,8-tetrahidro-6-[propil[2- (2-tienil)etil]amino]-1-naftol o una sal, prodroga o metabolito del mismo farmacéuticamente aceptables. Reivindicacion 18: Uso de acuerdo con una de las reivindicaciones precedentes, que comprende adicionalmente administrar al menos un agente activo adicional. Reivindicacion 20: Uso de acuerdo con la reivindicacion 18, en donde el agente activo adicional es dextrometorfano.
ARP070102756A 2006-06-22 2007-06-22 Uso de 2-aminotetralinas sustituidas para la fabricacion de un medicamento para la prevencion, alivio y/o tratamiento de diversos tipos de dolor AR061584A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06012815 2006-06-22

Publications (1)

Publication Number Publication Date
AR061584A1 true AR061584A1 (es) 2008-09-03

Family

ID=38436802

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102756A AR061584A1 (es) 2006-06-22 2007-06-22 Uso de 2-aminotetralinas sustituidas para la fabricacion de un medicamento para la prevencion, alivio y/o tratamiento de diversos tipos de dolor

Country Status (15)

Country Link
US (2) US20080008748A1 (es)
EP (1) EP2032128B1 (es)
JP (1) JP2009541237A (es)
KR (1) KR20090024277A (es)
CN (1) CN101534809B (es)
AR (1) AR061584A1 (es)
AU (1) AU2007263308B2 (es)
BR (1) BRPI0712976A2 (es)
CA (1) CA2656361A1 (es)
EA (1) EA017746B1 (es)
ES (1) ES2393211T3 (es)
MX (1) MX2008016037A (es)
NO (1) NO20090321L (es)
TW (1) TWI392670B (es)
WO (1) WO2007147556A1 (es)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
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DE10041479A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US20040048779A1 (en) * 2002-05-06 2004-03-11 Erwin Schollmayer Use of rotigotine for treating the restless leg syndrome
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8246979B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
DE10261696A1 (de) 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE10334187A1 (de) * 2003-07-26 2005-03-03 Schwarz Pharma Ag Substituierte 2-Aminotetraline zur Behandlung von Depressionen
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10359528A1 (de) * 2003-12-18 2005-07-28 Schwarz Pharma Ag (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum
DE10361258A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
US20050197385A1 (en) * 2004-02-20 2005-09-08 Schwarz Pharma Ag Use of rotigotine for treatment or prevention of dopaminergic neuron loss
DE102004014841B4 (de) * 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
TWI392670B (zh) * 2006-06-22 2013-04-11 Ucb Pharma Gmbh 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途
EP1987815A1 (en) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
EP2215072B1 (en) * 2007-11-28 2015-09-02 UCB Pharma GmbH Polymorphic form of rotigotine
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US20110313176A1 (en) * 2008-12-26 2011-12-22 Actavis Group Ptc Ehf Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof
EP2201941A1 (de) 2008-12-29 2010-06-30 UCB Pharma GmbH Pflaster-Herstellungstechnologie
EP2281559A1 (en) 2009-06-26 2011-02-09 UCB Pharma GmbH Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
PL3257504T3 (pl) 2009-12-22 2024-10-21 UCB Biopharma SRL Poliwinylopirolidon do stabilizacji stałej dyspersji niekrystalicznej postaci rotygotyny
JP5699030B2 (ja) * 2010-07-05 2015-04-08 Ａｘｉｓ株式会社 エタネルセプトを含む線維筋痛症の治療剤
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DE102012013439A1 (de) 2012-07-03 2014-01-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermales therapeutisches System umfassend Rotigotin und Kristallisationsinhibitor
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